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Dr Vanja Pekovic-Vaughan
BSc, PhD, FHEA

Senior Lecturer in Circadian & Musculoskeletal Physiology; Science of Medicine Theme Lead (School of Medicine)
Musculoskeletal & Ageing Science

Publications

Selected publications

  1. Redox changes in obesity, metabolic syndrome, and diabetes (Journal article - 2021)
  2. Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration? (Journal article - 2018)
  3. N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene (Journal article - 2018)
  4. Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue (Journal article - 2017)
  5. Cellular mechano-environment regulates the mammary circadian clock (Journal article - 2017)
  6. Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression (Journal article - 2016)
  7. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis (Journal article - 2014)
  8. Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation (Journal article - 2011)
  9. The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation (Journal article - 2008)
  10. Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts (Journal article - 2007)
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2024

A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.

Thoma, A., Alomosh, R., Bond, H. L., Akter-Miah, T., Al-Shanti, N., Degens, H., . . . Lightfoot, A. P. (2024). A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.. Journal of cellular physiology, e31458. doi:10.1002/jcp.31458

DOI
10.1002/jcp.31458
Journal article

Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue.

Zakic, T., Pekovic-Vaughan, V., Cvoro, A., Korac, A., Jankovic, A., & Korac, B. (2024). Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue.. FEBS letters, 598(17), 2106-2134. doi:10.1002/1873-3468.14794

DOI
10.1002/1873-3468.14794
Journal article

NRF2/AMPK AXIS IS REQUIRED FOR REDOX-MEDIATED PHASE RESETTING OF MUSCULOSKELETAL CLOCKS UPON ACUTE MECHANICAL LOADING

Ersoy, U., Winstanley-Zarach, P., Poulet, B., & Pekovic-Vaughan, V. (n.d.). NRF2/AMPK AXIS IS REQUIRED FOR REDOX-MEDIATED PHASE RESETTING OF MUSCULOSKELETAL CLOCKS UPON ACUTE MECHANICAL LOADING. RedoXplore, 1(1). doi:10.70200/rx202401038e

DOI
10.70200/rx202401038e
Journal article

Lifelong effects of maternal low protein diet on skeletal muscle development and ageing in male offsprings

Altinpinar, A. E., Ersoy, U., Alameddine, M., Pekovic-Vaughan, V., Kanakis, I., Whysall, K. G., & Vasilaki, A. (2024). Lifelong effects of maternal low protein diet on skeletal muscle development and ageing in male offsprings. Free Radical Biology and Medicine, 218, 39. doi:10.1016/j.freeradbiomed.2024.04.142

DOI
10.1016/j.freeradbiomed.2024.04.142
Journal article

The role of Nrf2 in redox coupling of tumor and adipose tissue in orthotopic breast cancer model

Zakic, T., Vukobratovic, M., Djuric, S., Korac, A., Pekovic-Vaughan, V., Jankovic, A., & Korac, B. (2024). The role of Nrf2 in redox coupling of tumor and adipose tissue in orthotopic breast cancer model. Free Radical Biology and Medicine, 218, 15-16. doi:10.1016/j.freeradbiomed.2024.04.060

DOI
10.1016/j.freeradbiomed.2024.04.060
Journal article

Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.

Dalby, M. J., Pekovic-Vaughan, V., Shanley, D. P., Swift, J., White, L. J., & Canty-Laird, E. G. (2024). Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.. BioEssays : news and reviews in molecular, cellular and developmental biology, 46(5), e2300223. doi:10.1002/bies.202300223

DOI
10.1002/bies.202300223
Journal article

A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts

DOI
10.1101/2024.04.10.588847
Preprint

2023

ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING

Pekovic-Vaughan, V., Sutton, E., Carter, A., Fawcett, S., Moore, H., Sarumi, D., & Bou-Gharios, G. (2023). ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 4). doi:10.1016/j.freeradbiomed.2023.03.042

DOI
10.1016/j.freeradbiomed.2023.03.042
Conference Paper

THE DISCREPANCY BETWEEN MORPHOLOGICAL AND FUNCTIONAL ACTIVATION OF BROWN ADIPOSE TISSUE IN THE ABSENCE OF FUNCTIONAL NRF2

Zakic, T., Soskic, M. B., Stojanovic, S., Jankovic, A., Korac, A., Pekovic-Vaughan, V., & Korac, B. (2023). THE DISCREPANCY BETWEEN MORPHOLOGICAL AND FUNCTIONAL ACTIVATION OF BROWN ADIPOSE TISSUE IN THE ABSENCE OF FUNCTIONAL NRF2. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 25). doi:10.1016/j.freeradbiomed.2023.03.109

