Publications
Selected publications
- Pathophysiological insights into atrial fibrillation: revisiting the electrophysiological substrate, anatomical substrate, and possible insights from proteomics (Journal article - 2021)
- Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring (Journal article - 2019)
- Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking (Journal article - 2019)
- A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate (Journal article - 2021)
- Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit (Journal article - 2021)
- Evaluation of Huawei Smart Wearables for Detection of Atrial Fibrillation in Patients Following Ischaemic Stroke: The Liverpool-Huawei Stroke Study (Journal article - 2022)
- Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension (Journal article - 2023)
2024
Inherent Atrial Fibrillation Vulnerability in the Appendages Exacerbated in Heart Failure
Agrawal, S., Ashby, J., Bai, J., Feng, F., Cai, X. J., Yanni, J., . . . Zhao, J. (2024). Inherent Atrial Fibrillation Vulnerability in the Appendages Exacerbated in Heart Failure. In Unknown Conference (pp. 220-229). Springer Nature Switzerland. doi:10.1007/978-3-031-52448-6_21
2023
Subclinical thyroid dysfunction and the risk of incident atrial fibrillation: A systematic review and meta-analysis.
Singh, H., Shahid, M. Z., Harrison, S. L., Lane, D. A., Lip, G. Y. H., & Logantha, S. J. R. J. (2024). Subclinical thyroid dysfunction and the risk of incident atrial fibrillation: A systematic review and meta-analysis.. PloS one, 19(1), e0296413. doi:10.1371/journal.pone.0296413
Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension
Logantha, S. J. R. J., Yamanushi, T. T., Absi, M., Temple, I. P., Kabuto, H., Hirakawa, E., . . . Yanni, J. (2023). Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 378(1879). doi:10.1098/rstb.2022.0178
2022
Evaluation of Huawei Smart Wearables for Detection of Atrial Fibrillation in Patients Following Ischaemic Stroke: The Liverpool-Huawei Stroke Study
Harrison, S. L., Buckley, B. J. R., Zheng, Y., Hill, A., Hlaing, T., Davies, R., . . . Jones, I. (2022). Evaluation of Huawei Smart Wearables for Detection of Atrial Fibrillation in Patients Following Ischaemic Stroke: The Liverpool-Huawei Stroke Study. American Heart Journal. doi:10.1016/j.ahj.2022.12.004
2021
Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease
Boyett, M. R., Yanni, J., Tellez, J., Bucchi, A., Mesirca, P., Cai, X., . . . D'Souza, A. (2021). Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 166, 61-85. doi:10.1016/j.pbiomolbio.2021.06.008
Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit
Logantha, S. J. R. J., Cai, X. J., Yanni, J., Jones, C. B., Stephenson, R. S., Stuart, L., . . . Hart, G. (2021). Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit. CIRCULATION-HEART FAILURE, 14(7), 800-816. doi:10.1161/CIRCHEARTFAILURE.120.007505
Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes
Mesirca, P., Nakao, S., Nissen, S. D., Forte, G., Anderson, C., Trussell, T., . . . D'Souza, A. (2021). Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes. CIRCULATION RESEARCH, 129(1), E1-E20. doi:10.1161/CIRCRESAHA.119.316386
A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate
D'Souza, A., Wang, Y., Anderson, C., Bucchi, A., Baruscotti, M., Olieslagers, S., . . . Boyett, M. R. (2021). A circadian clock in the sinus node mediates day-night rhythms in <i>Hcn4</i> and heart rate. HEART RHYTHM, 18(5), 801-810. doi:10.1016/j.hrthm.2020.11.026
Structural and Functional Properties of Subsidiary Atrial Pacemakers in a Goat Model of Sinus Node Disease
