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Dr Rebecca-Ann Burton
BSc MSc MBA DPhil FHEA FRSA

Contact

R.A.B.Burton@liverpool.ac.uk

+44 (0)151 794 9812

Publications

Selected publications

  1. Compartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation (Journal article - 2024)
  2. Lysosomal calcium loading promotes spontaneous calcium release by potentiating ryanodine receptors. (Journal article - 2023)
  3. Cross-talk between cAMP and Ca<sup>2+</sup> signalling in cardiac pacemaker cells involves IP<sub>3</sub>-evoked Ca<sup>2+</sup> release and stimulation of adenylyl cyclase 1 (Preprint - 2022)
  4. A modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue. (Journal article - 2021)
  5. IP<sub>3</sub>-mediated Ca<sup>2+</sup> release regulates atrial Ca<sup>2+</sup> transients and pacemaker function by stimulation of adenylyl cyclases. (Journal article - 2021)
  6. Optical Interrogation of Sympathetic Neuronal Effects on Macroscopic Cardiomyocyte Network Dynamics. (Journal article - 2020)
  7. Optical interrogation of sympathetic neuronal effects on macroscopic cardiac monolayer dynamics (Preprint - 2019)
  8. Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential. (Journal article - 2015)
  9. Optical control of excitation waves in cardiac tissue. (Journal article - 2015)
  10. Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP (Journal article - 2024)
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2024

Lysosomal calcium signalling contributes to the acute α-adrenergic response via calcium-stimulated adenylyl cyclase 1 and 8

DOI
10.1101/2024.11.25.625232
Preprint

2023

Compartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation

DOI
10.1101/2023.03.10.532119
Preprint

Cardiovascular concentration-effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies.

Chan, X. H. S., Chotsiri, P., Capel, R. A., Pike, J., Hanboonkunupakarn, B., Lee, S. J., . . . White, N. J. (2023). Cardiovascular concentration-effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies.. British journal of clinical pharmacology, 89(3), 1176-1186. doi:10.1111/bcp.15569

DOI
10.1111/bcp.15569
Journal article

2022

Lysosomal calcium loading promotes arrhythmias by potentiating ryanodine receptor release

DOI
10.1101/2022.11.09.515777
Preprint

Cross-talk between cAMP and Ca<sup>2+</sup> signalling in cardiac pacemaker cells involves IP<sub>3</sub>-evoked Ca<sup>2+</sup> release and stimulation of adenylyl cyclase 1

DOI
10.1101/2022.01.06.475211
Preprint

Chapter 3 Lysosomal proteases and their role in signaling pathways

Bose, S. J., Ayagama, T., & Burton, R. A. B. (2022). Chapter 3 Lysosomal proteases and their role in signaling pathways. In Proteolytic Signaling in Health and Disease (pp. 41-61). Elsevier. doi:10.1016/b978-0-323-85696-6.00007-x

DOI
10.1016/b978-0-323-85696-6.00007-x
Chapter

2021

Cardiac Atrial Compartmentalisation Proteomics: A Modified Density Gradient Method to Analyse Endo-lysosomal Proteins

DOI
10.1101/2021.02.22.432193
Preprint

IP<sub>3</sub>-mediated Ca<sup>2+</sup> release regulates atrial Ca<sup>2+</sup> transients and pacemaker function by stimulation of adenylyl cyclases.

Capel, R. A., Bose, S. J., Collins, T. P., Rajasundaram, S., Ayagama, T., Zaccolo, M., . . . Terrar, D. A. (2021). IP<sub>3</sub>-mediated Ca<sup>2+</sup> release regulates atrial Ca<sup>2+</sup> transients and pacemaker function by stimulation of adenylyl cyclases.. American journal of physiology. Heart and circulatory physiology, 320(1), H95-H107. doi:10.1152/ajpheart.00380.2020

DOI
10.1152/ajpheart.00380.2020
Journal article

Lysosomal proteases and their role in signaling pathways

Bose, S. J., Ayagama, T., & Burton, R. A. B. (2022). Lysosomal proteases and their role in signaling pathways. In Proteolytic Signaling in Health and Disease (pp. 41-61). Elsevier. doi:10.1016/b978-0-323-85696-6.00007-x

DOI
10.1016/b978-0-323-85696-6.00007-x
Chapter

2020

The Role of NAADP-Mediated Endo-Lysosomal Calcium Release in the Cardiac Atria

Capel, R. A., Mu-u-Min, R., Aston, D., Ruas, M., Christian, H., Galione, A., . . . Burton, R. A. B. (2020). The Role of NAADP-Mediated Endo-Lysosomal Calcium Release in the Cardiac Atria. Biophysical Journal, 118(3), 568a. doi:10.1016/j.bpj.2019.11.3093

