Publications
2024
The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress.
McCarron, K. R., Elcocks, H., Mortiboys, H., Urbé, S., & Clague, M. J. (2024). The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress.. The Biochemical journal, 481(4), 265-278. doi:10.1042/bcj20230492
Fluorescence Methods to Measure Pexophagy.
Barone, F. G., Urbé, S., & Clague, M. J. (2024). Fluorescence Methods to Measure Pexophagy.. Methods in molecular biology (Clifton, N.J.), 2845, 141-150. doi:10.1007/978-1-0716-4067-8_11
2023
Microtubule association of TRIM3 revealed by differential extraction proteomics.
Glover, H. L., Mendes, M., Gomes-Neto, J., Rusilowicz-Jones, E. V., Rigden, D. J., Dittmar, G., . . . Clague, M. J. (2023). Microtubule association of TRIM3 revealed by differential extraction proteomics.. Journal of cell science, jcs.261522. doi:10.1242/jcs.261522
The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress
ISGylation-independent protection of cell growth by USP18 following interferon stimulation.
Clancy, A., Rusilowicz-Jones, E. V., Wallace, I., Swatek, K. N., Urbé, S., & Clague, M. J. (2023). ISGylation-independent protection of cell growth by USP18 following interferon stimulation.. The Biochemical journal, 480(19), 1571-1581. doi:10.1042/bcj20230301
ISGylation-independent protection of cell growth by USP18 following interferon stimulation
Segregation of pathways leading to pexophagy
Barone, F. G., Urbe, S., & Clague, M. J. (2023). Segregation of pathways leading to pexophagy. LIFE SCIENCE ALLIANCE, 6(5). doi:10.26508/lsa.202201825
FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.
Elcocks, H., Brazel, A. J., McCarron, K. R., Kaulich, M., Husnjak, K., Mortiboys, H., . . . Urbé, S. (2023). FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.. The EMBO journal, e112799. doi:10.15252/embj.2022112799
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation
Zanin, N., de Lesegno, C. V., Podkalicka, J., Meyer, T., Troncoso, P. G., Bun, P., . . . Lamaze, C. (2023). STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation. NATURE CELL BIOLOGY, 25(3), 425-+. doi:10.1038/s41556-022-01085-6
2022
FBXL4 deficiency promotes mitophagy by elevating NIX
Protein degradation on the global scale
V. Rusilowicz-Jones, E., Urbe, S., & Clague, M. J. (2022). Protein degradation on the global scale. MOLECULAR CELL, 82(8), 1414-1423. doi:10.1016/j.molcel.2022.02.027
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy
Rusilowicz-Jones, E. V., Barone, F. G., Lopes, F. M., Stephen, E., Mortiboys, H., Urbe, S., & Clague, M. J. (2022). Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. LIFE SCIENCE ALLIANCE, 5(2). doi:10.26508/lsa.202101287
2021
Membrane compartmentalisation of the ubiquitin system.
Rusilowicz-Jones, E. V., Brazel, A. J., Frigenti, F., Urbé, S., & Clague, M. J. (2021). Membrane compartmentalisation of the ubiquitin system.. Seminars in cell & developmental biology. doi:10.1016/j.semcdb.2021.11.016
The PINK1 repertoire: Not just a one trick pony
Pollock, L., Jardine, J., Urbe, S., & Clague, M. J. (2021). The PINK1 repertoire: Not just a one trick pony. BIOESSAYS, 43(11). doi:10.1002/bies.202100168
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
Ruiz, E. J., Pinto-Fernandez, A., Turnbull, A. P., Lan, L., Charlton, T. M., Scott, H. C., . . . Behrens, A. (2021). USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. ELIFE, 10. doi:10.7554/eLife.71596
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy
Rusilowicz-Jones, E., Barone, F., Lopes, F. M., Stephen, E., Mortiboys, H., Urbé, S., & Clague, M. (2021). Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. doi:10.1101/2021.04.28.441730
The deubiquitylase USP9X controls ribosomal stalling
Clancy, A., Heride, C., Pinto-Fernandez, A., Elcocks, H., Kallinos, A., Kayser-Bricker, K. J., . . . Clague, M. J. (2021). The deubiquitylase USP9X controls ribosomal stalling. JOURNAL OF CELL BIOLOGY, 220(3). doi:10.1083/jcb.202004211
The deubiquitylase USP9X controls ribosomal stalling (vol 220, e202004211, 2021)
Clancy, A., Heride, C., Pinto-Fernandez, A., Elcocks, H., Kallinos, A., Kayser-Bricker, K. J., . . . Clague, M. J. (2021). The deubiquitylase USP9X controls ribosomal stalling (vol 220, e202004211, 2021). JOURNAL OF CELL BIOLOGY, 220(3). doi:10.1083/jcb.20200421102102021c
