Publications
Selected publications
- Redox changes in obesity, metabolic syndrome, and diabetes (Journal article - 2021)
- Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration? (Journal article - 2018)
- N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene (Journal article - 2018)
- Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue (Journal article - 2017)
- Cellular mechano-environment regulates the mammary circadian clock (Journal article - 2017)
- Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression (Journal article - 2016)
- The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis (Journal article - 2014)
- Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation (Journal article - 2011)
- The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation (Journal article - 2008)
- Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts (Journal article - 2007)
2024
A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.
Thoma, A., Alomosh, R., Bond, H. L., Akter-Miah, T., Al-Shanti, N., Degens, H., . . . Lightfoot, A. P. (2024). A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.. Journal of cellular physiology, e31458. doi:10.1002/jcp.31458
Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue.
Zakic, T., Pekovic-Vaughan, V., Cvoro, A., Korac, A., Jankovic, A., & Korac, B. (2024). Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue.. FEBS letters, 598(17), 2106-2134. doi:10.1002/1873-3468.14794
NRF2/AMPK AXIS IS REQUIRED FOR REDOX-MEDIATED PHASE RESETTING OF MUSCULOSKELETAL CLOCKS UPON ACUTE MECHANICAL LOADING
Ersoy, U., Winstanley-Zarach, P., Poulet, B., & Pekovic-Vaughan, V. (n.d.). NRF2/AMPK AXIS IS REQUIRED FOR REDOX-MEDIATED PHASE RESETTING OF MUSCULOSKELETAL CLOCKS UPON ACUTE MECHANICAL LOADING. RedoXplore, 1(1). doi:10.70200/rx202401038e
Lifelong effects of maternal low protein diet on skeletal muscle development and ageing in male offsprings
Altinpinar, A. E., Ersoy, U., Alameddine, M., Pekovic-Vaughan, V., Kanakis, I., Whysall, K. G., & Vasilaki, A. (2024). Lifelong effects of maternal low protein diet on skeletal muscle development and ageing in male offsprings. Free Radical Biology and Medicine, 218, 39. doi:10.1016/j.freeradbiomed.2024.04.142
The role of Nrf2 in redox coupling of tumor and adipose tissue in orthotopic breast cancer model
Zakic, T., Vukobratovic, M., Djuric, S., Korac, A., Pekovic-Vaughan, V., Jankovic, A., & Korac, B. (2024). The role of Nrf2 in redox coupling of tumor and adipose tissue in orthotopic breast cancer model. Free Radical Biology and Medicine, 218, 15-16. doi:10.1016/j.freeradbiomed.2024.04.060
Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.
Dalby, M. J., Pekovic-Vaughan, V., Shanley, D. P., Swift, J., White, L. J., & Canty-Laird, E. G. (2024). Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.. BioEssays : news and reviews in molecular, cellular and developmental biology, 46(5), e2300223. doi:10.1002/bies.202300223
A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts
2023
ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING
Pekovic-Vaughan, V., Sutton, E., Carter, A., Fawcett, S., Moore, H., Sarumi, D., & Bou-Gharios, G. (2023). ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 4). doi:10.1016/j.freeradbiomed.2023.03.042
THE DISCREPANCY BETWEEN MORPHOLOGICAL AND FUNCTIONAL ACTIVATION OF BROWN ADIPOSE TISSUE IN THE ABSENCE OF FUNCTIONAL NRF2
Zakic, T., Soskic, M. B., Stojanovic, S., Jankovic, A., Korac, A., Pekovic-Vaughan, V., & Korac, B. (2023). THE DISCREPANCY BETWEEN MORPHOLOGICAL AND FUNCTIONAL ACTIVATION OF BROWN ADIPOSE TISSUE IN THE ABSENCE OF FUNCTIONAL NRF2. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 25). doi:10.1016/j.freeradbiomed.2023.03.109
Shorter sleep duration is associated with greater visceral fat mass in US adults: Findings from NHANES, 2011-2014.