DOI
10.1016/j.bpj.2019.11.3093
Journal article

2019

Optical interrogation of sympathetic neuronal effects on macroscopic cardiac monolayer dynamics

DOI
10.1101/717991
Preprint

cAMP signalling is required for the actions of IP<sub>3</sub>on Ca<sup>2+</sup>-transients in cardiac atria and beating rate in sino-atrial node

DOI
10.1101/694349
Preprint

Optical Interrogation of Sympathetic Neuronal Effects on Macroscopic Cardiomyocyte Network Dynamics

DOI
10.2139/ssrn.3461775
Preprint

2018

Cross Talk between IP3 and Adenylyl Cyclase Signaling Pathways in Cardiac Atrial Myocytes

Terrar, D. A., Capel, R. A., Collins, T. P., Rajasumdaram, S., Ayagamar, T., & AB Burton, R. (2018). Cross Talk between IP3 and Adenylyl Cyclase Signaling Pathways in Cardiac Atrial Myocytes. Biophysical Journal, 114(3), 466a. doi:10.1016/j.bpj.2017.11.2571

DOI
10.1016/j.bpj.2017.11.2571
Journal article

2017

2016

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Rodriguez, B., Carusi, A., Abi-Gerges, N., Ariga, R., Britton, O., Bub, G., . . . Zhou, X. (2016). Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop. EUROPACE, 18(9), 1287-1298. doi:10.1093/europace/euv320

DOI
10.1093/europace/euv320
Journal article

Mapping cardiac microstructure of rabbit heart in different mechanical states by high resolution diffusion tensor imaging: A proof-of-principle study.

Teh, I., Burton, R. A. B., McClymont, D., Capel, R. A., Aston, D., Kohl, P., & Schneider, J. E. (2016). Mapping cardiac microstructure of rabbit heart in different mechanical states by high resolution diffusion tensor imaging: A proof-of-principle study.. Progress in biophysics and molecular biology, 121(2), 85-96. doi:10.1016/j.pbiomolbio.2016.06.001

DOI
10.1016/j.pbiomolbio.2016.06.001
Journal article

2015

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.

Capel, R. A., Bolton, E. L., Lin, W. K., Aston, D., Wang, Y., Liu, W., . . . Terrar, D. A. (2015). Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.. The Journal of biological chemistry, 290(50), 30087-30098. doi:10.1074/jbc.m115.684076

DOI
10.1074/jbc.m115.684076
Journal article

Optical control of excitation waves in cardiac tissue.

Burton, R. A. B., Klimas, A., Ambrosi, C. M., Tomek, J., Corbett, A., Entcheva, E., & Bub, G. (2015). Optical control of excitation waves in cardiac tissue.. Nature photonics, 9(12), 813-816. doi:10.1038/nphoton.2015.196

DOI
10.1038/nphoton.2015.196
Journal article

Sympathetic stellate neurons increases cardiac conduction velocity and alters wave patterns in a myocyte-neuron co-culture model system

Burton, R. A. B., Tomek, J., Aslam, S., Bilton, S., Larsen, H. E., Sharkey, A., . . . Bub, G. (2015). Sympathetic stellate neurons increases cardiac conduction velocity and alters wave patterns in a myocyte-neuron co-culture model system. Autonomic Neuroscience, 192, 72-73. doi:10.1016/j.autneu.2015.07.062

DOI
10.1016/j.autneu.2015.07.062
Journal article

The sympathetic co-transmitter Neuropeptide Y is a novel pro-arrhythmic trigger even in the presence of maximal beta-blockade

Kalla, M., Bub, G., Burton, R., Larsen, H., Paterson, D. J., & Herring, N. (2015). The sympathetic co-transmitter Neuropeptide Y is a novel pro-arrhythmic trigger even in the presence of maximal beta-blockade. Autonomic Neuroscience, 192, 74. doi:10.1016/j.autneu.2015.07.067

DOI
10.1016/j.autneu.2015.07.067
Journal article

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.

Capel, R. A., Herring, N., Kalla, M., Yavari, A., Mirams, G. R., Douglas, G., . . . Burton, R. -A. B. (2015). Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.. Heart rhythm, 12(10), 2186-2194. doi:10.1016/j.hrthm.2015.05.027

DOI
10.1016/j.hrthm.2015.05.027
Journal article

Macro-micro imaging of cardiac-neural circuits in co-cultures from normal and diseased hearts.

