Research
Clinical Trials in Head & Neck Oncology / Surgery
Chief and Principal Investigator on a number of clinical trials:
SAVER
HOPON
DAHANCA21
PATHOS-T
TITAN
REALISTIC
PREVALENCE
Translational research in head & neck oncology
I have an interest in the underlying biology of, translational aspects of and developing biomarkers for:
Premalignant lesions of oral cavity
HPV associated HNSCC
Markers of treatments resistance and metastasis in HNSCC
Osteoradionecrosis
Research grants
Defining biomarkers of response to inhibition of the novel YAP/TAZ oncogenes in head and neck cancer: the role of MST2 as a predictive biomarker
THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST (UK)
March 2015 - August 2016
Pathos-T: A Bioresource Collection associated with PATHOS, a Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer
CANCER RESEARCH UK (UK)
November 2015 - December 2025
Novel epigenetic biomarkers in the diagnosis of minimal residual disease in head and neck cancer.
CANCER RESEARCH UK (UK)
September 2007 - April 2009
HOPON Phase III Randomised Controlled Trial of Hyperbaric Oxygen to prevent Osteoradionecrosis of the Irradiated Randomised Controlled Trial of Hyperbaric Oxygen to prevent Osteoradionecrosis of the Irradiated Mandible
CANCER RESEARCH UK (UK)
June 2010 - November 2018
Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A randomised clinical trial. (DAHANCA-21)
CANCER RESEARCH UK (UK)
July 2012 - June 2016
pump priming award
ROYAL COLLEGE OF SURGEONS OF ENGLAND(UK)
October 2008 - September 2009
Molecular and clinical determinants of malignant progression in oral dysplasia
BRITISH ASSOCIATION OF ORAL MAXILLOFACIAL SURGEONS (UK)
September 2013 - August 2014
The role of promoter methylation in the malignant transformation of salivary pleomorphic adenoma
THE BRITISH ASSOCIATION OF HEAD AND NECK ONCOLOGISTS (BAHNO) (UK)
May 2007 - October 2008
REALISTIC: A Phase I, dose escalation of trial of recombinant listeria moncytogenes (Lm) based vaccine encloding human papilloma virus serotype 16 target antigens (ADXS11-001) in patients with HPV-16+ oropharyngeal SCC.
CANCER RESEARCH UK (UK)
October 2010 - September 2014
Clinical application of epigenetic biomarkers in HNSCC
BRITISH ASSOCIATION OF ORAL MAXILLOFACIAL SURGEONS (UK)
December 2008 - November 2010
North West Surgical Trials Centre
CANCER RESEARCH UK (UK), ROYAL COLLEGE OF SURGEONS OF ENGLAND(UK)
January 2013 - August 2023
TITAN: Trial of induction TPF therapy in advance head and neck cancer
CANCER RESEARCH UK (UK)
October 2010 - September 2013
Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible (HOPON)
CANCER RESEARCH UK (UK)
May 2008 - April 2011
Personalising head and neck cancer survivorship: Evaluating the head and neck patient concerns inventory and the role of genetic polymorphyisms in radiotoxicity and health-related quality of life
BRITISH ASSOCIATION OF ORAL MAXILLOFACIAL SURGEONS (UK)
February 2013 - June 2013
Laboratory to support heart, neck and liver research
THE JOHNSON FOUNDATION (UK)
August 2013 - November 2017
Molecular and clinical determinants of malignant progression in oral dysplasia
ROYAL COLLEGE OF SURGEONS OF ENGLAND(UK)
August 2012 - August 2013
Detection of oral squamous cell carcinoma using epigenetic markers in saliva-derived DNA
BRITISH ASSOCIATION OF ORAL MAXILLOFACIAL SURGEONS (UK)
April 2010 - March 2012
Clinical application of epigenetic biomarkers
ROYAL COLLEGE OF SURGEONS OF ENGLAND(UK)
September 2008 - August 2009
Workshop on the design and analysis of clinical trials in Head and Neck Cancer
MEDICAL RESEARCH COUNCIL
June 2013 - April 2014
Bench fees to support PhD student Khaled Ben Salah
MINISTRY OF HIGHER EDUCATION (LIBYA) 🚩
October 2014 - September 2017
Molecular and clinical determinants of malignant progression in oral dysplasia
ROYAL COLLEGE OF SURGEONS OF ENGLAND(UK)
May 2014 - April 2015
Research collaborations
Dr Max Robinson
University of Newcastle upon Tyne
Collaboration on DNA/RNA versus FFPE cISH testing for HPV-16 in HNSCC
Professor Donna Albertsson
University of San Francisco
Collaborating on array CGH data in metastasis models for Oral SCC
Professor Catharine West
University of Manchester, UK
SniP determinants of radiation toxicity after HNSCC
Dr Janet Risk
H&N SCC epigenetics Role of cytoglobin in sporadic SCC as TSG Premalignant /Malignant transformation
Ross Sibson
Genomics of HNSCC
Dr Lakis Liloglou
Epigenetic biomarkers