Publications
2024
Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions
Dysregulated<i>SASS6</i>expression promotes increased ciliogenesis and cell invasion phenotypes
2023
3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration.
Newman, D., Young, L. E., Waring, T., Brown, L., Wolanska, K. I., MacDonald, E., . . . Zech, T. (2023). 3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration.. Cell reports, 42(12), 113554. doi:10.1016/j.celrep.2023.113554
Increased LANTA31 activates Akt signalling in breast cancer and changes the mode of tumour invasion into laminin matrixes
Asiri, F. M., Troughton, L. D., Zech, T., Bou-Gharios, G., Yamamoto, K., & Hamill, K. J. (2023). Increased LANTA31 activates Akt signalling in breast cancer and changes the mode of tumour invasion into laminin matrixes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A10). Retrieved from https://www.webofscience.com/
LANT α31 induces an epithelial to mesenchymal-like transition in pancreatic adenocarcinoma cells and changes laminin α3 expression
Sari, B., Hamill, K. J., Zech, T., & Yamamoto, K. (2023). LANT α31 induces an epithelial to mesenchymal-like transition in pancreatic adenocarcinoma cells and changes laminin α3 expression. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A8). Retrieved from https://www.webofscience.com/
2022
Laminin N-terminus α31 is upregulated in invasive ductal breast cancer and changes the mode of tumour invasion
Troughton, L. D., O’Loughlin, D. A., Zech, T., & Hamill, K. J. (n.d.). Laminin N-terminus α31 is upregulated in invasive ductal breast cancer and changes the mode of tumour invasion. PLOS ONE, 17(3), e0264430. doi:10.1371/journal.pone.0264430
Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection
Casas-Sanchez, A., Romero-Ramirez, A., Hargreaves, E., Ellis, C. C., Grajeda, B. I., Estevao, I. L., . . . Acosta-Serrano, Á. (2022). Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection. mBio, 13(1). doi:10.1128/mbio.03718-21
2021
Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures
Schnauss, J., Kunschmann, T., Grosser, S., Mollenkopf, P., Zech, T., Freitag, J. S., . . . Kaes, J. A. (2021). Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures. ADVANCED MATERIALS, 33(29). doi:10.1002/adma.202101840
Cells in Slow Motion: Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures (Adv. Mater. 29/2021)
Schnauß, J., Kunschmann, T., Grosser, S., Mollenkopf, P., Zech, T., Freitag, J. S., . . . Käs, J. A. (2021). Cells in Slow Motion: Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures (Adv. Mater. 29/2021). Advanced Materials, 33(29). doi:10.1002/adma.202170230
3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration
Protein <i>N</i>-glycosylation is essential for SARS-CoV-2 infection
2020
Connecting the dots: combined control of endocytic recycling and degradation
MacDonald, E., Savage, B., & Zech, T. (2020). Connecting the dots: combined control of endocytic recycling and degradation. BIOCHEMICAL SOCIETY TRANSACTIONS, 48(6), 2377-2386. doi:10.1042/BST20180255
Laminin N-terminus α31 is upregulated in invasive ductal breast cancer and changes the mode of tumour invasion
Troughton, L., Zech, T., & Hamill, K. (2020). Laminin N-terminus α31 is upregulated in invasive ductal breast cancer and changes the mode of tumour invasion. doi:10.1101/2020.05.28.120964
2019
Membrane tension orchestrates rear retraction in matrix directed cell migration
Hetmanski., de Belly., Busnelli., Waring, T., Nair., Sokleva., . . . Caswell. (2019). Membrane tension orchestrates rear retraction in matrix directed cell migration. Developmental Cell, 51(4), 460-475. doi:10.1016/j.devcel.2019.09.006
Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Thomas, J. R., Moore, K. M., Sproat, C., Mo, S., Wolanska, K. I., Maldonado, H., . . . Morgan, M. (2019). Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A39). doi:10.1111/iep.12332
Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis