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., . . . Tong, C. -K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). AUTOPHAGY, 17(1), 1-382. doi:10.1080/15548627.2020.1797280
2020
USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma
Ruiz, E. J., Pinto-Fernandez, A., Turnbull, A. P., Lan, L., Charlton, T. M., Scott, H. C., . . . Behrens, A. (2020). USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma. doi:10.1101/2020.11.17.377705
USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
Rusilowicz-Jones, E. V., Jardine, J., Kallinos, A., Pinto-Fernandez, A., Guenther, F., Giurrandino, M., . . . Clague, M. J. (2020). USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation. Life Science Alliance, 3(8). doi:10.26508/lsa.202000768
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation
Rusilowicz-Jones, E. V., Jardine, J., Kallinos, A., Pinto-Fernandez, A., Guenther, F., Giurrandino, M., . . . Clague, M. J. (2020). USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. LIFE SCIENCE ALLIANCE, 3(8). doi:10.26508/lsa.202000768
The deubiquitylase USP9X controls ribosomal stalling
Clancy, A., Heride, C., Pinto-Fernández, A., Kallinos, A., Kayser-Bricker, K. J., Wang, W., . . . Clague, M. J. (2020). The deubiquitylase USP9X controls ribosomal stalling. doi:10.1101/2020.04.15.042291
Data mining for traffic information
Clague, M. J., & Urbe, S. (2020). Data mining for traffic information. TRAFFIC, 21(1), 162-168. doi:10.1111/tra.12702
2019
New aspects of USP30 biology in the regulation of pexophagy
Marcassa, E., Kallinos, A., Jardine, J., Rusilowicz-Jones, E. V., Clague, M. J., & Urbe, S. (2019). New aspects of USP30 biology in the regulation of pexophagy. AUTOPHAGY. doi:10.1080/15548627.2019.1615304
Breaking the chains: deubiquitylating enzyme specificity begets function
Clague, M. J., Urbe, S., & Komander, D. (2019). Breaking the chains: deubiquitylating enzyme specificity begets function. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 20(6), 338-352. doi:10.1038/s41580-019-0099-1
Breaking the chains: deubiquitylating enzyme specificity begets function (vol 20, pg 1, 2019)
Clague, M. J., Urbe, S., & Komander, D. (2019). Breaking the chains: deubiquitylating enzyme specificity begets function (vol 20, pg 1, 2019). NATURE REVIEWS MOLECULAR CELL BIOLOGY, 20(5), 321. doi:10.1038/s41580-019-0112-8
2018
A chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation
Pruneda, J., Robert, B., Bertsoulaki, E., Swatek, K., Santhanam, B., Clague, M. J., . . . Komander, D. (2018). A chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation. Nature Microbiology, 3, 1377-1384. doi:10.1038/s41564-018-0271-y
HRS-WASH axis governs Actin mediated endosomal recycling and cell invasion
MacDonald, E., Brown, L., Selvais, A., Liu, H., Waring, T., Newman, D., . . . Zech, T. N. (2018). HRS-WASH axis governs Actin mediated endosomal recycling and cell invasion. The Journal of Cell Biology, 217(7), 2549-2564. doi:10.1083/jcb.201710051
Dual role of USP 30 in controlling basal pexophagy and mitophagy
Marcassa, E., Kallinos, A., Jardine, J., Rusilowicz, E., Martinez, A., Kuehl, S., . . . Urbe, S. (2018). Dual role of USP 30 in controlling basal pexophagy and mitophagy. EMBO Reports, 19(07), 14 pages. doi:10.15252/embr.201745595
The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity
Fielding, A. B., Concannon, M., Darling, S., Rusilowicz, E., Sacco, J., Prior, I. A., . . . Coulson, J. M. (2018). The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity. Oncogene, 37(17), 2326-2342. doi:10.1038/s41388-017-0092-0
2017
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Turnbull, A. P., Ioannidis, S., Krajewski, W. W., Pinto-Fernandez, A., Heride, C., Martin, A. C. L., . . . Komander, D. (2017). Molecular basis of USP7 inhibition by selective small-molecule inhibitors. NATURE, 550(7677), 481-486. doi:10.1038/nature24451
Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
Clague, M. J., & Urbe, S. (2017). Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases. FEBS JOURNAL, 284(12), 1753-1766. doi:10.1111/febs.14007
Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.
