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Dr Stephen Aston
MBChB BMedSc MRCP DTMH PhD

Publications

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2024

HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.

Shafiqa, N., Aston, S., Howard, A., Turtle, L., Abrams, S., Young, B., . . . Wootton, D. G. (2024). HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.. BMJ open, 14(7), e088490. doi:10.1136/bmjopen-2024-088490

DOI
10.1136/bmjopen-2024-088490
Journal article

Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop.

Howard, A., Reza, N., Aston, S., Woods, B., Gerada, A., Buchan, I., . . . Märtson, A. -G. (2024). Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop.. The Lancet. Infectious diseases, 24(1), e47-e58. doi:10.1016/s1473-3099(23)00367-5

DOI
10.1016/s1473-3099(23)00367-5
Journal article

2023

Clinical features and management of individuals admitted to hospital with monkeypox and associated complications acrossthe UK: a retrospective cohort study

Fink, D. L., Callaby, H., Luintel, A., Beynon, W., Bond, H., Lim, E. Y., . . . Dunning, J. (2023). Clinical features and management of individuals admitted to hospital with monkeypox and associated complications acrossthe UK: a retrospective cohort study. LANCET INFECTIOUS DISEASES, 23(5), 589-597. doi:10.1016/S1473-3099(22)00806-4

DOI
10.1016/S1473-3099(22)00806-4
Journal article

Update on drug treatments for multidrug resistant tuberculosis

Davies, G. R., & Aston, S. (2023). Update on drug treatments for multidrug resistant tuberculosis. CURRENT OPINION IN INFECTIOUS DISEASES, 36(2), 132-139. doi:10.1097/QCO.0000000000000899

DOI
10.1097/QCO.0000000000000899
Journal article

2022

15 A curious case of chronic cough and complex partial seizures

Yeoh, A., Aston, S., Brookfield, C., Wong, N., & Wingfield, T. (2022). 15 A curious case of chronic cough and complex partial seizures. Clinical Infection in Practice, 15, 100176. doi:10.1016/j.clinpr.2022.100176

DOI
10.1016/j.clinpr.2022.100176
Journal article

PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO protocol for a multicentre, open-label, randomised controlled trial

Euden, J., Thomas-Jones, E., Aston, S., Brookes-Howell, L., Carman, J., Carrol, E., . . . French, N. (2022). PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO protocol for a multicentre, open-label, randomised controlled trial. BMJ OPEN, 12(6). doi:10.1136/bmjopen-2022-063424

DOI
10.1136/bmjopen-2022-063424
Journal article

2021

MAGNITUDE OF COMMUNITY ACQUIRED PNEUMONIA AMONG TREATED ADULTS IN TIKUR ANBESSA SPECIALIZED HOSPITAL: A RETROSPECTIVE STUDY

Desissa, T. A., Bekele, A., Amogne, W., Woldeamanuel, Y., Asrat, D., Abebe, T., & Aston, S. (2021). MAGNITUDE OF COMMUNITY ACQUIRED PNEUMONIA AMONG TREATED ADULTS IN TIKUR ANBESSA SPECIALIZED HOSPITAL: A RETROSPECTIVE STUDY. Ethiopian Medical Journal, 59(2), 137-142.

Journal article

Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol

Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317

DOI
10.1136/bmjopen-2020-048317
Journal article

Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis

Lafond, K. E., Porter, R. M., Whaley, M. J., Suizan, Z., Ran, Z., Aleem, M. A., . . . Widdowson, M. -A. (2021). Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis. PLOS MEDICINE, 18(3). doi:10.1371/journal.pmed.1003550

DOI
10.1371/journal.pmed.1003550
Journal article

The rapid development and deployment of a new multidisciplinary CPAP service outside of a critical care environment during the early stages of the COVID-19 pandemic.

Robinson, R. E., Nightingale, R., Frost, F., Green, T., Jones, G., Nwosu, N., . . . Gautam, M. (2021). The rapid development and deployment of a new multidisciplinary CPAP service outside of a critical care environment during the early stages of the COVID-19 pandemic.. Future healthcare journal, 8(1), e156-e159. doi:10.7861/fhj.2020-0167

DOI
10.7861/fhj.2020-0167
Journal article

2020

Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19 A Living Systematic Review of Multiple Streams of Evidence

Schunemann, H. J., Khabsa, J., Solo, K., Khamis, A. M., Brignardello-Petersen, R., El-Harakeh, A., . . . Akl, E. A. (2020). Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19 A Living Systematic Review of Multiple Streams of Evidence. ANNALS OF INTERNAL MEDICINE, 173(3), 204-+. doi:10.7326/M20-2306

