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2024

Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.

Mittendorfer, M., Pierre, L., Huzevka, T., Schofield, J., Abrams, S. T., Wang, G., . . . Lindstedt, S. (2024). Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 43(12), 1919-1929. doi:10.1016/j.healun.2024.07.007

DOI
10.1016/j.healun.2024.07.007
Journal article

Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.

Toh, J. M., Yong, J., Abrams, S. T., Wang, L., Schofield, J., Lane, S., . . . Toh, C. -H. (2024). Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.. Journal of thrombosis and haemostasis : JTH, 22(8), 2247-2260. doi:10.1016/j.jtha.2024.05.009

DOI
10.1016/j.jtha.2024.05.009
Journal article

HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.

Shafiqa, N., Aston, S., Howard, A., Turtle, L., Abrams, S., Young, B., . . . Wootton, D. G. (2024). HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.. BMJ open, 14(7), e088490. doi:10.1136/bmjopen-2024-088490

DOI
10.1136/bmjopen-2024-088490
Journal article

Are NETs a Novel, Exciting, Thrombosis Risk Marker?

Wang, G., Abrams, S. T., & Toh, C. -H. (2024). Are NETs a Novel, Exciting, Thrombosis Risk Marker?. Thrombosis and haemostasis, 124(5), 455-458. doi:10.1055/a-2187-0645

DOI
10.1055/a-2187-0645
Journal article

2023

Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.

Abrams, S. T., Du, M., Shaw, R. J., Johnson, C., McGuinness, D., Schofield, J., . . . Toh, C. -H. (2023). Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00873-5. doi:10.1016/j.jtha.2023.12.008

DOI
10.1016/j.jtha.2023.12.008
Journal article

OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia

Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L., . . . Toh, C. (2023). OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 100487. doi:10.1016/j.rpth.2023.100487

DOI
10.1016/j.rpth.2023.100487
Journal article

PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia

Yong, J., Abrams, S., Alhamdi, Y., Wang, G., & Toh, C. (2023). PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 101370. doi:10.1016/j.rpth.2023.101370

DOI
10.1016/j.rpth.2023.101370
Journal article

Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs

Mittendorfer, M., Pierre, L., Kjellberg, G., Schofield, J., Abrams, S., Wang, G., . . . Lindstedt, S. (2023). Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 42 (pp. S115). Retrieved from https://www.webofscience.com/

Conference Paper

Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis

Abrams, S. T. T., Alhamdi, Y., Zi, M., Guo, F., Du, M., Wang, G., . . . Toh, C. -H. (2023). Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4). doi:10.3390/ijms24043225

DOI
10.3390/ijms24043225
Journal article

2022

Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179

DOI
10.1093/ofid/ofac179
Journal article

2021

Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation

Abrams, S. T., Su, D., Sahraoui, Y., Lin, Z., Cheng, Z., Nesbitt, K., . . . Toh, C. -H. (2021). Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation. BLOOD, 137(1), 103-114. doi:10.1182/blood.2019002973

DOI
10.1182/blood.2019002973
Journal article

2020

Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway

Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513

DOI
10.3748/wjg.v26.i47.7513
Journal article

Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation

Shaw, R. J., Austin, J., Taylor, J., Dutt, T., Wang, G., Abrams, S. T., & Toh, C. H. (2020). Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation. In BLOOD Vol. 136. doi:10.1182/blood-2020-142344

DOI
10.1182/blood-2020-142344
Conference Paper

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway

DOI
10.1101/2020.09.17.302240
Preprint

The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development

Cheng, Z., Abrams, S. T., Austin, J., Toh, J., Wang, S. S., Wang, Z., . . . Wang, G. (2020). The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development. MEDIATORS OF INFLAMMATION, 2020. doi:10.1155/2020/7418342

DOI
10.1155/2020/7418342
Journal article

Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria

Moxon, C. A., Alhamdi, Y., Storm, J., Toh, J. M. H., McGuinness, D., Ko, J. Y., . . . Toh, C. (n.d.). Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), 2851-2864. doi:10.1182/bloodadvances.2019001258

DOI
10.1182/bloodadvances.2019001258
Journal article

A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.

Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.. Clinical medicine (London, England), 20(Suppl 2), s114-s115. doi:10.7861/clinmed.20-2-s114

DOI
10.7861/clinmed.20-2-s114
Journal article

2019

A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies

Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. Retrieved from https://www.webofscience.com/

Conference Paper

A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients

Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Lane, S., Welters, I. D., . . . Toh, C. -H. (2019). A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. American journal of respiratory and critical care medicine, 200(07), 869-880. doi:10.1164/rccm.201811-2111oc

DOI
10.1164/rccm.201811-2111oc
Journal article

Disseminated intravascular coagulation - what can we do?