Martinez, A., Lectez, B., Ramirez, J., Popp, O., Sutherland, J. D., Urbé, S., . . . Mayor, U. (2017). Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.. Molecular neurodegeneration, 12, 1-19. doi:10.1186/s13024-017-0170-3
2016
The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer
Clague, M. J., wymant, J. M., Hiscox, S., Westwell, A. D., Urbe, S., & Jones, A. T. (2016). The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer. Journal of Cancer.
The centrosomal Deubiquitylase USP21 regulates Gli1 transcriptional activity and stability
Heride, C., Rigden, D. J., Bertsoulaki, E., Cucchi, D., De Smaele, E., Clague, M. J., & Urbe, S. (2016). The centrosomal Deubiquitylase USP21 regulates Gli1 transcriptional activity and stability. Journal of Cell Science, 129(21), 4001-4013. doi:10.1242/jcs.188516
Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6
Perrody, E., Abrami, L., Feldman, M., Kunz, B., Urbe, S., & van der Goot, F. G. (2016). Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6. eLife, 5. doi:10.7554/eLife.19083
Bimodal antagonism of PKA signalling by ARHGAP36
Eccles, R. L., Czajkowski, M. T., Barth, C., Müller, P. M., McShane, E., Grunwald, S., . . . Rocks, O. (2016). Bimodal antagonism of PKA signalling by ARHGAP36. Nature Communications, 7. doi:10.1038/ncomms12963
The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL
Nelson, J. K., Sorrentino, V., Trezza, R. A., Heride, C., Urbe, S., Distel, B., & Zelcer, N. (2016). The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL. Circulation Research, 118(3), 410-419. doi:10.1161/CIRCRESAHA.115.307298
2015
Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells
Malec, V., Coulson, J. M., Urbe, S., & Clague, M. J. (2015). Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells. JOURNAL OF PROTEOME RESEARCH, 14(12), 5263-5272. doi:10.1021/acs.jproteome.5b00692
The demographics of the ubiquitin system
Clague, M., Heride, C., & Urbe, S. (2015). The demographics of the ubiquitin system. Trends in Cell Biology, 25(7), 417-426. doi:10.1016/j.tcb.2015.03.002
USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death
Liang, J. R., Martinez Zarate, A., Lane, J. D., Mayor, U., Clague, M., & Urbe, S. (2015). USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death. EMBO Reports, 16(5), 618-627. doi:10.15252/embr.201439820
Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors
Sacco, J., Kenyani, J., Butt, Z., Carter, R., Chew, H. Y., Cheeseman, L. P., . . . Coulson, J. (2015). Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. Oncotarget, 6(15), 13757-13771. doi:10.18632/oncotarget.3765
Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors
Sacco, J. J., Kenyani, J., Butt, Z., Carter, R., Chew, H. Y., Cheeseman, L. P., . . . Coulson, J. M. (2015). Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. Oncotarget, 6(15), 1-15.
2014
Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
Nishi, R., Wijnhoven, P., le Sage, C., Tjeertes, J., Galanty, Y., Forment, J. V., . . . Jackson, S. P. (2014). Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nature Cell Biology, 16(10), 1016-1026. doi:10.1038/ncb3028
Plasticity of Mammary Cell Boundaries Governed by EGF and Actin Remodeling
Tang, W. Y., Beckett, A., Prior, I., Coulson, J., Urbe, S., & Clague, M. (2014). Plasticity of Mammary Cell Boundaries Governed by EGF and Actin Remodeling. Cell Reports, 8(06), 1722-1730. doi:10.1016/j.celrep.2014.08.026
The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells
Sacco, J., Yau, T. Y., Darling, S., Patel, V., Liu, H., Urbe, S., . . . Coulson, J. (2014). The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells. Oncogene, 33(33), 4265-4272. doi:10.1038/onc.2013.512
The role of Breast Cancer Associated gene 2 in EGFR endocytosis, downregulation and breast cancer survival
Wymant, J., Hiscox, S., Westwell, A., Urbe, S., Clague, M., & Jones, A. T. (2014). The role of Breast Cancer Associated gene 2 in EGFR endocytosis, downregulation and breast cancer survival. EUROPEAN JOURNAL OF CANCER, 50, S115. doi:10.1016/S0959-8049(14)50425-X
Systematic characterization of deubiquitylating enzymes for DNA repair identifies UCHL5 as a DNA end-resection factor.
