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2024

Progress on improving animal welfare and experiment translatability using an animal model of venom induced consumption coagulopathy

Marriott, A. E., Stars, E., Casewell, N., & Ainsworth, S. (2024). Progress on improving animal welfare and experiment translatability using an animal model of venom induced consumption coagulopathy. Toxicon, 248, 107924. doi:10.1016/j.toxicon.2024.107924

DOI
10.1016/j.toxicon.2024.107924
Journal article

African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.

Solano, G., Cunningham, S., Edge, R. J., Duran, G., Sanchez, A., Villalta, M., . . . Ainsworth, S. (2024). African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.. BMJ global health, 9(3), e014813. doi:10.1136/bmjgh-2023-014813

DOI
10.1136/bmjgh-2023-014813
Journal article

Characterisation of Putative Outer Membrane Proteins from Leptospira borgpetersenii Serovar Hardjo-Bovis Identifies Novel Adhesins and Diversity in Adhesion across Genomospecies Orthologs

Kamaruzaman, I. N. A., Staton, G. J., Ainsworth, S., Carter, S. D., & Evans, N. J. (n.d.). Characterisation of Putative Outer Membrane Proteins from Leptospira borgpetersenii Serovar Hardjo-Bovis Identifies Novel Adhesins and Diversity in Adhesion across Genomospecies Orthologs. Microorganisms, 12(2), 245. doi:10.3390/microorganisms12020245

DOI
10.3390/microorganisms12020245
Journal article

2023

OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia

Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L., . . . Toh, C. (2023). OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 100487. doi:10.1016/j.rpth.2023.100487

DOI
10.1016/j.rpth.2023.100487
Journal article

2022

Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition

Menzies, S. K., Dawson, C. A., Crittenden, E., Edge, R. J., Hall, S. R., Alsolaiss, J., . . . Ainsworth, S. (2022). Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-13376-x

DOI
10.1038/s41598-022-13376-x
Journal article

Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.

Alomran, N., Alsolaiss, J., Albulescu, L. -O., Crittenden, E., Harrison, R. A., Ainsworth, S., & Casewell, N. R. (2022). Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.. PLoS neglected tropical diseases, 16(6), e0010511. doi:10.1371/journal.pntd.0010511

DOI
10.1371/journal.pntd.0010511
Journal article

Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms

DOI
10.1101/2022.05.07.491032
Preprint

2021

Welcome to online-only production of <i>Parasitology</i> and future-proofing of the journal's academic standards

Stothard, J. R., Ainsworth, S., & Marriott, A. E. (2021). Welcome to online-only production of <i>Parasitology</i> and future-proofing of the journal's academic standards. PARASITOLOGY, 148(13), 1529-1531. doi:10.1017/S003118202100144X

DOI
10.1017/S003118202100144X
Journal article

Virus-like particles displaying conserved toxin epitopes stimulate broadly reactive, polyspecific, murine antibody responses capable of snake venom recognition

DOI
10.21203/rs.3.rs-1044937/v1
Preprint

Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.

Alomran, N., Alsolaiss, J., Albulescu, L. -O., Crittenden, E., Harrison, R. A., Ainsworth, S., & Casewell, N. R. (2021). Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.. PLoS neglected tropical diseases, 15(8), e0009659. doi:10.1371/journal.pntd.0009659

DOI
10.1371/journal.pntd.0009659
Journal article

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite (vol 11, 6094, 2020)

Albulescu, L. -O., Xie, C., Ainsworth, S., Alsolaiss, J., Crittenden, E., Dawson, C. A., . . . Casewell, N. R. (2021). A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite (vol 11, 6094, 2020). NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-24308-0

DOI
10.1038/s41467-021-24308-0
Journal article

Animal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19

Ainsworth, S., Menzies, S., & Pleass, R. (2020). Animal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19. doi:10.12688/wellcomeopenres.15990.1

DOI
10.12688/wellcomeopenres.15990.1
Journal article

2020

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Albulescu, L. -O., Xie, C., Ainsworth, S., Alsolaiss, J., Crittenden, E., Dawson, C. A., . . . Casewell, N. R. (2020). A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-19981-6

DOI
10.1038/s41467-020-19981-6
Journal article

Differences in the antibody response to adult Fasciola hepatica excretory/secretory products in experimentally and naturally infected cattle and sheep

Walsh, T. R., Ainsworth, S., Armstrong, S., Hodgkinson, J., & Williams, D. (2020). Differences in the antibody response to adult Fasciola hepatica excretory/secretory products in experimentally and naturally infected cattle and sheep. Veterinary Parasitology, 109321. doi:10.1016/j.vetpar.2020.109321

DOI
10.1016/j.vetpar.2020.109321
Journal article

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management.

