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Sonia Rocha

Professor Sonia Rocha
PhD, FRSB

Executive Dean of the Institute of Systems, Molecular and Integrative Biology
Biochemistry, Cell and Systems Biology

Contact

Sonia.Rocha@liverpool.ac.uk

My research website

+44 (0)151 794 9084 Ext. 49084

Publications

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2024

TMT-Based Quantitative Proteomic Profiling of Human Esophageal Cancer Cells Reveals the Potential Mechanism and Potential Therapeutic Targets Associated With Radioresistance.

Gao, A., He, C., Chen, H., Liu, Q., Chen, Y., Sun, J., . . . Zhou, J. (2024). TMT-Based Quantitative Proteomic Profiling of Human Esophageal Cancer Cells Reveals the Potential Mechanism and Potential Therapeutic Targets Associated With Radioresistance.. Proteomics. Clinical applications, e202400010. doi:10.1002/prca.202400010

DOI
10.1002/prca.202400010
Journal article

2023

Endotyping COPD: hypoxia-inducible factor-2 as a molecular "switch" between the vascular and airway phenotypes?

Myronenko, O., Foris, V., Crnkovic, S., Olschewski, A., Rocha, S., Nicolls, M. R., & Olschewski, H. (2023). Endotyping COPD: hypoxia-inducible factor-2 as a molecular "switch" between the vascular and airway phenotypes?. European respiratory review : an official journal of the European Respiratory Society, 32(167), 220173. doi:10.1183/16000617.0173-2022

DOI
10.1183/16000617.0173-2022
Journal article

2022

Regulation of chromatin accessibility by hypoxia and HIF

Batie, M., Frost, J., Shakir, D., & Rocha, S. (2022). Regulation of chromatin accessibility by hypoxia and HIF. BIOCHEMICAL JOURNAL, 479(6), 767-786. doi:10.1042/BCJ20220008

DOI
10.1042/BCJ20220008
Journal article

Author Correction: Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.

Teresa Pinto, A., Laranjeiro Pinto, M., Patrícia Cardoso, A., Monteiro, C., Teixeira Pinto, M., Filipe Maia, A., . . . José Oliveira, M. (2022). Author Correction: Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.. Scientific reports, 12(1), 4774. doi:10.1038/s41598-022-08498-1

DOI
10.1038/s41598-022-08498-1
Journal article

2021

Transcription | Regulation of Gene Transcription by Hypoxia-Inducible Factor 1α

Child, F., Frost, J., Shakir, D., Wilson, J. W., & Rocha, S. (2021). Transcription | Regulation of Gene Transcription by Hypoxia-Inducible Factor 1α. In Encyclopedia of Biological Chemistry III (pp. 480-489). Elsevier. doi:10.1016/b978-0-12-819460-7.00033-5

DOI
10.1016/b978-0-12-819460-7.00033-5
Chapter

2020

2019

2018

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2 S ,4 R )-1-(( S )-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy- N -(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Soares, P., Gadd, M. S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., . . . Ciulli, A. (2018). Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2<i>S</i>,4<i>R</i>)-1-((<i>S</i>)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyI)-4-hydroxy-<i>N</i>-(4-(4-methylthiazol-5-yl)benzyppyrrolidine-2-carboxamide (VH298). JOURNAL OF MEDICINAL CHEMISTRY, 61(2), 599-618. doi:10.1021/acs.jmedchem.7b00675

DOI
10.1021/acs.jmedchem.7b00675
Journal article

2017

2016

Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.

Teresa Pinto, A., Laranjeiro Pinto, M., Patrícia Cardoso, A., Monteiro, C., Teixeira Pinto, M., Filipe Maia, A., . . . José Oliveira, M. (2016). Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.. Scientific reports, 6, 18765. doi:10.1038/srep18765

DOI
10.1038/srep18765
Journal article

2015

The Prolylhydroxylase PHD2 Modulates Centromere Function through the Hydroxylation of CENP-N

Moser, S., Bensaddek, D., Ortmann, B., Rocha, S., Lamond, A., & Swedlow, J. (2015). The Prolylhydroxylase PHD2 Modulates Centromere Function through the Hydroxylation of CENP-N. doi:10.1101/030452

DOI
10.1101/030452
Journal article

Cezanne regulates E2F1-dependent HIF2α expression.