Nishi, R., Wijnhoven, P., Tjeertes, J., le Sage, C., Clague, M., Urbe, S., & Jackson, S. P. (2014). Systematic characterization of deubiquitylating enzymes for DNA repair identifies UCHL5 as a DNA end-resection factor.. Nature Cell Biology.
USP8 controls the trafficking and sorting of lysosomal enzymes.
MacDonald, E., Urbe, S., & Clague, M. (2014). USP8 controls the trafficking and sorting of lysosomal enzymes.. Traffic, 15(8), 879-888. doi:10.1111/tra.12180
Ubiquitin code assembly and disassembly.
Heride, C., Urbe, S., Clague, M., & Heride, C. (2014). Ubiquitin code assembly and disassembly.. Unknown Journal, 6(24), 215-220. Retrieved from http://dx.doi.org/10.1016/j.cub.2014.02.002
2013
Deubiquitylases From Genes to Organism
Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbé, S. (2013). Deubiquitylases From Genes to Organism. Physiological Reviews, 93(3), 1289-1315. doi:10.1152/physrev.00002.2013
Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes
Liu, H., Urbé, S., & Clague, M. J. (2013). Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes. In Vesicle Trafficking in Cancer (pp. 245-259). Springer New York. doi:10.1007/978-1-4614-6528-7_12
The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit
Faronato, M., Patel, V., Darling, S., Dearden, L., Clague, M. J., Urbe, S., & Coulson, J. M. (2013). The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit. CELL CYCLE, 12(12), 1964-1977. doi:10.4161/cc.25035
Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB
Ali, N., Zhang, L., Taylor, S., Mironov, A., Urbe, S., & Woodman, P. (2013). Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB. CURRENT BIOLOGY, 23(6), 453-461. doi:10.1016/j.cub.2013.02.033
Plasticity of mammary cell boundaries governed by EGF
Tang, Y., Beckett, A. J., Prior, I. A., Coulson, J. M., Urbe, S., & Clague, M. J. (2013). Plasticity of mammary cell boundaries governed by EGF. MOLECULAR BIOLOGY OF THE CELL, 24. Retrieved from https://www.webofscience.com/
2012
Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15
Hayes, S. D., Liu, H., MacDonald, E., Sanderson, C. M., Coulson, J. M., Clague, M. J., & Urbe, S. (2012). Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(51), 43007-43018. doi:10.1074/jbc.M112.386938
Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation
Clague, M. J., Liu, H., & Urbe, S. (2012). Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation. DEVELOPMENTAL CELL, 23(3), 457-467. doi:10.1016/j.devcel.2012.08.011
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions
Urbé, S., Liu, H., Hayes, S. D., Heride, C., Rigden, D. J., & Clague, M. J. (2012). Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Molecular Biology of the Cell, 23(6), 1095-1103. doi:10.1091/mbc.e11-08-0668
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions
Urbe, S., Liu, H., Hayes, S. D., Heride, C., Rigden, D. J., & Clague, M. J. (2012). Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. MOLECULAR BIOLOGY OF THE CELL, 23(6), 1095-1103. doi:10.1091/mbc.E11-08-0668
Cellular functions of the DUBs
Clague, M. J., Coulson, J. M., & Urbe, S. (2012). Cellular functions of the DUBs. JOURNAL OF CELL SCIENCE, 125(2), 277-286. doi:10.1242/jcs.090985
Selective protein degradation in cell signalling
Liu, H., Urbe, S., & Clague, M. J. (2012). Selective protein degradation in cell signalling. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 23(5), 509-514. doi:10.1016/j.semcdb.2012.01.014
2011
Structural variability of the ubiquitin specific protease DUSP-UBL double domains
Elliott, P. R., Liu, H., Pastok, M. W., Grossmann, G. J., Rigden, D. J., Clague, M. J., . . . Barsukov, I. L. (2011). Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS LETTERS, 585(21), 3385-3390. doi:10.1016/j.febslet.2011.09.040
Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus
Thorne, C., Eccles, R. L., Coulson, J. M., Urbe, S., & Clague, M. J. (2011). Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus. TRAFFIC, 12(11), 1563-1574. doi:10.1111/j.1600-0854.2011.01261.x
Moving In With Ubiquitin
Urbe, S. (2011). Moving In With Ubiquitin. TRAFFIC, 12(2), 135-136. doi:10.1111/j.1600-0854.2010.01143.x
USP15 (ubiquitin specific peptidase 15)
Faronato, M., Urbé, S., & Coulson, J. M. (n.d.). USP15 (ubiquitin specific peptidase 15). Atlas of Genetics and Cytogenetics in Oncology and Haematology, (8). doi:10.4267/2042/46013
2010
Ubiquitin: Same Molecule, Different Degradation Pathways
Clague, M. J., & Urbe, S. (2010). Ubiquitin: Same Molecule, Different Degradation Pathways. CELL, 143(5), 682-685. doi:10.1016/j.cell.2010.11.012
Molecular mechanisms of secretory granule biogenesis in neuroendocrine cells.
