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2024

Typhi Mykrobe: fast and accurate lineage identification and antimicrobial resistance genotyping directly from sequence reads for the typhoid fever agent<i>Salmonella</i>Typhi

DOI
10.1101/2024.09.30.613582
Preprint

Interplay Between the Gut Microbiome and Typhoid Fever: Insights from Endemic Countries and a Controlled Human Infection Model

DOI
10.1101/2024.09.02.24312347
Preprint

Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study.

Dyson, Z. A., Ashton, P. M., Khanam, F., Chunga Chirambo, A., Shakya, M., Meiring, J. E., . . . STRATAA Study Group. (2024). Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study.. The Lancet. Microbe, 5(8), 100841. doi:10.1016/s2666-5247(24)00047-8

DOI
10.1016/s2666-5247(24)00047-8
Journal article

Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study.

Ashton, P. M., Chunga Chirambo, A., Meiring, J. E., Patel, P. D., Mbewe, M., Silungwe, N., . . . Gordon, M. A. (2024). Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study.. The Lancet. Microbe, 5(3), e226-e234. doi:10.1016/s2666-5247(23)00327-0

DOI
10.1016/s2666-5247(23)00327-0
Journal article

&lt;i&gt;Salmonella enterica&lt;/i&gt; serovar Typhimurium ST313 sublineage 2.2 has emerged in Malawi with a characteristic gene expression signature and a fitness advantage.

Kumwenda, B., Canals, R., Predeus, A. V., Zhu, X., Kröger, C., Pulford, C., . . . Hinton, J. C. D. (2024). &lt;i&gt;Salmonella enterica&lt;/i&gt; serovar Typhimurium ST313 sublineage 2.2 has emerged in Malawi with a characteristic gene expression signature and a fitness advantage.. microLife, 5, uqae005. doi:10.1093/femsml/uqae005

DOI
10.1093/femsml/uqae005
Journal article

2023

Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 &lt;i&gt;Salmonella&lt;/i&gt; Typhi genomes.

Carey, M. E., Dyson, Z. A., Ingle, D. J., Amir, A., Aworh, M. K., Chattaway, M. A., . . . Global Typhoid Genomics Consortium Group Authorship. (2023). Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 &lt;i&gt;Salmonella&lt;/i&gt; Typhi genomes.. eLife, 12, e85867. doi:10.7554/elife.85867

DOI
10.7554/elife.85867
Journal article

Utilizing river and wastewater as a SARS-CoV-2 surveillance tool to predict trends and identify variants of concern in settings with limited formal sewage systems.

DOI
10.21203/rs.3.rs-2801767/v1
Preprint

Different clinical features in Malawian outpatients presenting with COVID-19 prior to and during Omicron variant dominance: A prospective observational study.

Chibwana, M. G., Thole, H. W., Anscombe, C., Ashton, P. M., Green, E., Barnes, K. G., . . . Jambo, K. C. (2023). Different clinical features in Malawian outpatients presenting with COVID-19 prior to and during Omicron variant dominance: A prospective observational study.. PLOS global public health, 3(3), e0001575. doi:10.1371/journal.pgph.0001575

DOI
10.1371/journal.pgph.0001575
Journal article

2022

Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission.

Koolman, L., Prakash, R., Diness, Y., Msefula, C., Nyirenda, T. S., Olgemoeller, F., . . . Gordon, M. A. (2022). Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission.. PLoS neglected tropical diseases, 16(12), e0010982. doi:10.1371/journal.pntd.0010982

DOI
10.1371/journal.pntd.0010982
Journal article

What is the source of infections causing invasive non-typhoidal Salmonella disease?

DOI
10.31219/osf.io/5b3un
Preprint

Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission

Koolman, L., Prakash, R., Diness, Y., Msefula, C., Nyirenda, T., Olgemoeller, F., . . . Gordon, M. (2022). Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission. doi:10.1101/2022.01.31.22270114

DOI
10.1101/2022.01.31.22270114
Journal article

2020

Sources of Multidrug Resistance in Patients With Previous Isoniazid-Resistant Tuberculosis Identified Using Whole Genome Sequencing: A Longitudinal Cohort Study

Srinivasan, V., Ha, V. T. N., Vinh, D. N., Thai, P. V. K., Ha, D. T. M., Lan, N. H., . . . Thuong, N. T. T. (2020). Sources of Multidrug Resistance in Patients With Previous Isoniazid-Resistant Tuberculosis Identified Using Whole Genome Sequencing: A Longitudinal Cohort Study. CLINICAL INFECTIOUS DISEASES, 71(10), E532-E539. doi:10.1093/cid/ciaa254

DOI
10.1093/cid/ciaa254
Journal article

The virulence of the<i>Cryptococcus neoformans</i>VNIa-5 lineage is highly plastic and associated with isolate background

DOI
10.1101/2020.02.24.962134
Preprint

2019

Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues.