Toh, C. -H., Toh, J. M. H., & Abrams, S. T. (2019). Disseminated intravascular coagulation - what can we do?. HEMASPHERE, 3, 92-94. doi:10.1097/HS9.0000000000000232

DOI
10.1097/HS9.0000000000000232
Journal article

Parasite histones mediate leak and coagulopathy in cerebral malaria

DOI
10.1101/563551
Preprint

2018

Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation

Abrams, S. T., Su, D., Sahraoui, Y., Alhamdi, Y., Wang, G., & Toh, C. H. (2018). Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-116117

DOI
10.1182/blood-2018-99-116117
Conference Paper

Circulating histones are major mediators of cardiac complications in sepsis

Wang, G., Alhamdi, Y., Abrams, S. T., & Toh, C. H. (2018). Circulating histones are major mediators of cardiac complications in sepsis. In CARDIOVASCULAR RESEARCH Vol. 114 (pp. S99). doi:10.1093/cvr/cvy060.294

DOI
10.1093/cvr/cvy060.294
Conference Paper

2017

Extracellular histones inhibit complement activation through interactions with complement component C4b

Qaddoori, Y., Abrams, S. T., Su, D., Liu, T., Alhamdi, Y., Wang, G., & Toh, C. -H. (2017). Extracellular histones inhibit complement activation through interactions with complement component C4b. In MOLECULAR IMMUNOLOGY Vol. 89 (pp. 132). doi:10.1016/j.molimm.2017.06.067

DOI
10.1016/j.molimm.2017.06.067
Conference Paper

Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (vol 36, pg 505, 2016)

Toh, C. -H., Alhamdi, Y., & Abrams, S. T. (2017). Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (vol 36, pg 505, 2016). ANNALS OF LABORATORY MEDICINE, 37(1), 95. doi:10.3343/alm.2017.37.1.95

DOI
10.3343/alm.2017.37.1.95
Journal article

2016

Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission

Liu, T., Huang, W., Szatmary, P., Abrams, S., Alhamdi, Y., Lin, Z., . . . Toh, C. -H. (2016). Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission. Pancreatology, 16(3), S100-S101. doi:10.1016/j.pan.2016.05.338

DOI
10.1016/j.pan.2016.05.338
Journal article

Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones

Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2016). Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones. Pancreatology, 16(1), S34. doi:10.1016/j.pan.2015.12.107

DOI
10.1016/j.pan.2015.12.107
Journal article

2015

Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis

Liu, T., Abrams, S., Szatmary, P., Cheng, Z., Huang, W., Ou, X., . . . Toh, C. -H. (2015). Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis. Pancreatology, 15(3), S63. doi:10.1016/j.pan.2015.05.242

DOI
10.1016/j.pan.2015.05.242
Journal article

2013

The clinical utility of fibrin-related biomarkers in sepsis.

Toh, J. M. H., Ken-Dror, G., Downey, C., & Abrams, S. T. (2013). The clinical utility of fibrin-related biomarkers in sepsis.. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 24(8), 839-843. doi:10.1097/mbc.0b013e3283646659

DOI
10.1097/mbc.0b013e3283646659
Journal article

Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response

Abrams, S. T., Zhang, N., Wang, G., & Toh, C. -H. (2013). Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response. In BLOOD Vol. 122. doi:10.1182/blood.V122.21.457.457

DOI
10.1182/blood.V122.21.457.457
Conference Paper

Human CRP Defends against the Toxicity of Circulating Histones

Abrams, S. T., Zhang, N., Dart, C., Wang, S. S., Thachil, J., Guan, Y., . . . Toh, C. -H. (2013). Human CRP Defends against the Toxicity of Circulating Histones. JOURNAL OF IMMUNOLOGY, 191(5), 2495-2502. doi:10.4049/jimmunol.1203181

DOI
10.4049/jimmunol.1203181
Journal article

2011

Lipoproteins, statins and septic haematology patients.

Thachil, J., Abrams, S., Downey, C., & Toh, C. H. (2011). Lipoproteins, statins and septic haematology patients.. British journal of haematology, 155(1), 122-123. doi:10.1111/j.1365-2141.2011.08642.x

DOI
10.1111/j.1365-2141.2011.08642.x
Journal article

2010

Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells

Abrams, S. T., Brown, B. R. B., Zuzel, M., & Slupsky, J. R. (2010). Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells. BLOOD, 115(22), 4447-4454. doi:10.1182/blood-2009-06-229872

DOI
10.1182/blood-2009-06-229872
Journal article

2007

B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII

Abrams, S. T., Lakum, T., Lin, K., Jones, G. M., Treweeke, A. T., Farahani, M., . . . Slupsky, J. R. (2007). B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII. BLOOD, 109(3), 1193-1201. doi:10.1182/blood-2006-03-012021

DOI
10.1182/blood-2006-03-012021
Journal article