Farina, F., Ramkumar, N., Brown, L., Samander-Eweis, D., Anstatt, J., Waring, T., . . . Baum, B. (2019). Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis. The EMBO Journal, 38(11). doi:10.15252/embj.201899843
LaNt α31 influences cell adhesion and migration through modulation of laminin organisation and hemidesmosome maturation
Troughton, L. D., Iorio, V., Barrera, V., Shaw, L., Zech, T., Risk, J., & Hamill, K. J. (2019). LaNt α31 influences cell adhesion and migration through modulation of laminin organisation and hemidesmosome maturation. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A38-A39). Retrieved from https://www.webofscience.com/
Matrix adhesion site function in polarised invasive migration
Newman, D., Waring, T., Young, L., Brown, L., MacDonald, E., Ronn-Vehland, I., . . . Zech, T. (2019). Matrix adhesion site function in polarised invasive migration. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A28-A29). Retrieved from https://www.webofscience.com/
2018
Cell Scientist to Watch - Tobias Zech
Zech, T. (2018). Cell Scientist to Watch - Tobias Zech. JOURNAL OF CELL SCIENCE, 131(22). doi:10.1242/jcs.227223
Actin-Based Cell Protrusion in a 3D Matrix
Caswell, P. T., & Zech, T. (2018). Actin-Based Cell Protrusion in a 3D Matrix. TRENDS IN CELL BIOLOGY, 28(10), 823-834. doi:10.1016/j.tcb.2018.06.003
Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Thomas, J. R., Moore, K. M., Sproat, C., Mo, S., Wolanska, K. I., Maldonado, H., . . . Morgan, M. R. (2019). Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 100(4), A39. Retrieved from https://www.webofscience.com/
Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Thomas, J., Moore, K., Sproat, C., Maldonado-Lorca, H., Mo, S., Haider, S., . . . Morgan, M. (2018). Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion. doi:10.1101/407908
HRS-WASH axis governs Actin mediated endosomal recycling and cell invasion
MacDonald, E., Brown, L., Selvais, A., Liu, H., Waring, T., Newman, D., . . . Zech, T. N. (2018). HRS-WASH axis governs Actin mediated endosomal recycling and cell invasion. The Journal of Cell Biology, 217(7), 2549-2564. doi:10.1083/jcb.201710051
STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
Woroniuk, A., porter, A., White, G., Newman, D., Diamantopoulou, Z., Waring, T., . . . Malliri, A. (2018). STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. Nature Communications, 9. doi:10.1038/s41467-018-04404-4
A splicing switch provides dual layer control of laminin alpha3: Implications for squamous cell carcinoma
Troughton, L. D., Barrera, V., Brown, L., Zech, T., Willoughby, C. E., Risk, J. M., & Hamill, K. J. (2018). A splicing switch provides dual layer control of laminin alpha3: Implications for squamous cell carcinoma. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 138 (pp. S147). doi:10.1016/j.jid.2018.03.876
2016
WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion
Garcia, E., Ragazzini, C., Xinzi, Y., Cuesta-Garcia, E., Bernardino de la Serna, J., Zech, T., . . . Anton, I. M. (n.d.). WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion. Scientific Reports, 6. doi:10.1038/srep23590
2014
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
Oppelt, A., Haugsten, E. M., Zech, T., Danielson, H. E., Sveen, A., Lobert, V. H., . . . Wesche, J. (2014). PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. Biochemical Journal, 461(3), 383-390. doi:10.1042/BJ20140132
N-WASP/WIP mediated matrix adhesion site maturation drives 3D cancer cell migration through direct force coupling to the nucleus.
Zech, T., Chatzidoukaki, O., Charles-Orszag, A., Sender, S., & Machesky, L. (2014). N-WASP/WIP mediated matrix adhesion site maturation drives 3D cancer cell migration through direct force coupling to the nucleus.. In MOLECULAR BIOLOGY OF THE CELL Vol. 25. Retrieved from https://www.webofscience.com/
2013
Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.
