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Reinhold J. Medina

Professor Reinhold J. Medina
MD, PhD, FHEA

Publications

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2024

A new gene signature for endothelial senescence identifies self‐<scp>RNA</scp> sensing by retinoic acid‐inducible gene I as a molecular facilitator of vascular aging

Guduric-Fuchs, J., Pedrini, E., Bertelli, P. M., McDonnell, S., Pathak, V., McLoughlin, K., . . . Medina, R. J. (2024). A new gene signature for endothelial senescence identifies self-RNA sensing by retinoic acid-inducible gene I as a molecular facilitator of vascular aging.. Aging cell, 23(9), e14240. doi:10.1111/acel.14240

DOI
10.1111/acel.14240
Journal article

Retinal vascular regeneration

Pathak, V., Bertelli, P. M., Guduric-Fuchs, J., Eyre, J., Reid, E., Lois, N., . . . Medina, R. J. (2024). Retinal vascular regeneration. In Retinal and Choroidal Vascular Diseases of the Eye (pp. 581-588). Elsevier. doi:10.1016/b978-0-443-15583-3.00044-5

DOI
10.1016/b978-0-443-15583-3.00044-5
Chapter

2023

Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer

Feng, J., Pathak, V., Byrne, N. M., Wang, T., Yin, C., Medina, R. J., & Coulter, J. A. (2023). Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer. Cancer Nanotechnology, 14(1). doi:10.1186/s12645-023-00185-8

DOI
10.1186/s12645-023-00185-8
Journal article

Ocular application of electrospun materials for drug delivery and cellular therapies.

Mishra, D., Gade, S., Pathak, V., Vora, L. K., Mcloughlin, K., Medina, R., . . . Raghu Raj Singh, T. (2023). Ocular application of electrospun materials for drug delivery and cellular therapies.. Drug discovery today, 28(9), 103676. doi:10.1016/j.drudis.2023.103676

DOI
10.1016/j.drudis.2023.103676
Journal article

2022

Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina.

Kurzawa-Akanbi, M., Whitfield, P., Burté, F., Bertelli, P. M., Pathak, V., Doherty, M., . . . Lako, M. (2022). Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina.. Journal of extracellular vesicles, 11(12), e12295. doi:10.1002/jev2.12295

DOI
10.1002/jev2.12295
Journal article

2021

miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia.

Guduric-Fuchs, J., Pedrini, E., Lechner, J., Chambers, S. E. J., O'Neill, C. L., Mendes Lopes de Melo, J., . . . Medina, R. J. (2021). miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia.. Molecular therapy. Nucleic acids, 23, 968-981. doi:10.1016/j.omtn.2021.01.015

DOI
10.1016/j.omtn.2021.01.015
Journal article

2020

Vascular Regeneration for Ischemic Retinopathies: Hope from Cell Therapies.

Bertelli, P. M., Pedrini, E., Guduric-Fuchs, J., Peixoto, E., Pathak, V., Stitt, A. W., & Medina, R. J. (2020). Vascular Regeneration for Ischemic Retinopathies: Hope from Cell Therapies.. Current eye research, 45(3), 372-384. doi:10.1080/02713683.2019.1681004

DOI
10.1080/02713683.2019.1681004
Journal article

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes post-ischaemic revascularization.

O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., . . . Grieve, D. J. (2020). NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes post-ischaemic revascularization.. Cardiovascular research, 116(2), 393-405. doi:10.1093/cvr/cvz090

DOI
10.1093/cvr/cvz090
Journal article

2019

The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic.

O'Leary, O. E., Canning, P., Reid, E., Bertelli, P. M., McKeown, S., Brines, M., . . . Stitt, A. W. (2019). The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic.. Experimental eye research, 182, 144-155. doi:10.1016/j.exer.2019.03.001

DOI
10.1016/j.exer.2019.03.001
Journal article

2018

Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood-Derived Endothelial Colony-Forming Cells for Ischemic Retinopathies.

