Publications
2024
Attitudes towards deprescribing in patients with multimorbidity and polypharmacy in primary care
Employing community Parent Champions is associated with reduced hospitalisation rates for bronchiolitis
Lee, A., Schofield, P., Hawcutt, D., Sinha, I., & Buchan, I. (2024). Employing community Parent Champions is associated with reduced hospitalisation rates for bronchiolitis. In Paediatric respiratory epidemiology (pp. PA4075). European Respiratory Society. doi:10.1183/13993003.congress-2024.pa4075
A qualitative exploration of barriers to efficient and effective structured medication reviews in primary care: Findings from the DynAIRx study.
Abuzour, A. S., Wilson, S. A., Woodall, A. A., Mair, F. S., Clegg, A., Shantsila, E., . . . Walker, L. E. (2024). A qualitative exploration of barriers to efficient and effective structured medication reviews in primary care: Findings from the DynAIRx study.. PloS one, 19(8), e0299770. doi:10.1371/journal.pone.0299770
An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol.
Mbizvo, G. K., Martin, G. P., Sperrin, M., Bonnett, L. J., Schofield, P., Buchan, I., . . . Marson, A. G. (2024). An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol.. PloS one, 19(8), e0306226. doi:10.1371/journal.pone.0306226
Risk of type 2 diabetes, MASLD and cardiovascular disease in people living with polycystic ovary syndrome.
Henney, A. E., Gillespie, C. S., Lai, J. Y. M., Schofield, P., Riley, D. R., Caleyachetty, R., . . . Cuthbertson, D. J. (2024). Risk of type 2 diabetes, MASLD and cardiovascular disease in people living with polycystic ovary syndrome.. The Journal of clinical endocrinology and metabolism, dgae481. doi:10.1210/clinem/dgae481
2023
Outcomes of first emergency admissions for alcohol-related liver disease in England over a 10-year period: retrospective observational cohort study using linked electronic databases.
Bodger, K., Mair, T., Schofield, P., Silberberg, B., Hood, S., & Fleming, K. M. (2023). Outcomes of first emergency admissions for alcohol-related liver disease in England over a 10-year period: retrospective observational cohort study using linked electronic databases.. BMJ open, 13(11), e076955. doi:10.1136/bmjopen-2023-076955
The predictive accuracy of cardiovascular risk prediction tools in inflammatory arthritis and psoriasis: an observational validation study using the Clinical Practice Research Datalink.
Hughes, D. M., Coronado, J. I. C., Schofield, P., Yiu, Z. Z. N., & Zhao, S. S. (2023). The predictive accuracy of cardiovascular risk prediction tools in inflammatory arthritis and psoriasis: an observational validation study using the Clinical Practice Research Datalink.. Rheumatology (Oxford, England), kead610. doi:10.1093/rheumatology/kead610
O20 Characteristics and outcomes of first emergency admissions for alcohol-related liver disease: linkage analysis of the English CPRD population, 2008–2017
Bodger, K., Mair, T., Schofield, P., Silberberg, B., Fleming, K., & Hood, S. (2023). O20 Characteristics and outcomes of first emergency admissions for alcohol-related liver disease: linkage analysis of the English CPRD population, 2008–2017. In Oral presentations (pp. A10.1-A10). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2023-bsg.19
Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells.
Steiner, I., Flores-Tellez, T. D. N. J., Mevel, R., Ali, A., Wang, P., Schofield, P., . . . Baena, E. (2023). Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells.. Cell reports, 42(4), 112377. doi:10.1016/j.celrep.2023.112377
2021
REGIONAL INEQUALITIES IN MULTIMORBIDITY WITHIN ENGLAND BETWEEN 2004 AND 2019: A DESCRIPTIVE EPIDEMIOLOGY STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK
Head, A., Fleming, K., Kypridemos, C., Schofield, P., & O'Flaherty, M. (2021). REGIONAL INEQUALITIES IN MULTIMORBIDITY WITHIN ENGLAND BETWEEN 2004 AND 2019: A DESCRIPTIVE EPIDEMIOLOGY STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK. In JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH Vol. 75 (pp. A69-A70). doi:10.1136/jech-2021-SSMabstracts.149
Inequalities in incident and prevalent multimorbidity in England, 2004-19: a population-based, descriptive study
Head, A., Fleming, K., Kypridemos, C., Schofield, P., Pearson-Stuttard, J., & O'Flaherty, M. (2021). Inequalities in incident and prevalent multimorbidity in England, 2004-19: a population-based, descriptive study. LANCET HEALTHY LONGEVITY, 2(8), E489-E497. doi:10.1016/S2666-7568(21)00146-X
2020
DYNAMICS OF MULTIMORBIDITY IN ENGLAND BETWEEN 2004 AND 2019: A DESCRIPTIVE EPIDEMIOLOGY STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK
Head, A., Fleming, K., Kypridemos, C., Schofield, P., & O'Flaherty, M. (2020). DYNAMICS OF MULTIMORBIDITY IN ENGLAND BETWEEN 2004 AND 2019: A DESCRIPTIVE EPIDEMIOLOGY STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK. In JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH Vol. 74 (pp. A14). doi:10.1136/jech-2020-SSMabstracts.29
Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study
Head, A., Fleming, K., Kypridemos, C., Schofield, P., & O'Flaherty, M. (2020). Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study. In EUROPEAN JOURNAL OF PUBLIC HEALTH Vol. 30 (pp. V301). Retrieved from https://www.webofscience.com/
OP29 Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study using the clinical practice research datalink
Head, A., Fleming, K., Kypridemos, C., Schofield, P., & O'Flaherty, M. (2020). OP29 Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study using the clinical practice research datalink. In Journal of Epidemiology and Community Health Vol. 74 (pp. A14). SSM: BMJ.
