Publications
2024
Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017.
Kovacs, D., Mambule, I., Read, J. M., Kiran, A., Chilombe, M., Bvumbwe, T., . . . Ho, A. (2024). Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017.. The Journal of infectious diseases, 230(2), e363-e373. doi:10.1093/infdis/jiad587
HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.
Shafiqa, N., Aston, S., Howard, A., Turtle, L., Abrams, S., Young, B., . . . Wootton, D. G. (2024). HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.. BMJ open, 14(7), e088490. doi:10.1136/bmjopen-2024-088490
System-wide approaches to antimicrobial therapy and antimicrobial resistance in the UK: the AMR-X framework.
AMR-X Collaborators. (2024). System-wide approaches to antimicrobial therapy and antimicrobial resistance in the UK: the AMR-X framework.. The Lancet. Microbe, 5(5), e500-e507. doi:10.1016/s2666-5247(24)00003-x
Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018-20; a multicentre UK cohort study.
Lansbury, L., Lawrence, H., McKeever, T. M., French, N., Aston, S., Hill, A. T., . . . Lim, W. S. (2024). Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018-20; a multicentre UK cohort study.. The Lancet regional health. Europe, 37, 100812. doi:10.1016/j.lanepe.2023.100812
Antimicrobial learning systems: an implementation blueprint for artificial intelligence to tackle antimicrobial resistance.
Howard, A., Aston, S., Gerada, A., Reza, N., Bincalar, J., Mwandumba, H., . . . Buchan, I. (2024). Antimicrobial learning systems: an implementation blueprint for artificial intelligence to tackle antimicrobial resistance.. The Lancet. Digital health, 6(1), e79-e86. doi:10.1016/s2589-7500(23)00221-2
Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop.
Howard, A., Reza, N., Aston, S., Woods, B., Gerada, A., Buchan, I., . . . Märtson, A. -G. (2024). Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop.. The Lancet. Infectious diseases, 24(1), e47-e58. doi:10.1016/s1473-3099(23)00367-5
2023
An unexpected diagnosis of disseminated sarcoidosis in a patient investigated for drug-resistant tuberculosis: A case report
Yeoh, A., Brookfield, C., Aston, S., Wat, D., & Wingfield, T. (2023). An unexpected diagnosis of disseminated sarcoidosis in a patient investigated for drug-resistant tuberculosis: A case report. Clinical Infection in Practice, 20, 100244. doi:10.1016/j.clinpr.2023.100244
Clinical features and management of individuals admitted to hospital with monkeypox and associated complications acrossthe UK: a retrospective cohort study
Fink, D. L., Callaby, H., Luintel, A., Beynon, W., Bond, H., Lim, E. Y., . . . Dunning, J. (2023). Clinical features and management of individuals admitted to hospital with monkeypox and associated complications acrossthe UK: a retrospective cohort study. LANCET INFECTIOUS DISEASES, 23(5), 589-597. doi:10.1016/S1473-3099(22)00806-4
Update on drug treatments for multidrug resistant tuberculosis
Davies, G. R., & Aston, S. (2023). Update on drug treatments for multidrug resistant tuberculosis. CURRENT OPINION IN INFECTIOUS DISEASES, 36(2), 132-139. doi:10.1097/QCO.0000000000000899
Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.