Meehan, C. J., Goig, G. A., Kohl, T. A., Verboven, L., Dippenaar, A., Ezewudo, M., . . . Van Rie, A. (2019). Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues.. Nature reviews. Microbiology, 17(9), 533-545. doi:10.1038/s41579-019-0214-5

DOI
10.1038/s41579-019-0214-5
Journal article

Informal genomic surveillance of regional distribution of <i>Salmonella</i> Typhi genotypes and antimicrobial resistance via returning travellers

DOI
10.1101/510461
Preprint

Informal genomic surveillance of regional distribution of <i>Salmonella</i> Typhi genotypes and antimicrobial resistance via returning travellers

Ingle, D. J., Nair, S., Hartman, H., Ashton, P. M., Dyson, Z. A., Day, M., . . . Dallman, T. J. (2019). Informal genomic surveillance of regional distribution of <i>Salmonella</i> Typhi genotypes and antimicrobial resistance via returning travellers. PLOS NEGLECTED TROPICAL DISEASES, 13(9). doi:10.1371/journal.pntd.0007620

DOI
10.1371/journal.pntd.0007620
Journal article

2018

Virulence of <i>Mycobacterium tuberculosis</i> Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response.

Tram, T. T. B., Nhung, H. N., Vijay, S., Hai, H. T., Thu, D. D. A., Ha, V. T. N., . . . Thuong, N. T. T. (2018). Virulence of <i>Mycobacterium tuberculosis</i> Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response.. Frontiers in cellular and infection microbiology, 8, 417. doi:10.3389/fcimb.2018.00417

DOI
10.3389/fcimb.2018.00417
Journal article

SnapperDB: a database solution for routine sequencing analysis of bacterial isolates.

Dallman, T., Ashton, P., Schafer, U., Jironkin, A., Painset, A., Shaaban, S., . . . Grant, K. (2018). SnapperDB: a database solution for routine sequencing analysis of bacterial isolates.. Bioinformatics (Oxford, England), 34(17), 3028-3029. doi:10.1093/bioinformatics/bty212

DOI
10.1093/bioinformatics/bty212
Journal article

Genomics of<i>Cryptococcus neoformans</i>

DOI
10.1101/356816
Preprint

Epidemiological analysis of Salmonella clusters identified by whole genome sequencing, England and Wales 2014.

Waldram, A., Dolan, G., Ashton, P. M., Jenkins, C., & Dallman, T. J. (2018). Epidemiological analysis of Salmonella clusters identified by whole genome sequencing, England and Wales 2014.. Food microbiology, 71, 39-45. doi:10.1016/j.fm.2017.02.012

DOI
10.1016/j.fm.2017.02.012
Journal article

Whole genome sequencing reveals an outbreak of Salmonella Enteritidis associated with reptile feeder mice in the United Kingdom, 2012-2015.

Kanagarajah, S., Waldram, A., Dolan, G., Jenkins, C., Ashton, P. M., Carrion Martin, A. I., . . . Elson, R. (2018). Whole genome sequencing reveals an outbreak of Salmonella Enteritidis associated with reptile feeder mice in the United Kingdom, 2012-2015.. Food microbiology, 71, 32-38. doi:10.1016/j.fm.2017.04.005

DOI
10.1016/j.fm.2017.04.005
Journal article

<i>Salmonella</i> Enteritidis ST183: emerging and endemic biotypes affecting western European hedgehogs (<i>Erinaceus europaeus</i>) and people in Great Britain

Lawson, B., Franklinos, L. H. V., Fernandez, J. R. -R., Wend-Hansen, C., Nair, S., Macgregor, S. K., . . . de Pinna, E. M. (2018). <i>Salmonella</i> Enteritidis ST183: emerging and endemic biotypes affecting western European hedgehogs (<i>Erinaceus europaeus</i>) and people in Great Britain. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-017-18667-2

DOI
10.1038/s41598-017-18667-2
Journal article

Comparison of phenotypic and WGS-derived antimicrobial resistance profiles of Salmonella enterica serovars Typhi and Paratyphi.