Urbe, S. (2010). Molecular mechanisms of secretory granule biogenesis in neuroendocrine cells..
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
Polson, H. E. J., de lartigue, J., Rigden, D. J., Reedijk, M., Urbe, S., Clague, M. J., & Tooze, S. A. (2010). Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. AUTOPHAGY, 6(4), 506-522. doi:10.4161/auto.6.4.11863
Emerging roles of deubiquitinases in cancer‐associated pathways
Sacco, J. J., Coulson, J. M., Clague, M. J., & Urbé, S. (2010). Emerging roles of deubiquitinases in cancer‐associated pathways. IUBMB Life, 62(2), 140-157. doi:10.1002/iub.300
2009
Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes
Popoff, V., Mardones, G. A., Bai, S. -K., Chambon, V., Tenza, D., Burgos, P. V., . . . Johannes, L. (2009). Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes. TRAFFIC, 10(12), 1868-1880. doi:10.1111/j.1600-0854.2009.00993.x
Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells
Buus, R., Faronato, M., Hammond, D. E., Urbe, S., & Clague, M. J. (2009). Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells. CURRENT BIOLOGY, 19(17), 1463-1466. doi:10.1016/j.cub.2009.07.040
Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells
Buus, R., Faronato, M., Hammond, D. E., Urbé, S., & Clague, M. J. (2009). Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells. Current Biology, 19(17), 1463-1466. doi:10.1016/j.cub.2009.07.040
Breaking the chains: structure and function of the deubiquitinases
Komander, D., Clague, M. J., & Urbe, S. (2009). Breaking the chains: structure and function of the deubiquitinases. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 10(8), 550-563. doi:10.1038/nrm2731
PIKfyve Regulation of Endosome-Linked Pathways
de Lartigue, J., Polson, H., Feldman, M., Shokat, K., Tooze, S. A., Urbe, S., & Clague, M. J. (2009). PIKfyve Regulation of Endosome-Linked Pathways. TRAFFIC, 10(7), 883-893. doi:10.1111/j.1600-0854.2009.00915.x
Phosphoinositides and the endocytic pathway
Clague, M. J., Urbe, S., & de Lartigue, J. (2009). Phosphoinositides and the endocytic pathway. EXPERIMENTAL CELL RESEARCH, 315(9), 1627-1631. doi:10.1016/j.yexcr.2008.10.005
Regulation of ErbB2 Receptor Status by the Proteasomal DUB POH1
Liu, H., Buus, R., Clague, M. J., & Urbe, S. (2009). Regulation of ErbB2 Receptor Status by the Proteasomal DUB POH1. PLOS ONE, 4(5). doi:10.1371/journal.pone.0005544
Erratum: The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (The Journal of Biological Chemistry (2007) vol. 282 (30929-30937))
Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbé, S. (2009). Erratum: The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (The Journal of Biological Chemistry (2007) vol. 282 (30929-30937)). Journal of Biological Chemistry, 284(12), 8207.
