Publications
2022
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials
Asiimwe, I. G., Pushpakom, S. P., Turner, R. M., Kolamunnage-Dona, R., Jorgensen, A. L., & Pirmohamed, M. (2022). Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(8), 3577-3599. doi:10.1111/bcp.15331
Introduction and Historical Overview of Drug Repurposing Opportunities
Pushpakom, S. (2022). Introduction and Historical Overview of Drug Repurposing Opportunities. In Drug Repurposing (pp. 1-13). The Royal Society of Chemistry. doi:10.1039/9781839163401-00001
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials
Asiimwe, I., Pushpakom, S., Turner, R., Kolamunnage-Dona, R., Jorgensen, A., & Pirmohamed, M. (2022). Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials. doi:10.22541/au.164431813.39836023/v1
2021
Cardiovascular drugs and COVID-19 clinical outcomes: A living systematic review and meta-analysis
Asiimwe, I. G., Pushpakom, S., Turner, R. M., Kolamunnage-Dona, R., Jorgensen, A. L., & Pirmohamed, M. (2021). Cardiovascular drugs and COVID-19 clinical outcomes: A living systematic review and meta-analysis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4534-+. doi:10.1111/bcp.14927
Clinical and pharmacogenetic determinants of tenofovir-induced renal toxicity in HIV positive patients in Zambia
Hamachila, A., Pushpakom, S., Jorgensen, A., & Pirmohamed, M. (2021). Clinical and pharmacogenetic determinants of tenofovir-induced renal toxicity in HIV positive patients in Zambia. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 87 (pp. 4889). Retrieved from https://www.webofscience.com/
2020
Cardiovascular drugs and COVID-19 clinical outcomes: a living systematic review and meta-analysis
Asiimwe, I., Pushpakom, S., Turner, R., Kolamunnage-Dona, R., Jorgensen, A., & Pirmohamed, M. (2020). Cardiovascular drugs and COVID-19 clinical outcomes: a living systematic review and meta-analysis. doi:10.1101/2020.10.07.20208918
TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy
Pushpakom, S. P., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., Garcia-Finana, M., . . . Pirmohamed, M. (n.d.). TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy. Clinical Infectious Diseases. doi:10.1093/cid/ciz589
2019
Development and validation of an in vitro model for drug-induced non-alcoholic fatty liver disease
Nedzveckaite, R., Sharma, P., & Pushpakom, S. (2019). Development and validation of an in vitro model for drug-induced non-alcoholic fatty liver disease. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3058-3059). Retrieved from https://www.webofscience.com/
Nilotinib-induced metabolic dysfunction: insights from a translational study using in vitro adipocyte models and patient cohorts
Sadiq, S., Owen, E., Foster, T., Knight, K., Wang, L., Pirmohamed, M., . . . Pushpakom, S. (2019). Nilotinib-induced metabolic dysfunction: insights from a translational study using in vitro adipocyte models and patient cohorts. Leukemia, 33, 1810-1814. doi:10.1038/s41375-018-0337-0
Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT
Pushpakom, S., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., Garcia-Finana, M., . . . Pirmohamed, M. (2019). Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT.
2018
Drug repurposing: progress, challenges and recommendations
Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., . . . Pirmohamed, M. (2019). Drug repurposing: progress, challenges and recommendations. NATURE REVIEWS DRUG DISCOVERY, 18(1), 41-58. doi:10.1038/nrd.2018.168
Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.