Ainsworth, S., Menzies, S. K., Casewell, N. R., & Harrison, R. A. (2020). An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management.. PLoS neglected tropical diseases, 14(8), e0008579. doi:10.1371/journal.pntd.0008579

DOI
10.1371/journal.pntd.0008579
Journal article

Correction: Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.

Harrison, R. A., Oluoch, G. O., Ainsworth, S., Alsolaiss, J., Bolton, F., Arias, A. -S., . . . Casewell, N. R. (2020). Correction: Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.. PLoS neglected tropical diseases, 14(8), e0008698. doi:10.1371/journal.pntd.0008698

DOI
10.1371/journal.pntd.0008698
Journal article

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity.

Krause, K. E., Jenkins, T. P., Skaarup, C., Engmark, M., Casewell, N. R., Ainsworth, S., . . . Laustsen, A. H. (2020). An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity.. PLoS neglected tropical diseases, 14(6), e0008366. doi:10.1371/journal.pntd.0008366

DOI
10.1371/journal.pntd.0008366
Journal article

A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

DOI
10.1101/2020.05.13.094599
Preprint

Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite

Albulescu, L. -O., Hale, M. S., Ainsworth, S., Alsolaiss, J., Crittenden, E., Calvete, J. J., . . . Casewell, N. R. (2020). Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite. SCIENCE TRANSLATIONAL MEDICINE, 12(542). doi:10.1126/scitranslmed.aay8314

DOI
10.1126/scitranslmed.aay8314
Journal article

CONVERGENT EVOLUTION OF DEFENSIVE VENOM COMPONENTS IN SPITTING COBRAS

Kazandjian, T., Petras, D., Robinson, S., Undheim, E., Arbuckle, K., Whiteley, G., . . . Casewell, N. (2020). CONVERGENT EVOLUTION OF DEFENSIVE VENOM COMPONENTS IN SPITTING COBRAS. TOXICON, 177, S37. Retrieved from https://www.webofscience.com/

Journal article

CROSS-SPECIES AND GEOGRAPHIC POTENTIAL OF B-CELL EPITOPE STRINGS IDENTIFIED FOR GENERATION OF AN AFRICA-SPECIFIC SNAKE VENOM-INDUCED NECROSIS THERAPEUTIC

Dawson, C., Ainsworth, S., Wilkinson, M., & Harrison, R. (2020). CROSS-SPECIES AND GEOGRAPHIC POTENTIAL OF B-CELL EPITOPE STRINGS IDENTIFIED FOR GENERATION OF AN AFRICA-SPECIFIC SNAKE VENOM-INDUCED NECROSIS THERAPEUTIC. TOXICON, 177, S34-S35. Retrieved from https://www.webofscience.com/

Journal article

Putative β-Barrel Outer Membrane Proteins of the Bovine Digital Dermatitis-Associated Treponemes: Identification, Functional Characterization, and Immunogenicity

Staton, G. J., Carter, S. D., Ainsworth, S., Mullin, J., Smith, R. F., & Evans, N. J. (2020). Putative β-Barrel Outer Membrane Proteins of the Bovine Digital Dermatitis-Associated Treponemes: Identification, Functional Characterization, and Immunogenicity. INFECTION AND IMMUNITY, 88(5). doi:10.1128/IAI.00050-20

DOI
10.1128/IAI.00050-20
Journal article

Snake Venom Gland Organoids

Post, Y., Puschhof, J., Beumer, J., Kerkkamp, H. M., de Bakker, M. A. G., Slagboom, J., . . . Clevers, H. (2020). Snake Venom Gland Organoids. CELL, 180(2), 233-+. doi:10.1016/j.cell.2019.11.038

DOI
10.1016/j.cell.2019.11.038
Journal article

2019

The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims

Harrison, R. A., Casewell, N. R., Ainsworth, S. A., & Lalloo, D. G. (2019). The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 113(12), 834-837. doi:10.1093/trstmh/try134