Bub, G., & Burton, R. -A. B. (2015). Macro-micro imaging of cardiac-neural circuits in co-cultures from normal and diseased hearts.. The Journal of physiology, 593(14), 3047-3053. doi:10.1113/jphysiol.2014.285460

DOI
10.1113/jphysiol.2014.285460
Journal article

Uniquely identifying cell orientation and sarcomere length in the intact rodent heart with oblique plane remote focussing microscopy

Corbett, A. D., Burton, R. A. B., Bub, G., & Wilson, T. (2015). Uniquely identifying cell orientation and sarcomere length in the intact rodent heart with oblique plane remote focussing microscopy. In E. Beaurepaire, P. T. C. So, F. Pavone, & E. M. Hillman (Eds.), SPIE Proceedings Vol. 9536 (pp. 95360A). SPIE. doi:10.1117/12.2183843

DOI
10.1117/12.2183843
Conference Paper

Quantitative imaging of intact cardiac tissue using remote focusing microscopy

Corbett, A. D., Burton, R. A. B., Bub, G., & Wilson, T. (2015). Quantitative imaging of intact cardiac tissue using remote focusing microscopy. In T. G. Brown, C. J. Cogswell, & T. Wilson (Eds.), SPIE Proceedings Vol. 9330 (pp. 93300R). SPIE. doi:10.1117/12.2076133

DOI
10.1117/12.2076133
Conference Paper

Imaging cardiomyocytes in intact tissue with a remote focusing microscope

Corbett, A. D., Burton, R. A. B., Bub, G., & Wilson, T. (2015). Imaging cardiomyocytes in intact tissue with a remote focusing microscope. In A. Periasamy, P. T. C. So, & K. König (Eds.), SPIE Proceedings Vol. 9329 (pp. 932936). SPIE. doi:10.1117/12.2087342

DOI
10.1117/12.2087342
Conference Paper

Uniquely identifying cell orientation and sarcomere length in the intact rodent heart with oblique plane remote focussing microscopy

Corbett, A. D., Burton, R. A. B., Bub, G., & Wilson, T. (2015). Uniquely identifying cell orientation and sarcomere length in the intact rodent heart with oblique plane remote focussing microscopy. In Advanced Microscopy Techniques IV; and Neurophotonics II (pp. 95360A). OSA. doi:10.1364/ecbo.2015.95360a

DOI
10.1364/ecbo.2015.95360a
Conference Paper

2014

Three-dimensional histology: tools and application to quantitative assessment of cell-type distribution in rabbit heart.

Burton, R. A. B., Lee, P., Casero, R., Garny, A., Siedlecka, U., Schneider, J. E., . . . Grau, V. (2014). Three-dimensional histology: tools and application to quantitative assessment of cell-type distribution in rabbit heart.. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 16 Suppl 4, iv86-iv95. doi:10.1093/europace/euu234

DOI
10.1093/europace/euu234
Journal article

Label‐free proteomic analysis uncovers early molecular link to abnormal cardiac neurotransmission in pro‐hypertension rats (856.2)

Burton, R., Schmidt, C., Lu, C., Larsen, H., Gallone, G., Li, D., . . . Paterson, D. (2014). Label‐free proteomic analysis uncovers early molecular link to abnormal cardiac neurotransmission in pro‐hypertension rats (856.2). The FASEB Journal, 28(S1). doi:10.1096/fasebj.28.1_supplement.856.2

DOI
10.1096/fasebj.28.1_supplement.856.2
Journal article

Mechanism of reentry induction by a 9-V battery in rabbit ventricles.

Bishop, M. J., Burton, R. A. B., Kalla, M., Nanthakumar, K., Plank, G., Bub, G., & Vigmond, E. J. (2014). Mechanism of reentry induction by a 9-V battery in rabbit ventricles.. American journal of physiology. Heart and circulatory physiology, 306(7), H1041-H1053. doi:10.1152/ajpheart.00591.2013

DOI
10.1152/ajpheart.00591.2013
Journal article

Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures

Burton, R. A. B., Stephens, G., Sharkey, A., Bilton, S., Larsen, H., Kramer, H., . . . Bub, G. (2014). Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures. Biophysical Journal, 106(2), 630a. doi:10.1016/j.bpj.2013.11.3487

DOI
10.1016/j.bpj.2013.11.3487
Journal article

2013

Rearrangement of atrial bundle architecture and consequent changes in anisotropy of conduction constitute the 3-dimensional substrate for atrial fibrillation.