Moniz, S., Bandarra, D., Biddlestone, J., Campbell, K. J., Komander, D., Bremm, A., & Rocha, S. (2015). Cezanne regulates E2F1-dependent HIF2α expression.. Journal of Cell Science, 128(16), 3082-3093. doi:10.1242/jcs.168864

DOI
10.1242/jcs.168864
Journal article

HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals

Bandarra, D., Biddlestone, J., Mudie, S., Müller, H. -A. J., & Rocha, S. (2015). HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals. Disease Models and Mechanisms, 8(2), 169-181. doi:10.1242/dmm.017285

DOI
10.1242/dmm.017285
Journal article

2014

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia

Mudie, S., Bandarra, D., Batie, M., Biddlestone, J., Moniz, S., Ortmann, B., . . . Rocha, S. (2014). PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. CELL CYCLE, 13(24), 3878-3891. doi:10.4161/15384101.2014.972889

DOI
10.4161/15384101.2014.972889
Journal article

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner

Bremm, A., Moniz, S., Mader, J., Rocha, S., & Komander, D. (2014). Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner. EMBO Reports, 15(12), 1268-1277. doi:10.15252/embr.201438850

DOI
10.15252/embr.201438850
Journal article

Chromatin and oxygen sensing in the context of JmjC histone demethylases

Shmakova, A., Batie, M., Druker, J., & Rocha, S. (2014). Chromatin and oxygen sensing in the context of JmjC histone demethylases. BIOCHEMICAL JOURNAL, 462, 385-395. doi:10.1042/BJ20140754

DOI
10.1042/BJ20140754
Journal article

SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells.

Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Rocha, S., & Hay, R. T. (2014). SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells.. Journal of visualized experiments : JoVE, (87). doi:10.3791/51572

DOI
10.3791/51572
Journal article

Grow₂: the HIF system, energy homeostasis and the cell cycle.

Moniz, S., Biddlestone, J., & Rocha, S. (2014). Grow₂: the HIF system, energy homeostasis and the cell cycle.. Histology and histopathology, 29(5), 589-600. doi:10.14670/hh-29.10.589

DOI
10.14670/hh-29.10.589
Journal article

2013

PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

Moser, S. C., Bensaddek, D., Ortmann, B., Maure, J. -F., Mudie, S., Blow, J. J., . . . Rocha, S. (2013). PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192. DEVELOPMENTAL CELL, 26(4), 381-392. doi:10.1016/j.devcel.2013.06.014

DOI
10.1016/j.devcel.2013.06.014
Journal article

FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21

Yamada, K., Ono, M., Bensaddek, D., Lamond, A. I., & Rocha, S. (2013). FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21. CELL CYCLE, 12(15), 2348-2354. doi:10.4161/cc.25511

DOI
10.4161/cc.25511
Journal article

The P-body component USP52/PAN2 is a novel regulator of <i>HIF1A</i> mRNA stability

Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S., & Hay, R. T. (2013). The P-body component USP52/PAN2 is a novel regulator of <i>HIF1A</i> mRNA stability. BIOCHEMICAL JOURNAL, 451, 185-194. doi:10.1042/BJ20130026

DOI
10.1042/BJ20130026
Journal article

Identification and Functional Characterization of FMN2, a Regulator of the Cyclin-Dependent Kinase Inhibitor p21

Yamada, K., Ono, M., Perkins, N. D., Rocha, S., & Lamond, A. I. (2013). Identification and Functional Characterization of FMN2, a Regulator of the Cyclin-Dependent Kinase Inhibitor p21. MOLECULAR CELL, 49(5), 922-933. doi:10.1016/j.molcel.2012.12.023

DOI
10.1016/j.molcel.2012.12.023
Journal article

TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling

Kenneth, N. S., Mudie, S., Naron, S., & Rocha, S. (2013). TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling. BIOCHEMICAL JOURNAL, 449, 275-284. doi:10.1042/BJ20120625

DOI
10.1042/BJ20120625
Journal article

2012

Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

Munoz, I. M., MacArtney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S., & Rouse, J. (2012). Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(39), 32346-32353. doi:10.1074/jbc.M112.382499

DOI
10.1074/jbc.M112.382499
Journal article

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

Arabi, A., Ullah, K., Branca, R. M. M., Johansson, J., Bandarra, D., Haneklaus, M., . . . Sangfelt, O. (2012). Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. NATURE COMMUNICATIONS, 3. doi:10.1038/ncomms1975