DOI
10.1093/trstmh/try134
Journal article

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

DOI
10.1101/717280
Preprint

Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming

Williams, D. J., Abul Faiz, M., Abela-Ridder, B., Ainsworth, S., Bulfone, T. C., Nickerson, A. D., . . . Warrell, D. A. (2019). Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming. PLOS NEGLECTED TROPICAL DISEASES, 13(2). doi:10.1371/journal.pntd.0007059

DOI
10.1371/journal.pntd.0007059
Journal article

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

Albulescu, L. -O., Kazandjian, T., Slagboom, J., Bruyneel, B., Ainsworth, S., Alsolaiss, J., . . . Casewell, N. R. (2019). A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite. FRONTIERS IN PHARMACOLOGY, 10. doi:10.3389/fphar.2019.00848

DOI
10.3389/fphar.2019.00848
Journal article

2018

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.

Vanzolini, K. L., Ainsworth, S., Bruyneel, B., Herzig, V., Seraus, M. G. L., Somsen, G. W., . . . Kool, J. (2018). Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.. Toxicon : official journal of the International Society on Toxinology, 152, 1-8. doi:10.1016/j.toxicon.2018.06.080

DOI
10.1016/j.toxicon.2018.06.080
Journal article

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.

Ainsworth, S., Petras, D., Engmark, M., Süssmuth, R. D., Whiteley, G., Albulescu, L. -O., . . . Calvete, J. J. (2018). The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.. Journal of proteomics, 172, 173-189. doi:10.1016/j.jprot.2017.08.016

DOI
10.1016/j.jprot.2017.08.016
Journal article

2017

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.

Harrison, R. A., Oluoch, G. O., Ainsworth, S., Alsolaiss, J., Bolton, F., Arias, A. -S., . . . Casewell, N. R. (2017). Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.. PLoS neglected tropical diseases, 11(10), e0005969. doi:10.1371/journal.pntd.0005969

DOI
10.1371/journal.pntd.0005969
Journal article

2016

Isolation of digital dermatitis treponemes from cattle hock skin lesions

Clegg, S. R., Bell, J., Ainsworth, S., Blowey, R. W., Bell, N. J., Carter, S. D., & Evans, N. J. (2016). Isolation of digital dermatitis treponemes from cattle hock skin lesions. VETERINARY DERMATOLOGY, 27(2), 106-E30. doi:10.1111/vde.12286

DOI
10.1111/vde.12286
Journal article

2015

Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the <i>plasminogen</i> (<i>PLG</i>) gene

Ainsworth, S., Carter, S., Fisher, C., Dawson, J., Makrides, L., Nuttall, T., & Mason, S. L. (2015). Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the <i>plasminogen</i> (<i>PLG</i>) gene. ANIMAL GENETICS, 46(6), 707-710. doi:10.1111/age.12339

DOI
10.1111/age.12339
Journal article

2014

The Lactococcus lactis plasmidome: much learnt, yet still lots to discover.

Ainsworth, S., Stockdale, S., Bottacini, F., Mahony, J., & van Sinderen, D. (2014). The Lactococcus lactis plasmidome: much learnt, yet still lots to discover.. FEMS microbiology reviews, 38(5), 1066-1088. doi:10.1111/1574-6976.12074

DOI
10.1111/1574-6976.12074
Journal article

2013

Investigation of the relationship between lactococcal host cell wall polysaccharide genotype and 936 phage receptor binding protein phylogeny.

Mahony, J., Kot, W., Murphy, J., Ainsworth, S., Neve, H., Hansen, L. H., . . . van Sinderen, D. (2013). Investigation of the relationship between lactococcal host cell wall polysaccharide genotype and 936 phage receptor binding protein phylogeny.. Applied and environmental microbiology, 79(14), 4385-4392. doi:10.1128/aem.00653-13

DOI
10.1128/aem.00653-13
Journal article

2012

Phages of lactic acid bacteria: the role of genetics in understanding phage-host interactions and their co-evolutionary processes.

Mahony, J., Ainsworth, S., Stockdale, S., & van Sinderen, D. (2012). Phages of lactic acid bacteria: the role of genetics in understanding phage-host interactions and their co-evolutionary processes.. Virology, 434(2), 143-150. doi:10.1016/j.virol.2012.10.008

DOI
10.1016/j.virol.2012.10.008
Journal article