Maesen, B., Zeemering, S., Afonso, C., Eckstein, J., Burton, R. A. B., van Hunnik, A., . . . Schotten, U. (2013). Rearrangement of atrial bundle architecture and consequent changes in anisotropy of conduction constitute the 3-dimensional substrate for atrial fibrillation.. Circulation. Arrhythmia and electrophysiology, 6(5), 967-975. doi:10.1161/circep.113.000050

DOI
10.1161/circep.113.000050
Journal article

Fast measurement of sarcomere length and cell orientation in Langendorff-perfused hearts using remote focusing microscopy.

Botcherby, E. J., Corbett, A., Burton, R. A. B., Smith, C. W., Bollensdorff, C., Booth, M. J., . . . Bub, G. (2013). Fast measurement of sarcomere length and cell orientation in Langendorff-perfused hearts using remote focusing microscopy.. Circulation research, 113(7), 863-870. doi:10.1161/circresaha.113.301704

DOI
10.1161/circresaha.113.301704
Journal article

2012

Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart.

Burton, R. A. B., Schneider, J. E., Bishop, M. J., Hales, P. W., Bollensdorff, C., Robson, M. D., . . . Kohl, P. (2012). Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart.. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 14 Suppl 5, v73-v81. doi:10.1093/europace/eus276

DOI
10.1093/europace/eus276
Journal article

Resolving the Three-Dimensional Histology of the Heart

Gibb, M., Burton, R. A. B., Bollensdorff, C., Afonso, C., Mansoori, T., Schotten, U., . . . Grau, V. (2012). Resolving the Three-Dimensional Histology of the Heart. In Unknown Conference (pp. 2-16). Springer Berlin Heidelberg. doi:10.1007/978-3-642-33636-2_2

DOI
10.1007/978-3-642-33636-2_2
Conference Paper

Histo-anatomical structure of the living isolated rat heart in two contraction states assessed by diffusion tensor MRI.

Hales, P. W., Schneider, J. E., Burton, R. A. B., Wright, B. J., Bollensdorff, C., & Kohl, P. (2012). Histo-anatomical structure of the living isolated rat heart in two contraction states assessed by diffusion tensor MRI.. Progress in biophysics and molecular biology, 110(2-3), 319-330. doi:10.1016/j.pbiomolbio.2012.07.014

DOI
10.1016/j.pbiomolbio.2012.07.014
Journal article

2011

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

Quinn, T. A., Granite, S., Allessie, M. A., Antzelevitch, C., Antzelevitch, C., Bollensdorff, C., . . . Kohl, P. (2011). Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.. Progress in biophysics and molecular biology, 107(1), 4-10. doi:10.1016/j.pbiomolbio.2011.07.001

DOI
10.1016/j.pbiomolbio.2011.07.001
Journal article

Progressive changes in T₁, T₂ and left-ventricular histo-architecture in the fixed and embedded rat heart.

Hales, P. W., Burton, R. A. B., Bollensdorff, C., Mason, F., Bishop, M., Gavaghan, D., . . . Schneider, J. E. (2011). Progressive changes in T₁, T₂ and left-ventricular histo-architecture in the fixed and embedded rat heart.. NMR in biomedicine, 24(7), 836-843. doi:10.1002/nbm.1629

DOI
10.1002/nbm.1629
Journal article

Rediscovering the third coronary artery.

Burton, R. A. B., Quinn, T. A., & Kohl, P. (2011). Rediscovering the third coronary artery.. European heart journal, 32(12), 1435-1437.

Journal article

The new European Society of Cardiology declaration of interest procedure: a step towards improved transparency in relations between professionals and industry partners.

Jaques, H. (2011). The new European Society of Cardiology declaration of interest procedure: a step towards improved transparency in relations between professionals and industry partners.. European heart journal, 32(12), 1433-1434. doi:10.1093/eurheartj/ehr159

DOI
10.1093/eurheartj/ehr159
Journal article

2010

Cardiac valve annulus manual segmentation using computer assisted visual feedback in three-dimensional image data.

Casero, R., Burton, R. A. B., Quinn, T., Bollensdorff, C., Hales, P., Schneider, J. E., . . . Grau, V. (2010). Cardiac valve annulus manual segmentation using computer assisted visual feedback in three-dimensional image data.. In Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Vol. 2010 (pp. 738-741). doi:10.1109/iembs.2010.5626303

DOI
10.1109/iembs.2010.5626303
Conference Paper

Integrated approach for the study of anatomical variability in the cardiac Purkinje system: from high resolution MRI to electrophysiology simulation.