Giannos, P., Prokopidis, K., Candow, D. G., Forbes, S. C., Celoch, K., Isanejad, M., . . . Scott, D. (2023). Shorter sleep duration is associated with greater visceral fat mass in US adults: Findings from NHANES, 2011-2014.. Sleep medicine, 105, 78-84. doi:10.1016/j.sleep.2023.03.013
2022
Redox-metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation
Zakic, T., Stojanovic, S., Jankovic, A., Korac, A., Pekovic-Vaughan, V., & Korac, B. (2022). Redox-metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation. BIOFACTORS. doi:10.1002/biof.1931
STRUCTURAL AND REDOX-METABOLIC REMODELLING OF BROWN ADIPOSE TISSUE IN MICE LACKING NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 UNDER BASAL CONDITIONS AND COLD ACCLIMATION
Zakic, T., Ninkovic, A., Stojanovic, S., Soskic, M. B., Kalezic, A., Jankovic, A., . . . Korac, B. (2022). STRUCTURAL AND REDOX-METABOLIC REMODELLING OF BROWN ADIPOSE TISSUE IN MICE LACKING NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 UNDER BASAL CONDITIONS AND COLD ACCLIMATION. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 189 (pp. 5-6). Retrieved from https://www.webofscience.com/
2021
A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock
Sutton, E., Carter, A., Fawcett, S., Sarumi, D., Copple, I., & Pekovic-Vaughan, V. (2021). A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.103
NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions
Sutton, E., Early, J., Hughes, A., Gall, L., Carter, A., Copple, I., . . . Pekovic-Vaughan, V. (2021). NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.042
Redox changes in obesity, metabolic syndrome, and diabetes
Korac, B., Kalezic, A., Pekovic-Vaughan, V., Korac, A., & Jankovic, A. (2021). Redox changes in obesity, metabolic syndrome, and diabetes. REDOX BIOLOGY, 42. doi:10.1016/j.redox.2021.101887
2019
Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner
Sutton, E., Carter, A., Early, J., Fawcett, S., Sarumi, D., Bechtold, D., & Pekovic-Vaughan, V. (2019). Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 139 (pp. S52). Retrieved from https://www.webofscience.com/
The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis
Sarumi, D., Carter, A., Fawcett, S. A., Sutton, E., Van derhorst, G. T. J., Kearns, V., . . . Pekovic-Vaughan, V. (2019). The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A45). Retrieved from https://www.webofscience.com/
2018
Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration?
Rogers, E. H., Hunt, J. A., & Pekovic-Vaughan, V. (2018). Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration?. BIOGERONTOLOGY, 19(6), 497-517. doi:10.1007/s10522-018-9772-6
Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials
Rogers, E. H., Pekovic-Vaughan, V., & Hunt, J. A. (2018). Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials. BIOMEDICINE-TAIWAN, 8(3), 3-12. doi:10.1051/bmdcn/2018080314
N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene
Rodriguez, B. M., Khouzami, L., Decostre, V., Varnous, S., Pekovic-Vaughan, V., Hutchison, C. J., . . . Muchir, A. (2018). N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene. Human Molecular Genetics, 27(19), 3353-3360. doi:10.1093/hmg/ddy243
A novel role for fibrillin 1 in the regulation of clock gene transcription and circadian rhythmicity through the TGF b pathway
Fawcett, S. A., & Pekovic-Vaughan, V. (2018). A novel role for fibrillin 1 in the regulation of clock gene transcription and circadian rhythmicity through the TGF b pathway. In Matrix biology Europe. Manchester.
