Research
Research Interest 1
Pharmacokinetics and Pharmacodynamics:
Personalised Dosing Algorithms:
Pharmacokinetics is the study of what the body does to a drug and Pharmacodynamics is the study of what a drug does to the body. As well as identifying the variables that contribute to inter-patient variability in the response to specific drugs (e.g. Warfarin), the aim is then to combine this information into personalised dosing algorithms to improve both the efficacy and safety of prescribed doses.
Research groups
- Medical Statistics
Research grants
MICA: Towards using historical data for research prioritisation in children
MEDICAL RESEARCH COUNCIL
March 2015 - February 2018
Testing the Fear of Childbirth Questionnaire and feasibility of routine completion for antenatal services
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2022 - January 2025
Preventing Post Traumatic stress Disorder: the Stress and Wellbeing after Childbirth Study (STRAWB).
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
November 2016 - September 2019
TERSC a pilot prospective randomised controlled trial of thoracic epidural analgesia (TEA) versus rectus sheath catheters (RSC) for open midline incisions in major abdominal surgery within an enhanced recovery programme
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2014 - January 2017
Dynamic Electronic Tracking and Escalation to reduce Critical Care Transfers (The DETECT study)
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
October 2018 - August 2022
The Impact of continuous haemofiltration with high volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function- A pilot study
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
July 2010 - March 2012
A pilot randomised control trial, in intensive care patients, comparing seven days versus two days treatment with empirical antibiotics to treat hospital acquired infection of unknown origins
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2010 - March 2012
A pilot study to assess whethr humidified oxygen is more effective than standard oxygen therapy in treating children with acute severe asthma
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
November 2013 - October 2016
Research collaborations
Dr B. Matata
Royal Liverpool and Broadgreen University Hospital NHS Trust
I have collaborated on two successful HTA programme awards with Dr Matata and collegues A pilot randomised control trial comparing seven days verses two days of empirical antibiotics to treat hospital acquired infections of unknown origin in intensive care patients, NIHR Health Technology Assessment Programme, £170,000, Matata B, Toh C-H, Ruben M, Haycock A, Stables R., Scawn N. and Lane S. The impact of continuous haemofiltration with high volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function- a pilot study, NIHR Health Technology Assessment Programme, Matata B, Toh C-H, Ruben M, Haycock A, Mediratta N., Jackson M., Sharma A., Stables R., Scawn N., and Lane S.