Pushpakom, S. P., Adaikalakoteswari, A., Owen, A., Back, D. J., Tripathi, G., Kumar, S., . . . Pirmohamed, M. (2018). Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.. Diabetes & vascular disease research, 15(3), 233-242. doi:10.1177/1479164118757924
2017
NILOTINIB-INDUCED METABOLIC DYSFUNCTION: INSIGHTS FROM A TRANSLATIONAL PILOT STUDY USING <i>IN VITRO</i> ADIPOCYTE MODELS AND PATIENT COHORTS
Sadiq, S., Owen, E., Foster, T., Knight, K., Wang, L., Pirmohamed, M., . . . Pushpakom, S. (2017). NILOTINIB-INDUCED METABOLIC DYSFUNCTION: INSIGHTS FROM A TRANSLATIONAL PILOT STUDY USING <i>IN VITRO</i> ADIPOCYTE MODELS AND PATIENT COHORTS. Poster session presented at the meeting of Unknown Conference. Retrieved from https://www.webofscience.com/
A synonymous variant in TREX1 is associated with systemic sclerosis and severe digital ischaemia
Hughes, M., Little, J., Herrick, A. L., Pushpakom, S., Byers, H., Worthington, J., & Newman, W. G. (2017). A synonymous variant in TREX1 is associated with systemic sclerosis and severe digital ischaemia. Scandinavian Journal of Rheumatology, 46(01), 77-78. doi:10.1080/03009742.2016.1195872
2016
Pivotal role of NFATc4 in antiretroviral-induced adipocyte toxicity
Majid, R., Pushpakom, S., & Pirmohamed, M. (2016). Pivotal role of NFATc4 in antiretroviral-induced adipocyte toxicity. Poster session presented at the meeting of Unknown Conference. Retrieved from https://www.webofscience.com/
2015
Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIVpositive individuals on combination antiretroviral therapy
Pushpakom, S., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcia Finana, M., . . . Pirmohamed, M. (2015). Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIVpositive individuals on combination antiretroviral therapy. BMJ Open, 5(10). doi:10.1136/bmjopen-2015-009566
Pharmacotherapy for alcohol dependence: A stratified approach
Thompson, A., Owens, L., Pushpakom, S. P., Faizal, M., & Pirmohamed, M. (2015). Pharmacotherapy for alcohol dependence: A stratified approach. PHARMACOLOGY & THERAPEUTICS, 153, 10-24. doi:10.1016/j.pharmthera.2015.05.010
2013
Simultaneous Pharmacogenetics-Based Population Pharmacokinetic Analysis of Darunavir and Ritonavir in HIV-Infected Patients
Molto, J., Xinarianos, G., Miranda, C., Pushpakom, S., Cedeno, S., Clotet, B., . . . Valle, M. (2013). Simultaneous Pharmacogenetics-Based Population Pharmacokinetic Analysis of Darunavir and Ritonavir in HIV-Infected Patients. CLINICAL PHARMACOKINETICS, 52(7), 543-553. doi:10.1007/s40262-013-0057-6
The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia
Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia. BLOOD, 121(4), 628-637. doi:10.1182/blood-2012-01-405035
<i>RXR</i> gene variants are associated with HIV lipodystrophy
Pushpakom, S. P., Owen, A., Back, D. J., & Pirmohamed, M. (2013). <i>RXR</i> gene variants are associated with HIV lipodystrophy. PHARMACOGENETICS AND GENOMICS, 23(8), 438-441. doi:10.1097/FPC.0b013e328362cfc6
Role of IL18 in HIV lipodystrophy
Majid, R., Pushpakom, S., & Pirmohamed, M. (2013). Role of IL18 in HIV lipodystrophy. In HIV MEDICINE Vol. 14 (pp. 40). Retrieved from https://www.webofscience.com/
The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK
Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73
The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia
Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia. Blood, 121, 628-637.
2012
Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists
Cuthbertson, D. J., Irwin, A., Gardner, C. J., Daousi, C., Purewal, T., Furlong, N., . . . Kemp, G. J. (2012). Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050117
Association of <i>ABCC10</i> polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS
Liptrott, N. J., Pushpakom, S., Wyen, C., Faetkenheuer, G., Hoffmann, C., Mauss, S., . . . Owen, A. (2012). Association of <i>ABCC10</i> polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. PHARMACOGENETICS AND GENOMICS, 22(1), 10-19. doi:10.1097/FPC.0b013e32834dd82e
Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS
Liptrott, N. J., Pushpakom, S., Wyen, C., Fätkenheuer, G., Hoffmann, C., Mauss, S., . . . Owen, A. (2012). Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. Pharmacogenetics and Genomics, 22(1), 10-19. doi:10.1097/fpc.0b013e32834dd82e
Telmisartan Reverses Antiretroviral Induced Insulin Resistance In An in vitro Human Primary Adipocyte Model
Pushpakom, S., Koteshwari, A., Owen, A., Back, D., McTernan, P., Kumar, S., . . . Pirmohamed, M. (2012). Telmisartan Reverses Antiretroviral Induced Insulin Resistance In An in vitro Human Primary Adipocyte Model. In CROI (pp. 1). Seattle, USA: CROI.