DOI
10.1038/ncomms1975
Journal article

IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function

IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function (2012). The EMBO journal, 31(11), 2660-2661. doi:10.1038/emboj.2012.135

DOI
10.1038/emboj.2012.135
Journal article

Chromatin as an oxygen sensor and active player in the hypoxia response

Melvin, A., & Rocha, S. (2012). Chromatin as an oxygen sensor and active player in the hypoxia response. CELLULAR SIGNALLING, 24(1), 35-43. doi:10.1016/j.cellsig.2011.08.019

DOI
10.1016/j.cellsig.2011.08.019
Journal article

2011

The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH

Melvin, A., Mudie, S., & Rocha, S. (2011). The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH. MOLECULAR BIOLOGY OF THE CELL, 22(21), 4171-4181. doi:10.1091/mbc.E11-02-0163

DOI
10.1091/mbc.E11-02-0163
Journal article

The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

Msaki, A., Sanchez, A. M., Koh, L. F., Barre, B., Rocha, S., Perkins, N. D., & Johnson, R. F. (2011). The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. MOLECULAR BIOLOGY OF THE CELL, 22(17), 3032-3040. doi:10.1091/mbc.E11-04-0280

DOI
10.1091/mbc.E11-04-0280
Journal article

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Mauro, C., Leow, S. C., Anso, E., Rocha, S., Thotakura, A. K., Tornatore, L., . . . Franzoso, G. (2011). NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. NATURE CELL BIOLOGY, 13(10), 1272-U234. doi:10.1038/ncb2324

DOI
10.1038/ncb2324
Journal article

Antagonistic crosstalk between APC and HIF-1α

Naethke, I., & Rocha, S. (2011). Antagonistic crosstalk between APC and HIF-1α. CELL CYCLE, 10(10), 1545-1547. doi:10.4161/cc.10.10.15638

DOI
10.4161/cc.10.10.15638
Journal article

HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs

Culver, C., Melvin, A., Mudie, S., & Rocha, S. (2011). HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs. CELL CYCLE, 10(8), 1249-1260. doi:10.4161/cc.10.8.15326

DOI
10.4161/cc.10.8.15326
Journal article

Mechanism of hypoxia-induced NFκB

Melvin, A., Mudie, S., & Rocha, S. (2011). Mechanism of hypoxia-induced NFκB. CELL CYCLE, 10(6), 879-882. doi:10.4161/cc.10.6.14910

DOI
10.4161/cc.10.6.14910
Journal article

Evolutionary Conserved Regulation of HIF-1β by NF-κB

van Uden, P., Kenneth, N. S., Webster, R., Mueller, H. A., Mudie, S., & Rocha, S. (2011). Evolutionary Conserved Regulation of HIF-1β by NF-κB. PLOS GENETICS, 7(1). doi:10.1371/journal.pgen.1001285

DOI
10.1371/journal.pgen.1001285
Journal article

2010

Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Naethke, I., & Rocha, S. (2010). Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection. MOLECULAR BIOLOGY OF THE CELL, 21(21), 3630-3638. doi:10.1091/mbc.E10-04-0312

DOI
10.1091/mbc.E10-04-0312
Journal article

Mechanism of Hypoxia-Induced NF-κB

Culver, C., Sundqvist, A., Mudie, S., Melvin, A., Xirodimas, D., & Rocha, S. (2010). Mechanism of Hypoxia-Induced NF-κB. MOLECULAR AND CELLULAR BIOLOGY, 30(20), 4901-4921. doi:10.1128/MCB.00409-10

DOI
10.1128/MCB.00409-10
Journal article

IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function

Kenneth, N. S., Mudie, S., & Rocha, S. (2010). IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function. EMBO JOURNAL, 29(17), 2966-2978. doi:10.1038/emboj.2010.171

DOI
10.1038/emboj.2010.171
Journal article

2009

SWI/SNF Regulates the Cellular Response to Hypoxia

Kenneth, N. S., Mudie, S., van Uden, P., & Rocha, S. (2009). SWI/SNF Regulates the Cellular Response to Hypoxia. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(7), 4123-4131. doi:10.1074/jbc.M808491200

DOI
10.1074/jbc.M808491200
Journal article

2008

Regulation of gene expression by hypoxia

Kenneth, N. S., & Rocha, S. (2008). Regulation of gene expression by hypoxia. BIOCHEMICAL JOURNAL, 414, 19-29. doi:10.1042/BJ20081055

