Publications
2024
Extracellular vesicles from human cardiac stromal cells up-regulate cardiomyocyte protective responses to hypoxia
Czosseck, A., Chen, M. M., Hsu, C. -C., Shamrin, G., Meeson, A., Oldershaw, R., . . . Lundy, D. J. (n.d.). Extracellular vesicles from human cardiac stromal cells up-regulate cardiomyocyte protective responses to hypoxia. Stem Cell Research & Therapy, 15(1). doi:10.1186/s13287-024-03983-y
Differentiation, Metabolism, and Cardioprotective Secretory Functions of Human Cardiac Stromal Cells from Ischemic and Endocarditis Patients.
Nguyen, H., Hsu, C. -C., Meeson, A., Oldershaw, R., Richardson, G., Czosseck, A., & Lundy, D. J. (2024). Differentiation, Metabolism, and Cardioprotective Secretory Functions of Human Cardiac Stromal Cells from Ischemic and Endocarditis Patients.. Stem cells and development, 33(17-18), 484-495. doi:10.1089/scd.2024.0103
Inline dynamometry provides reliable measurements of quadriceps strength in healthy and ACL-reconstructed individuals and is a valid substitute for isometric electromechanical dynamometry following ACL reconstruction.
Norris, R., Morrison, S., Price, A., Pulford, S., Meira, E., O'Neill, S., . . . Oldershaw, R. A. (2024). Inline dynamometry provides reliable measurements of quadriceps strength in healthy and ACL-reconstructed individuals and is a valid substitute for isometric electromechanical dynamometry following ACL reconstruction.. The Knee, 46, 136-147. doi:10.1016/j.knee.2023.12.006
2023
Mesenchymal Stem Cells in the Pathogenesis and Therapy of Autoimmune and Autoinflammatory Diseases.
Zaripova, L. N., Midgley, A., Christmas, S. E., Beresford, M. W., Pain, C., Baildam, E. M., & Oldershaw, R. A. (2023). Mesenchymal Stem Cells in the Pathogenesis and Therapy of Autoimmune and Autoinflammatory Diseases.. International journal of molecular sciences, 24(22), 16040. doi:10.3390/ijms242216040
Abstract P3162: Evaluating Cargo And Cardioprotective Effects Of Extracellular Vesicles From Human Right Atrial Appendage Mesenchymal Cells
Czosseck, A., Chen, M. M., Hsu, C. -C., Meeson, A., Oldershaw, R., & Lundy, D. (2023). Abstract P3162: Evaluating Cargo And Cardioprotective Effects Of Extracellular Vesicles From Human Right Atrial Appendage Mesenchymal Cells. Circulation Research, 133(Suppl_1). doi:10.1161/res.133.suppl_1.p3162
Application of a novel 3D porous Poly-epsilon-lysine hydrogel, Trabeculate™, to create a biomimetic structure of the trabecular meshwork of the eye
Kingston, O. A., Meeson, A., Wellings, D., Oldershaw, R., & Sheridan, C. (2023). Application of a novel 3D porous Poly-epsilon-lysine hydrogel, Trabeculate™, to create a biomimetic structure of the trabecular meshwork of the eye. In TISSUE ENGINEERING PART A Vol. 29. Retrieved from https://www.webofscience.com/
Glaucomatous trabecular meshwork cell-derived extracellular matrix influences differentiation of healthy adult trabecular meshwork stem cells
Kingston, O., Bilir, E. K., Fan, X. C., Oldershaw, R., Meeson, A., Wellings, D., & Sheridan, C. (2023). Glaucomatous trabecular meshwork cell-derived extracellular matrix influences differentiation of healthy adult trabecular meshwork stem cells. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A19-A20). Retrieved from https://www.webofscience.com/
2022
Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations
Al-Maslamani, N. A., Oldershaw, R., Tew, S., Curran, J., D'Hooghe, P., Yamamoto, K., & Horn, H. F. (2022). Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations. CELLS, 11(24). doi:10.3390/cells11244011
Cardiac Mesenchymal Stem Cell-Like Cells Derived from a Young Patient with Bicuspid Aortic Valve Disease Have a Prematurely Aged Phenotype.
