Publications
2024
Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes
Skeletal muscle aquaporin function and role in redox signalling
Staunton, C. A., Peterson, M. P., Heaton, R. A., Jackson, M. J., & Barrett-Jolley, R. (2024). Skeletal muscle aquaporin function and role in redox signalling. Free Radical Biology and Medicine, 218, 38-39. doi:10.1016/j.freeradbiomed.2024.04.139
Fluorescent characterization of differentiated myotubes using flow cytometry.
Nolan, A., Heaton, R. A., Adamova, P., Cole, P., Turton, N., Gillham, S. H., . . . Sexton, D. W. (2024). Fluorescent characterization of differentiated myotubes using flow cytometry.. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 105(5), 332-344. doi:10.1002/cyto.a.24822
2023
Regulation of Peroxiredoxin Oxidation for the Maintenance of Muscle Mass and Function in Ageing
Heaton, R., clare stretton., Pugh, J., Close, G., McArdle, A., & Jackson, M. (2023). Regulation of Peroxiredoxin Oxidation for the Maintenance of Muscle Mass and Function in Ageing. Free Radical Biology and Medicine, 208, S54. doi:10.1016/j.freeradbiomed.2023.10.122
Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency
Lund, M., Heaton, R., Hargreaves, I. P., Gregersen, N., & Olsen, R. K. J. (2023). Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1868(2). doi:10.1016/j.bbalip.2022.159248
2022
Regulation of Peroxiredoxin Oxidation for the Maintenance of Muscle Mass and Function in Ageing
Heaton, R., Stretton, C., Pugh, J., McArdle, A., & Jackson, M. (2022). Regulation of Peroxiredoxin Oxidation for the Maintenance of Muscle Mass and Function in Ageing. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 192. doi:10.1016/j.freeradbiomed.2022.10.012
The effects of cannabidiol on ROS signalling and cytokine/chemokine production in mature C2C12 myotubes
Gillham, S., Heaton, R., Kumiscia, K., Jackson, M., McArdle, A., & Close, G. (2022). The effects of cannabidiol on ROS signalling and cytokine/chemokine production in mature C2C12 myotubes. Free Radical Biology and Medicine, 192, 29-30. doi:10.1016/j.freeradbiomed.2022.10.036
Biallelic variants in coenzyme Q10 biosynthesis pathway genes cause a retinitis pigmentosa phenotype
Jurkute, N., Cancellieri, F., Pohl, L., Li, C. H. Z., Heaton, R. A., Reurink, J., . . . Arno, G. (2022). Biallelic variants in coenzyme Q10 biosynthesis pathway genes cause a retinitis pigmentosa phenotype. NPJ GENOMIC MEDICINE, 7(1). doi:10.1038/s41525-022-00330-z
Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance
Hufnagel, A., Fernandez-Twinn, D. S., Blackmore, H. L., Ashmore, T. J., Heaton, R. A., Jenkins, B., . . . Ozanne, S. E. (2022). Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance. JOURNAL OF PHYSIOLOGY-LONDON, 600(4), 903-919. doi:10.1113/JP281902
COVID-19 and the Assessment of Coenzyme Q10.