Day, M. R., Doumith, M., Do Nascimento, V., Nair, S., Ashton, P. M., Jenkins, C., . . . Godbole, G. (2018). Comparison of phenotypic and WGS-derived antimicrobial resistance profiles of Salmonella enterica serovars Typhi and Paratyphi.. The Journal of antimicrobial chemotherapy, 73(2), 365-372. doi:10.1093/jac/dkx379

DOI
10.1093/jac/dkx379
Journal article

2017

Investigation using whole genome sequencing of a prolonged restaurant outbreak of <i>Salmonella</i> Typhimurium linked to the building drainage system, England, February 2015 to March 2016.

Mair-Jenkins, J., Borges-Stewart, R., Harbour, C., Cox-Rogers, J., Dallman, T., Ashton, P., . . . Puleston, R. (2017). Investigation using whole genome sequencing of a prolonged restaurant outbreak of <i>Salmonella</i> Typhimurium linked to the building drainage system, England, February 2015 to March 2016.. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 22(49). doi:10.2807/1560-7917.es.2017.22.49.17-00037

DOI
10.2807/1560-7917.es.2017.22.49.17-00037
Journal article

Multilocus Sequence Typing Reveals A Unique Co-Dominant Population Structure of<i>Cryptococcus Neoformans</i>Var.<i>Grubii</i>in Vietnam

DOI
10.1101/190785
Preprint

Assessing the virulence of<i>Cryptococcus neoformans</i>causing meningitis in HIV infected and uninfected patients in Vietnam

DOI
10.1101/189274
Preprint

SnapperDB: A database solution for routine sequencing analysis of bacterial isolates

DOI
10.1101/189118
Preprint

Comparative genomics of Cryptococcus neoformans var. grubii associated with meningitis in HIV infected and uninfected patients in Vietnam.

Day, J. N., Qihui, S., Thanh, L. T., Trieu, P. H., Van, A. D., Thu, N. H., . . . Baker, S. (2017). Comparative genomics of Cryptococcus neoformans var. grubii associated with meningitis in HIV infected and uninfected patients in Vietnam.. PLoS neglected tropical diseases, 11(6), e0005628. doi:10.1371/journal.pntd.0005628

DOI
10.1371/journal.pntd.0005628
Journal article

<i>Salmonella enterica</i> serovar Typhimurium ST313 responsible for gastroenteritis in the UK are genetically distinct from isolates causing bloodstream infections in Africa

DOI
10.1101/139576
Preprint

Multinational outbreak of travel-related Salmonella Chester infections in Europe, summers 2014 and 2015.

Fonteneau, L., Jourdan Da Silva, N., Fabre, L., Ashton, P., Torpdahl, M., Müller, L., . . . Le Hello, S. (2017). Multinational outbreak of travel-related Salmonella Chester infections in Europe, summers 2014 and 2015.. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 22(7). doi:10.2807/1560-7917.es.2017.22.7.30463

DOI
10.2807/1560-7917.es.2017.22.7.30463
Journal article

Prospective use of whole genome sequencing (WGS) detected a multi-country outbreak of Salmonella Enteritidis

Inns, T., Ashton, P. M., Herrera-Leon, S., Lighthill, J., Foulkes, S., Jombart, T., . . . Vivancos, R. (2017). Prospective use of whole genome sequencing (WGS) detected a multi-country outbreak of Salmonella Enteritidis. EPIDEMIOLOGY AND INFECTION, 145(2), 289-298. doi:10.1017/S0950268816001941

DOI
10.1017/S0950268816001941
Journal article

2016

WGS for surveillance of antimicrobial resistance: a pilot study to detect the prevalence and mechanism of resistance to azithromycin in a UK population of non-typhoidal Salmonella.

Nair, S., Ashton, P., Doumith, M., Connell, S., Painset, A., Mwaigwisya, S., . . . Day, M. (2016). WGS for surveillance of antimicrobial resistance: a pilot study to detect the prevalence and mechanism of resistance to azithromycin in a UK population of non-typhoidal Salmonella.. The Journal of antimicrobial chemotherapy, 71(12), 3400-3408. doi:10.1093/jac/dkw318

DOI
10.1093/jac/dkw318
Journal article

Detection of the plasmid-mediated mcr-1 gene conferring colistin resistance in human and food isolates of Salmonella enterica and Escherichia coli in England and Wales.