Oldershaw, R., Richardson, G., Carling, P., Owens, W. A., Lundy, D., & Meeson, A. (2022). Cardiac Mesenchymal Stem Cell-Like Cells Derived from a Young Patient with Bicuspid Aortic Valve Disease Have a Prematurely Aged Phenotype.. Biomedicines.
The diagnostic accuracy of clinical tests for anterior cruciate ligament tears are comparable but the Lachman test has been previously overestimated: a systematic review and meta-analysis
Sokal, P. A., Norris, R., Maddox, T. W., & Oldershaw, R. A. (n.d.). The diagnostic accuracy of clinical tests for anterior cruciate ligament tears are comparable but the Lachman test has been previously overestimated: a systematic review and meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy. doi:10.1007/s00167-022-06898-4
<SUP>1</SUP>H NMR Metabolite Monitoring during the Differentiation of Human Induced Pluripotent Stem Cells Provides New Insights into the Molecular Events That Regulate Embryonic Chondrogenesis
Coope, A., Ghanameh, Z., Kingston, O., Sheridan, C. M., Barrett-Jolley, R., Phelan, M. M., & Oldershaw, R. A. (2022). <SUP>1</SUP>H NMR Metabolite Monitoring during the Differentiation of Human Induced Pluripotent Stem Cells Provides New Insights into the Molecular Events That Regulate Embryonic Chondrogenesis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(16). doi:10.3390/ijms23169266
DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS INTO THE FUNCTIONING TRABECULAR MESHWORK CELLS
Bilir, E. K., Fan, X., Oldershaw, R., & Sheridan, C. (2022). DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS INTO THE FUNCTIONING TRABECULAR MESHWORK CELLS. In TISSUE ENGINEERING PART A Vol. 28 (pp. S512-S513). Retrieved from https://www.webofscience.com/
EXTRACELLULAR MATRIX CHANGES IN GLAUCOMATOUS TRABECULAR MESHWORK EFFECT THE RATE OF ADULT STEM CELL DIFFERENTIATION
Kingston, O., Sheridan, C., Oldershaw, R., Meeson, A., & Wellings, D. (2022). EXTRACELLULAR MATRIX CHANGES IN GLAUCOMATOUS TRABECULAR MESHWORK EFFECT THE RATE OF ADULT STEM CELL DIFFERENTIATION. In TISSUE ENGINEERING PART A Vol. 28 (pp. S525-S526). Retrieved from https://www.webofscience.com/
2021
Replacement of the Trabecular Meshwork Cells-A Way Ahead in IOP Control?
Fan, X., Bilir, E. K., Kingston, O. A., Oldershaw, R. A., Kearns, V. R., Willoughby, C. E., & Sheridan, C. M. (2021). Replacement of the Trabecular Meshwork Cells-A Way Ahead in IOP Control?. BIOMOLECULES, 11(9). doi:10.3390/biom11091371
Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches
Zaripova, L. N., Midgley, A., Christmas, S. E., Beresford, M. W., Baildam, E. M., & Oldershaw, R. A. (2021). Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches. PEDIATRIC RHEUMATOLOGY, 19(1). doi:10.1186/s12969-021-00629-8
2020
NOVEL UNDERSTANDING OF THE PATHOGENESIS OF JUVENILE IDIOPATHIC ARTHRITIS: FOCUS ON MESENCHYMAL STEM CELLS IMPAIRMENT, SENESCENCE AND IMMUNOREGULATORY FUNCTION
Zaripova, L., Midgley, A., Christmas, S., Baildam, E., & Oldershaw, R. (2020). NOVEL UNDERSTANDING OF THE PATHOGENESIS OF JUVENILE IDIOPATHIC ARTHRITIS: FOCUS ON MESENCHYMAL STEM CELLS IMPAIRMENT, SENESCENCE AND IMMUNOREGULATORY FUNCTION. In ANNALS OF THE RHEUMATIC DISEASES Vol. 79 (pp. 479-480). doi:10.1136/annrheumdis-2020-eular.3845
2019
Human cardiac mesenchymal stem cell like cells, a novel cell population with therapeutic potential.