Turtle, L., Thorpe, M., Drake, T. M., Swets, M., Palmieri, C., Russell, C. D., . . . Docherty, A. B. (2023). Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.. PLoS medicine, 20(1), e1004086. doi:10.1371/journal.pmed.1004086
2022
15 A curious case of chronic cough and complex partial seizures
Yeoh, A., Aston, S., Brookfield, C., Wong, N., & Wingfield, T. (2022). 15 A curious case of chronic cough and complex partial seizures. Clinical Infection in Practice, 15, 100176. doi:10.1016/j.clinpr.2022.100176
Clinical features and management of human monkeypox: a retrospective observational study in the UK
Adler, H., Gould, S., Hine, P., Snell, L. B., Wong, W., Houlihan, C. F., . . . Price, N. M. (2022). Clinical features and management of human monkeypox: a retrospective observational study in the UK. LANCET INFECTIOUS DISEASES, 22(8), 1153-1162. doi:10.1016/S1473-3099(22)00228-6
PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO protocol for a multicentre, open-label, randomised controlled trial
Euden, J., Thomas-Jones, E., Aston, S., Brookes-Howell, L., Carman, J., Carrol, E., . . . French, N. (2022). PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO protocol for a multicentre, open-label, randomised controlled trial. BMJ OPEN, 12(6). doi:10.1136/bmjopen-2022-063424
2021
CPAP delivered outside critical care during the second wave of COVID-19: outcomes from a UK respiratory surge unit
Nightingale, R., Lewis, J., Monsell, K. R., Jones, L., Smith, C., Kundu, S., . . . Aston, S. (2021). CPAP delivered outside critical care during the second wave of COVID-19: outcomes from a UK respiratory surge unit. BMJ OPEN RESPIRATORY RESEARCH, 8(1). doi:10.1136/bmjresp-2021-000907
Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK
Vaselli, N. M., Setiabudi, W., Subramaniam, K., Adams, E. R., Turtle, L., Iturriza-Gomara, M., . . . Hungerford, D. (2021). Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06443-7
MAGNITUDE OF COMMUNITY ACQUIRED PNEUMONIA AMONG TREATED ADULTS IN TIKUR ANBESSA SPECIALIZED HOSPITAL: A RETROSPECTIVE STUDY
Desissa, T. A., Bekele, A., Amogne, W., Woldeamanuel, Y., Asrat, D., Abebe, T., & Aston, S. (2021). MAGNITUDE OF COMMUNITY ACQUIRED PNEUMONIA AMONG TREATED ADULTS IN TIKUR ANBESSA SPECIALIZED HOSPITAL: A RETROSPECTIVE STUDY. Ethiopian Medical Journal, 59(2), 137-142.
Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol
Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317
Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis
Lafond, K. E., Porter, R. M., Whaley, M. J., Suizan, Z., Ran, Z., Aleem, M. A., . . . Widdowson, M. -A. (2021). Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis. PLOS MEDICINE, 18(3). doi:10.1371/journal.pmed.1003550
The rapid development and deployment of a new multidisciplinary CPAP service outside of a critical care environment during the early stages of the COVID-19 pandemic.
Robinson, R. E., Nightingale, R., Frost, F., Green, T., Jones, G., Nwosu, N., . . . Gautam, M. (2021). The rapid development and deployment of a new multidisciplinary CPAP service outside of a critical care environment during the early stages of the COVID-19 pandemic.. Future healthcare journal, 8(1), e156-e159. doi:10.7861/fhj.2020-0167
2020
Experimental Human Pneumococcal Colonisation in Older Adults is Feasible and Safe, Not Immunogenic.
Adler, H., German, E. L., Mitsi, E., Nikolaou, E., Pojar, S., Hales, C., . . . Rylance, J. (2020). Experimental Human Pneumococcal Colonisation in Older Adults is Feasible and Safe, Not Immunogenic.. American Journal of Respiratory and Critical Care Medicine. doi:10.1164/rccm.202004-1483oc
Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19 A Living Systematic Review of Multiple Streams of Evidence
Schunemann, H. J., Khabsa, J., Solo, K., Khamis, A. M., Brignardello-Petersen, R., El-Harakeh, A., . . . Akl, E. A. (2020). Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19 A Living Systematic Review of Multiple Streams of Evidence. ANNALS OF INTERNAL MEDICINE, 173(3), 204-+. doi:10.7326/M20-2306
Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service
Nightingale, R., Nwosu, N., Kutubudin, F., Fletcher, T., Lewis, J., Frost, F., . . . Burhan, H. (2020). Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service. BMJ open respiratory research, 7(1). doi:10.1136/bmjresp-2020-000639
Recommendations for fluid management of adults with sepsis in sub-Saharan Africa: a systematic review of guidelines
Silberberg, B., Aston, S., Boztepe, S., Jacob, S., & Rylance, J. (2020). Recommendations for fluid management of adults with sepsis in sub-Saharan Africa: a systematic review of guidelines. CRITICAL CARE, 24(1). doi:10.1186/s13054-020-02978-4
Experimental human pneumococcal colonisation in older adults is feasible and safe, not immunogenic
Adler, H., German, E., Mitsi, E., Nikolaou, E., Pojar, S., Hales, C., . . . Rylance, J. (2020). Experimental human pneumococcal colonisation in older adults is feasible and safe, not immunogenic. doi:10.1101/2020.04.23.20077073
Recommendations for fluid management of adults with sepsis in sub-Saharan Africa: A systematic review of guidelines
The challenge of antimicrobial prescribing for hospital-acquired pneumonia
Wootton, D., Aston, S., & Felton, T. (2020). The challenge of antimicrobial prescribing for hospital-acquired pneumonia. Journal of Hospital Infection, 104(2), 198-199. doi:10.1016/j.jhin.2019.11.002
Botulism
Aston, S. J., & Beeching, N. J. (2020). Botulism. In Hunter's Tropical Medicine and Emerging Infectious Diseases (pp. 551-554). Elsevier. doi:10.1016/b978-0-323-55512-8.00060-0
2019
Community-acquired pneumonia due to drug-resistant Enterobacteriaceae: A global perspective
Aston, S. J., & Wootton, D. G. (2019). Community-acquired pneumonia due to drug-resistant Enterobacteriaceae: A global perspective. Respirology. doi:10.1111/resp.13720
Etiology and Risk Factors for Mortality in an Adult Community-Acquired Pneumonia Cohort in Malawi.