Ab initio protein modelling reveals novel human MIT domains
Rigden, D. J., Liu, H., Hayes, S. D., Urbe, S., & Clague, M. J. (2009). Ab initio protein modelling reveals novel human MIT domains. FEBS LETTERS, 583(5), 872-878. doi:10.1016/j.febslet.2009.02.012
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (vol 282, pg 30929, 2007)
Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbe, S. (2009). The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (vol 282, pg 30929, 2007). JOURNAL OF BIOLOGICAL CHEMISTRY, 284(12), 8207. Retrieved from https://www.webofscience.com/
2008
Multivesicular bodies
Clague, M. J., & Urbe, S. (2008). Multivesicular bodies. CURRENT BIOLOGY, 18(10), R402-R404. doi:10.1016/j.cub.2008.02.068
Protein Sorting to the Lysosome
McCullough, J., Clague, M. J., & Urbé, S. (n.d.). Protein Sorting to the Lysosome. In Unknown Book (pp. 76-102). Wiley. doi:10.1002/9783527610754.dd08
Deciphering histone 2A deubiquitination
Clague, M. J., Coulson, J. M., & Urbe, S. (2008). Deciphering histone 2A deubiquitination. GENOME BIOLOGY, 9(1). doi:10.1186/gb-2008-9-1-202
2007
Ubiquitin and Protein Sorting to the Lysosome
McCullough, J., Clague, M. J., & Urbé, S. (2007). Ubiquitin and Protein Sorting to the Lysosome. In Unknown Book (pp. 76-102). Wiley. doi:10.1002/9783527619320.ch4b
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation
Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbe, S. (2007). The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(42), 30929-30937. doi:10.1074/jbc.M704009200
The emerging shape of the ESCRT machinery
Williams, R. L., & Urbe, S. (2007). The emerging shape of the ESCRT machinery. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 8(5), 355-368. doi:10.1038/nrm2162
2006
Endocytosis:: the DUB version
Clague, M. J., & Urbe, S. (2006). Endocytosis:: the DUB version. TRENDS IN CELL BIOLOGY, 16(11), 551-559. doi:10.1016/j.tcb.2006.09.002
Control of growth factor receptor dynamics by reversible ubiquitination
Urbe, S., McCullough, J., Row, P. E., Prior, I. A., Welchman, R., & Clague, M. J. (2006). Control of growth factor receptor dynamics by reversible ubiquitination. BIOCHEMICAL SOCIETY TRANSACTIONS, 34, 754-756. doi:10.1042/BST0340754
Membrane Traffic: Vesicle Budding and Fusion
Clague, M. J., & Urb��, S. (n.d.). Membrane Traffic: Vesicle Budding and Fusion. Wiley-VCH Verlag GmbH & Co. KGaA. doi:10.1002/3527600906.mcb.200400097
Ubiquitin and Protein Sorting to the Lysosome
McCullough, J., Clague, M. J., & Urbé, S. (2006). Ubiquitin and Protein Sorting to the Lysosome. In Unknown Book (pp. 76-102). Wiley. doi:10.1002/9783527620227.ch4
Systematic analysis of myotubularins:: heteromeric interactions, subcellular localisation and endosome-related functions
Lorenzo, O., Urbe, S., & Clague, M. J. (2006). Systematic analysis of myotubularins:: heteromeric interactions, subcellular localisation and endosome-related functions. JOURNAL OF CELL SCIENCE, 119(14), 2953-2959. doi:10.1242/jcs.03040
The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation
Row, P. E., Prior, I. A., McCullough, J., Clague, M. J., & Urbé, S. (2006). The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(18), 12618-12624. doi:10.1074/jbc.M512615200
Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery
McCullough, J., Row, P. E., Lorenzo, O., Doherty, M., Beynon, R., Clague, M. J., & Urbé, S. (2006). Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. CURRENT BIOLOGY, 16(2), 160-165. doi:10.1016/j.cub.2005.11.073
2005
Ubiquitin and endocytic protein sorting
Urbé, S. (2005). Ubiquitin and endocytic protein sorting. ESSAYS IN BIOCHEMISTRY, VOL 41: THE UBIQUITIN-PROTEASOME SYSTEM, 41, 81-98. doi:10.1042/EB0410081
Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