DOI
10.1016/j.freeradbiomed.2023.03.109
Conference Paper

2022

Redox-metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation

Zakic, T., Stojanovic, S., Jankovic, A., Korac, A., Pekovic-Vaughan, V., & Korac, B. (2022). Redox-metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation. BIOFACTORS. doi:10.1002/biof.1931

DOI
10.1002/biof.1931
Journal article

STRUCTURAL AND REDOX-METABOLIC REMODELLING OF BROWN ADIPOSE TISSUE IN MICE LACKING NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 UNDER BASAL CONDITIONS AND COLD ACCLIMATION

Zakic, T., Ninkovic, A., Stojanovic, S., Soskic, M. B., Kalezic, A., Jankovic, A., . . . Korac, B. (2022). STRUCTURAL AND REDOX-METABOLIC REMODELLING OF BROWN ADIPOSE TISSUE IN MICE LACKING NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 UNDER BASAL CONDITIONS AND COLD ACCLIMATION. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 189 (pp. 5-6). Retrieved from https://www.webofscience.com/

Conference Paper

2021

A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock

Sutton, E., Carter, A., Fawcett, S., Sarumi, D., Copple, I., & Pekovic-Vaughan, V. (2021). A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.103

DOI
10.1016/j.freeradbiomed.2021.08.103
Conference Paper

NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions

Sutton, E., Early, J., Hughes, A., Gall, L., Carter, A., Copple, I., . . . Pekovic-Vaughan, V. (2021). NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.042

DOI
10.1016/j.freeradbiomed.2021.08.042
Conference Paper

2019

Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner

Sutton, E., Carter, A., Early, J., Fawcett, S., Sarumi, D., Bechtold, D., & Pekovic-Vaughan, V. (2019). Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 139 (pp. S52). Retrieved from https://www.webofscience.com/

Conference Paper

The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis

Sarumi, D., Carter, A., Fawcett, S. A., Sutton, E., Van derhorst, G. T. J., Kearns, V., . . . Pekovic-Vaughan, V. (2019). The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A45). Retrieved from https://www.webofscience.com/

Conference Paper

2018

N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene

Rodriguez, B. M., Khouzami, L., Decostre, V., Varnous, S., Pekovic-Vaughan, V., Hutchison, C. J., . . . Muchir, A. (2018). N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene. Human Molecular Genetics, 27(19), 3353-3360. doi:10.1093/hmg/ddy243

DOI
10.1093/hmg/ddy243
Journal article

A novel role for fibrillin 1 in the regulation of clock gene transcription and circadian rhythmicity through the TGF b pathway

Fawcett, S. A., & Pekovic-Vaughan, V. (2018). A novel role for fibrillin 1 in the regulation of clock gene transcription and circadian rhythmicity through the TGF b pathway. In Matrix biology Europe. Manchester.

Conference Paper

Cellular mechano-environment regulates the mammary circadian clock

Yang, N., Williams, J., Pekovic-Vaughan, V., Wang, P., Olabi, S., McConnell, J., . . . Meng, Q. J. (2018). Cellular mechano-environment regulates the mammary circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A67). Retrieved from https://www.webofscience.com/

Conference Paper

2017

NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function

Horton, N. S., Copple, I. M., Vasilaki, A., Jackson, M. J., McArdle, A., & Pekovic-Vaughan, V. (2017). NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 108 (pp. S48). doi:10.1016/j.freeradbiomed.2017.04.174

DOI
10.1016/j.freeradbiomed.2017.04.174
Conference Paper

Ageing-induced osteoarthritis in nrf2 knockout mice

Lyon, M., Pekovic-Vaughan, V., & Poulet, B. (2017). Ageing-induced osteoarthritis in nrf2 knockout mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 98 (pp. A4). Retrieved from https://www.webofscience.com/

Conference Paper

2016

Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression

Goljanek-Whysall, K., Iwanejko, L. A., Vasilaki, A., Pekovic-Vaughan, V., & McDonagh, B. (2016). Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression. MAMMALIAN GENOME, 27(7-8), 341-357. doi:10.1007/s00335-016-9643-x

DOI
10.1007/s00335-016-9643-x
Journal article

Antioxidant transcription factor Nrf2 mediates diurnal control of cutaneous wound repair by a redox mechanism that declines with ageing