Soattin, L., Borbas, Z., Caldwell, J., Prendergast, B., Vohra, A., Saeed, Y., . . . Dobrzynski, H. (2021). Structural and Functional Properties of Subsidiary Atrial Pacemakers in a Goat Model of Sinus Node Disease. FRONTIERS IN PHYSIOLOGY, 12. doi:10.3389/fphys.2021.592229
Pathophysiological insights into atrial fibrillation: revisiting the electrophysiological substrate, anatomical substrate, and possible insights from proteomics
Bentley, R., Logantha, S. J. R. J., Sharma, P., Rainbow, R. R., & Lip, G. Y. H. (2021). Pathophysiological insights into atrial fibrillation: revisiting the electrophysiological substrate, anatomical substrate, and possible insights from proteomics. CARDIOVASCULAR RESEARCH, 117(3), E41-E45. doi:10.1093/cvr/cvaa276
2020
Silencing miR-370-3p rescues funny current and sinus node function in heart failure
Yanni, J., D'Souza, A., Wang, Y., Li, N., Hansen, B. J., Zakharkin, S. O., . . . Boyett, M. R. (2020). Silencing miR-370-3p rescues funny current and sinus node function in heart failure. Scientific Reports, 10. doi:10.1038/s41598-020-67790-0
2019
A sexy approach to pacemaking: differences in function and molecular make up of the sinoatrial node
Doris, U., Kharche, S., Petkova, M., Borbas, B., Logantha, S. J. R. J., Fedorenko, O., . . . Yanni, J. (2019). A sexy approach to pacemaking: differences in function and molecular make up of the sinoatrial node. HISTOLOGY AND HISTOPATHOLOGY, 34(11), 1255-1268. doi:10.14670/HH-18-115
Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring
Logantha, S. J. R. J., Kharche, S. R., Zhang, Y., Atkinson, A. J., Hao, G., Boyett, M. R., & Dobrzynski, H. (2019). Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-48276-0
Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart
Zhang, Y., Wang, Y., Yanni, J., Qureshi, M. A., Logantha, S. J. R. J., Kassab, S., . . . Dobrzynski, H. (2019). Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart. FRONTIERS IN PHYSIOLOGY, 10. doi:10.3389/fphys.2019.00826
Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
Linscheid, N., Logantha, S. J. R. J., Poulsen, C., Zhang, S., Schrolkamp, M., Egerod, K. L., . . . Lundby, A. (2019). Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking. Nature Communications, 10. doi:10.1038/s41467-019-10709-9
2018
Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels
Saeed, Y., Temple, I. P., Borbas, Z., Atkinson, A., Yanni, J., Maczewski, M., . . . Dobrzynski, H. (2018). Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels. HEART RHYTHM, 15(5), 752-760. doi:10.1016/j.hrthm.2017.12.027
Obesity causes cardiac ion channel remodelling and increases the propensity for atrial arrhythmias
Webb, K., Logantha, S. J., Absi, M., Cartwright, E., Zhang, H., Monfredi, O., & Boyett, M. R. (2018). Obesity causes cardiac ion channel remodelling and increases the propensity for atrial arrhythmias. In EUROPEAN HEART JOURNAL Vol. 39 (pp. 1204). Retrieved from https://www.webofscience.com/
2017
Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia
D'Souza, A., Pearman, C. M., Wang, Y., Nakao, S., Logantha, S. J. R. J., Cox, C., . . . Boyett, M. R. (2017). Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia. Circulation Research, 121(9), 1058-1068. doi:10.1161/CIRCRESAHA.117.311607
A Sexy Approach to Pacemaking
Doris, U., Logantha, S., Petkova, M., Zhang, Y., Kharche, S., Dobrzynski, H., & Yanni, J. (2017). A Sexy Approach to Pacemaking. In BIOPHYSICAL JOURNAL Vol. 112 (pp. 403A). doi:10.1016/j.bpj.2016.11.2182
Obesity increases the propensity for atrial arrhythmias
Webb, K., Absi, M., Logantha, S., Zaborska, K., Gurney, A., Heagarty, A., . . . Boyett, M. (2017). Obesity increases the propensity for atrial arrhythmias. In EUROPEAN HEART JOURNAL Vol. 38 (pp. 637). Retrieved from https://www.webofscience.com/
