Publications
2024
Development and translation of a method of clinical utility for LC-MS/MS analysis to detect SARS-CoV-2 antigens from ONP swabs and saliva
Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality.
Schofield, J., Abrams, S. T., Jenkins, R., Lane, S., Wang, G., & Toh, C. -H. (2024). Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality.. Blood advances, bloodadvances.2023012473. doi:10.1182/bloodadvances.2023012473
Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers.
Clarke, E., Varela, L., Jenkins, R. E., Lozano-Andrés, E., Cywińska, A., Przewozny, M., . . . Wauben, M. H. M. (2024). Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers.. Biochemistry and biophysics reports, 37, 101635. doi:10.1016/j.bbrep.2023.101635
2023
A systems approach reveals species differences in hepatic stress response capacity
Russomanno, G., Sison-Young, R., Livoti, L. A., Coghlan, H., Jenkins, R. E., Kunnen, S. J., . . . Copple, I. M. (2023). A systems approach reveals species differences in hepatic stress response capacity. TOXICOLOGICAL SCIENCES. doi:10.1093/toxsci/kfad085
Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis.
Anderson, J. R., Johnson, E., Jenkins, R., Jacobsen, S., Green, D., Walters, M., . . . Peffers, M. J. (2023). Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis.. International journal of molecular sciences, 24(19), 14888. doi:10.3390/ijms241914888
Ras protein abundance correlates with Ras isoform mutation patterns in cancer
Hood, F. E., Sahraoui, Y. M., Jenkins, R. E., & Prior, I. A. (2023). Ras protein abundance correlates with Ras isoform mutation patterns in cancer. ONCOGENE, 42(15), 1224-1232. doi:10.1038/s41388-023-02638-1
2022
Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis.
Clarke, E. J., Johnson, E., Caamaño Gutierrez, E., Andersen, C., Berg, L. C., Jenkins, R. E., . . . Peffers, M. J. (2022). Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis.. Frontiers in veterinary science, 9, 1057667. doi:10.3389/fvets.2022.1057667
2021
Glycation of Host Proteins Increases Pathogenic Potential of <i>Porphyromonas gingivalis</i>
Smiga, M., Smalley, J. W., Slezak, P., Brown, J. L., Sieminska, K., Jenkins, R. E., . . . Olczak, T. (2021). Glycation of Host Proteins Increases Pathogenic Potential of <i>Porphyromonas gingivalis</i>. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(21). doi:10.3390/ijms222112084
The application of cytokeratin-18 as a biomarker for drug-induced liver injury
Korver, S., Bowen, J., Pearson, K., Gonzalez, R. J., French, N., Park, K., . . . Goldring, C. (2021). The application of cytokeratin-18 as a biomarker for drug-induced liver injury. ARCHIVES OF TOXICOLOGY, 95(11), 3435-3448. doi:10.1007/s00204-021-03121-0
Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification
Howell, L., Jenkins, R. E., Lynch, S., Duckworth, C., Kevin Park, B., & Goldring, C. (2021). Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification. ARCHIVES OF TOXICOLOGY, 95(7), 2413-2430. doi:10.1007/s00204-021-03075-3
Absolute Quantitation of GTPase Protein Abundance
Hood, F. E., Sahraoui, Y. M., Jenkins, R. E., & Prior, I. (2021). Absolute Quantitation of GTPase Protein Abundance. RAS ACTIVITY AND SIGNALING, 2262, 65-90. doi:10.1007/978-1-0716-1190-6_4
The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells
Ide, K., Takahashi, S., Sakai, K., Taga, Y., Ueno, T., Dickens, D., . . . Sakai, T. (2021). The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells. Journal of Biological Chemistry, 100819. doi:10.1016/j.jbc.2021.100819
Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells.
Eagle, G. L., Herbert, J. M. J., Zhuang, J., Oates, M., Khan, U. T., Kitteringham, N. R., . . . Falciani, F. (2021). Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells.. Scientific Reports, 11(1), 2932. doi:10.1038/s41598-021-82609-2
2020
Characterization of Clozapine-Responsive Human T Cells
Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646
Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation
Waddington, J. C., Meng, X., Illing, P. T., Tailor, A., Adair, K., Whitaker, P., . . . Park, B. K. (2020). Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation. TOXICOLOGICAL SCIENCES, 177(2), 454-465. doi:10.1093/toxsci/kfaa124
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly, C. E., Douglas, O., Kamalian, L., Jenkins, R. E., Beckett, A. J., Penman, S. L., . . . Chadwick, A. E. (2020). The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.. Toxicology and applied pharmacology, 403, 115163. doi:10.1016/j.taap.2020.115163
2019
Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.
Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology, 70(5), 1732-1749. doi:10.1002/hep.30701
Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells
Austin, J. A., Jenkins, R. E., Austin, G. M., Glenn, M. A., Dunn, K., Scott, L., . . . Clark, R. E. (2019). Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells. BIOCHEMICAL JOURNAL, 476, 2255-2269. doi:10.1042/BCJ20190121
2018
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response
Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. doi:10.1016/j.jprot.2018.02.030
In chronic myeloid leukaemia cells, the oncoprotein CIP2A binds directly to and alters expression of many cellular proteins, independent of effects on protein phosphatase 2A (PP2A)
Austin, J. A., Lucas, C. M., Jenkins, R. E., Dunn, K., Scott, L. J., Glenn, M. A., . . . Clark, R. E. (2018). In chronic myeloid leukaemia cells, the oncoprotein CIP2A binds directly to and alters expression of many cellular proteins, independent of effects on protein phosphatase 2A (PP2A). In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 52-53). Retrieved from https://www.webofscience.com/
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. TOXICOLOGICAL SCIENCES, 162(2), 655-666. doi:10.1093/toxsci/kfx289
2017
Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts
Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. doi:10.1021/acs.chemrestox.7b00291
Ethanol Stimulates Locomotion via a G(alpha s)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans
Johnson, J. R., Edwards, M. R., Davies, H., Newman, D., Holden, W., Jenkins, R. E., . . . Barclay, J. W. (2017). Ethanol Stimulates Locomotion via a G(alpha s)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans. GENETICS, 207(3), 1023-1039. doi:10.1534/genetics.117.300119
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients
Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R., Marlot, P., Marson, A., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. Chemical Research in Toxicology, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063
Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells
Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. doi:10.1093/toxsci/kfx069
Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.. Journal of Immunology, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209
Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways
Brandi, J., Dando, I., Dalla Pozza, E., Biondani, G., Jenkins, R., Elliott, V., . . . Palmieri, M. (2017). Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. JOURNAL OF PROTEOMICS, 150, 310-322. doi:10.1016/j.jprot.2016.10.002
Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile
Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Kevin Park, B. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. Archives of Toxicology, 91(1), 439-452. doi:10.1007/s00204-016-1694-y
2016
Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients
Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., . . . Ingelman-Sundberg, M. (2016). Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Scientific Reports, 6. doi:10.1038/srep25187
Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus
Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R., O'Brien, D., . . . Costello-Goldring, E. (2016). Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus. Clinical Cancer Research, 22(7), 1734-1743. doi:10.1158/1078-0432.ccr-15-0879
Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites
Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292
Secretome protein signature of human pancreatic cancer stem-like cells
Brandi, J., Dalla Pozza, E., Dando, I., Biondani, G., Robotti, E., Jenkins, R., . . . Cecconi, D. (2016). Secretome protein signature of human pancreatic cancer stem-like cells. JOURNAL OF PROTEOMICS, 136, 1-12. doi:10.1016/j.jprot.2016.01.017
2015
Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney
Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(06), 1261-1273. doi:10.1038/ki.2015.286
Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome
Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., . . . Park, B. K. (2015). Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. SCIENTIFIC REPORTS, 5. doi:10.1038/srep16423
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
Sison-Young, R. L. C., Mitsa, D., Jenkins, R. E., Mottram, D., Alexandre, E., Richert, L., . . . Park, B. K. (2015). Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. TOXICOLOGICAL SCIENCES, 147(2), 412-424. doi:10.1093/toxsci/kfv136
Promiscuous T-cell responses to drugs and drug-haptens
Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036
Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia
Eagle, G., Zhuang, J., Jenkins, R., Till, K., Jithesh, P., Lin, K., . . . Pettitt, A. (2015). Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia. Molecular and Cellular Proteomics, 14(4), 933-945. doi:10.1074/mcp.M114.044479
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
Baxter, M., Withey, S., Harrison, S., Segeritz, C. -P., Zhang, F., Atkinson-Dell, R., . . . Hanley, N. A. (2015). Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. Journal of Hepatology, 62(3), 581-589. doi:10.1016/j.jhep.2014.10.016
Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase
Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458k
2014
107. High NQO1 expression in primary colorectal cancer predicts chemoresistance in colorectal liver metastases
Sutton, P., Jones, R., Jenkins, R., Vimalachandran, D., Goldring, C., Kitteringham, N., . . . Palmer, D. (2014). 107. High NQO1 expression in primary colorectal cancer predicts chemoresistance in colorectal liver metastases. European Journal of Surgical Oncology (EJSO), 40(11), S50-S51. doi:10.1016/j.ejso.2014.08.103
Antigen exposure required for T cell activation
Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-s3-p115
Characterization of Flucloxacillin-specific CD8+ T-cells in a mouse model
Nattrass, R., Faulkner, L., Jenkins, R., Nicolas, J., Vocanson, M., Rozieres, A., . . . Naisbitt, D. (2014). Characterization of Flucloxacillin-specific CD8+ T-cells in a mouse model. Clinical and translational allergy, 4(Suppl 3), P41. doi:10.1186/2045-7022-4-s3-p41
Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis
Amali, M., Sullivan, A., Farrell, J., Meng, X., Jenkins, R., Whitaker, P., . . . Naisbitt, D. J. (2014). Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis. Clinical and translational allergy, 4(Suppl 3), P113. doi:10.1186/2045-7022-4-s3-p113
Proteomic analysis of primary colorectal cancer to generate response biomarkers for liver metastases
Sutton, P. A., Jones, R., Rowe, C., Jenkins, R., Malik, H. Z., Vimalachandran, D., . . . Palmer, D. H. (2014). Proteomic analysis of primary colorectal cancer to generate response biomarkers for liver metastases. In JOURNAL OF CLINICAL ONCOLOGY Vol. 32. doi:10.1200/jco.2014.32.15_suppl.e14535
Phenotypic analysis of primary colorectal cancer to inform management of metastatic disease
Sutton, P., Jones, R., Rowe, C., Jenkins, R., Malik, H., Vimalachandran, D., . . . Kitteringham, N. (2014). Phenotypic analysis of primary colorectal cancer to inform management of metastatic disease. In LANCET Vol. 383 (pp. 98). Retrieved from https://www.webofscience.com/
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients
Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079
2013
Safety pharmacology - Current and emerging concepts
Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039
Proteomic profiling of a mouse model of acute intestinal <i>Apc</i> deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC)
Hammoudi, A., Song, F., Reed, K. R., Jenkins, R. E., Meniel, V. S., Watson, A. J. M., . . . Jenkins, J. R. (2013). Proteomic profiling of a mouse model of acute intestinal <i>Apc</i> deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 440(3), 364-370. doi:10.1016/j.bbrc.2013.08.076
Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study
Jones, R. P., Sutton, P., Greensmith, R. M. D., Santoyo-Castelazo, A., Carr, D. F., Jenkins, R., . . . Kitteringham, N. R. (2013). Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 72(2), 359-368. doi:10.1007/s00280-013-2199-5
Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation.
Rowe, C., Gerrard, D. T., Jenkins, R., Berry, A., Durkin, K., Sundstrom, L., . . . Hanley, N. A. (2013). Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation.. Hepatology (Baltimore, Md.), 58(2), 799-809. doi:10.1002/hep.26414
Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells
Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041v
β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis
Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m
iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance
Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. BRITISH JOURNAL OF CANCER, 108(9), 1846-1853. doi:10.1038/bjc.2013.150
iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance
Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. British Journal of Cancer, 108(9), 1846-1853. doi:10.1038/bjc.2013.150
Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients
Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107
Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury
Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077
2012
Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation
Goldring, C., Rowe, C., Jenkins, R. E., Kitteringham, N. R., & Park, K. B. (n.d.). Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation. Journal of Integrated OMICS, 2(2). doi:10.5584/jiomics.v2i2.102
Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.
Holmberg, C., Quante, M., Steele, I., Kumar, J. D., Balabanova, S., Duval, C., . . . Varro, A. (2012). Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.. Carcinogenesis, 33(8), 1553-1562. doi:10.1093/carcin/bgs180
Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis
El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900
PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion
Edwards, M. R., Johnson, J. R., Rankin, K., Jenkins, R. E., Maguire, C., Morgan, A., . . . Barclay, J. W. (2012). PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion. JOURNAL OF NEUROSCIENCE, 32(20), 7042-7051. doi:10.1523/JNEUROSCI.4029-11.2012
Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.
Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., . . . Park, B. K. (2012). Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.. Pharmacological reports : PR, 64(3), 680-697. doi:10.1016/s1734-1140(12)70863-0
HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury
Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.
2011
In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin
Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, J. G., . . . Park, B. K. (2011). In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin. Toxicology, 290(2-3), 142-143. doi:10.1016/j.tox.2011.09.072
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871
MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility
Polanski, R., Maguire, M., Nield, P. C., Jenkins, R. E., Park, B. K., Krawczynska, K., . . . Boyd, M. T. (2011). MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility. CARCINOGENESIS, 32(8), 1133-1142. doi:10.1093/carcin/bgr070
Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis
Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis. JOURNAL OF IMMUNOLOGY, 187(1), 200-211. doi:10.4049/jimmunol.1100647
Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression
Tonack, S., Patel, S., Jalali, M., Nedjadi, T., Jenkins, R. E., Goldring, C., . . . Costello, E. (2011). Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression. WORLD JOURNAL OF GASTROENTEROLOGY, 17(15), 1947-1960. doi:10.3748/wjg.v17.i15.1947
Combined LC-MS/MS and iTRAQ analysis of serum and pancreatic juice for the detection of biomarkers for pancreatic cancer: Influence of biliary obstruction
Tonack, S., Jenkinson, C., Elliot, V., Dajani, K., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2011). Combined LC-MS/MS and iTRAQ analysis of serum and pancreatic juice for the detection of biomarkers for pancreatic cancer: Influence of biliary obstruction. Pancreas, 40, 1358.
2010
Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites
Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, G. L., . . . Park, B. K. (2010). Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites. Toxicology, 278(3), 357-358. doi:10.1016/j.tox.2010.08.108
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer
Tweedle, E. M., Khattak, I., Ang, C. W., Nedjadi, T., Jenkins, R., Park, B. K., . . . Costello, E. (2010). Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. GUT, 59(11), 1501-1510. doi:10.1136/gut.2009.196626
Network Analysis of Primary Hepatocyte Dedifferentiation Using a Shotgun Proteomics Approach
Rowe, C., Goldring, C. E. P., Kitteringham, N. R., Jenkins, R. E., Lane, B. S., Sanderson, C., . . . Park, B. K. (2010). Network Analysis of Primary Hepatocyte Dedifferentiation Using a Shotgun Proteomics Approach. Journal of Proteome Research, 9(8), 4313-4314. doi:10.1021/pr100603e
Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells
Ang, C. W., Nedjadi, T., Sheikh, A. A., Tweedle, E. M., Tonack, S., Honap, S., . . . Costello, E. (2010). Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. CARCINOGENESIS, 31(9), 1541-1551. doi:10.1093/carcin/bgq137
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. JOURNAL OF PROTEOMICS, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018
Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., . . . Park, B. K. (2010). Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(22), 16782-16788. doi:10.1074/jbc.M109.096545
Characterization of <i>p</i>-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein
Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of <i>p</i>-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271
2009
A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ
Tonack, S., Aspinall-O'Dea, M., Jenkins, R. E., Elliot, V., Murray, S., Lane, C. S., . . . Costello, E. (2009). A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ. JOURNAL OF PROTEOMICS, 73(2), 352-356. doi:10.1016/j.jprot.2009.07.009
Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>
Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222
S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility
Nedjadi, T., Kitteringham, N., Campbell, F., Jenkins, R. E., Park, B. K., Navarro, P., . . . Costello, E. (2009). S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. BRITISH JOURNAL OF CANCER, 101(7), 1145-1154. doi:10.1038/sj.bjc.6605289
Proteomic Analysis of Metastatic Laryngeal Squamous Cell Carcinoma
Goodyear, P., Jenkins, R., Kitteringham, N., Boyd, M., Hamlett, J., & Jones, T. (2009). Proteomic Analysis of Metastatic Laryngeal Squamous Cell Carcinoma. Clinical Oncology, 21(8), 645.