Aston, S. J., Ho, A., Jary, H., Huwa, J., Mitchell, T., Ibitoye, S., . . . Gordon, S. B. (2019). Etiology and Risk Factors for Mortality in an Adult Community-acquired Pneumonia Cohort in Malawi. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 200(3), 359-369. doi:10.1164/rccm.201807-1333OC
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018)
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Griffiths, M. J. (2019). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018). NATURE IMMUNOLOGY, 20(3), 373. doi:10.1038/s41590-019-0328-y
Latent tuberculosis infection screening in HIV-infected patients: guidelines versus everyday practice in a UK HIV centre
Aston, S. J., Doherty, K., Black, B., & Davies, G. (2019). Latent tuberculosis infection screening in HIV-infected patients: guidelines versus everyday practice in a UK HIV centre. HIV MEDICINE, 20(1), E3-E4. doi:10.1111/hiv.12678
2018
Extraordinary virtual multidisciplinary team meetings: a novel forum for coordinated care of patients with complex conditions within a secondary care setting
Aston, S. J., Reade, S., Petersen, B., Ward, C., Duffy, A., & Nsutebu, E. (2018). Extraordinary virtual multidisciplinary team meetings: a novel forum for coordinated care of patients with complex conditions within a secondary care setting. Future Healthcare Journal, 5(3), 218-223. doi:10.7861/futurehosp.5-3-218
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Openshaw, P. J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19(06), 625-635. doi:10.1038/s41590-018-0111-5
Impact of Human Immunodeficiency Virus on the Burden and Severity of Influenza Illness in Malawian Adults: A Prospective Cohort and Parallel Case-Control Study
Ho, A., Aston, S. J., Jary, H., Mitchell, T., Alaerts, M., Menyere, M., . . . French, N. (2018). Impact of Human Immunodeficiency Virus on the Burden and Severity of Influenza Illness in Malawian Adults: A Prospective Cohort and Parallel Case-Control Study. Clinical Infectious Diseases, 66(6), 865-876. doi:10.1093/cid/cix903
2017
Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study
Jary, H. R., Aston, S., Ho, A., Giorgi, E., Kalata, N., Nyirenda, M., . . . Mortimer, K. (2017). Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study. Wellcome open research. doi:10.12688/wellcomeopenres.12621.1
Pneumonia in the developing world: Characteristic features and approach to management
Aston, S. J. (2017). Pneumonia in the developing world: Characteristic features and approach to management. RESPIROLOGY, 22(7), 1276-1287. doi:10.1111/resp.13112
Community-acquired pneumonia in Malawian adults: Aetiology and predictors of mortality.
Aston, S. J. (2017, March 30). Community-acquired pneumonia in Malawian adults: Aetiology and predictors of mortality..