Turton, N., Heaton, R. A., & Hargreaves, I. P. (2022). COVID-19 and the Assessment of Coenzyme Q10.. Methods in molecular biology (Clifton, N.J.), 2511, 355-365. doi:10.1007/978-1-0716-2395-4_27
2021
Coenzyme Q10, Ageing and the Nervous System: An Overview
Mantle, D., Heaton, R. A., & Hargreaves, I. P. (2022). Coenzyme Q10, Ageing and the Nervous System: An Overview. ANTIOXIDANTS, 11(1). doi:10.3390/antiox11010002
Bezafibrate activation of PPAR drives disturbances in mitochondrial redox bioenergetics and decreases the viability of cells from patients with VLCAD deficiency
Lund, M., Andersen, K. G., Heaton, R., Hargreaves, I. P., Gregersen, N., & Olsen, R. K. J. (2021). Bezafibrate activation of PPAR drives disturbances in mitochondrial redox bioenergetics and decreases the viability of cells from patients with VLCAD deficiency. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1867(6). doi:10.1016/j.bbadis.2021.166100
Coenzyme Q10 and Immune Function: An Overview
Mantle, D., Heaton, R. A., & Hargreaves, I. P. (2021). Coenzyme Q10 and Immune Function: An Overview. ANTIOXIDANTS, 10(5). doi:10.3390/antiox10050759
Coenzyme Q<sub>10</sub> and the exclusive club of diseases that show a limited response to treatment
Turton, N., Bowers, N., Khajeh, S., Hargreaves, I. P., & Heaton, R. A. (2021). Coenzyme Q<sub>10</sub> and the exclusive club of diseases that show a limited response to treatment. EXPERT OPINION ON ORPHAN DRUGS, 9(5), 151-160. doi:10.1080/21678707.2021.1932459
Effects of Feeding Coenzyme Q10-Ubiquinol on Plasma Coenzyme Q10 Concentrations and Semen Quality in Stallions
Ruiz, A. J., Tibary, A., Heaton, R. A., Hargreaves, I. P., Leadon, D. P., & Bayly, W. M. (2021). Effects of Feeding Coenzyme Q10-Ubiquinol on Plasma Coenzyme Q10 Concentrations and Semen Quality in Stallions. JOURNAL OF EQUINE VETERINARY SCIENCE, 96. doi:10.1016/j.jevs.2020.103303
No Effect of Coenzyme Q10 on Cognitive Function, Psychological Symptoms, and Health-related Outcomes in Schizophrenia and Schizoaffective Disorder Results of a Randomized, Placebo-Controlled Trial
Maguire, A., Mooney, C., Flynn, G., Ferguson, Y., O'Keane, V., O'Rourke, D., . . . Hargreaves, A. (2021). No Effect of Coenzyme Q10 on Cognitive Function, Psychological Symptoms, and Health-related Outcomes in Schizophrenia and Schizoaffective Disorder Results of a Randomized, Placebo-Controlled Trial. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 41(1), 53-57. doi:10.1097/JCP.0000000000001330
The Effect of Organophosphate Exposure on Neuronal Cell Coenzyme Q<sub>10</sub> Status
Turton, N., Heaton, R. A., Ismail, F., Roberts, S., Nelder, S., Phillips, S., & Hargreaves, I. P. (2021). The Effect of Organophosphate Exposure on Neuronal Cell Coenzyme Q<sub>10</sub> Status. NEUROCHEMICAL RESEARCH, 46(1), 131-139. doi:10.1007/s11064-020-03033-y
2020
The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme Q<sub>10</sub> Status and Mitochondrial Function
Proctor, E. C., Turton, N., Boan, E. J., Bennett, E., Philips, S., Heaton, R. A., & Hargreaves, I. P. (2020). The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme Q<sub>10</sub> Status and Mitochondrial Function. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(23). doi:10.3390/ijms21239137
Disorders of Human Coenzyme Q10 Metabolism: An Overview
Hargreaves, I., Heaton, R. A., & Mantle, D. (2020). Disorders of Human Coenzyme Q10 Metabolism: An Overview. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(18). doi:10.3390/ijms21186695
Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review