2011
Pharmacogenetics of Adverse Drug Reactions
Pushpakom, S. P., & Pirmohamed, M. (2011). Pharmacogenetics of Adverse Drug Reactions. In Unknown Book (pp. 121-156). Wiley. doi:10.1002/9780470975053.ch2
The <i>SLCO1B1</i> rs4149032 Polymorphism Is Highly Prevalent in South Africans and Is Associated with Reduced Rifampin Concentrations: Dosing Implications
Chigutsa, E., Visser, M. E., Swart, E. C., Denti, P., Pushpakom, S., Egan, D., . . . McIlleron, H. (2011). The <i>SLCO1B1</i> rs4149032 Polymorphism Is Highly Prevalent in South Africans and Is Associated with Reduced Rifampin Concentrations: Dosing Implications. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55(9), 4122-4127. doi:10.1128/AAC.01833-10
Genetic Variants of <i>ABCC10</i>, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction
Pushpakom, S. P., Liptrott, N. J., Rodriguez-Novoa, S., Labarga, P., Soriano, V., Albalater, M., . . . Owen, A. (2011). Genetic Variants of <i>ABCC10</i>, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction. JOURNAL OF INFECTIOUS DISEASES, 204(1), 145-153. doi:10.1093/infdis/jir215
Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction
Pushpakom, S. P., Liptrott, N. J., Rodríguez-Nóvoa, S., Labarga, P., Soriano, V., Albalater, M., . . . Owen, A. (2011). Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction. The Journal of Infectious Diseases, 204(1), 145-153. doi:10.1093/infdis/jir215
A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study
Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., . . . Ollier, W. E. R. (2011). A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study. PHARMACOGENOMICS, 12(6), 815-826. doi:10.2217/PGS.11.32
Exacerbation of hereditary warfarin resistance by azathioprine.
Pushpakom, S. P., Gambhir, N., Latif, A., Hadfield, K. D., Campbell, S., & Newman, W. G. (2011). Exacerbation of hereditary warfarin resistance by azathioprine.. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(3), 293-296. doi:10.1177/1076029609356427
Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients: A prospective observational study
Rifai, A. A., Prasad, N., Shuttleworth, E., McBurney, H., Pushpakom, S., Robinson, A., . . . Campbell, S. (2011). Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients: A prospective observational study. European Journal of Gastroenterology and Hepatology, 23(2), 153-158. doi:10.1097/MEG.0b013e32834233a2
Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients: a prospective observational study.
Al Rifai, A., Prasad, N., Shuttleworth, E., McBurney, H., Pushpakom, S., Robinson, A., . . . Campbell, S. (2011). Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients: a prospective observational study.. European journal of gastroenterology & hepatology, 23(2), 153-158. doi:10.1097/meg.0b013e32834233a2
Adipogenic Gene Variants are Associated with Lipid Changes in HIV-infected Adults on Efavirenz and Lopinavir-based Regimens
Pushpakom, S., Mahungu, T., Farragher, T., Nair, D., Youle, M., Owen, A., . . . Pirmohamed, M. (2011). Adipogenic Gene Variants are Associated with Lipid Changes in HIV-infected Adults on Efavirenz and Lopinavir-based Regimens. In Conference on Retroviruses (pp. 1). Boston: Conference on Retroviruses.
Adipogenic gene variants in patients with HIV-associated lipodystrophy
Pushpakom, S. P., Owen, A., Vilar, F. J., Castro, H., Dunn, D. T., Back, D. J., & Pirmohamed, M. (2011). Adipogenic gene variants in patients with HIV-associated lipodystrophy. PHARMACOGENETICS AND GENOMICS, 21(2), 76-83. doi:10.1097/FPC.0b013e328342a917
Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses
Fleeman, N., Dundar, Y., Dickson, R., Jorgensen, A., Pushpakom, S., McLeod, C., . . . Walley, T. (2011). Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses. PHARMACOGENOMICS JOURNAL, 11(1), 1-14. doi:10.1038/tpj.2010.73
Pharmacogenetics of adverse drug reactions
Pushpakom, S., & Pirmohamed, M. (2011). Pharmacogenetics of adverse drug reactions. In J. Talbott, & P. Waller (Eds.), Stephens' Detection of New Adverse Drug Reactions (pp. Not known). Malden, MA, USA: John Wiley & Sons.