Reid, E., Guduric-Fuchs, J., O'Neill, C. L., Allen, L. -D., Chambers, S. E. J., Stitt, A. W., & Medina, R. J. (2018). Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood-Derived Endothelial Colony-Forming Cells for Ischemic Retinopathies.. Stem cells translational medicine, 7(1), 59-67. doi:10.1002/sctm.17-0187

DOI
10.1002/sctm.17-0187
Journal article

2017

MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy.

Dellett, M., Brown, E. D., Guduric-Fuchs, J., O'Connor, A., Stitt, A. W., Medina, R. J., & Simpson, D. A. (2017). MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy.. Journal of cellular and molecular medicine, 21(12), 3405-3419. doi:10.1111/jcmm.13251

DOI
10.1111/jcmm.13251
Journal article

2016

The progress in understanding and treatment of diabetic retinopathy.

Stitt, A. W., Curtis, T. M., Chen, M., Medina, R. J., McKay, G. J., Jenkins, A., . . . Lois, N. (2016). The progress in understanding and treatment of diabetic retinopathy.. Progress in retinal and eye research, 51, 156-186. doi:10.1016/j.preteyeres.2015.08.001

DOI
10.1016/j.preteyeres.2015.08.001
Journal article

2015

2014

2013

The role of immune-related myeloid cells in angiogenesis.

Chambers, S. E. J., O'Neill, C. L., O'Doherty, T. M., Medina, R. J., & Stitt, A. W. (2013). The role of immune-related myeloid cells in angiogenesis.. Immunobiology, 218(11), 1370-1375. doi:10.1016/j.imbio.2013.06.010

DOI
10.1016/j.imbio.2013.06.010
Journal article

Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.

Medina, R. J., O'Neill, C. L., O'Doherty, T. M., Chambers, S. E. J., Guduric-Fuchs, J., Neisen, J., . . . Stitt, A. W. (2013). Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.. Stem cells (Dayton, Ohio), 31(8), 1657-1668. doi:10.1002/stem.1414

DOI
10.1002/stem.1414
Journal article

Advances in our understanding of diabetic retinopathy.

Stitt, A. W., Lois, N., Medina, R. J., Adamson, P., & Curtis, T. M. (2013). Advances in our understanding of diabetic retinopathy.. Clinical science (London, England : 1979), 125(1), 1-17. doi:10.1042/cs20120588

DOI
10.1042/cs20120588
Journal article

Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis

Stitt, A. W., & Medina, R. J. (2013). Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis. In Biochemical Basis and Therapeutic Implications of Angiogenesis (pp. 445-458). Springer New York. doi:10.1007/978-1-4614-5857-9_23

DOI
10.1007/978-1-4614-5857-9_23
Chapter

2012

A Review of Patents Relating to Therapeutic Angiogenesis Using Endothelial Progenitors and Other Vasculogenesis-Related Cell Types

J. Medina, R., L. O’Neill, C., M. O’Doherty, T., E.J. Wilson, S., & W. Stitt., A. (2012). A Review of Patents Relating to Therapeutic Angiogenesis Using Endothelial Progenitors and Other Vasculogenesis-Related Cell Types. Recent Patents on Regenerative Medicinee, 3(1), 63-73. doi:10.2174/2210296511303010063

DOI
10.2174/2210296511303010063
Journal article

Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells.

Liu, Y., Teoh, S. -H., Chong, M. S. K., Lee, E. S. M., Mattar, C. N. Z., Randhawa, N. K., . . . Chan, J. K. Y. (2012). Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells.. Stem cells (Dayton, Ohio), 30(9), 1911-1924. doi:10.1002/stem.1164

DOI
10.1002/stem.1164
Journal article

Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.

Guduric-Fuchs, J., O'Connor, A., Cullen, A., Harwood, L., Medina, R. J., O'Neill, C. L., . . . Simpson, D. A. (2012). Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.. Journal of cellular biochemistry, 113(6), 2098-2111. doi:10.1002/jcb.24084

DOI
10.1002/jcb.24084
Journal article

Endothelial progenitor therapy: Innately beneficial, innately complicated

Neu, M., Bhatwadekar, A., Medina, R., Stitt, A., & Grant, M. (2012). Endothelial progenitor therapy: Innately beneficial, innately complicated. In Therapy for Ocular Angiogenesis: Principles and Practice.