Profiling of Circulating Free DNA Using Targeted and Genome-wide Sequencing in Patients with SCLC
Mohan, S., Foy, V., Ayub, M., Leong, H. S., Schofield, P., Sahoo, S., . . . Brady, G. (2020). Profiling of Circulating Free DNA Using Targeted and Genome-wide Sequencing in Patients with SCLC. JOURNAL OF THORACIC ONCOLOGY, 15(2), 216-230. doi:10.1016/j.jtho.2019.10.007
2019
Corrigendum: Mutational signatures of DNA mismatch repair deficiency in <i>C. elegans</i> and human cancers
Meier, B., Volkova, N. V., Hong, Y., Schofield, P., Campbell, P. J., Gerstung, M., & Gartner, A. (2019). Corrigendum: Mutational signatures of DNA mismatch repair deficiency in <i>C. elegans</i> and human cancers. Genome Research, 29(9), 1566_2. doi:10.1101/gr.255596.119
Hypoxia Induces Rapid Changes to Histone Methylation and Reprograms Chromatin
Batie, M., Frost, J., Frost, M., Wilson, J. W., Schofield, P., & Rocha, S. (2019). Hypoxia Induces Rapid Changes to Histone Methylation and Reprograms Chromatin. Science, 363(6432), 1222-1226. doi:10.1126/science.aau5870
Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response: Supplementary material
Batie, M., Frost, J., Frost, M., Wilson, J., Schofield, P., & Rocha, S. (2019). Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response: Supplementary material. doi:10.1101/513069
2018
Abstract 5602: Detection of circulating cell-free tumor DNA (ctDNA) in patients with small cell lung cancer (SCLC)
Mohan, S., Foy, V., Leong, H. S., Schofield, P. G., Ayub, M., Smith, N. K., . . . Brady, G. (2018). Abstract 5602: Detection of circulating cell-free tumor DNA (ctDNA) in patients with small cell lung cancer (SCLC). Cancer Research, 78(13_Supplement), 5602. doi:10.1158/1538-7445.am2018-5602
Mutational signatures of DNA mismatch repair deficiency in C. <i>elegans</i> and human cancers
Meier, B., Volkova, N. V., Hong, Y., Schofield, P., Campbell, P. J., Gerstung, M., & Gartner, A. (2018). Mutational signatures of DNA mismatch repair deficiency in C. <i>elegans</i> and human cancers. GENOME RESEARCH, 28(5), 666-675. doi:10.1101/gr.226845.117
2017
The application of liquid biopsies in metastatic salivary gland cancer to identify candidate therapeutic targets
Metcalf, R., Mohan, S., Hilton, S., Pierce, J., Hudson, J., Betts, G., . . . Dive, C. (2017). The application of liquid biopsies in metastatic salivary gland cancer to identify candidate therapeutic targets. Annals of Oncology, 28, vii8. doi:10.1093/annonc/mdx508.016
Mutational signatures of DNA mismatch repair deficiency in<i>C. elegans</i>and human cancers
Examining the role of individual movement in promoting coexistence in a spatially explicit prisoner's dilemma
Burgess, A. E. F., Lorenzi, T., Schofield, P. G., Hubbard, S. F., & Chaplain, M. A. J. (2017). Examining the role of individual movement in promoting coexistence in a spatially explicit prisoner's dilemma. JOURNAL OF THEORETICAL BIOLOGY, 419, 323-332. doi:10.1016/j.jtbi.2017.02.028
2016
What's in a name? Word inflation, punctuation, abbreviation and cloud formation
Schofield, S. J., & Schofield, P. G. (2016). What's in a name? Word inflation, punctuation, abbreviation and cloud formation. MEDICAL EDUCATION, 50(12), 1264-1268. doi:10.1111/medu.13099
Dynamical patterns of coexisting strategies in a hybrid discrete-continuum spatial evolutionary game model
Erratum: How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?