Cellular mechano-environment regulates the mammary circadian clock
Yang, N., Williams, J., Pekovic-Vaughan, V., Wang, P., Olabi, S., McConnell, J., . . . Meng, Q. J. (2018). Cellular mechano-environment regulates the mammary circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A67). Retrieved from https://www.webofscience.com/
2017
Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue
Rogers, E. H., Fawcett, S. A., Pekovic-Vaughan, V., & Hunt, J. A. (2017). Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue. STEM CELLS INTERNATIONAL, 2017, 13 pages. doi:10.1155/2017/2057168
NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function
Horton, N. S., Copple, I. M., Vasilaki, A., Jackson, M. J., McArdle, A., & Pekovic-Vaughan, V. (2017). NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 108 (pp. S48). doi:10.1016/j.freeradbiomed.2017.04.174
Cellular mechano-environment regulates the mammary circadian clock
Yang, N., Williams, J., Pekovic-Vaughan, V., Wang, P., Olabi, S., McConnell, J., . . . Meng, Q. -J. (2017). Cellular mechano-environment regulates the mammary circadian clock. Nature Communications, 8. doi:10.1038/ncomms14287
Ageing-induced osteoarthritis in nrf2 knockout mice
Lyon, M., Pekovic-Vaughan, V., & Poulet, B. (2017). Ageing-induced osteoarthritis in nrf2 knockout mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 98 (pp. A4). Retrieved from https://www.webofscience.com/
2016
Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression
Goljanek-Whysall, K., Iwanejko, L. A., Vasilaki, A., Pekovic-Vaughan, V., & McDonagh, B. (2016). Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression. MAMMALIAN GENOME, 27(7-8), 341-357. doi:10.1007/s00335-016-9643-x
Antioxidant transcription factor Nrf2 mediates diurnal control of cutaneous wound repair by a redox mechanism that declines with ageing
Pekovic-Vaughan, V., Carter, A., Marr, N., Roskell, C., Clegg, P., Jackson, M., & Bou-Gharios, G. (2016). Antioxidant transcription factor Nrf2 mediates diurnal control of cutaneous wound repair by a redox mechanism that declines with ageing. Free Radical Biology and Medicine, 96, S40. doi:10.1016/j.freeradbiomed.2016.04.081
Pharmacological manipulation of Nrf2/Keap1-mediated antioxidant defence pathway regulates the circadian clock
Horton, N., Copple, I., Park, K., Jackson, M., McArdle, A., & Pekovic-Vaughan, V. (2016). Pharmacological manipulation of Nrf2/Keap1-mediated antioxidant defence pathway regulates the circadian clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 96 (pp. S38-S39). doi:10.1016/j.freeradbiomed.2016.04.077
An ageing matrix weakens the breast circadian clock
Williams, J. L., Yang, N., Pekovic-Vaughan, V., Wang, P., McConnell, J., Olabi, S., . . . Meng, Q. J. (2016). An ageing matrix weakens the breast circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A2-A3). Retrieved from https://www.webofscience.com/
Nuclear lamins as mediators of mechano-transduction pathways regulating the temporal activation of circadian clock genes in skeletal muscle cells in response to mechanical cues
Roskell, C., Goldberg, M., Shanley, D., Clegg, P., & Pekovic-Vaughan, V. (2016). Nuclear lamins as mediators of mechano-transduction pathways regulating the temporal activation of circadian clock genes in skeletal muscle cells in response to mechanical cues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A19-A20). Retrieved from https://www.webofscience.com/
Tissue mechanics control the robustness of the circadian clock
Yang, N., Williams, J., Pekovic-Vaughan, V., Gossan, N., Hughes, A., Cheung, J., . . . Meng, Q. J. (2016). Tissue mechanics control the robustness of the circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A3). Retrieved from https://www.webofscience.com/
2014
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
Pekovic-Vaughan, V., Gibbs, J., Yoshitane, H., Yang, N., Pathiranage, D., Guo, B., . . . Meng, Q. -J. (2014). The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes and Development, 28(6), 548-560. doi:10.1101/gad.237081.113
2011
Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation
Pekovic, V., Gibbs-Seymour, I., Markiewicz, E., Alzoghaibi, F., Benham, A. M., Edwards, R., . . . Hutchison, C. J. (2011). Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation. AGING CELL, 10(6), 1067-1079. doi:10.1111/j.1474-9726.2011.00750.x
A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal
Korfali, N., Srsen, V., Waterfall, M., Batrakou, D. G., Pekovic, V., Hutchison, C. J., & Schirmer, E. C. (2011). A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal. PLOS ONE, 6(4). doi:10.1371/journal.pone.0018762
2009
A-type lamins, disease and ageing: a stress-induced relationship?
Pekovic, V., & Hutchison, C. J. (2009). A-type lamins, disease and ageing: a stress-induced relationship?. In Unknown Book (Vol. 62, pp. 139-170).
2008
The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation
Ojeh, N., Pekovic, V., Jahoda, C., & Maatta, A. (2008). The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. JOURNAL OF CELL SCIENCE, 121(16), 2705-2717. doi:10.1242/jcs.025643
Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches
Pekovic, V., & Hutchison, C. J. (2008). Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches. JOURNAL OF ANATOMY, 213(1), 5-25. doi:10.1111/j.1469-7580.2008.00928.x
2007
Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts
Pekovic, V., Harborth, J., Broers, J. L. V., Ramaekers, F. C. S., van Engelen, B., Lammens, M., . . . Markiewicz, E. (2007). Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts. JOURNAL OF CELL BIOLOGY, 176(2), 163-172. doi:10.1083/jcb.200606139