Research
Research Interests:
Joint Modelling of Longitudinal & Time-to-Event Data
Longitudinal Data Analysis
Survival Analysis
Competing Risks Data Analysis
Statistical Analysis with Missing Data
Time-dependent ROC Curves
Statistical Shape Analysis
Biomarker-Guided Clinical Trials: Design, Analysis & Interpretation
JoineR Collaboration:
https://www.liverpool.ac.uk/translational-medicine/departmentsandgroups/joine-r/
Biomarker-guided trial designs (BiGTeD):
www.BiGTeD.org
Centre of Excellence in Infectious Diseases Research (CEIDR)
Research groups
- Medical Statistics
- Joint Modelling Group
Research grants
Data Accelerator Project (System P & AMR-X)
NHS CHESHIRE AND MERSEYSIDE ICB (UK)
December 2023 - October 2027
Mental Health Research for Innovation Centre (M-RIC)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2023 - December 2027
Serial measurement of the subclinical leukaemic burden as an early biomarker for overt relapse in chronic lymphocytic leukaemia
CANCER RESEARCH UK (UK)
March 2014 - March 2021
Online tool to guide biomarker-guided randomised controlled trials
MEDICAL RESEARCH COUNCIL
March 2016 - August 2017
R19 Evidence synthesis for biomarker validity to inform biomarker-stratified trials
MEDICAL RESEARCH COUNCIL
September 2017 - June 2021
Joint modelling of multivariate longitudinal and event time outcomes in clinical research (JoineR-M)
MEDICAL RESEARCH COUNCIL
August 2015 - December 2018
Improving the efficiency of biomarker-driven designs by using continuous biomarker information
MEDICAL RESEARCH COUNCIL
January 2018 - November 2019
Development of New Mathematical Sciences Capabilities for Healthcare Technologies
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
December 2015 - April 2021
TAILoR (TelmisArtan and InsuLin Resistance in HIV): A dose-ranging Phase II randomised open trial of telmistartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on Combination Antiretroviral Therapy (CART)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2012 - February 2020
A Randomised Control Trial of Extended Brief Interventions for alcohol-dependent patients in an acute care setting.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
November 2009 - October 2012
DISTINCTIVE - Diagnostic comparison of procalcitonin and the aPTT biphasic waveform in children with bacterial sepsis on the intensive care unit
ALDER HEY IMAGINE APPEAL (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2010 - August 2014
Developing a rapid, robust and comprehensive assay for histones and chromatin breakdown products via xMAP technology
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
March 2011 - September 2012
Development of a rapid salivary test to detect serious bacterial infection in children presenting to the accident and emergency department. SPICED.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2010 - May 2012
The Prospective Investigation into urinary NGAL Utility in Paediatric Oncology Patients (PINGU Project) : A pilot study
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
January 2012 - December 2014
Phase IIa, randomised, open label, controlled trial of rostuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (PROteKT)
THE MOULTON CHARITABLE FOUNDATION (UK)
June 2014 - January 2018
Research collaborations
Dr John H. Rex
New Opportunities for Treatment of Multi-Drug Resistant Fungal Disease
Infection, Global Medicines Development, AstraZeneca Pharmaceuticals & F2G, Ltd.
Pharmacodynamics of the Orotomides Against Aspergillus fumigatus.
Dr Laura Kovanda
Pharmacodynamics of Isavuconazole for Invasive Mould Disease
Astellas Pharma Global Development, Inc., Northbrook, IL, USA
Role of Galactomannan for Real-Time Monitoring of Therapeutic Response
Professor Robin Henderson
JoineR
The University of Newcastle-upon-Tyne
Joint modelling of longitudinal and event time outcomes in clinical research
Professor Barry Pizer
Paediatric Oncology
Alder Hey Hospital
Diagnosis and management of paediatric oncology patients with central venous catheter-associated infections.
Dr Pete Philipson
Joint modelling of multivariate longitudinal and event time outcomes in clinical research (JoineR-M)
The University of Northumbria at Newcastle
Development of a novel but sufficiently flexible joint modelling approach for multiple longitudinal biomarkers and correlated event time outcomes. MEDICAL RESEARCH COUNCIL Methodology Research Panel grant.
Professor Peter Diggle
JoineR
The University of Lancaster
Joint modelling of longitudinal and event time outcomes in clinical research
Professor William Hope
Antimicrobial Pharmacodynamics
Antimicrobial drug development and individualisation of antimicrobial therapy
Professor Philip Johnson
Hepatobiliary cancer and biomarkers
Pre-radiographic detection of Hepatocellular Carcinoma: Implications for Surveillance and Resection
Professor Enitan D Carrol
SPICED and DISTINCIVE
SPICED study: Development of a rapid salivary test to detect serious bacterial infection (SBI) in children presenting to the accident and emergency department. DISTINCIVE study: Diagnostic comparison of procalcitonin and the aPTT biphasic waveform in children with bacterial sepsis on the intensive care unit.
Professor Mari Lloyd-Williams
Academic Palliative and Supportive Care Studies Group (APSCSG)
A prospective longitudinal study to determine the prevalence, aetiology and natural history of depression and demoralisation in patients with advanced metastatic cancer
Professor Cheng-Hock Toh
Haemostasis & Thrombosis
Biomarkers (aPTT Waveform, Lipoprotein-Complexed C Reactive Protein Assays, etc) in the Early Diagnosis and Prognosis of Sepsis