A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of <i>p</i>-Phenylenediamine
Jenkinson, C., Jenkins, R. E., Maggs, J. L., Kitteringham, N. R., Aleksic, M., Park, B. K., & Naisbitt, D. J. (2009). A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of <i>p</i>-Phenylenediamine. CHEMICAL RESEARCH IN TOXICOLOGY, 22(6), 1172-1180. doi:10.1021/tx900095r
Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation
Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2009). Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation. CHEMICAL RESEARCH IN TOXICOLOGY, 22(5), 937-948. doi:10.1021/tx900034r
Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.
Kitteringham, N. R., Jenkins, R. E., Lane, C. S., Elliott, V. L., & Park, B. K. (2009). Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(13), 1229-1239. doi:10.1016/j.jchromb.2008.11.013
Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer
Yan, L., Tonack, S., Smith, R., Dodd, S., Jenkins, R. E., Kitteringham, N., . . . Costello, E. (2009). Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer. JOURNAL OF PROTEOME RESEARCH, 8(1), 142-148. doi:10.1021/pr800451h
An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype
Curley, P., Kelly, L., Shaw, R., Kitteringham, N., Jenkins, R., Alder, J., . . . Park, K. (2009). An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype. In British Pharmacology Society Winter Meeting. London, UK.
2008
Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding
Prescott, G. R., Jenkins, R. E., Walsh, C. M., & Morgan, A. (2008). Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 377(3), 809-814. doi:10.1016/j.bbrc.2008.10.069
Proteomic analysis of metastatic laryngeal squamous cell carcinoma
Goodyear, P. W. A., Boyd, M. T., Jenkins, R., Hamlett, J., Kitteringham, N., & Jones, T. M. (2008). Proteomic analysis of metastatic laryngeal squamous cell carcinoma. Clinical Otolaryngology, 33(6), 642. doi:10.1111/j.1749-4486.2008.01843_5.x
PROTEOMIC ANALYSIS OF SERUM AND PANCREATIC JUICE FROM PANCREATIC DUCTAL ADENOCARCINOMA PATIENS USING ITRAQ LABELLING
Tonack, S., Aspinall-O'Dea, M., Sheikh, A., Jenkins, R., Elliott, V., Neoptolemos, J., & Costello, E. (2008). PROTEOMIC ANALYSIS OF SERUM AND PANCREATIC JUICE FROM PANCREATIC DUCTAL ADENOCARCINOMA PATIENS USING ITRAQ LABELLING. Pancreas, 37(4), 498. doi:10.1097/01.mpa.0000335401.70046.eb
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system
Copple, I. M., Goldring, C. E., Jenkins, R. E., Chia, A. J. L., Randle, L. E., Hayes, J. D., . . . Park, B. K. (2008). The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. HEPATOLOGY, 48(4), 1292-1301. doi:10.1002/hep.22472
MDM2 regulates dihydrofolate reductase activity through monoubiquitination
Maguire, M., Nield, P. C., Devling, T., Jenkins, R. E., Park, B. K., Polanski, R., . . . Boyd, M. T. (2008). MDM2 regulates dihydrofolate reductase activity through monoubiquitination. CANCER RESEARCH, 68(9), 3232-3242. doi:10.1158/0008-5472.CAN-07-5271
Albumin and immunoglobulin depletion of human plasma
Jenkins, R. E., Kitteringham, N. R., Greenough, C., & Park, B. K. (2008). Albumin and immunoglobulin depletion of human plasma. Methods Mol Biol, 425, 15-25.
Albumin and immunoglobulin depletion of human plasma.
Jenkins, R. E., Kitteringham, N. R., Greenough, C., & Park, B. K. (2008). Albumin and immunoglobulin depletion of human plasma.. In Unknown Book (Vol. 425, pp. 15-25). doi:10.1007/978-1-60327-210-0_2
Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.
Jenkins, R. E., Kitteringham, N. R., Goldring, C. E. P., Dowdall, S. M. J., Hamlett, J., Lane, C. S., . . . Park, B. K. (2008). Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.. Proteomics, 8(2), 301-315. doi:10.1002/pmic.200700843
2007
Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts.