Park, L., Thomason, P. A., Zech, T., King, J. S., Veltman, D. M., Carnell, M., . . . Insall, R. H. (2013). Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.. Developmental cell, 24(2), 169-181. doi:10.1016/j.devcel.2012.12.014
Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion
Tang, H., Li, A., Bi, J., Veltman, D. M., Zech, T., Spence, H. J., . . . Machesky, L. M. (2013). Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion. CURRENT BIOLOGY, 23(2), 107-117. doi:10.1016/j.cub.2012.11.059
Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment
Park, L., Thomason, P. A., Zech, T., King, J. S., Veltman, D. M., Carnell, M., . . . Insall, R. H. (2013). Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment. DEVELOPMENTAL CELL, 24(2), 169-181. doi:10.1016/j.devcel.2012.12.014
2012
Actin on trafficking Could actin guide directed receptor transport?
Zech, T., Calaminus, S. D. J., & Machesky, L. M. (2012). Actin on trafficking Could actin guide directed receptor transport?. CELL ADHESION & MIGRATION, 6(6), 476-481. doi:10.4161/cam.21373
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods
Yu, X., Zech, T., McDonald, L., Garcia Gonzalez, E., Li, A., Macpherson, I., . . . Machesky, L. M. (2012). N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. JOURNAL OF CELL BIOLOGY, 199(3), 527-544. doi:10.1083/jcb.201203025
Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex
Maritzen, T., Zech, T., Schmidt, M. R., Krause, E., Machesky, L. M., & Haucke, V. (2012). Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(26), 10382-10387. doi:10.1073/pnas.1206468109
2011
The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration
Zech, T., Calaminus, S. D. J., Caswell, P., Spence, H. J., Carnell, M., Insall, R. H., . . . Machesky, L. M. (2011). The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration. JOURNAL OF CELL SCIENCE, 124(22), 3753-3759. doi:10.1242/jcs.080986
Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis
Carnell, M., Zech, T., Calaminus, S. D., Ura, S., Hagedorn, M., Johnston, S. A., . . . Insall, R. H. (2011). Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. JOURNAL OF CELL BIOLOGY, 193(5), 831-839. doi:10.1083/jcb.201009119
Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses
de Wet, B., Zech, T., Salek, M., Acuto, O., & Harder, T. (2011). Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(6), 4072-4080. doi:10.1074/jbc.M110.165415
2009
Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling
Zech, T., Ejsing, C. S., Gaus, K., de Wet, B., Shevchenko, A., Simons, K., & Harder, T. (2009). Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling. EMBO JOURNAL, 28(5), 466-476. doi:10.1038/emboj.2009.6
2008
Rab5 and Rac team up in cell motility
Zech, T., & Machesky, L. (2008). Rab5 and Rac team up in cell motility. CELL, 134(1), 18-20. doi:10.1016/j.cell.2008.06.039
Functional Implications of Plasma Membrane Condensation for T Cell Activation
Rentero, C., Zech, T., Quinn, C. M., Engelhardt, K., Williamson, D., Grewal, T., . . . Gaus, K. (2008). Functional Implications of Plasma Membrane Condensation for T Cell Activation. PLOS ONE, 3(5). doi:10.1371/journal.pone.0002262
2007
Plasma membrane segregation during T cell activation: probing the order of domains
Harder, T., Rentero, C., Zech, T., & Gaus, K. (2007). Plasma membrane segregation during T cell activation: probing the order of domains. CURRENT OPINION IN IMMUNOLOGY, 19(4), 470-475. doi:10.1016/j.coi.2007.05.002
2006
Visualizing membrane microdomains by Laurdan 2-photon microscopy (Review)
Gaus, K., Zech, T., & Harder, T. (2006). Visualizing membrane microdomains by Laurdan 2-photon microscopy (Review). MOLECULAR MEMBRANE BIOLOGY, 23(1), 41-48. doi:10.1080/09687860500466857
2004
Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2
Kofler, M., Heuer, K., Zech, T., & Freund, C. (2004). Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(27), 28292-28297. doi:10.1074/jbc.M402008200
Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies
Kim, M., Yang, H. L., Kim, S. K., Reche, P. A., Tirabassi, R. S., Hussey, R. E., . . . Reinherz, E. L. (2004). Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(24), 25838-25848. doi:10.1074/jbc.M400343200
2003
Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains
Hartgroves, L. C., Lin, J., Langen, H., Zech, T., Weiss, A., & Harder, T. (2003). Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(22), 20389-20394. doi:10.1074/jbc.M301212200