Skip to main content

Publications

What type of publication do you want to show?

2024

Optimization of SARS-CoV-2 culture from clinical samples for clinical trial applications.

Wooding, D., Buist, K., Romero-Ramirez, A., Savage, H., Watkins, R., Bengey, D., . . . Edwards, T. (2024). Optimization of SARS-CoV-2 culture from clinical samples for clinical trial applications.. mSphere, e0030424. doi:10.1128/msphere.00304-24

DOI
10.1128/msphere.00304-24
Journal article

Tenofovir, emtricitabine, lamivudine and dolutegravir concentrations in plasma and urine following drug intake cessation in a randomized controlled directly observed pharmacokinetic trial to aid point-of-care testing.

Else, L. J., Dickinson, L., Edick, S., Zyhowski, A., Ho, K., Meyn, L., . . . Brand, R. M. (2024). Tenofovir, emtricitabine, lamivudine and dolutegravir concentrations in plasma and urine following drug intake cessation in a randomized controlled directly observed pharmacokinetic trial to aid point-of-care testing.. The Journal of antimicrobial chemotherapy, 79(7), 1597-1605. doi:10.1093/jac/dkae147

DOI
10.1093/jac/dkae147
Journal article

2023

K-Ras independence due to N-Ras expression in cancer cell lines giving resistance to K-Ras specific inhibitors

Ferguson, R., Aughton, K., Evans, A., Shaw, V., Costello, E., & Greenhalf, W. (2023). K-Ras independence due to N-Ras expression in cancer cell lines giving resistance to K-Ras specific inhibitors. Pancreatology, 23, e149. doi:10.1016/j.pan.2023.06.783

DOI
10.1016/j.pan.2023.06.783
Journal article

Wild-type N-Ras Complements Mutant K-Ras in Pancreatic Cancer Cell Lines but K-Ras has a Specific Role in Cell Cycle Independent Regulation of G2 Cyclins

DOI
10.20944/preprints202210.0296.v2
Preprint

2022

Wild-type N-Ras Complements Mutant K-Ras in Pancreatic Cancer Cell Lines but K-Ras has a Specific Role in Cell Cycle Independent Regulation of G2 Cyclins

DOI
10.20944/preprints202210.0296.v1
Preprint

Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial

Khoo, S. H., FitzGerald, R., Saunders, G., Middleton, C., Ahmad, S., Edwards, C. J., . . . Vyas, A. (2022). Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. The Lancet Infectious Diseases. doi:10.1016/s1473-3099(22)00644-2

DOI
10.1016/s1473-3099(22)00644-2
Journal article

Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

FitzGerald, R., Dickinson, L., Else, L., Fletcher, T., Hale, C., Amara, A., . . . Khoo, S. (2022). Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. CLINICAL INFECTIOUS DISEASES. doi:10.1093/cid/ciac199

DOI
10.1093/cid/ciac199
Journal article

2021

Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

Khoo, S. H., Fitzgerald, R., Fletcher, T., Ewings, S., Jaki, T., Lyon, R., . . . Griffiths, G. (2021). Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 76(12), 3286-3295. doi:10.1093/jac/dkab318

DOI
10.1093/jac/dkab318
Journal article

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study

Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2

DOI
10.1016/S2666-5247(21)00090-2
Journal article

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2

DOI
10.1016/S2213-2600(21)00175-2
Journal article

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.

Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1

DOI
10.1016/s2665-9913(21)00104-1
Journal article

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178

DOI
10.1002/oby.23178
Journal article

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8

DOI
10.1016/S2213-2600(21)00013-8
Journal article

Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol

Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317

DOI
10.1136/bmjopen-2020-048317
Journal article

2020

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (vol 10, 1796, 2020)

McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., . . . Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (vol 10, 1796, 2020). SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-61783-9

DOI
10.1038/s41598-020-61783-9
Journal article

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.

McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., . . . Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.. Scientific reports, 10(1). doi:10.1038/s41598-020-58790-1

DOI
10.1038/s41598-020-58790-1
Journal article

2018

Biomarker predication of efficacy to gemcitabine plus vandetanib in phase II, double blind multicentre randomised controlled trial of gemcitabine placebo in locally advanced or metastatic pancreatic carcinoma

Evans, A., Jackson, R., Shaw, V. E., Ghaneh, P., Wadsley, J., Valle, J. W., . . . Middleton, G. (2018). Biomarker predication of efficacy to gemcitabine plus vandetanib in phase II, double blind multicentre randomised controlled trial of gemcitabine placebo in locally advanced or metastatic pancreatic carcinoma. Pancreatology, 18(4), S127-S128. doi:10.1016/j.pan.2018.05.343

DOI
10.1016/j.pan.2018.05.343
Journal article

2017

Biomarker prediction of efficacy to vandetanib plus gemcitabine in a phase II double blind multicenter randomized placebo controlled trial in locally advanced or metastatic pancreatic carcinoma.