Abella, J. V., Peschard, P., Naujokas, M. A., Lin, T., Saucier, C., Urbé, S., & Park, M. (2005). Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. MOLECULAR AND CELLULAR BIOLOGY, 25(21), 9632-9645. doi:10.1128/MCB.25.21.9632-9645.2005
Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction
Regan-Klapisz, E., Sorokina, I., Voortman, J., de Keizer, P., Roovers, R. C., Verheesen, P., . . . Henegouwen, P. M. P. V. E. (2005). Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. JOURNAL OF CELL SCIENCE, 118(19), 4437-4450. doi:10.1242/jcs.02571
Ubiquitin and endocytic protein sorting
Urbé, S. (2005). Ubiquitin and endocytic protein sorting. Essays in Biochemistry, 41, 81-98. doi:10.1042/bse0410081
Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex:: a common node in signalling networks with signal-specific properties
Row, P. E., Clague, M. J., & Urbé, S. (2005). Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex:: a common node in signalling networks with signal-specific properties. BIOCHEMICAL JOURNAL, 389, 629-636. doi:10.1042/BJ20050067
Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3
Lorenzo, O., Urbé, S., & Clague, M. J. (2005). Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3. JOURNAL OF CELL SCIENCE, 118(9), 2005-2012. doi:10.1242/jcs.02325
2004
The Met receptor degradation pathway -: Requirement for Lys<SUP>48</SUP>-linked polyubiquitin independent of proteasome activity
Carter, S., Urbé, S., & Clague, M. J. (2004). The Met receptor degradation pathway -: Requirement for Lys<SUP>48</SUP>-linked polyubiquitin independent of proteasome activity. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(51), 52835-52839. doi:10.1074/jbc.M407769200
AMSH is an endosome-associated ubiquitin isopeptidase
McCullough, J., Clague, M. J., & Urbé, S. (2004). AMSH is an endosome-associated ubiquitin isopeptidase. JOURNAL OF CELL BIOLOGY, 166(4), 487-492. doi:10.1083/jcb.200401141
2003
The UIM domain of Hrs couples receptor sorting to vesicle formation
Urbé, S., Sachse, M., Row, P. E., Preisinger, C., Barr, F. A., Strous, G., . . . Clague, M. J. (2003). The UIM domain of Hrs couples receptor sorting to vesicle formation. JOURNAL OF CELL SCIENCE, 116(20), 4169-4179. doi:10.1242/jcs.00723
Endosomal dynamics of Met determine signaling output
Hammond, D. E., Carter, S., McCullough, J., Urbé, S., Vande Woude, G., & Clague, M. J. (2003). Endosomal dynamics of Met determine signaling output. MOLECULAR BIOLOGY OF THE CELL, 14(4), 1346-1354. doi:10.1091/mbc.E02-09-0578
Hrs function:: viruses provide the clue
Clague, M. J., & Urbé, S. (2003). Hrs function:: viruses provide the clue. TRENDS IN CELL BIOLOGY, 13(12), 603-606. doi:10.1016/j.tcb.2003.10.002
2002
Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes
Sachse, M., Urbé, S., Oorschot, V., Strous, G. J., & Klumperman, J. (2002). Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes. MOLECULAR BIOLOGY OF THE CELL, 13(4), 1313-1328. doi:10.1091/mbc.01-10-0525
2001
Characterization of MTMR3:: an inositol lipid 3-phosphatase with novel substrate specificity
Walker, D. M., Urbé, S., Dove, S. K., Tenza, D., Raposo, G., & Clague, M. J. (2001). Characterization of MTMR3:: an inositol lipid 3-phosphatase with novel substrate specificity. CURRENT BIOLOGY, 11(20), 1600-1605. doi:10.1016/S0960-9822(01)00501-2
The interface of receptor trafficking and signalling.
Clague, M. J., & Urbé, S. (2001). The interface of receptor trafficking and signalling.. Journal of cell science, 114(Pt 17), 3075-3081. doi:10.1242/jcs.114.17.3075
Down-regulation of MET, the receptor for hepatocyte growth factor
Hammond, D. E., Urbé, S., Woude, G. F. V., & Clague, M. J. (2001). Down-regulation of MET, the receptor for hepatocyte growth factor. ONCOGENE, 20(22), 2761-2770. doi:10.1038/sj.onc.1204475
Relationships between EEA1 binding partners and their role in endosome fusion.