Oldershaw, R., Owens, W. A., Sutherland, R., Linney, M., Liddle, R., Magana, L., . . . Meeson, A. (2019). Human cardiac mesenchymal stem cell like cells, a novel cell population with therapeutic potential.. Stem cells and development, 28(9), 593-607. doi:10.1089/scd.2018.0170
2018
Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm
Stevens, A., Smith, H., Garner, T., Minogue, B., Sneddon, S., Shaw, L., . . . Kimber, S. J. (2018). Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm. doi:10.1101/411439
Isolation of a multipotent mesenchymal stem cell-like population from human adrenal cortex
Gan, E., Robson, W., Murphy, P., Pickard, R., Pearce, S., & Oldershaw, R. (2018). Isolation of a multipotent mesenchymal stem cell-like population from human adrenal cortex. Endocrine Connections, 7(5), 617-629. doi:10.1530/EC-18-0067
CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS'
Barrow, M., Tew, S., Comerford, E., McNicholas, M., & Oldershaw, R. (2018). CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS'. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S405-S406). doi:10.1016/j.joca.2018.02.786
MESENCHYMAL STEM CELLS IN CHRONIC JOINT INFLAMMATION
Zaripova, L., Midgley, A., Christmas, S., Baildam, E., & Oldershaw, R. (2018). MESENCHYMAL STEM CELLS IN CHRONIC JOINT INFLAMMATION. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S130-S131). doi:10.1016/j.joca.2018.02.283
2016
Human limbal mesenchymal stem cells express ABCB5 and can grow on amniotic membrane
Shaharuddin, B., Osei-Bempong, C., Ahmad, S., Rooney, P., Ali, S., Oldershaw, R., & Meeson, A. (2016). Human limbal mesenchymal stem cells express ABCB5 and can grow on amniotic membrane. REGENERATIVE MEDICINE, 11(03), 273-286. doi:10.2217/rme-2016-0009
2015
Cartilage Regeneration: How Do We Meet the Increasing Demands of an Ageing Population?
J McNicholas, M., & Oldershaw, R. A. (n.d.). Cartilage Regeneration: How Do We Meet the Increasing Demands of an Ageing Population?. SM Journal of Orthopedics, 1(2), 1-3. doi:10.36876/smjo.1010
2014
Investigating the biological response of human mesenchymal stem cells to titanium surfaces.
German, M. J., Osei-Bempong, C., Knuth, C. A., Deehan, D. J., & Oldershaw, R. A. (2014). Investigating the biological response of human mesenchymal stem cells to titanium surfaces.. Journal of orthopaedic surgery and research, 9. doi:10.1186/s13018-014-0135-y
Biocompatibility and enhanced osteogenic differentiation of human mesenchymal stem cells in response to surface engineered poly(d,l‐lactic‐co‐glycolic acid) microparticles
Rogers, C. M., Deehan, D. J., Knuth, C. A., Rose, F. R. A. J., Shakesheff, K. M., & Oldershaw, R. A. (2014). Biocompatibility and enhanced osteogenic differentiation of human mesenchymal stem cells in response to surface engineered poly(d,l‐lactic‐co‐glycolic acid) microparticles. Journal of biomedical materials research. Part A, 102(11), 3872-3882. doi:10.1002/jbm.a.35063
ARE UMBILICAL CORD MESENCHYMAL STEM CELLS ADVANTAGEOUS OVER BONE MARROW MESENCHYMAL STEM CELLS FOR CELL THERAPY IN ORTHOPAEDICS?
Mennan, C., Owen, S., Mayrogonatou, E., Kletsas, D., Oldershaw, R., Richardson, J., & Roberts, S. (2014). ARE UMBILICAL CORD MESENCHYMAL STEM CELLS ADVANTAGEOUS OVER BONE MARROW MESENCHYMAL STEM CELLS FOR CELL THERAPY IN ORTHOPAEDICS?. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S486-S487). doi:10.1016/j.joca.2014.02.924
Characterisation of adrenocortical progenitor cells: isolation of mesenchymal stem cell-like cell populations from human adrenal cortex
Gan, E., Robson, W., Lennard, T., Pearce, S., & Oldershaw, R. (n.d.). Characterisation of adrenocortical progenitor cells: isolation of mesenchymal stem cell-like cell populations from human adrenal cortex. Endocrine Abstracts. doi:10.1530/endoabs.34.oc1.2
2013
Low oxygen tension is critical for the culture of human mesenchymal stem cells with strong osteogenic potential from haemarthrosis fluid.