DOI
10.7326/M20-2306
Journal article

Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service

Nightingale, R., Nwosu, N., Kutubudin, F., Fletcher, T., Lewis, J., Frost, F., . . . Burhan, H. (2020). Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service. BMJ open respiratory research, 7(1). doi:10.1136/bmjresp-2020-000639

DOI
10.1136/bmjresp-2020-000639
Journal article

Experimental human pneumococcal colonisation in older adults is feasible and safe, not immunogenic

Adler, H., German, E., Mitsi, E., Nikolaou, E., Pojar, S., Hales, C., . . . Rylance, J. (2020). Experimental human pneumococcal colonisation in older adults is feasible and safe, not immunogenic. doi:10.1101/2020.04.23.20077073

DOI
10.1101/2020.04.23.20077073
Journal article

Recommendations for fluid management of adults with sepsis in sub-Saharan Africa: A systematic review of guidelines

DOI
10.21203/rs.2.23183/v1
Preprint

The challenge of antimicrobial prescribing for hospital-acquired pneumonia

Wootton, D., Aston, S., & Felton, T. (2020). The challenge of antimicrobial prescribing for hospital-acquired pneumonia. Journal of Hospital Infection, 104(2), 198-199. doi:10.1016/j.jhin.2019.11.002

DOI
10.1016/j.jhin.2019.11.002
Journal article

Botulism

Aston, S. J., & Beeching, N. J. (2020). Botulism. In Hunter's Tropical Medicine and Emerging Infectious Diseases (pp. 551-554). Elsevier. doi:10.1016/b978-0-323-55512-8.00060-0

DOI
10.1016/b978-0-323-55512-8.00060-0
Chapter

2019

Community-acquired pneumonia due to drug-resistant Enterobacteriaceae: A global perspective

Aston, S. J., & Wootton, D. G. (2019). Community-acquired pneumonia due to drug-resistant Enterobacteriaceae: A global perspective. Respirology. doi:10.1111/resp.13720

DOI
10.1111/resp.13720
Journal article

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018)

Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Griffiths, M. J. (2019). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018). NATURE IMMUNOLOGY, 20(3), 373. doi:10.1038/s41590-019-0328-y

DOI
10.1038/s41590-019-0328-y
Journal article

Latent tuberculosis infection screening in HIV-infected patients: guidelines versus everyday practice in a UK HIV centre

Aston, S. J., Doherty, K., Black, B., & Davies, G. (2019). Latent tuberculosis infection screening in HIV-infected patients: guidelines versus everyday practice in a UK HIV centre. HIV MEDICINE, 20(1), E3-E4. doi:10.1111/hiv.12678

DOI
10.1111/hiv.12678
Journal article

2018

Extraordinary virtual multidisciplinary team meetings: a novel forum for coordinated care of patients with complex conditions within a secondary care setting

Aston, S. J., Reade, S., Petersen, B., Ward, C., Duffy, A., & Nsutebu, E. (2018). Extraordinary virtual multidisciplinary team meetings: a novel forum for coordinated care of patients with complex conditions within a secondary care setting. Future Healthcare Journal, 5(3), 218-223. doi:10.7861/futurehosp.5-3-218

DOI
10.7861/futurehosp.5-3-218
Journal article

Impact of Human Immunodeficiency Virus on the Burden and Severity of Influenza Illness in Malawian Adults: A Prospective Cohort and Parallel Case-Control Study

Ho, A., Aston, S. J., Jary, H., Mitchell, T., Alaerts, M., Menyere, M., . . . French, N. (2018). Impact of Human Immunodeficiency Virus on the Burden and Severity of Influenza Illness in Malawian Adults: A Prospective Cohort and Parallel Case-Control Study. Clinical Infectious Diseases, 66(6), 865-876. doi:10.1093/cid/cix903

DOI
10.1093/cid/cix903
Journal article

2017

Age Related Patterns of Disease and Mortality in Hospitalised Adults in Malawi

Allain, T. J., Aston, S., Mapurisa, G., Ganiza, T. N., Banda, N. P., Sakala, S., . . . Peterson, I. (2017). Age Related Patterns of Disease and Mortality in Hospitalised Adults in Malawi. PLOS ONE, 12(1). doi:10.1371/journal.pone.0168368

DOI
10.1371/journal.pone.0168368
Journal article

2016

Community-Acquired Pneumonia in Sub-Saharan Africa

Aston, S. J., & Rylance, J. (2016). Community-Acquired Pneumonia in Sub-Saharan Africa. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 37(6), 855-867. doi:10.1055/s-0036-1592126