Pekovic-Vaughan, V., Carter, A., Marr, N., Roskell, C., Clegg, P., Jackson, M., & Bou-Gharios, G. (2016). Antioxidant transcription factor Nrf2 mediates diurnal control of cutaneous wound repair by a redox mechanism that declines with ageing. Free Radical Biology and Medicine, 96, S40. doi:10.1016/j.freeradbiomed.2016.04.081

DOI
10.1016/j.freeradbiomed.2016.04.081
Journal article

Pharmacological manipulation of Nrf2/Keap1-mediated antioxidant defence pathway regulates the circadian clock

Horton, N., Copple, I., Park, K., Jackson, M., McArdle, A., & Pekovic-Vaughan, V. (2016). Pharmacological manipulation of Nrf2/Keap1-mediated antioxidant defence pathway regulates the circadian clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 96 (pp. S38-S39). doi:10.1016/j.freeradbiomed.2016.04.077

DOI
10.1016/j.freeradbiomed.2016.04.077
Conference Paper

An ageing matrix weakens the breast circadian clock

Williams, J. L., Yang, N., Pekovic-Vaughan, V., Wang, P., McConnell, J., Olabi, S., . . . Meng, Q. J. (2016). An ageing matrix weakens the breast circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A2-A3). Retrieved from https://www.webofscience.com/

Conference Paper

Nuclear lamins as mediators of mechano-transduction pathways regulating the temporal activation of circadian clock genes in skeletal muscle cells in response to mechanical cues

Roskell, C., Goldberg, M., Shanley, D., Clegg, P., & Pekovic-Vaughan, V. (2016). Nuclear lamins as mediators of mechano-transduction pathways regulating the temporal activation of circadian clock genes in skeletal muscle cells in response to mechanical cues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A19-A20). Retrieved from https://www.webofscience.com/

Conference Paper

Tissue mechanics control the robustness of the circadian clock

Yang, N., Williams, J., Pekovic-Vaughan, V., Gossan, N., Hughes, A., Cheung, J., . . . Meng, Q. J. (2016). Tissue mechanics control the robustness of the circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A3). Retrieved from https://www.webofscience.com/

Conference Paper

2014

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

Pekovic-Vaughan, V., Gibbs, J., Yoshitane, H., Yang, N., Pathiranage, D., Guo, B., . . . Meng, Q. -J. (2014). The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes and Development, 28(6), 548-560. doi:10.1101/gad.237081.113

DOI
10.1101/gad.237081.113
Journal article

2011

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

Pekovic, V., Gibbs-Seymour, I., Markiewicz, E., Alzoghaibi, F., Benham, A. M., Edwards, R., . . . Hutchison, C. J. (2011). Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation. AGING CELL, 10(6), 1067-1079. doi:10.1111/j.1474-9726.2011.00750.x

DOI
10.1111/j.1474-9726.2011.00750.x
Journal article

A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal

Korfali, N., Srsen, V., Waterfall, M., Batrakou, D. G., Pekovic, V., Hutchison, C. J., & Schirmer, E. C. (2011). A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal. PLOS ONE, 6(4). doi:10.1371/journal.pone.0018762

DOI
10.1371/journal.pone.0018762
Journal article

2009

A-type lamins, disease and ageing: a stress-induced relationship?

Pekovic, V., & Hutchison, C. J. (2009). A-type lamins, disease and ageing: a stress-induced relationship?. In Unknown Book (Vol. 62, pp. 139-170).

Chapter

2008

The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation

Ojeh, N., Pekovic, V., Jahoda, C., & Maatta, A. (2008). The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. JOURNAL OF CELL SCIENCE, 121(16), 2705-2717. doi:10.1242/jcs.025643

DOI
10.1242/jcs.025643
Journal article

Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches

Pekovic, V., & Hutchison, C. J. (2008). Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches. JOURNAL OF ANATOMY, 213(1), 5-25. doi:10.1111/j.1469-7580.2008.00928.x

DOI
10.1111/j.1469-7580.2008.00928.x
Journal article

2007

Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts

Pekovic, V., Harborth, J., Broers, J. L. V., Ramaekers, F. C. S., van Engelen, B., Lammens, M., . . . Markiewicz, E. (2007). Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts. JOURNAL OF CELL BIOLOGY, 176(2), 163-172. doi:10.1083/jcb.200606139

DOI
10.1083/jcb.200606139
Journal article