Knuth, C. A., Clark, M. E., Meeson, A. P., Khan, S. K., Dowen, D. J., Deehan, D. J., & Oldershaw, R. A. (2013). Low oxygen tension is critical for the culture of human mesenchymal stem cells with strong osteogenic potential from haemarthrosis fluid.. Stem cell reviews and reports, 9(5), 599-608. doi:10.1007/s12015-013-9446-3
2012
Cell sources for the regeneration of articular cartilage: the past, the horizon and the future.
Oldershaw, R. A. (2012). Cell sources for the regeneration of articular cartilage: the past, the horizon and the future.. International journal of experimental pathology, 93(6), 389-400. doi:10.1111/j.1365-2613.2012.00837.x
Chondrocyte protocol
Oldershaw, R. (2014). Chondrocyte protocol. StemBook. doi:10.3824/stembook.1.56.1
Differential release of heterogeneous human mesenchymal stem cell populations from haemarthrotic traumatic knee injury.
Deehan, D. J., Dowen, D. J., Sprowson, A. P., Ferguson, L. C., Prathalingham, M. S., Isaacs, J. D., . . . Oldershaw, R. A. (2012). Differential release of heterogeneous human mesenchymal stem cell populations from haemarthrotic traumatic knee injury.. American Journal of Stem Cell Research. doi:10.5923/j.ajscr.20120101.01
Production and validation of a good manufacturing practice grade human fibroblast line for supporting human embryonic stem cell derivation and culture
Prathalingam, N., Ferguson, L., Young, L., Lietz, G., Oldershaw, R., Healy, L., . . . Herbert, M. (2012). Production and validation of a good manufacturing practice grade human fibroblast line for supporting human embryonic stem cell derivation and culture. STEM CELL RESEARCH & THERAPY, 3. doi:10.1186/scrt103
Keynote: Generation of skeletal hard tissues from pluripotent stem cells
Cheng, A., Kapacee, Z., Ray, S., Dilal, K. S., Oldershaw, R., Bates, N., . . . Kimber, S. (2012). Keynote: Generation of skeletal hard tissues from pluripotent stem cells. In JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE Vol. 6 (pp. 249). Retrieved from https://www.webofscience.com/
2010
A chemically-defined protocol for generating chondrocytes from human embryonic stem cells
Oldershaw, R., Baxter, M., Lowe, E., Bates, N., Grady, L., Soncin, F., . . . Kimber, S. (n.d.). A chemically-defined protocol for generating chondrocytes from human embryonic stem cells. Protocol Exchange. doi:10.1038/protex.2010.201
Directed differentiation of human embryonic stem cells toward chondrocytes.
Oldershaw, R. A., Baxter, M. A., Lowe, E. T., Bates, N., Grady, L. M., Soncin, F., . . . Kimber, S. J. (2010). Directed differentiation of human embryonic stem cells toward chondrocytes.. Nature biotechnology, 28(11), 1187-1194. doi:10.1038/nbt.1683
Derivation of Man-1 and Man-2 research grade human embryonic stem cell lines.
Camarasa, M. V., Kerr, R. W., Sneddon, S. F., Bates, N., Shaw, L., Oldershaw, R. A., . . . Kimber, S. J. (2010). Derivation of Man-1 and Man-2 research grade human embryonic stem cell lines.. In vitro cellular & developmental biology. Animal, 46(3-4), 386-394. doi:10.1007/s11626-010-9291-5
Notch signaling during chondrogenesis of human bone marrow stem cells.
