Research
Structure-function studies of metalloproteins and regulatory systems
Structure-function-misfunction of metalloproteins and metal regulatory systems. We utilise X-ray techniques (Protein Crystallography, X-ray Scattering and XAFS), Cryo Electron Microscopy (cryoEM) together with other biophysical techniques.
See: https://www.liverpool.ac.uk/integrative-biology/research/research-groups/molecular-biophysics/research/
Research grants
Development of non-covalent binders to SOD1 with scope for developing as PROTAC degraders of SOD1 for the treatment of MND
MOTOR NEURONE DISEASE ASSOCIATION (UK)
October 2023 - January 2027
Design and development of novel SOD1 degraders for the treatment of Motor Neurone Disease
ROYAL SOCIETY OF CHEMISTRY (UK)
September 2022 - August 2023
Towards a paradigm shift in understanding of membrane-bound Nitric Oxide reductase and its complexes with the electron donor and NO-producing enzyme
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
November 2023 - November 2026
Japan Partnering : Damage free structures of enzymes of denitrification pathway and their complexes using SF-ROX and SFX at SACLA XFEL
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
July 2019 - July 2024
Why does Nature use modular enzyme architectures for biological catalysis
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
January 2017 - July 2020
Damage Free structures of quinol dependent nitric oxide reductase (qNOR) in complex with nitrite reductase (NiR) from A. xylosoxidans
SCIENCE AND TECHNOLOGY FACILITIES COUNCIL
September 2015 - September 2019
A new generation of Crystallographic detector for Multi-user Barkla X-ray laboratory
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
July 2017 - July 2018
Structure-function studies of faulty proteins and their complexes involved in motor neuron disease
MOTOR NEURONE DISEASE ASSOCIATION
October 2015 - September 2018
The cause and effect of SOD1 destabilization on motor neuron disease
MEDICAL RESEARCH FOUNDATION (UK)
October 2015 - April 2019
Transient and Stable Macromolecular complexes formed by Denitrifying Enzymes
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
June 2014 - June 2019
Support of SESAME Networking Activities
DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY (BEIS) (UK), DEPARTMENT FOR BUSINESS, INNOVATION AND SKILLS (UK), DEPARTMENT FOR SCIENCE, INNOVATION & TECHNOLOGY
April 2014 - March 2025
CIC BioGUNE studentships
CIC BIOGUNE (SPAIN)
October 2013 - September 2017
Towards a complete structure-function description of the dentrification pathway
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
April 2008 - October 2009
CIC BiomaGUNE studentships
CIC BIOMAGUNE (SPAIN)
October 2013 - September 2017
From structures to identification of ligand binding pockets to the discovery of therapeutic compounds using fragment based approach for SOD1 MND
MOTOR NEURONE DISEASE ASSOCIATION
January 2010 - December 2012
TDP-43 and the molecular causes of its pathogenicity in neurodegenerative disease
MOTOR NEURONE DISEASE ASSOCIATION
October 2011 - February 2015
Synchrotoran x-ray studies on the stability of dimeric native and FALS mutant structures of CuZn superoxide dismutase: Structure-based lead optimisation with the aim of stabilising the structure.
MOTOR NEURONE DISEASE ASSOCIATION
May 2008 - June 2009
Probing the structure of biological macromolecules in the gas phase with intense x-ray pulses
SCIENCE AND TECHNOLOGY FACILITIES COUNCIL
October 2009 - March 2013
New challenges of Structural biology arising from the emergence of brilliant X-ray beams from X-ray Lasers
SCIENCE AND TECHNOLOGY FACILITIES COUNCIL
July 2014 - June 2018
Provisionsof MAD/XAFS facililty of the UK structural biology community
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
January 2009 - July 2010
Elucidating mechanisms of proton coupled and conformationally coupled electron transfer in redox enzymes catalysis
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
October 2009 - September 2012
CIC bioGUNE / University of Liverpool PhD programme for 2012/13
CIC BIOGUNE (SPAIN)
October 2012 - December 2016
Structural Protemeomics of Metallo and Membrane Proteins of Pathogens - China Partnering Award
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
April 2008 - March 2010
Structural studies of proteins related to liver disease
CIC BIOGUNE (SPAIN)
September 2011 - August 2015