DOI
10.1042/BJ20081055
Journal article

Regulation of hypoxia-inducible factor-1α by NF-κB

van Uden, P., Kenneth, N. S., & Rocha, S. (2008). Regulation of hypoxia-inducible factor-1α by NF-κB. BIOCHEMICAL JOURNAL, 412, 477-484. doi:10.1042/BJ20080476

DOI
10.1042/BJ20080476
Journal article

2007

Gene regulation under low oxygen: holding your breath for transcription

Rocha, S. (2007). Gene regulation under low oxygen: holding your breath for transcription. TRENDS IN BIOCHEMICAL SCIENCES, 32(8), 389-397. doi:10.1016/j.tibs.2007.06.005

DOI
10.1016/j.tibs.2007.06.005
Journal article

Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1

Roche, K. C., Rocha, S., Bracken, C. P., & Perkins, N. D. (2007). Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1. ONCOGENE, 26(31), 4523-4530. doi:10.1038/sj.onc.1210233

DOI
10.1038/sj.onc.1210233
Journal article

2006

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

Fujii, M., Lyakh, L. A., Bracken, C. P., Fukuoka, J., Hayakawa, M., Tsukiyama, T., . . . Roberts, A. B. (2006). SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. MOLECULAR CELL, 24(5), 771-783. doi:10.1016/j.molcel.2006.11.006

DOI
10.1016/j.molcel.2006.11.006
Journal article

Regulation of p53 tumour suppressor target gene expression by the p52 NF-κB subunit

Schumm, K., Rocha, S., Caamano, J., & Perkins, N. D. (2006). Regulation of p53 tumour suppressor target gene expression by the p52 NF-κB subunit. EMBO JOURNAL, 25(20), 4820-4832. doi:10.1038/sj.emboj.7601343

DOI
10.1038/sj.emboj.7601343
Journal article

Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-κB transactivation

Campbell, K. J., Witty, J. M., Rocha, S., & Perkins, N. D. (2006). Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-κB transactivation. CANCER RESEARCH, 66(2), 929-935. doi:10.1158/0008-5472.CAN-05-2234

DOI
10.1158/0008-5472.CAN-05-2234
Journal article

2005

ARF the integrator -: Linking NF-κB, p53 and checkpoint kinases

Rocha, S., & Perkins, N. D. (2005). ARF the integrator -: Linking NF-κB, p53 and checkpoint kinases. CELL CYCLE, 4(6), 756-759. doi:10.4161/cc.4.6.1739

DOI
10.4161/cc.4.6.1739
Journal article

Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

Rocha, S., Garrett, M. D., Campbell, K. J., Schumm, K., & Perkins, N. D. (2005). Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO JOURNAL, 24(6), 1157-1169. doi:10.1038/sj.emboj.7600608

DOI
10.1038/sj.emboj.7600608
Journal article

2004

Active repression of antiapoptotic gene expression by ReIA(p65) NF-κB

Campbell, K. J., Rocha, S., & Perkins, N. D. (2004). Active repression of antiapoptotic gene expression by ReIA(p65) NF-κB. MOLECULAR CELL, 13(6), 853-865. doi:10.1016/S1097-2765(04)00131-5

DOI
10.1016/S1097-2765(04)00131-5
Journal article

2003

The p53-inhibitor Pifithrin-α inhibits Firefly Luciferase activity <i>in vivo</i> and <i>in vitro</i> -: art. no. 9

Rocha, S., Campbell, K. J., Roche, K. C., & Perkins, N. D. (2003). The p53-inhibitor Pifithrin-α inhibits Firefly Luciferase activity <i>in vivo</i> and <i>in vitro</i> -: art. no. 9. BMC MOLECULAR BIOLOGY, 4. doi:10.1186/1471-2199-4-9

DOI
10.1186/1471-2199-4-9
Journal article

p53 Represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-κB subunit with histone deacetylase 1

Rocha, S., Martin, A. M., Meek, D. W., & Perkins, N. D. (2003). p53 Represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-κB subunit with histone deacetylase 1. MOLECULAR AND CELLULAR BIOLOGY, 23(13), 4713-4727. doi:10.1128/MCB.23.13.4713-4727.2003