2016
Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension
Temple, I. P., Logantha, S. J. R. J., Absi, M., Zhang, Y., Pervolaraki, E., Yanni, J., . . . Dobrzynski, H. (2016). Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 9(12). doi:10.1161/CIRCEP.115.003432
Expression of connexin 43, ion channels and Ca<SUP>2+</SUP>-handling proteins in rat pulmonary vein cardiomyocytes
Xiao, Y., Cai, X., Atkinson, A., Logantha, S. J., Boyett, M., & Dobrzynski, H. (2016). Expression of connexin 43, ion channels and Ca<SUP>2+</SUP>-handling proteins in rat pulmonary vein cardiomyocytes. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 12(5), 3233-3241. doi:10.3892/etm.2016.3766
Ca<SUP>2+</SUP>-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
Logantha, S. J. R. J., Stokke, M. K., Atkinson, A. J., Kharche, S. R., Parveen, S., Saeed, Y., . . . Dobrzynski, H. (2016). Ca<SUP>2+</SUP>-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance. FRONTIERS IN PHYSIOLOGY, 7. doi:10.3389/fphys.2016.00197
Bradycardia in Hypothyroidism is Caused by Intrinsic Remodelling of the Sinus Node
Logantha, S. J. R. J., Ozbeyli, D., Yanni, J., D'souza, A., Dobrzynski, H., Cakir, O. K., & Boyett, M. R. (2016). Bradycardia in Hypothyroidism is Caused by Intrinsic Remodelling of the Sinus Node. In ACTA PHYSIOLOGICA Vol. 218 (pp. 26). Retrieved from https://www.webofscience.com/
Decremental conduction in the atrioventricular node and heart block in pulmonary arterial hypertension
Logantha, S. J., Temple, P., Absi, M., Zhang, Y., Petkova, M. A., Yanni, J., . . . Boyett, M. R. (2016). Decremental conduction in the atrioventricular node and heart block in pulmonary arterial hypertension. In EUROPEAN HEART JOURNAL Vol. 37 (pp. 618-619). Retrieved from https://www.webofscience.com/
Sinus Node-Like Pacemaker Phenotype is the Basis of Ectopic Activity Originating in Atrioventricular Rings
Logantha, S. J. R., Atkinson, A. J., Kharche, S. R., & Dobrzynski, H. (2016). Sinus Node-Like Pacemaker Phenotype is the Basis of Ectopic Activity Originating in Atrioventricular Rings. In CIRCULATION Vol. 134. Retrieved from https://www.webofscience.com/
2015
From the Purkinje Fibres to the Ventricle: One Dimensional Computer Simulation for the Healthy and Failing Heart
Li, J., Logantha, S. J., Yanni, J., Cai, X., Dobrzynski, H., Hart, G., & Boyett, M. R. (2015). From the Purkinje Fibres to the Ventricle: One Dimensional Computer Simulation for the Healthy and Failing Heart. 2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 34-37. Retrieved from https://www.webofscience.com/
Molecular Basis of Sinus Bradycardia in Hypothyroidism
Logantha, S. J., Ozbeyli, D., Yanni, J., Dobrzynski, H., Kasimay, O., & Boyett, M. (2015). Molecular Basis of Sinus Bradycardia in Hypothyroidism. In ACTA PHYSIOLOGICA Vol. 215 (pp. 74-75). Retrieved from https://www.webofscience.com/
Molecular basis of sinus bradycardia in hypothyroidism
Logantha, S. J. R. J., Ozbeyli, D., Yanni, J., Dobrzynski, H., Kasimay, O., & Boyett, M. R. (2015). Molecular basis of sinus bradycardia in hypothyroidism. In ACTA PHYSIOLOGICA Vol. 215 (pp. 67). Retrieved from https://www.webofscience.com/
2014
Molecular Basis of Arrhythmias Associated with the Cardiac Conduction System
Logantha, S. J. R. J., Atkinson, A. J., Boyett, M. R., & Dobrzynski, H. (2014). Molecular Basis of Arrhythmias Associated with the Cardiac Conduction System. In Cardiac Arrhythmias (pp. 19-34). Springer London. doi:10.1007/978-1-4471-5316-0_3
Exercise training reduces resting heart rate via downregulation of the funny channel HCN4