Age Related Patterns of Disease and Mortality in Hospitalised Adults in Malawi
Allain, T. J., Aston, S., Mapurisa, G., Ganiza, T. N., Banda, N. P., Sakala, S., . . . Peterson, I. (2017). Age Related Patterns of Disease and Mortality in Hospitalised Adults in Malawi. PLOS ONE, 12(1). doi:10.1371/journal.pone.0168368
2016
Community-Acquired Pneumonia in Sub-Saharan Africa
Aston, S. J., & Rylance, J. (2016). Community-Acquired Pneumonia in Sub-Saharan Africa. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 37(6), 855-867. doi:10.1055/s-0036-1592126
Combined infection training-a pioneering collaborative approach to educating infection specialists
Sunny, S. S., Nedumaran, S., Aston, S., Neal, T., & Taegtmeyer, M. (2016). Combined infection training-a pioneering collaborative approach to educating infection specialists. FEMS MICROBIOLOGY LETTERS, 363(15). doi:10.1093/femsle/fnw154
The impact of HIV infection on the burden and severity of influenza illness in Malawian adults
Ho, A., Aston, S., Jary, H., Alaerts, M., Menyere, M., Mallewa, J., . . . Heyderman, R. (2016). The impact of HIV infection on the burden and severity of influenza illness in Malawian adults. Retrieved from https://www.webofscience.com/
Impact of HIV on the burden and severity of influenza illness in adults in Malawi: a cohort and case-control study
Ho, A., Aston, S., Jary, H., Mitchell, T., Alaerts, M., Menyere, M., . . . French, N. (2016). Impact of HIV on the burden and severity of influenza illness in adults in Malawi: a cohort and case-control study. In The Lancet Vol. 387 (pp. 51). Elsevier. doi:10.1016/S0140-6736(16)00438-4
2015
THE IMPACT OF HIV ON THE BURDEN AND SEVERITY OF INFLUENZA ILLNESS IN MALAWIAN ADULTS: THE BASH-FLU STUDY
Ho, A., Aston, S. J., Mitchell, T., Alaerts, M., Menyere, M., Mallewa, J., . . . French, N. (2015). THE IMPACT OF HIV ON THE BURDEN AND SEVERITY OF INFLUENZA ILLNESS IN MALAWIAN ADULTS: THE BASH-FLU STUDY. JOURNAL OF INFECTION, 71(6), 687-688. doi:10.1016/j.jinf.2015.09.030
2014
127 * A DESCRIPTIVE STUDY OF PATTERNS OF DISEASE AND CLINICAL OUTCOMES IN OLDER ADULTS ADMITTED TO MEDICAL WARDS IN A CENTRAL HOSPITAL IN MALAWI
Allain, T. J., Aston, S., Mapurisa, G., Banda, N. P. K., Sakala, S., Gonani, A., . . . Peterson, I. (2014). 127 * A DESCRIPTIVE STUDY OF PATTERNS OF DISEASE AND CLINICAL OUTCOMES IN OLDER ADULTS ADMITTED TO MEDICAL WARDS IN A CENTRAL HOSPITAL IN MALAWI. Age and Ageing, 43(suppl 1), i35. doi:10.1093/ageing/afu046.10
The pathophysiology of pneumococcal pneumonia
Wootton, D. G., Aston, S. J., & Gordon, S. B. (2014). The pathophysiology of pneumococcal pneumonia. In COMMUNITY-ACQUIRED PNEUMONIA (pp. 42-63). doi:10.1183/1025448x.10003313
The role of rapid diagnostic tests in managing adults with pneumonia in low-resource settings.
Aston, S. J. (2014). The role of rapid diagnostic tests in managing adults with pneumonia in low-resource settings.. Pneumonia (Nathan Qld.), 5(Spec Iss -quotPneumonia Diagnosis-quot), 8-17. doi:10.15172/pneu.2014.5/444
2013
Pneumonia in low and middle income countries: progress and challenges
Zar, H. J., Madhi, S. A., Aston, S. J., & Gordon, S. B. (2013). Pneumonia in low and middle income countries: progress and challenges. THORAX, 68(11), 1052-1056. doi:10.1136/thoraxjnl-2013-204247
56 Botulism
Aston, S. J., & Beeching, N. J. (2013). 56 Botulism. In Hunter's Tropical Medicine and Emerging Infectious Disease (pp. 511-513). Elsevier. doi:10.1016/b978-1-4160-4390-4.00056-4
2012
IFITM3 restricts the morbidity and mortality associated with influenza
Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., . . . Kellam, P. (2012). IFITM3 restricts the morbidity and mortality associated with influenza. NATURE, 484(7395), 519-U146. doi:10.1038/nature10921
Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man
Barnes, E., Folgori, A., Capone, S., Swadling, L., Aston, S., Kurioka, A., . . . Klenerman, P. (2012). Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man. SCIENCE TRANSLATIONAL MEDICINE, 4(115). doi:10.1126/scitranslmed.3003155
Botulism
Aston, S. J., & Beeching, N. J. (2013). Botulism. In Hunter's Tropical Medicine and Emerging Infectious Disease (pp. 511-513). Elsevier. doi:10.1016/b978-1-4160-4390-4.00056-4