Stepien, K. M., Roncaroli, F., Turton, N., Hendriksz, C. J., Roberts, M., Heaton, R. A., & Hargreaves, I. (2020). Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review. JOURNAL OF CLINICAL MEDICINE, 9(8). doi:10.3390/jcm9082596
Production of Mannosylerythritol Lipids (MELs) to be Used as Antimicrobial Agents Against <i>S. aureus</i> ATCC 6538
Ceresa, C., Hutton, S., Lajarin-Cuesta, M., Heaton, R., Hargreaves, I., Fracchia, L., & De Rienzo, M. A. D. (2020). Production of Mannosylerythritol Lipids (MELs) to be Used as Antimicrobial Agents Against <i>S. aureus</i> ATCC 6538. CURRENT MICROBIOLOGY, 77(8), 1373-1380. doi:10.1007/s00284-020-01927-2
The Effect of Cellular Coenzyme Q<sub>10</sub> Deficiency on Lysosomal Acidification
Heaton, R. A., Heales, S., Rahman, K., Sexton, D. W., & Hargreaves, I. (2020). The Effect of Cellular Coenzyme Q<sub>10</sub> Deficiency on Lysosomal Acidification. JOURNAL OF CLINICAL MEDICINE, 9(6). doi:10.3390/jcm9061923
Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction
Ghosh, R., Wood-Kaczmar, A., Dobson, L., Smith, E. J., Sirinathsinghji, E. C., Kriston-Vizi, J., . . . Tabrizi, S. J. (2020). Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction. FASEB JOURNAL, 34(6), 8139-8154. doi:10.1096/fj.201902277RR
T58. EFFECTIVENESS OF ORALLY ADMINISTERED CO-ENZYME Q10 FOR SCHIZOPHRENIA: COGNITIVE, FUNCTIONAL AND BIOCHEMICAL OUTCOMES FROM A DOUBLE BLIND, RANDOMISED, PLACEBO CONTROLLED TRIAL
Hargreaves, A., Maguire, A., Mooney, C., Hargreaves, I., Heaton, R., Phillips, S., & Gill, M. (2020). T58. EFFECTIVENESS OF ORALLY ADMINISTERED CO-ENZYME Q10 FOR SCHIZOPHRENIA: COGNITIVE, FUNCTIONAL AND BIOCHEMICAL OUTCOMES FROM A DOUBLE BLIND, RANDOMISED, PLACEBO CONTROLLED TRIAL. Schizophrenia Bulletin, 46(Supplement_1), S253. doi:10.1093/schbul/sbaa029.618
Coenzyme Q<sub>10</sub> Assessment and the Establishment of a Neuronal Cell Model of CoQ<sub>10</sub> Deficiency
Heaton, R., Duberley, K., & Hargreaves, I. P. (2020). Coenzyme Q<sub>10</sub> Assessment and the Establishment of a Neuronal Cell Model of CoQ<sub>10</sub> Deficiency. CLINICAL AND PRECLINICAL MODELS FOR MAXIMIZING HEALTHSPAN, 2138, 277-287. doi:10.1007/978-1-0716-0471-7_19
EFFECTIVENESS OF ORALLY ADMINISTERED CO-ENZYME Q10 FOR SCHIZOPHRENIA: COGNITIVE, FUNCTIONAL AND BIOCHEMICAL OUTCOMES FROM A DOUBLE BLIND, RANDOMISED, PLACEBO CONTROLLED TRIAL
Hargreaves, A., Maguire, A., Mooney, C., Hargreaves, I., Heaton, R., Phillips, S., & Gill, M. (2020). EFFECTIVENESS OF ORALLY ADMINISTERED CO-ENZYME Q10 FOR SCHIZOPHRENIA: COGNITIVE, FUNCTIONAL AND BIOCHEMICAL OUTCOMES FROM A DOUBLE BLIND, RANDOMISED, PLACEBO CONTROLLED TRIAL. In SCHIZOPHRENIA BULLETIN Vol. 46 (pp. S253). Retrieved from https://www.webofscience.com/
2019
Effect of daily supplementation with ubiquinol on muscle coenzyme Q10 concentrations in Thoroughbred racehorses
Thueson, E., Leadon, D. P., Heaton, R., Hargreaves, I. P., & Bayly, W. M. (2019). Effect of daily supplementation with ubiquinol on muscle coenzyme Q10 concentrations in Thoroughbred racehorses. Comparative Exercise Physiology, 15(3), 219-226. doi:10.3920/cep190023
Current biochemical treatments of mitochondrial respiratory chain disorders
Heaton, R., Millichap, L., Saleem, F., Gannon, J., Begum, G., & Hargreaves, I. P. (2019). Current biochemical treatments of mitochondrial respiratory chain disorders. EXPERT OPINION ON ORPHAN DRUGS, 7(6), 277-285. doi:10.1080/21678707.2019.1638250
2017
Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders
Stepien, K. M., Heaton, R., Rankin, S., Murphy, A., Bentley, J., Sexton, D., & Hargreaves, I. P. (2017). Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders. JOURNAL OF CLINICAL MEDICINE, 6(7). doi:10.3390/jcm6070071