Mills, I. G., Urbé, S., & Clague, M. J. (2001). Relationships between EEA1 binding partners and their role in endosome fusion.. Journal of cell science, 114(Pt 10), 1959-1965. doi:10.1242/jcs.114.10.1959
Homotypic fusion of immature secretory granules during maturation requires syntaxin 6
Wendler, F., Page, L., Urbé, S., & Tooze, S. A. (2001). Homotypic fusion of immature secretory granules during maturation requires syntaxin 6. MOLECULAR BIOLOGY OF THE CELL, 12(6), 1699-1709. doi:10.1091/mbc.12.6.1699
Relationships between EEA1 binding partners and their role in endosome fusion
Mills, I. G., Urbé, S., & Clague, M. J. (2001). Relationships between EEA1 binding partners and their role in endosome fusion. JOURNAL OF CELL SCIENCE, 114(10), 1959-1965. Retrieved from https://www.webofscience.com/
The interface of receptor trafficking and signalling
Clague, M. J., & Urbé, S. (2001). The interface of receptor trafficking and signalling. JOURNAL OF CELL SCIENCE, 114(17), 3075-3081. Retrieved from https://www.webofscience.com/
2000
Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate
Urbé, S., Mills, I. G., Stenmark, H., Kitamura, N., & Clague, M. J. (2000). Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate. MOLECULAR AND CELLULAR BIOLOGY, 20(20), 7685-7692. doi:10.1128/MCB.20.20.7685-7692.2000
1999
Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins
Clague, M. J., Jones, A. T., Mills, I. G., Walker, D. M., & Urbé, S. (1999). Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins. BIOCHEMICAL SOCIETY TRANSACTIONS, 27(4), 662-666. doi:10.1042/bst0270662
REGULATION OF EARLY ENDOSOME DYNAMICS BY EEA1: A PHOSPHATIDYLINOSITOL 3-PHOSPHATE BINDING PROTEIN
Claque, M. J., Jones, A. T., Mills, I. G., Walker, D., & Urbé, S. (1999). REGULATION OF EARLY ENDOSOME DYNAMICS BY EEA1: A PHOSPHATIDYLINOSITOL 3-PHOSPHATE BINDING PROTEIN. Biochemical Society Transactions, 27(3), A76. doi:10.1042/bst027a076b
1998
Homotypic fusion of immature secretory granules during maturation in a cell-free assay
Urbé, S., Page, L. J., & Tooze, S. A. (1998). Homotypic fusion of immature secretory granules during maturation in a cell-free assay. JOURNAL OF CELL BIOLOGY, 143(7), 1831-1844. doi:10.1083/jcb.143.7.1831
1997
Formation of secretory vesicles in the biosynthetic pathway
Urbe, S., Tooze, S. A., & Barr, F. A. (1997). Formation of secretory vesicles in the biosynthetic pathway. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1358(1), 6-22. doi:10.1016/S0167-4889(97)00050-5
pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules
Urbe, S., Dittie, A. S., & Tooze, S. A. (1997). pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules. BIOCHEMICAL JOURNAL, 321, 65-74. doi:10.1042/bj3210065
1996
Rab11 regulates recycling through the pericentriolar recycling endosome
Ullrich, O., Reinsch, S., Urbe, S., Zerial, M., & Parton, R. G. (1996). Rab11 regulates recycling through the pericentriolar recycling endosome. JOURNAL OF CELL BIOLOGY, 135(4), 913-924. doi:10.1083/jcb.135.4.913
1995
Rabll
Urbe, S., & Parton, R. G. (1995). Rabll. In Guidebook to the Sinall GTPases (pp. 345-346). Oxford University PressOxford. doi:10.1093/oso/9780198599456.003.0101
1994
VACUOLAR ATPASE ACTIVITY IS REQUIRED FOR ENDOSOMAL CARRIER VESICLE FORMATION
CLAGUE, M. J., URBE, S., ANIENTO, F., & GRUENBERG, J. (1994). VACUOLAR ATPASE ACTIVITY IS REQUIRED FOR ENDOSOMAL CARRIER VESICLE FORMATION. JOURNAL OF BIOLOGICAL CHEMISTRY, 269(1), 21-24. Retrieved from https://www.webofscience.com/
1993
RAB11, A SMALL GTPASE ASSOCIATED WITH BOTH CONSTITUTIVE AND REGULATED SECRETORY PATHWAYS IN PC12-CELLS
URBE, S., HUBER, L. A., ZERIAL, M., TOOZE, S. A., & PARTON, R. G. (1993). RAB11, A SMALL GTPASE ASSOCIATED WITH BOTH CONSTITUTIVE AND REGULATED SECRETORY PATHWAYS IN PC12-CELLS. FEBS LETTERS, 334(2), 175-182. doi:10.1016/0014-5793(93)81707-7