Pennington, S. R., Foster, B. J., Hawley, S. R., Jenkins, R. E., Zolle, O., White, M. R. H., . . . Simpson, A. W. M. (2007). Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts.. The Journal of biological chemistry, 282(44), 32112-32120. doi:10.1074/jbc.m705067200
INVOLVEMENT OF S100A6 (CALCYCLIN) IN PANCREATIC CANCER PROGRESSION
Nedjadi, T., Smith, R., Jenkins, R. E., & Costello, E. (2007). INVOLVEMENT OF S100A6 (CALCYCLIN) IN PANCREATIC CANCER PROGRESSION. Pancreas, 35(4), 419. doi:10.1097/01.mpa.0000297757.44337.a8
Interaction between pancreatic cancer cells and tumour stromal monocytes
Sheikh, A. A., Vimalachandran, D., Jenkins, R., Campbell, F., Dodson, A. R., Neoptolemos, J. P., & Costello, E. (2007). Interaction between pancreatic cancer cells and tumour stromal monocytes. PANCREAS, 35(4), 427. doi:10.1097/01.mpa.0000297784.25519.d5
Detection and biochemical characterisation of a novel polymorphism in the human <i>GSTP1</i> gene
Kitteringham, N. R., Palmer, L., Owen, A., Lian, L. -Y., Jenkins, R., Dowdall, S., . . . Goldring, C. E. (2007). Detection and biochemical characterisation of a novel polymorphism in the human <i>GSTP1</i> gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1240-1247. doi:10.1016/j.bbagen.2007.05.001
Characterization of a bifunctional catalase-peroxidase of <i>Burkholderia cenocepacia</i>
Charalabous, P., Risk, J. M., Jenkins, R., Birss, A. J., Hart, C. A., & Smalley, J. W. (2007). Characterization of a bifunctional catalase-peroxidase of <i>Burkholderia cenocepacia</i>. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 50(1), 37-44. doi:10.1111/j.1574-695X.2007.00224.x
The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells
Sheikh, A. A., Vimalachandran, D., Thompson, C. C., Jenkins, R. E., Nedjadi, T., Shekouh, A., . . . Costello, E. (2007). The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells. PROTEOMICS, 7(11), 1929-1940. doi:10.1002/pmic.200700072
Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility
Thompson, C. C., Ashcroft, F. J., Patel, S., Saraga, G., Vimalachandran, D., Prime, W., . . . Costello, E. (2007). Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. GUT, 56(1), 95-106. doi:10.1136/gut.2005.083691
2006
The expression of S100A8 in tumour-associated monocytes is directly associated with the Smad4 status of pancreatic cancer cells
Vimalachandran, D., Sheikh, A., Tweedle, E., Khattak, I., Thompson, C. C., Jenkins, R. E., . . . Costello, E. (2006). The expression of S100A8 in tumour-associated monocytes is directly associated with the Smad4 status of pancreatic cancer cells. In PANCREAS Vol. 33 (pp. 506). doi:10.1097/00006676-200611000-00233
Use of proteomics in development of biomarkers and early markers of toxicity
Pennington, S., Kitteringham, N., Jenkins, R., Hunt, T., Webb, S., & Hunter, C. (2006). Use of proteomics in development of biomarkers and early markers of toxicity. Toxicology Letters, 164, S316. doi:10.1016/j.toxlet.2006.07.322
Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements
Goldring, C., Kitteringham, N., Jenkins, R., Copple, I., Jeannin, J. F., & Park, B. K. (2006). Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements. JOURNAL OF EXPERIMENTAL BIOLOGY, 209(12), 2337-2343. doi:10.1242/jeb.02209
Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags
Jenkins, R. E., Kitteringham, N. R., Hunter, C. L., Webb, S., Hunt, T. J., Elsby, R., . . . Park, B. K. (2006). Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags. PROTEOMICS, 6(6), 1934-1947. doi:10.1002/pmic.200500432
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005
Protein chip technology in proteomics analysis
Jenkins, R. E., & Pennington, S. R. (2006). Protein chip technology in proteomics analysis. In J. E. Van Eyk, & M. J. Dunn (Eds.), Proteomic and genomic analysis of cardiovascular disease (pp. 235-254). Weinheim: Wiley-VCH Verlag Gmbh & Co..
2005
Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2
Kitteringham, N., Abdullah, A., Jenkins, R., Goldring, C., Hayes, J. D., & Park, K. (2005). Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2. Drug Metabolism Reviews, 37, 23.
