Publications
2024
What is ‘research-led teaching’ and how can we deliver it in University STEM degrees?
Canniffe, D., Cartmell, A., & McClurg, U. (2024). What is ‘research-led teaching’ and how can we deliver it in University STEM degrees?. Journal of Biological Education, 1-15. doi:10.1080/00219266.2024.2351389
A short guide to addressing accessibility at scientific conferences.
McClurg, U. L. (2024). A short guide to addressing accessibility at scientific conferences.. Journal of cell science, 137(10), jcs261858. doi:10.1242/jcs.261858
Conference accessibility should be a universal concern.
McClurg, U. L. (2024). Conference accessibility should be a universal concern.. Nature cell biology, 26(3), 309. doi:10.1038/s41556-024-01346-6
2023
Towards inclusive and sustainable scientific meetings.
Chalmers, S. B., Madgwick, S., Lloyd-Lewis, B., McClurg, U. L., Elias, S., Andersen, P., . . . Davis, F. M. (2023). Towards inclusive and sustainable scientific meetings.. Nature cell biology, 25(11), 1557-1560. doi:10.1038/s41556-023-01222-9
P46 Meiotic proteins – liver cancer specific drug targets
Guthrie, M., Williams, M., Valji, A., Jones, R., Vimalachandran, D., Palmer, D., . . . McClurg, U. (2023). P46 Meiotic proteins – liver cancer specific drug targets. In Poster presentations (pp. A42.1-A42). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2023-basl.62
ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.
Scott, E., Archer Goode, E., Garnham, R., Hodgson, K., Orozco-Moreno, M., Turner, H., . . . Munkley, J. (2023). ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.. The Journal of pathology. doi:10.1002/path.6152
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.
Zhang, J., Hu, Z., Chung, H. H., Tian, Y., Lau, K. W., Ser, Z., . . . Tee, W. -W. (2023). Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.. Nature communications, 14(1), 2439. doi:10.1038/s41467-023-38132-1
Upregulation of GALNT7 in prostate cancer modifies <i>O</i>-glycosylation and promotes tumour growth
Scott, E., Hodgson, K., Calle, B., Turner, H., Cheung, K., Bermudez, A., . . . Munkley, J. (2023). Upregulation of GALNT7 in prostate cancer modifies <i>O</i>-glycosylation and promotes tumour growth. ONCOGENE, 42(12), 926-937. doi:10.1038/s41388-023-02604-x
Cancer and meiotic gene expression: Two sides of the same coin?
Sou, I. F., Hamer, G., Tee, W. -W., Vader, G., & McClurg, U. L. (2023). Cancer and meiotic gene expression: Two sides of the same coin?. In Unknown Book (Vol. 151, pp. 43-68). doi:10.1016/bs.ctdb.2022.06.002
2022
2021
Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12
Sandhu, S., Sou, I. F., Hunter, J. E., Salmon, L., Wilson, C. L., Perkins, N. D., . . . McClurg, U. L. (2021). Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12. COMMUNICATIONS BIOLOGY, 4(1). doi:10.1038/s42003-021-02887-4
Meiosis initiation: a story of two sexes in all creatures great and small
Sou, I. F., Pryce, R. M., Tee, W. -W., & McClurg, U. L. (2021). Meiosis initiation: a story of two sexes in all creatures great and small. BIOCHEMICAL JOURNAL, 478(20), 3791-3805. doi:10.1042/BCJ20210412
2020
Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
Prendergast, L., McClurg, U. L., Hristova, R., Berlinguer-Palmini, R., Greener, S., Veitch, K., . . . Papamichos-Chronakis, M. (2020). Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability. Nature Communications, 11. doi:10.1038/s41467-020-18306-x
Metabolism of multiple glycosaminoglycans by <i>Bacteroides thetaiotaomicron</i> is orchestrated by a versatile core genetic locus (vol 11, 646, 2020)
Ndeh, D., Basle, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by <i>Bacteroides thetaiotaomicron</i> is orchestrated by a versatile core genetic locus (vol 11, 646, 2020). NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18097-1
Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus
Ndeh, D., Baslé, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nature Communications, 11. doi:10.1038/s41467-020-14509-4
2019
A pseudo-meiotic centrosomal function of TEX12 in cancer
Sandhu, S., Salmon, L. J., Hunter, J. E., Wilson, C. L., Perkins, N. D., Hunter, N., . . . McClurg, U. L. (2019). A pseudo-meiotic centrosomal function of TEX12 in cancer. doi:10.1101/509869
2018
<i>Ex vivo</i> Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples
McClurg, U. L., McCracken, S. R., Butler, L., Riabowol, K. T., & Binda, O. (2018). <i>Ex vivo</i> Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples. BIO-PROTOCOL, 8(21). doi:10.21769/BioProtoc.3075
The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival
McClurg, U. L., Azizyan, M., Dransfield, D. T., Namdev, N., Chit, N. C. T. H., Nakjang, S., & Robson, C. N. (2018). The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival. Oncotarget, 9(38), 24992-25007. doi:10.18632/oncotarget.25167
Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12
McClurg, U. L., Chit, N. C. T. H., Azizyan, M., Edwards, J., Nabbi, A., Riabowol, K. T., . . . Robson, C. N. (2018). Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12. ONCOGENE, 37(34), 4679-4691. doi:10.1038/s41388-018-0283-3
Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein
McClurg, U. L., Nabbi, A., Ricordel, C., Korolchuk, S., McCracken, S., Heer, R., . . . Binda, O. (2018). Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. British Journal of Cancer, 118, 713-726. doi:10.1038/bjc.2017.447
2017
The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
Munkley, J., McClurg, U. L., Livermore, K. E., Ehrmann, I., Knight, B., Mccullagh, P., . . . Elliott, D. J. (2017). The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-05489-5
ING3 promotes prostate cancer growth by activating the androgen receptor
Nabbi, A., McClurg, U. L., Thalappilly, S., Almami, A., Mobahat, M., Bismar, T. A., . . . Riabowol, K. T. (2017). ING3 promotes prostate cancer growth by activating the androgen receptor. BMC MEDICINE, 15. doi:10.1186/s12916-017-0854-0
Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity
McClurg, U. L., Cork, D. M. W., Darby, S., Ryan-Munden, C. A., Nakjang, S., Cortes, L. M., . . . Robson, C. N. (2017). Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity. NUCLEIC ACIDS RESEARCH, 45(04), 1793-1804. doi:10.1093/nar/gkw1162
2016
A novel anti-androgen candidate galeterone acts by targeting USP12, a deubiquitinating enzyme that controls prostate cancer growth and survival
McClurg, U., Dransfield, D., Namdev, N., Jacoby, D., Chit, N., Nakjang, S., . . . Robson, C. (2016). A novel anti-androgen candidate galeterone acts by targeting USP12, a deubiquitinating enzyme that controls prostate cancer growth and survival. European Journal of Cancer, 69, S25. doi:10.1016/s0959-8049(16)32654-5
Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells
Logan, I. R., McClurg, U. L., Jones, D. L., O'Neill, D. J., Shaheen, F. S., Lunec, J., . . . Robson, C. N. (2016). Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells. ONCOTARGET, 7(46), 74724-74733. doi:10.18632/oncotarget.12542
Glycosylation is a global target for androgen control in prostate cancer cells
Munkley, J., Livermore, K. E., Vodak, D., James, K., Wilson, B. T., McClurg, U. L., . . . Elliott, D. J. (n.d.). Glycosylation is a global target for androgen control in prostate cancer cells. Endocrine Abstracts. doi:10.1530/endoabs.42.oc10
The deubiquitinating enzyme USP12 controls prostate cancer cell survival by regulating the AR-AKT-p53 signalling network
McClurg, U. L., Chit, N. C. T. H., Nakjang, S., Edwards, J., McCracken, S. R., & Robson, C. N. (n.d.). The deubiquitinating enzyme USP12 controls prostate cancer cell survival by regulating the AR-AKT-p53 signalling network. Endocrine Abstracts. doi:10.1530/endoabs.42.p9
Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3
Kim, S., Natesan, S., Cornilescu, G., Carlson, S., Tonelli, M., McClurg, U. L., . . . Glass, K. C. (2016). Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(35), 18326-18341. doi:10.1074/jbc.M115.690651
2015
Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
McClurg, U. L., Harle, V. J., Nabbi, A., Batalha-Pereira, A., Walker, S., Coffey, K., . . . Robson, C. N. (2015). Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer. ONCOTARGET, 6(35), 37724-37736. doi:10.18632/oncotarget.6075
The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.
Munkley, J., Livermore, K. E., McClurg, U. L., Kalna, G., Knight, B., McCullagh, P., . . . Elliott, D. J. (2015). The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.. Oncoscience, 2(9), 755-764. doi:10.18632/oncoscience.243
Deubiquitinating enzymes as oncotargets
McClurg, U. L., & Robson, C. N. (2015). Deubiquitinating enzymes as oncotargets. ONCOTARGET, 6(12), 9657-9668. doi:10.18632/oncotarget.3922
Epithelial cell ADAM17 activation by <i>Helicobacter pylori</i>: role of ADAM17 <i>C</i>-terminus and Threonine-735 phosphorylation
McClurg, U. L., Danjo, K., King, H. O., Scott, G. B., Robinson, P. A., & Crabtree, J. E. (2015). Epithelial cell ADAM17 activation by <i>Helicobacter pylori</i>: role of ADAM17 <i>C</i>-terminus and Threonine-735 phosphorylation. MICROBES AND INFECTION, 17(3), 205-214. doi:10.1016/j.micinf.2014.11.011
2014
Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway
McClurg, U. L., Summerscales, E. E., Harle, V. J., Gaughan, L., & Robson, C. N. (2014). Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway. ONCOTARGET, 5(16), 7081-7092. doi:10.18632/oncotarget.2162
Literature Search and Review
Davis, M. I., Lea, W., Simeonov, A., & Auld, D. (2014). Literature Search and Review. ASSAY and Drug Development Technologies, 12(2), 101-109. doi:10.1089/adt.2014.1202.lr
Two plasmid-encoded genes of enteropathogenic <i>Escherichia coli</i> strain K798 promote invasion and survival within HEp-2 cells
Burska, U. L., & Fletcher, J. N. (2014). Two plasmid-encoded genes of enteropathogenic <i>Escherichia coli</i> strain K798 promote invasion and survival within HEp-2 cells. APMIS, 122(10), 922-930. doi:10.1111/apm.12234
2013
Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor
Burska, U. L., Harle, V. J., Coffey, K., Darby, S., Ramsey, H., O'Neill, D., . . . Robson, C. N. (2013). Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(45), 32641-32650. doi:10.1074/jbc.M113.485912