Bordas, R., Grau, V., Burton, R. B., Hales, P., Schneider, J. E., Gavaghan, D., . . . Rodriguez, B. (2010). Integrated approach for the study of anatomical variability in the cardiac Purkinje system: from high resolution MRI to electrophysiology simulation.. In Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Vol. 2010 (pp. 6793-6796). doi:10.1109/iembs.2010.5625979

DOI
10.1109/iembs.2010.5625979
Conference Paper

Towards High-Resolution Cardiac Atlases: Ventricular Anatomy Descriptors for a Standardized Reference Frame

Casero, R., Burton, R. A. B., Quinn, T. A., Bollensdorff, C., Hales, P., Schneider, J. E., . . . Grau, V. (2010). Towards High-Resolution Cardiac Atlases: Ventricular Anatomy Descriptors for a Standardized Reference Frame. In Unknown Conference (pp. 75-84). Springer Berlin Heidelberg. doi:10.1007/978-3-642-15835-3_8

DOI
10.1007/978-3-642-15835-3_8
Conference Paper

Measurement and analysis of sarcomere length in rat cardiomyocytes in situ and in vitro.

Bub, G., Camelliti, P., Bollensdorff, C., Stuckey, D. J., Picton, G., Burton, R. A. B., . . . Kohl, P. (2010). Measurement and analysis of sarcomere length in rat cardiomyocytes in situ and in vitro.. American journal of physiology. Heart and circulatory physiology, 298(5), H1616-H1625. doi:10.1152/ajpheart.00481.2009

DOI
10.1152/ajpheart.00481.2009
Journal article

Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function.

Bishop, M. J., Plank, G., Burton, R. A. B., Schneider, J. E., Gavaghan, D. J., Grau, V., & Kohl, P. (2010). Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function.. American journal of physiology. Heart and circulatory physiology, 298(2), H699-H718. doi:10.1152/ajpheart.00606.2009

DOI
10.1152/ajpheart.00606.2009
Journal article

2009

The Role of Blood Vessels in Rabbit Propagation Dynamics and Cardiac Arrhythmias

Gibb, M., Bishop, M., Burton, R., Kohl, P., Grau, V., Plank, G., & Rodriguez, B. (2009). The Role of Blood Vessels in Rabbit Propagation Dynamics and Cardiac Arrhythmias. In Unknown Conference (pp. 268-276). Springer Berlin Heidelberg. doi:10.1007/978-3-642-01932-6_29

DOI
10.1007/978-3-642-01932-6_29
Conference Paper

2007

AN ITERATIVE METHOD FOR REGISTRATION OF HIGH-RESOLUTION CARDIAC HISTOANATOMICAL AND MRI IMAGES

Mansoori, T., Plank, G., Burton, R., Schneider, J., Kohl, P., Gavaghan, D., & Grau, V. (2007). AN ITERATIVE METHOD FOR REGISTRATION OF HIGH-RESOLUTION CARDIAC HISTOANATOMICAL AND MRI IMAGES. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro (pp. 572-575). IEEE. doi:10.1109/isbi.2007.356916

DOI
10.1109/isbi.2007.356916
Conference Paper

2006

P1-13

Plank, G., Prassl, A. J., Vigmond, E. J., Burton, R. A. B., Schneider, J. E., Trayanova, N. A., & Kohl, P. (2006). P1-13. Heart Rhythm, 3(5), S111-S112. doi:10.1016/j.hrthm.2006.02.336

DOI
10.1016/j.hrthm.2006.02.336
Journal article

P5-22

Burton, R. A. B., Schneider, J. E., Plank, G., Sheldon, J. M., & Kohl, P. (2006). P5-22. Heart Rhythm, 3(5), S267. doi:10.1016/j.hrthm.2006.02.800

DOI
10.1016/j.hrthm.2006.02.800
Journal article

Three-dimensional models of individual cardiac histoanatomy: tools and challenges.

Burton, R. A. B., Plank, G., Schneider, J. E., Grau, V., Ahammer, H., Keeling, S. L., . . . Kohl, P. (2006). Three-dimensional models of individual cardiac histoanatomy: tools and challenges.. In Annals of the New York Academy of Sciences Vol. 1080 (pp. 301-319). doi:10.1196/annals.1380.023

DOI
10.1196/annals.1380.023
Conference Paper