Quantitative profiling of cytochromes P450 by isotope coded affinity tagging
Jenkins, R. E., Kitteringham, N. R., Hunt, T. J., Boucher, B. J., Minkoff, M. S., Elsby, R., . . . Park, B. K. (2005). Quantitative profiling of cytochromes P450 by isotope coded affinity tagging. Toxicology, 213(3), 260-261.
Quantitative profiling of cytochromes P450 by isotope coded affinity tagging
Jenkins, R. E., Kitteringham, N. R., Hunt, T. J., Boucher, B. J., Minkoff, M. S., Elsby, R., . . . Park, B. K. (2005). Quantitative profiling of cytochromes P450 by isotope coded affinity tagging. Toxicology, 213(3), 260-261.
Separation-independent approaches for protein expression profiling
Jenkins, R. E., & Pennington, S. R. (2005). Separation-independent approaches for protein expression profiling. In M. Dunn (Ed.), Encyclopaedia of Genetics, Genomics, Proteomics and Bioinformatics (pp. 1209-1220). Hoboken: John Wiley & Sons.
2004
A method for the rapid depletion of albumin and immunoglobulin from human plasma
Greenough, C., Jenkins, R. E., Kitteringham, N. R., Pirmohamed, M., Park, B. K., & Pennington, S. R. (2004). A method for the rapid depletion of albumin and immunoglobulin from human plasma. PROTEOMICS, 4(10), 3107-3111. doi:10.1002/pmic.200300815
2003
Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver.
Kitteringham, N. R., Powell, H., Jenkins, R. E., Hamlett, J., Lovatt, C., Elsby, R., . . . Park, B. K. (2003). Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver.. Proteomics, 3(2), 191-207. doi:10.1002/pmic.200390028
2002
Identification of Ca<SUP>2+</SUP>-dependent binding partners for the neuronal calcium sensor protein neurocalcin δ:: interaction with actin, clathrin and tubulin
Ivings, L., Pennington, S. R., Jenkins, R., Weiss, J. L., & Burgoyne, R. D. (2002). Identification of Ca<SUP>2+</SUP>-dependent binding partners for the neuronal calcium sensor protein neurocalcin δ:: interaction with actin, clathrin and tubulin. BIOCHEMICAL JOURNAL, 363, 599-608. doi:10.1042/0264-6021:3630599
Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin δ: interaction with actin, clathrin and tubulin
IVINGS, L., PENNINGTON, S. R., JENKINS, R., WEISS, J. L., & BURGOYNE, R. D. (2002). Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin δ: interaction with actin, clathrin and tubulin. Biochemical Journal, 363(3), 599-608. doi:10.1042/bj3630599
2001
Regulation of growth factor induced gene expression by calcium signalling: Integrated mRNA and protein expression analysis
Jenkins, R. E., Hawley, S. R., Promwikorn, W., Brown, J., Hamlett, J., & Pennington, S. R. (2001). Regulation of growth factor induced gene expression by calcium signalling: Integrated mRNA and protein expression analysis. Proteomics, 1(9), 1092-1104. doi:3.0.CO;2-S">10.1002/1615-9861(200109)1:9<1092::AID-PROT1092>3.0.CO;2-S
Regulation of growth factor induced gene expression by calcium signalling: integrated mRNA and protein expression analysis.
Jenkins, R. E., Hawley, S. R., Promwikorn, W., Brown, J., Hamlett, J., & Pennington, S. R. (2001). Regulation of growth factor induced gene expression by calcium signalling: integrated mRNA and protein expression analysis.. Proteomics, 1(9), 1092-1104. doi:3.0.co;2-s">10.1002/1615-9861(200109)1:9<1092::aid-prot1092>3.0.co;2-s
Arrays for protein expression profiling: Towards a viable alternative to two-dimensional gel electrophoresis?
Jenkins, R. E., & Pennington, S. R. (2001). Arrays for protein expression profiling: Towards a viable alternative to two-dimensional gel electrophoresis?. PROTEOMICS, 1(1), 13-29. doi:3.3.co;2-a">10.1002/1615-9861(200101)1:1<13::aid-prot13>3.3.co;2-a
Arrays for protein expression profiling: towards a viable alternative to two-dimensional gel electrophoresis?