D'Souza, A., Bucchi, A., Johnsen, A. B., Logantha, S. J. R. J., Monfredi, O., Yanni, J., . . . Boyett, M. R. (2014). Exercise training reduces resting heart rate via downregulation of the funny channel HCN4. Nature Communications, 5. doi:10.1038/ncomms4775
Changes in microRNAs could explain the dysfunction of the cardiac conduction system (CCS) in heart failure
Yanni, J., Zi, M., Cai, X., Logantha, S. J., Li, J., Cartwright, E., . . . Boyett, M. (2014). Changes in microRNAs could explain the dysfunction of the cardiac conduction system (CCS) in heart failure. In EUROPEAN HEART JOURNAL Vol. 35 (pp. 329). Retrieved from https://www.webofscience.com/
2013
Functional, Anatomical, and Molecular Investigation of the Cardiac Conduction System and Arrhythmogenic Atrioventricular Ring Tissue in the Rat Heart
Atkinson, A. J., Logantha, S. J. R. J., Hao, G., Yanni, J., Fedorenko, O., Sinha, A., . . . Dobrzynski, H. (2013). Functional, Anatomical, and Molecular Investigation of the Cardiac Conduction System and Arrhythmogenic Atrioventricular Ring Tissue in the Rat Heart. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2(6). doi:10.1161/JAHA.113.000246
Computer Simulation of Purkinje Fibres from a Rabbit Model of Congestive Heart Failure
Li, J., Logantha, S. J., Yanni, J., Cai, X., Zhang, H., Dobrzynski, H., . . . Boyett, M. (2013). Computer Simulation of Purkinje Fibres from a Rabbit Model of Congestive Heart Failure. In 2013 COMPUTING IN CARDIOLOGY CONFERENCE (CINC) Vol. 40 (pp. 361-364). Retrieved from https://www.webofscience.com/
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues
Dobrzynski, H., Anderson, R. H., Atkinson, A., Borbas, Z., D'Souza, A., Fraser, J. F., . . . Boyett, M. R. (2013). Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues. PHARMACOLOGY & THERAPEUTICS, 139(2), 260-288. doi:10.1016/j.pharmthera.2013.04.010
Adverse Remodelling of the Cardiac Conduction System (CCS) in Heart Failure Could be the Result of Up and Down Regulation of MicroRNAs
Yanni, J., Zi, M., Cai, X., Logantha, S. J. R., Li, J., Cartwright, E., . . . Boyett, M. (2013). Adverse Remodelling of the Cardiac Conduction System (CCS) in Heart Failure Could be the Result of Up and Down Regulation of MicroRNAs. In CIRCULATION Vol. 128. Retrieved from https://www.webofscience.com/
Popdc knock out results in sick sinus syndrome
Logantha, S. J., Simick, S., Schindler, R., Dobrzynski, H., Boyett, M. R., & Brand, T. (2013). Popdc knock out results in sick sinus syndrome. In EUROPEAN HEART JOURNAL Vol. 34 (pp. 419). Retrieved from https://www.webofscience.com/
2011
Anger, emotion, and arrhythmias: from brain to heart
Taggart, P., Boyett, M. R., Logantha, S. J. R. J., & Lambiase, P. D. (2011). Anger, emotion, and arrhythmias: from brain to heart. FRONTIERS IN PHYSIOLOGY, 2. doi:10.3389/fphys.2011.00067
2010
Spontaneous and electrically evoked Ca<SUP>2+</SUP> transients in cardiomyocytes of the rat pulmonary vein
Logantha, S. J. R. J., Cruickshank, S. F., Rowan, E. G., & Drummond, R. M. (2010). Spontaneous and electrically evoked Ca<SUP>2+</SUP> transients in cardiomyocytes of the rat pulmonary vein. CELL CALCIUM, 48(2-3), 150-160. doi:10.1016/j.ceca.2010.08.002
2006
Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors.
Yogeeswari, P., Sriram, D., Thirumurugan, R., Jeewanlal, L. R., Jit, S., Ragavendran, J. V., . . . Saraswat, V. (2006). Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors.. Acta pharmaceutica (Zagreb, Croatia), 56(3), 259-272.
2002
Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones
Yogeeswari, P., Sriram, D., Jit, L. R. J. S., Kumar, S. S., & Stables, J. P. (2002). Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 37(3), 231-236. doi:10.1016/S0223-5234(02)01338-7