Schurch, N. J., Schofield, P., Gierliński, M., Cole, C., Sherstnev, A., Singh, V., . . . Barton, G. J. (2016). Erratum: How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?. RNA (New York, N.Y.), 22(10), 1641. doi:10.1261/rna.058339.116
How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?
Schurch, N. J., Schofield, P., Gierlinski, M., Cole, C., Sherstnev, A., Singh, V., . . . Barton, G. J. (2016). How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?. RNA, 22(6), 839-851. doi:10.1261/rna.053959.115
The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors
Wiechens, N., Singh, V., Gkikopoulos, T., Schofield, P., Rocha, S., & Owen-Hughes, T. (2016). The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors. PLOS GENETICS, 12(3). doi:10.1371/journal.pgen.1005940
Dynamical Patterns of Coexisting Strategies in a Hybrid Discrete-continuum Spatial Evolutionary Game Model
Burgess, A. E. F., Sehofield, P. G., Hubbard, S. F., Chaplain, M. A. J., & Lorenzi, T. (2016). Dynamical Patterns of Coexisting Strategies in a Hybrid Discrete-continuum Spatial Evolutionary Game Model. MATHEMATICAL MODELLING OF NATURAL PHENOMENA, 11(5), 49-64. doi:10.1051/mmnp/201611504
2015
Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment
Gierlinski, M., Cole, C., Schofield, P., Schurch, N. J., Sherstnev, A., Singh, V., . . . Barton, G. J. (2015). Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment. BIOINFORMATICS, 31(22), 3625-3630. doi:10.1093/bioinformatics/btv425
Proteotoxic stress reprograms the chromatin landscape of SUMO modification
Seifert, A., Schofield, P., Barton, G. J., & Hay, R. T. (2015). Proteotoxic stress reprograms the chromatin landscape of SUMO modification. SCIENCE SIGNALING, 8(384). doi:10.1126/scisignal.aaa2213
Evaluation of tools for differential gene expression analysis by RNA-seq on a 48 biological replicate experiment
Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment
2012
Directed terminal restriction analysis tool (DRAT): an aid to enzyme selection for directed terminal-restriction fragment length polymorphisms
Roberts, D. M., Schofield, P. G., Donn, S., & Daniell, T. J. (2012). Directed terminal restriction analysis tool (DRAT): an aid to enzyme selection for directed terminal-restriction fragment length polymorphisms. METHODS IN ECOLOGY AND EVOLUTION, 3(1), 24-28. doi:10.1111/j.2041-210X.2011.00139.x
2011
A Role for Snf2-Related Nucleosome-Spacing Enzymes in Genome-Wide Nucleosome Organization
Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., . . . Owen-Hughes, T. (2011). A Role for Snf2-Related Nucleosome-Spacing Enzymes in Genome-Wide Nucleosome Organization. SCIENCE, 333(6050), 1758-1760. doi:10.1126/science.1206097
2010
High-Resolution Whole-Genome Sequencing Reveals That Specific Chromatin Domains from Most Human Chromosomes Associate with Nucleoli
van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., . . . Lamond, A. I. (2010). High-Resolution Whole-Genome Sequencing Reveals That Specific Chromatin Domains from Most Human Chromosomes Associate with Nucleoli. MOLECULAR BIOLOGY OF THE CELL, 21(21), 3735-3748. doi:10.1091/mbc.E10-06-0508
Modelling contact spread of infection in host-parasitoid systems: Vertical transmission of pathogens can cause chaos
Preedy, K. F., Schofield, P. G., Liu, S., Matzavinos, A., Chaplain, M. A. J., & Hubbard, S. F. (2010). Modelling contact spread of infection in host-parasitoid systems: Vertical transmission of pathogens can cause chaos. JOURNAL OF THEORETICAL BIOLOGY, 262(3), 441-451. doi:10.1016/j.jtbi.2009.10.003
2009
Gender Variance in the UK: Prevalence, Incidence Growth and Geographic Distribution.
Reed, B., Rhodes, S., Schofield, P., & Wylie, K. (2009). Gender Variance in the UK: Prevalence, Incidence Growth and Geographic Distribution.. GIRES Technical Report.
2008
Enhancing the Quality of Hardy Nursery Stock and Sustainability of the Industry through Novel Water-Saving Techniques
Davies, W. J., Bacon, M. A., Sharp, R. G., Jones, H. G., Schofield, P. G., Atkinson, C. J., . . . York, M. (2008). Enhancing the Quality of Hardy Nursery Stock and Sustainability of the Industry through Novel Water-Saving Techniques. Horticultural Development Company.
Thermal and Other Remote Sensing of Plant Stress.
Jones, H., & Schofield, P. (2008). Thermal and Other Remote Sensing of Plant Stress.. General Applications Plant Physiology.