DOI
10.1055/s-0036-1592126
Journal article

Combined infection training-a pioneering collaborative approach to educating infection specialists

Sunny, S. S., Nedumaran, S., Aston, S., Neal, T., & Taegtmeyer, M. (2016). Combined infection training-a pioneering collaborative approach to educating infection specialists. FEMS MICROBIOLOGY LETTERS, 363(15). doi:10.1093/femsle/fnw154

DOI
10.1093/femsle/fnw154
Journal article

Impact of HIV on the burden and severity of influenza illness in adults in Malawi: a cohort and case-control study

Ho, A., Aston, S., Jary, H., Mitchell, T., Alaerts, M., Menyere, M., . . . French, N. (2016). Impact of HIV on the burden and severity of influenza illness in adults in Malawi: a cohort and case-control study. In The Lancet Vol. 387 (pp. 51). Elsevier. doi:10.1016/S0140-6736(16)00438-4

DOI
10.1016/S0140-6736(16)00438-4
Conference Paper

2015

THE IMPACT OF HIV ON THE BURDEN AND SEVERITY OF INFLUENZA ILLNESS IN MALAWIAN ADULTS: THE BASH-FLU STUDY

Ho, A., Aston, S. J., Mitchell, T., Alaerts, M., Menyere, M., Mallewa, J., . . . French, N. (2015). THE IMPACT OF HIV ON THE BURDEN AND SEVERITY OF INFLUENZA ILLNESS IN MALAWIAN ADULTS: THE BASH-FLU STUDY. JOURNAL OF INFECTION, 71(6), 687-688. doi:10.1016/j.jinf.2015.09.030

DOI
10.1016/j.jinf.2015.09.030
Journal article

2014

127 * A DESCRIPTIVE STUDY OF PATTERNS OF DISEASE AND CLINICAL OUTCOMES IN OLDER ADULTS ADMITTED TO MEDICAL WARDS IN A CENTRAL HOSPITAL IN MALAWI

Allain, T. J., Aston, S., Mapurisa, G., Banda, N. P. K., Sakala, S., Gonani, A., . . . Peterson, I. (2014). 127 * A DESCRIPTIVE STUDY OF PATTERNS OF DISEASE AND CLINICAL OUTCOMES IN OLDER ADULTS ADMITTED TO MEDICAL WARDS IN A CENTRAL HOSPITAL IN MALAWI. Age and Ageing, 43(suppl 1), i35. doi:10.1093/ageing/afu046.10

DOI
10.1093/ageing/afu046.10
Journal article

The pathophysiology of pneumococcal pneumonia

Wootton, D. G., Aston, S. J., & Gordon, S. B. (2014). The pathophysiology of pneumococcal pneumonia. In COMMUNITY-ACQUIRED PNEUMONIA (pp. 42-63). doi:10.1183/1025448x.10003313

DOI
10.1183/1025448x.10003313
Chapter

2013

Pneumonia in low and middle income countries: progress and challenges

Zar, H. J., Madhi, S. A., Aston, S. J., & Gordon, S. B. (2013). Pneumonia in low and middle income countries: progress and challenges. THORAX, 68(11), 1052-1056. doi:10.1136/thoraxjnl-2013-204247

DOI
10.1136/thoraxjnl-2013-204247
Journal article

56 Botulism

Aston, S. J., & Beeching, N. J. (2013). 56 Botulism. In Hunter's Tropical Medicine and Emerging Infectious Disease (pp. 511-513). Elsevier. doi:10.1016/b978-1-4160-4390-4.00056-4

DOI
10.1016/b978-1-4160-4390-4.00056-4
Chapter

2012

IFITM3 restricts the morbidity and mortality associated with influenza

Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., . . . Kellam, P. (2012). IFITM3 restricts the morbidity and mortality associated with influenza. NATURE, 484(7395), 519-U146. doi:10.1038/nature10921

DOI
10.1038/nature10921
Journal article

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

Barnes, E., Folgori, A., Capone, S., Swadling, L., Aston, S., Kurioka, A., . . . Klenerman, P. (2012). Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man. SCIENCE TRANSLATIONAL MEDICINE, 4(115). doi:10.1126/scitranslmed.3003155

DOI
10.1126/scitranslmed.3003155
Journal article

Botulism

Aston, S. J., & Beeching, N. J. (2013). Botulism. In Hunter's Tropical Medicine and Emerging Infectious Disease (pp. 511-513). Elsevier. doi:10.1016/b978-1-4160-4390-4.00056-4

DOI
10.1016/b978-1-4160-4390-4.00056-4
Chapter