Oldershaw, R. A., & Hardingham, T. E. (2010). Notch signaling during chondrogenesis of human bone marrow stem cells.. Bone, 46(2), 286-293. doi:10.1016/j.bone.2009.04.242
2009
The differentiation of human embryonic stem cells towards chondroprogenitors using a chemically defined step-wise protocol
Oldershaw, R., Baxter, M., Brison, D., Hardingham, T., & Kimber, S. (2009). The differentiation of human embryonic stem cells towards chondroprogenitors using a chemically defined step-wise protocol. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 90 (pp. A71-A72). Retrieved from https://www.webofscience.com/
2008
Notch signaling through jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis
Oldershaw, R. A., Tew, S. R., Russell, A. M., Meade, K., Hawkins, R., McKay, T. R., . . . Hardingham, T. E. (2008). Notch signaling through jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis. STEM CELLS, 26(3), 666-674. doi:10.1634/stemcells.2007-0806
2006
Cartilage, SOX9 and notch signals in chondrogenesis
Hardingham, T. E., Oldershaw, R. A., & Tew, S. R. (2006). Cartilage, SOX9 and notch signals in chondrogenesis. JOURNAL OF ANATOMY, 209(4), 469-480. doi:10.1111/j.1469-7580.2006.00630.x
Control of chondrogenesis and the assembly of cartilage matrix
Hardingham, T., Tew, S., Oldershaw, R., & Murdoch, A. (2006). Control of chondrogenesis and the assembly of cartilage matrix. In JOURNAL OF ANATOMY Vol. 209 (pp. 573). Retrieved from https://www.webofscience.com/
Low-oxygen tension affects the chondrogenic potential of human mesenchymal stem cells
Oldershaw, R., & Hardingham, T. (2006). Low-oxygen tension affects the chondrogenic potential of human mesenchymal stem cells. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 87 (pp. A35). Retrieved from https://www.webofscience.com/
2005
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK (2005). In International Journal of Experimental Pathology Vol. 86. Wiley. doi:10.1111/j.0959-9673.2005.00426.x
The putative role of the notch ligand, jagged 1, in the mediation of the early events of human mesenchymal stem cell chondrogenesis
Oldershaw, R., Murdoch, A., Brennan, K., & Hardingham, T. (2005). The putative role of the notch ligand, jagged 1, in the mediation of the early events of human mesenchymal stem cell chondrogenesis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 86 (pp. A47-A48). Retrieved from https://www.webofscience.com/
2004
Investigating the role of heparin sulfate proteoglycans in hereditary multiple exostoses (HME) tumourigenesis
Scholefield, Z. M., Hassell, J. R., West, L., Govindraj, P., Hecht, J. T., Rushton, G., . . . Gallagher, J. T. (2004). Investigating the role of heparin sulfate proteoglycans in hereditary multiple exostoses (HME) tumourigenesis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 85 (pp. A73-A74). doi:10.1111/j.0959-9673.2004.390an.x
2003
expansion in FGF2 promotes matrix synthesis during chondrogenic differentiation of human bone marrow mesenchymal cells without upregulating SOX9
Murdoch, A. D., Oldershaw, R. A., & Hardingham, T. E. (2003). expansion in FGF2 promotes matrix synthesis during chondrogenic differentiation of human bone marrow mesenchymal cells without upregulating SOX9. In European Cells and Materials Vol. 6 (pp. 17).
Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis
Mongiat, M., Fu, J., Oldershaw, R., Greenhalgh, R., Gown, A. M., & Iozzo, R. V. (2003). Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(19), 17491-17499. doi:10.1074/jbc.M210529200
2002
Cell-surface proteoglycans are differentially regulated by chondrocytes during adaptation to cell culture
Murdoch, A. D., Oldershaw, R. A., & Hardingham, T. E. (2002). Cell-surface proteoglycans are differentially regulated by chondrocytes during adaptation to cell culture. In European Cells and Materials Vol. 4 (pp. 86-87).
2001
Fibroblast growth factor-binding protein is a novel partner for perlecan protein core
Mongiat, M., Otto, J., Oldershaw, R., Ferrer, F., Sato, J. D., & Iozzo, R. V. (2001). Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(13), 10263-10271. doi:10.1074/jbc.M011493200