DOI
10.1128/MCB.23.13.4713-4727.2003
Journal article

p53- and Mdm2-independent repression of NF-κB transactivation by the ARF tumor suppressor

Rocha, S., Campbell, K. J., & Perkins, N. D. (2003). p53- and Mdm2-independent repression of NF-κB transactivation by the ARF tumor suppressor. MOLECULAR CELL, 12(1), 15-25. doi:10.1016/S1097-2765(03)00223-5

DOI
10.1016/S1097-2765(03)00223-5
Journal article

Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionising radiation

Hostanska, K., Vuong, V., Rocha, S., Soengas, M. S., Glanzmann, C., Saller, R., . . . Pruschy, M. (2003). Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionising radiation. BRITISH JOURNAL OF CANCER, 88(11), 1785-1792. doi:10.1038/sj.bjc.6600982

DOI
10.1038/sj.bjc.6600982
Journal article

2002

NF-κB Function in Inflammation, Cellular Stress and Disease

Chapman, N. R., Rocha, S., Adcock, I. M., & Perkins, N. D. (2002). NF-κB Function in Inflammation, Cellular Stress and Disease. Unknown Journal, 61-73. doi:10.1016/s1568-1254(02)80007-9

DOI
10.1016/s1568-1254(02)80007-9
Journal article

2001

The phosphatidylinositide 3′-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C

Tenzer, A., Zingg, D., Rocha, S., Hemmings, B., Fabbro, D., Glanzmann, C., . . . Prusch, M. (2001). The phosphatidylinositide 3′-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. CANCER RESEARCH, 61(22), 8203-8210. Retrieved from https://www.webofscience.com/

Journal article

Overexpression of Bcl-2 enhances sensitivity of L929 cells to a lipophilic cationic photosensitiser.

Klein, S. D., Walt, H., Rocha, S., Ghafourifar, P., Pruschy, M., Winterhalter, K. H., & Richter, C. (2001). Overexpression of Bcl-2 enhances sensitivity of L929 cells to a lipophilic cationic photosensitiser.. Cell death and differentiation, 8(2), 204-206. doi:10.1038/sj.cdd.4400814

DOI
10.1038/sj.cdd.4400814
Journal article

Key targets for the execution of radiation-induced tumor cell apoptosis: The role of p53 and caspases

Pruschy, M., Rocha, S., Zaugg, K., Tenzer, A., Hess, C., Fisher, D. E., . . . Bodis, S. (2001). Key targets for the execution of radiation-induced tumor cell apoptosis: The role of p53 and caspases. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 49(2), 561-567. doi:10.1016/S0360-3016(00)01480-2

DOI
10.1016/S0360-3016(00)01480-2
Journal article

Differential p53-dependent mechanism of radiosensitization <i>in vitro</i> and <i>in vivo</i> by the protein kinase C-specific inhibitor PKC412

Zaugg, K., Rocha, S., Resch, H., Hegyi, I., Oehler, C., Glanzmann, C., . . . Pruschy, M. (2001). Differential p53-dependent mechanism of radiosensitization <i>in vitro</i> and <i>in vivo</i> by the protein kinase C-specific inhibitor PKC412. CANCER RESEARCH, 61(2), 732-738. Retrieved from https://www.webofscience.com/

Journal article

2000

Protein kinase C inhibitor and irradiation-induced apoptosis:: Relevance of the cytochrome <i>c</i>-mediated caspase-9 death pathway

Rocha, S., Soengas, M. S., Lowe, S. W., Glanzmann, C., Fabbro, D., Winterhalter, K., . . . Pruschy, M. (2000). Protein kinase C inhibitor and irradiation-induced apoptosis:: Relevance of the cytochrome <i>c</i>-mediated caspase-9 death pathway. CELL GROWTH & DIFFERENTIATION, 11(9), 491-499. Retrieved from https://www.webofscience.com/

Journal article

1999

Ceramide induces cytochrome <i>c</i> release from isolated mitochondria -: Importance of mitochondrial redox state

Ghafourifar, P., Klein, S. D., Schucht, O., Schenk, U., Pruschy, M., Rocha, S., & Richter, C. (1999). Ceramide induces cytochrome <i>c</i> release from isolated mitochondria -: Importance of mitochondrial redox state. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(10), 6080-6084. doi:10.1074/jbc.274.10.6080

DOI
10.1074/jbc.274.10.6080
Journal article