Jenkins, R. E., & Pennington, S. R. (2001). Arrays for protein expression profiling: towards a viable alternative to two-dimensional gel electrophoresis?. Proteomics, 1(1), 13-29. doi:3.0.co;2-j">10.1002/1615-9861(200101)1:1<13::aid-prot13>3.0.co;2-j
Novel approaches to protein expression analysis
Jenkins, R. E., & Pennington, S. R. (2001). Novel approaches to protein expression analysis. In S. R. Pennington, & M. J. Dunn (Eds.), Proteomics: A new era in the analysis of protein function (pp. 207-224). Oxford: Bios Scientific Publishers.
1998
Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis.
Jenkins, R. E., Taylor, M. J., Gilvary, N. J., & Bianco, A. E. (1998). Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis.. Proceedings of the National Academy of Sciences of the United States of America, 95(13), 7550-7555. doi:10.1073/pnas.95.13.7550
1996
Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential.
Jenkins, R. E., Taylor, M. J., Gilvary, N., & Bianco, A. E. (1996). Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential.. Parasite immunology, 18(1), 29-42. doi:10.1046/j.1365-3024.1996.d01-10.x
Protective immunity induced by vaccination with Onchocerca volvulus tropomyosin in rodents.
Taylor, M. J., Jenkins, R. E., & Bianco, A. E. (1996). Protective immunity induced by vaccination with Onchocerca volvulus tropomyosin in rodents.. Parasite immunology, 18(5), 219-225. doi:10.1046/j.1365-3024.1996.d01-93.x
Vaccination generates serum-mediated protection against Onchocerca lienalis microfilariae in the mouse.
Folkard, S. G., Jenkins, R. E., & Bianco, A. E. (1996). Vaccination generates serum-mediated protection against Onchocerca lienalis microfilariae in the mouse.. Tropical medicine & international health : TM & IH, 1(3), 359-362. doi:10.1046/j.1365-3156.1996.d01-48.x
1995
Onchocerca spp: a "family" of secreted acidic proteins expressed by infective larvae in blackflies.
Bianco, A. E., Wu, Y., & Jenkins, R. E. (1995). Onchocerca spp: a "family" of secreted acidic proteins expressed by infective larvae in blackflies.. Experimental parasitology, 81(3), 344-354. doi:10.1006/expr.1995.1125
Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis.
Taylor, M. J., Abdel-Wahab, N., Wu, Y., Jenkins, R. E., & Bianco, A. E. (1995). Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis.. Infection and immunity, 63(11), 4417-4422. doi:10.1128/iai.63.11.4417-4422.1995
1993
Localization, turnover and conservation of gp15/400 in different stages of Brugia malayi.
Selkirk, M. E., Gregory, W. F., Jenkins, R. E., & Maizels, R. M. (1993). Localization, turnover and conservation of gp15/400 in different stages of Brugia malayi.. Parasitology, 107 ( Pt 4), 449-457. doi:10.1017/s0031182000067810
1992
Cloning of a cuticular antigen that contains multiple tandem repeats from the filarial parasite Dirofilaria immitis.
Poole, C. B., Grandea, A. G., Maina, C. V., Jenkins, R. E., Selkirk, M. E., & McReynolds, L. A. (1992). Cloning of a cuticular antigen that contains multiple tandem repeats from the filarial parasite Dirofilaria immitis.. Proceedings of the National Academy of Sciences of the United States of America, 89(13), 5986-5990. doi:10.1073/pnas.89.13.5986
1991
A proline-rich structural protein of the surface sheath of larval Brugia filarial nematode parasites.
Selkirk, M. E., Yazdanbakhsh, M., Freedman, D., Blaxter, M. L., Cookson, E., Jenkins, R. E., & Williams, S. A. (1991). A proline-rich structural protein of the surface sheath of larval Brugia filarial nematode parasites.. The Journal of biological chemistry, 266(17), 11002-11008. doi:10.1016/s0021-9258(18)99119-2
1990
Cuticular localisation and turnover of the major surface glycoprotein (gp29) of adult Brugia malayi.
Selkirk, M. E., Gregory, W. F., Yazdanbakhsh, M., Jenkins, R. E., & Maizels, R. M. (1990). Cuticular localisation and turnover of the major surface glycoprotein (gp29) of adult Brugia malayi.. Molecular and biochemical parasitology, 42(1), 31-43. doi:10.1016/0166-6851(90)90110-8