2007
Chemotaxis-induced spatio-temporal heterogeneity in multi-species host-parasitoid systems
Pearce, I. G., Chaplain, M. A. J., Schofield, P. G., Anderson, A. R. A., & Hubbard, S. F. (2007). Chemotaxis-induced spatio-temporal heterogeneity in multi-species host-parasitoid systems. JOURNAL OF MATHEMATICAL BIOLOGY, 55(3), 365-388. doi:10.1007/s00285-007-0088-4
Disease induced dynamics in host-parasitoid systems: chaos and coexistence
Preedy, K. F., Schofield, P. G., Chaplain, M. A. J., & Hubbard, S. F. (2007). Disease induced dynamics in host-parasitoid systems: chaos and coexistence. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 4(14), 463-471. doi:10.1098/rsif.2006.0184
2006
Modelling the spatio-temporal dynamics of multi-species host-parasitoid interactions: Heterogeneous patterns and ecological implications
Pearce, I. G., Chaplain, M. A. J., Schofield, P. G., Anderson, A. R. A., & Hubbard, S. F. (2006). Modelling the spatio-temporal dynamics of multi-species host-parasitoid interactions: Heterogeneous patterns and ecological implications. JOURNAL OF THEORETICAL BIOLOGY, 241(4), 876-886. doi:10.1016/j.jtbi.2006.01.026
<i>Wolbachia</i> infection suppresses both host defence and parasitoid counter-defence
Fytrou, A., Schofield, P. G., Kraaijeveld, A. R., & Hubbard, S. F. (2006). <i>Wolbachia</i> infection suppresses both host defence and parasitoid counter-defence. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 273(1588), 791-796. doi:10.1098/rspb.2005.3383
2005
Evolution of searching and life history characteristics in individual-based models of host-parasitoid-microbe associations
Schofield, P., Chaplain, M., & Hubbard, S. (2005). Evolution of searching and life history characteristics in individual-based models of host-parasitoid-microbe associations. JOURNAL OF THEORETICAL BIOLOGY, 237(1), 1-16. doi:10.1016/j.jtbi.2005.03.025
Dynamic heterogeneous spatio-temporal pattern formation in host-parasitoid systems with synchronised generations
Schofield, P. G., Chaplain, M. A. J., & Hubbard, S. F. (2005). Dynamic heterogeneous spatio-temporal pattern formation in host-parasitoid systems with synchronised generations. JOURNAL OF MATHEMATICAL BIOLOGY, 50(5), 559-583. doi:10.1007/s00285-004-0298-y
2002
Spatially explicit models of Turelli-Hoffmann <i>Wolbachia</i> invasive wave fronts
Schofield, P. (2002). Spatially explicit models of Turelli-Hoffmann <i>Wolbachia</i> invasive wave fronts. JOURNAL OF THEORETICAL BIOLOGY, 215(1), 121-131. doi:10.1006/jtbi.2001.2493
Mathematical modelling of host-parasitoid systems: Effects of chemically mediated parasitoid foraging strategies on within- and between-generation spatio-temporal dynamics
Schofield, P., Chaplain, M., & Hubbard, S. (2002). Mathematical modelling of host-parasitoid systems: Effects of chemically mediated parasitoid foraging strategies on within- and between-generation spatio-temporal dynamics. JOURNAL OF THEORETICAL BIOLOGY, 214(1), 31-47. doi:10.1006/jtbi.2001.2418
Spatio-Temporal Mathematical Models for the Investigation of Host-Parasitoid Systems and Wolbachia-Infection Dynamics
Schofield, P. G. (2002). Spatio-Temporal Mathematical Models for the Investigation of Host-Parasitoid Systems and Wolbachia-Infection Dynamics. (PhD Thesis, University of Dundee).
2000
Spatio-Temporal Mathematical Models of Host-Parasitoid Systems
Schofield, P., Chaplain, M. A. J., & Hubbard, S. F. (2000). Spatio-Temporal Mathematical Models of Host-Parasitoid Systems. European Communications of Mathematical and Theoretical Biology, 2.
Undated
Risk of Type 2 Diabetes, Metabolic Dysfunction Associated Steatotic Liver Disease and Cardiovascular Disease in People Living with Polycystic Ovary Syndrome According to Disease Phenotype: An Analysis of Prospective Cohort and Multi-Organ Imaging Data from the UK Biobank
Henney, A. E., Gillespie, C. S., Lai, J. Y. M., Schofield, P., Riley, D., Caleyachetty, R., . . . Cuthbertson, D. J. (n.d.). Risk of Type 2 Diabetes, Metabolic Dysfunction Associated Steatotic Liver Disease and Cardiovascular Disease in People Living with Polycystic Ovary Syndrome According to Disease Phenotype: An Analysis of Prospective Cohort and Multi-Organ Imaging Data from the UK Biobank.