Neoptolemos, J. P., Palmer, D., Greenhalf, W., Ghaneh, P., Jackson, R., Evans, A., . . . Middleton, G. W. (2017). Biomarker prediction of efficacy to vandetanib plus gemcitabine in a phase II double blind multicenter randomized placebo controlled trial in locally advanced or metastatic pancreatic carcinoma.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 35. doi:10.1200/JCO.2017.35.15_suppl.4104

DOI
10.1200/JCO.2017.35.15_suppl.4104
Conference Paper

Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial

Middleton, G., Palmer, D. H., Greenhalf, W., Ghaneh, P., Jackson, R., Cox, T., . . . Neoptolemos, J. P. (2017). Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial. The Lancet Oncology, 18(4), 486-499. doi:10.1016/S1470-2045(17)30084-0

DOI
10.1016/S1470-2045(17)30084-0
Journal article

2016

miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer

Muehlberg, L., Kuehnemuth, B., Costello, E., Shaw, V., Sipos, B., Huber, M., . . . Michl, P. (2016). miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer. ONCOIMMUNOLOGY, 5(6). doi:10.1080/2162402X.2016.1160181

DOI
10.1080/2162402X.2016.1160181
Journal article

Single-Nucleotide Polymorphism to Associate Cancer Risk

Shaw, V., Bullock, K., & Greenhalf, W. (2016). Single-Nucleotide Polymorphism to Associate Cancer Risk. CANCER GENE PROFILING, 1381, 93-110. doi:10.1007/978-1-4939-3204-7_6

DOI
10.1007/978-1-4939-3204-7_6
Journal article

2015

Post-translational modifications of ribonucleotide reductase can explain acquired gemcitabine resistance in pancreatic cancer

Mann, K., Melling, J., Rogoyski, B., Shaw, V., Ghaneh, P., & Greenhalf, W. (2015). Post-translational modifications of ribonucleotide reductase can explain acquired gemcitabine resistance in pancreatic cancer. Pancreatology, 15(3), S20. doi:10.1016/j.pan.2015.05.105

DOI
10.1016/j.pan.2015.05.105
Journal article

miRNA-21 modulates tumour progression by altering the functional phenotype of tumour-associated macrophages in pancreatic cancer

Muehlberg, L., Kuehnemuth, B., Costello, E., Shaw, V., Griesmann, H., Egidi, M., . . . Michl, P. (2015). miRNA-21 modulates tumour progression by altering the functional phenotype of tumour-associated macrophages in pancreatic cancer. Pancreatology, 15(3), S41-S42. doi:10.1016/j.pan.2015.05.173

DOI
10.1016/j.pan.2015.05.173
Journal article

2014

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

Middleton, G., Silcocks, P., Cox, T. F., Valle, J., Wadsley, J., Propper, D., . . . Neoptolemos, J. P. (2014). Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. The Lancet Oncology, 15(8), 829-840. doi:10.1016/S1470-2045(14)70236-0

DOI
10.1016/S1470-2045(14)70236-0
Journal article

Predictive cytokine biomarkers for survival in patients with advanced pancreatic cancer randomized to sequential chemoimmunotherapy comprising gemcitabine and capecitabine (GemCap) followed by the telomerase vaccine GV1001 compared to concurrent chemoimmunotherapy in the TeloVac phase III trial

Neoptolemos, J. P., Greenhalf, W., Cox, T. F., Costello, E., Shaw, V., Valle, J. W., . . . Middleton, G. (2014). Predictive cytokine biomarkers for survival in patients with advanced pancreatic cancer randomized to sequential chemoimmunotherapy comprising gemcitabine and capecitabine (GemCap) followed by the telomerase vaccine GV1001 compared to concurrent chemoimmunotherapy in the TeloVac phase III trial. In JOURNAL OF CLINICAL ONCOLOGY Vol. 32 (pp. 4121). doi:10.1200/jco.2014.32.15_suppl.4121

DOI
10.1200/jco.2014.32.15_suppl.4121
Conference Paper

Serum cytokine biomarker panels for discriminating Pancreatic Cancer from Benign Pancreatic Disease

Shaw, V. E., Lane, B., Jenkinson, C., Cox, T. F., Greenhalf, W., Halloran, C. M., . . . Costello, E. (2014). Serum cytokine biomarker panels for discriminating Pancreatic Cancer from Benign Pancreatic Disease. Molecular Cancer, 13. Retrieved from https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-13-114

Journal article

The effects of gemcitabine and capecitabine combination chemotherapy and of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer

Annels, N. E., Shaw, V. E., Gabitass, R. F., Billingham, L., Corrie, P., Eatock, M., . . . Middleton, G. (2014). The effects of gemcitabine and capecitabine combination chemotherapy and of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY, 63(2), 175-183. doi:10.1007/s00262-013-1502-y

DOI
10.1007/s00262-013-1502-y
Journal article

2013

A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer.

Middleton, G. W., Valle, J. W., Wadsley, J., Propper, D., Coxon, F. Y., Ross, P. J., . . . Neoptolemos, J. P. (2013). A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer.. Journal of Clinical Oncology, 31(18_suppl), LBA4004. doi:10.1200/jco.2013.31.18_suppl.lba4004

DOI
10.1200/jco.2013.31.18_suppl.lba4004
Journal article

A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer.