The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: Dosing implications
Chigutsa, E., Visser, M. E., Swart, E. C., Denti, P., Pushpakom, S., Egan, D., . . . McIlleron, H. (2011). The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: Dosing implications. Antimicrob Agents Chemother, 55(9), 4122-4127.
2010
Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population.
Hakooz, N., Arafat, T., Payne, D., Ollier, W., Pushpakom, S., Andrews, J., & Newman, W. (2010). Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population.. European journal of clinical pharmacology, 66(10), 999-1003. doi:10.1007/s00228-010-0826-1
Association of ABCC10 Polymorphisms with Nevirapine Plasma Concentrations in the German Competence Network for HIV/AIDS
Liptrott, N. J., Pushpakom, S., Wyen, C., Rockstroh, J., Mauss, S., Knechten, H., . . . Owen, A. (2010). Association of ABCC10 Polymorphisms with Nevirapine Plasma Concentrations in the German Competence Network for HIV/AIDS. In 17th Conference on Retroviruses and Opportunistic Infections (pp. 286). San Francisco: Conference on Retroviruses and Opportunistic Infections.
Genetic Variants of ABCC10 Are Associated with Kidney Tubular Dysfunction in Patients Treated with Tenofovir-containing Regimens
Pushpakom, S., Liptrott, N. J., RodrÃguez-Nóvoa, S., Labarga, P., Soriano, V., Albalater, M., . . . Owen, A. (2010). Genetic Variants of ABCC10 Are Associated with Kidney Tubular Dysfunction in Patients Treated with Tenofovir-containing Regimens. In 17th Conference on Retroviruses and Opportunistic Infections (pp. 352). San Francisco: Conference on Retroviruses and Opportunistic Infections.
The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation
Fleeman, N., McLeod, C., Bagust, A., Beale, S., Boland, A., Dundar, Y., . . . Dickson, R. (2010). The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 14(3), 1-+. doi:10.3310/hta14030
2009
Adipogenic gene variants in patients with HIV-associated lipodystrophy
Pushpakom, S., Owen, A., Vilar, J., Back, D., & Pirmohamed, M. (2009). Adipogenic gene variants in patients with HIV-associated lipodystrophy. In HIV MEDICINE Vol. 10 (pp. 1). Retrieved from https://www.webofscience.com/
2008
Polymorphisms in COL15 gene are not associated with systemic sclerosis.
Pushpakom, S. P., Herrick, A. L., Kumar, S., & Worthington, J. (2008). Polymorphisms in COL15 gene are not associated with systemic sclerosis.. The Journal of rheumatology, 35(2), 251-253.
2007
Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events.
Chowdhury, J., Kaigala, G. V., Pushpakom, S., Lauzon, J., Makin, A., Atrazhev, A., . . . Pilarski, L. M. (2007). Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events.. The Journal of molecular diagnostics : JMD, 9(4), 521-529. doi:10.2353/jmoldx.2007.070014
2006
Quantitative analysis of plasma DNA in severe acute pancreatitis.
Bagul, A., Pushpakom, S., Boylan, J., Newman, W., & Siriwardena, A. K. (2006). Quantitative analysis of plasma DNA in severe acute pancreatitis.. JOP : Journal of the pancreas, 7(6), 602-607.
2004
Overexpression of CD105 in rat myoblasts: role of CD105 in cell attachment, spreading and survival.
Guo, B., Rooney, P., Slevin, M., Li, C., Parameshwar, S., Liu, D., . . . Kumar, S. (2004). Overexpression of CD105 in rat myoblasts: role of CD105 in cell attachment, spreading and survival.. International journal of oncology, 25(2), 285-291.
CD105 inhibits transforming growth factor-beta-Smad3 signalling
Parameshwar, S., Guo, B., Slevin, M., Li, C., Liu, D., Kumar, P., . . . Bernabeu, C. (2004). CD105 inhibits transforming growth factor-beta-Smad3 signalling. Anticancer Research.