Chapter

2011

Vascular stem cells and ischaemic retinopathies.

Stitt, A. W., O'Neill, C. L., O'Doherty, M. T., Archer, D. B., Gardiner, T. A., & Medina, R. J. (2011). Vascular stem cells and ischaemic retinopathies.. Progress in retinal and eye research, 30(3), 149-166. doi:10.1016/j.preteyeres.2011.02.001

DOI
10.1016/j.preteyeres.2011.02.001
Journal article

2010

Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy.

Medina, R. J., O'Neill, C. L., Humphreys, M. W., Gardiner, T. A., & Stitt, A. W. (2010). Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy.. Investigative ophthalmology & visual science, 51(11), 5906-5913. doi:10.1167/iovs.09-4951

DOI
10.1167/iovs.09-4951
Journal article

Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.

Yamamoto, K. -I., Sakaguchi, M., Medina, R. J., Niida, A., Sakaguchi, Y., Miyazaki, M., . . . Huh, N. -H. (2010). Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.. Biochemical and biophysical research communications, 400(1), 175-180. doi:10.1016/j.bbrc.2010.08.039

DOI
10.1016/j.bbrc.2010.08.039
Journal article

2009

A novel three-dimensional culture system for isolation and clonal propagation of neural stem cells using a thermo-reversible gelation polymer.

Yang, X. -Z., Kataoka, K., Medina, R., Yamamoto, K. -I., Than, S. S., Miyazaki, M., & Huh, N. -H. (2009). A novel three-dimensional culture system for isolation and clonal propagation of neural stem cells using a thermo-reversible gelation polymer.. Tissue engineering. Part C, Methods, 15(4), 615-623. doi:10.1089/ten.tec.2008.0516

DOI
10.1089/ten.tec.2008.0516
Journal article

2008

2007

Isolation of a bone marrow-derived stem cell line with high proliferation potential and its application for preventing acute fatal liver failure.

Miyazaki, M., Hardjo, M., Masaka, T., Tomiyama, K., Mahmut, N., Medina, R. J., . . . Huh, N. -H. (2007). Isolation of a bone marrow-derived stem cell line with high proliferation potential and its application for preventing acute fatal liver failure.. Stem cells (Dayton, Ohio), 25(11), 2855-2863. doi:10.1634/stemcells.2007-0078

DOI
10.1634/stemcells.2007-0078
Journal article

2006

Isolation of epithelial stem cells from dermis by a three-dimensional culture system.

Medina, R. J., Kataoka, K., Takaishi, M., Miyazaki, M., & Huh, N. -H. (2006). Isolation of epithelial stem cells from dermis by a three-dimensional culture system.. Journal of cellular biochemistry, 98(1), 174-184. doi:10.1002/jcb.20757

DOI
10.1002/jcb.20757
Journal article

Efficient differentiation into skin cells of bone marrow cells recovered in a pellet after density gradient fractionation.

Medina, R. J., Kataoka, K., Miyazaki, M., & Huh, N. -H. (2006). Efficient differentiation into skin cells of bone marrow cells recovered in a pellet after density gradient fractionation.. International journal of molecular medicine, 17(5), 721-727.

Journal article

2003

Participation of adult mouse bone marrow cells in reconstitution of skin.

Kataoka, K., Medina, R. J., Kageyama, T., Miyazaki, M., Yoshino, T., Makino, T., & Huh, N. -H. (2003). Participation of adult mouse bone marrow cells in reconstitution of skin.. The American journal of pathology, 163(4), 1227-1231. doi:10.1016/s0002-9440(10)63482-7

DOI
10.1016/s0002-9440(10)63482-7
Journal article

Differentiation of bone marrow cells in culture and in vivo

Miyazaki, M., Kataoka, K., Medina, R. J., Kageyama, T., & Huh, N. -H. (2003). Differentiation of bone marrow cells in culture and in vivo. International Congress Series, 1252, 461-464. doi:10.1016/s0531-5131(03)00005-0

DOI
10.1016/s0531-5131(03)00005-0
Journal article