Middleton, G. W., Valle, J. W., Wadsley, J., Propper, D., Coxon, F. Y., Ross, P. J., . . . Neoptolemos, J. P. (2013). A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer.. Journal of Clinical Oncology, 31(15_suppl), LBA4004. doi:10.1200/jco.2013.31.15_suppl.lba4004

DOI
10.1200/jco.2013.31.15_suppl.lba4004
Journal article

iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance

Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. BRITISH JOURNAL OF CANCER, 108(9), 1846-1853. doi:10.1038/bjc.2013.150

DOI
10.1038/bjc.2013.150
Journal article

Quantification of pancreatic ductal adenocarcinoma stroma

Hand, K., Oldfield, F., Shaw, V., Jenkinson, C., Campbell, F., Neoptolemos, J., . . . Greenhalf, W. (2013). Quantification of pancreatic ductal adenocarcinoma stroma. Pancreatology, 13(3), S28. doi:10.1016/j.pan.2013.04.088

DOI
10.1016/j.pan.2013.04.088
Journal article

iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance

Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. British Journal of Cancer, 108(9), 1846-1853. doi:10.1038/bjc.2013.150

DOI
10.1038/bjc.2013.150
Journal article

2012

Combination cytokine, chemokine and growth factor biomarkers for diagnosis of pancreatic cancer

Shaw, V. E., Jenkinson, C., Lane, B., Greenhalf, B., Neoptolemos, J. P., & Costello, E. (2012). Combination cytokine, chemokine and growth factor biomarkers for diagnosis of pancreatic cancer. Pancreatology, 12(6), 545. doi:10.1016/j.pan.2012.11.148

DOI
10.1016/j.pan.2012.11.148
Journal article

2010

Abstract P2-09-37: Immunohistochemical Markers Progesterone Receptor, HER2, Ki67 and bcl-2-Associated Athanogene 1 and Prediction of Adjuvant Tamoxifen Treatment Outcome in ER+ Early Breast Cancer

Gee, J. M., Aleskandarany, M. A., Finlay, P., Farrow, L., Nicholson, R. I., Habashy, H. O., . . . Ellis, I. O. (2010). Abstract P2-09-37: Immunohistochemical Markers Progesterone Receptor, HER2, Ki67 and bcl-2-Associated Athanogene 1 and Prediction of Adjuvant Tamoxifen Treatment Outcome in ER+ Early Breast Cancer. Cancer Research, 70(24_Supplement). doi:10.1158/0008-5472.sabcs10-p2-09-37

DOI
10.1158/0008-5472.sabcs10-p2-09-37
Journal article

Diagnostic Markers of Pancreatic Cancer: Serum Cytokines, Chemokines, and Growth Factors

Fung Tang, J. M., Shaw, V., Jenkinson, C., Greenhalf, W., Neoptolemos, J., & Costello, E. (2010). Diagnostic Markers of Pancreatic Cancer: Serum Cytokines, Chemokines, and Growth Factors. European Journal of Surgical Oncology, 36(11), 1096. doi:10.1016/j.ejso.2010.08.093

DOI
10.1016/j.ejso.2010.08.093
Journal article

Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer

Shaw, V. E., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. EXPERT REVIEW OF VACCINES, 9(9), 1007-1016. doi:10.1586/ERV.10.92

DOI
10.1586/ERV.10.92
Journal article

2009

The Dark Side of Antihormonal Action in Breast Cancer

Gee, J. M. W., Stone, A., McClelland, R. A., Hiscox, S., Hutcheson, I. R., Jordan, N. J., . . . Nicholson, R. I. (n.d.). The Dark Side of Antihormonal Action in Breast Cancer. In Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer (pp. 63-84). Springer Netherlands. doi:10.1007/978-1-4020-8526-0_4

DOI
10.1007/978-1-4020-8526-0_4
Chapter

2008

Anti-oestrogens but not oestrogen deprivation promote cellular invasion in intercellular adhesion-deficient breast cancer cells

Borley, A. C., Hiscox, S., Gee, J., Smith, C., Shaw, V., Barrett-Lee, P., & Nicholson, R. I. (2008). Anti-oestrogens but not oestrogen deprivation promote cellular invasion in intercellular adhesion-deficient breast cancer cells. BREAST CANCER RESEARCH, 10(6). doi:10.1186/bcr2206

DOI
10.1186/bcr2206
Journal article

2006

Deciphering antihormone-induced compensatory mechanisms in breast cancer and their therapeutic implications

Gee, J. M. W., Shaw, V. E., Hiscox, S. E., McClelland, R. A., Rushmere, N. K., & Nicholson, R. I. (2006). Deciphering antihormone-induced compensatory mechanisms in breast cancer and their therapeutic implications. ENDOCRINE-RELATED CANCER, 13, S77-S88. doi:10.1677/erc.1.01274

DOI
10.1677/erc.1.01274
Journal article