Doumith, M., Godbole, G., Ashton, P., Larkin, L., Dallman, T., Day, M., . . . Woodford, N. (2016). Detection of the plasmid-mediated mcr-1 gene conferring colistin resistance in human and food isolates of Salmonella enterica and Escherichia coli in England and Wales.. The Journal of antimicrobial chemotherapy, 71(8), 2300-2305. doi:10.1093/jac/dkw093

DOI
10.1093/jac/dkw093
Journal article

Association between use of proton pump inhibitors and non-typhoidal salmonellosis identified following investigation into an outbreak of Salmonella Mikawasima in the UK, 2013.

Freeman, R., Dabrera, G., Lane, C., Adams, N., Browning, L., Fowler, T., . . . Adak, G. K. (2016). Association between use of proton pump inhibitors and non-typhoidal salmonellosis identified following investigation into an outbreak of Salmonella Mikawasima in the UK, 2013.. Epidemiology and infection, 144(5), 968-975. doi:10.1017/s0950268815002332

DOI
10.1017/s0950268815002332
Journal article

2015

Revolutionising Public Health Reference Microbiology using Whole Genome Sequencing:<i>Salmonella</i>as an exemplar

DOI
10.1101/033225
Preprint

Identification and typing of Salmonella for public health surveillance using whole genome sequencing

DOI
10.7287/peerj.preprints.1425
Preprint

Applying phylogenomics to understand the emergence of Shiga-toxin-producing <i>Escherichia coli</i> O157:H7 strains causing severe human disease in the UK.

Dallman, T. J., Ashton, P. M., Byrne, L., Perry, N. T., Petrovska, L., Ellis, R., . . . Jenkins, C. (2015). Applying phylogenomics to understand the emergence of Shiga-toxin-producing <i>Escherichia coli</i> O157:H7 strains causing severe human disease in the UK.. Microbial genomics, 1(3), e000029. doi:10.1099/mgen.0.000029

DOI
10.1099/mgen.0.000029
Journal article

Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study

Baker, K. S., Dallman, T. J., Ashton, P. M., Day, M., Hughes, G., Crook, P. D., . . . Thomson, N. R. (2015). Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study. Lancet Infectious Diseases, 15(8), 913-921. doi:10.1016/S1473-3099(15)00002-X

DOI
10.1016/S1473-3099(15)00002-X
Journal article

A multi-country <i>Salmonella</i> Enteritidis phage type 14b outbreak associated with eggs from a German producer: 'near real-time' application of whole genome sequencing and food chain investigations, United Kingdom, May to September 2014

Inns, T., Lane, C., Peters, T., Dallman, T., Chatt, C., McFarland, N., . . . Cleary, P. (2015). A multi-country <i>Salmonella</i> Enteritidis phage type 14b outbreak associated with eggs from a German producer: 'near real-time' application of whole genome sequencing and food chain investigations, United Kingdom, May to September 2014. EUROSURVEILLANCE, 20(16), 15-22. doi:10.2807/1560-7917.ES2015.20.16.21098

DOI
10.2807/1560-7917.ES2015.20.16.21098
Journal article

Whole Genome Sequencing for the Retrospective Investigation of an Outbreak of Salmonella Typhimurium DT 8.

Ashton, P. M., Peters, T., Ameh, L., McAleer, R., Petrie, S., Nair, S., . . . Dallman, T. (2015). Whole Genome Sequencing for the Retrospective Investigation of an Outbreak of Salmonella Typhimurium DT 8.. PLoS currents, 7, ecurrents.outbreaks.2c05a47d292f376afc5a6fcdd8a7a3. doi:10.1371/currents.outbreaks.2c05a47d292f376afc5a6fcdd8a7a3b6

DOI
10.1371/currents.outbreaks.2c05a47d292f376afc5a6fcdd8a7a3b6
Journal article

MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island.

Ashton, P. M., Nair, S., Dallman, T., Rubino, S., Rabsch, W., Mwaigwisya, S., . . . O'Grady, J. (2015). MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island.. Nature biotechnology, 33(3), 296-300. doi:10.1038/nbt.3103

DOI
10.1038/nbt.3103
Journal article

2014

Insight into Shiga toxin genes encoded by <i>Escherichia coli </i>O157 from whole genome sequencing

DOI
10.7287/peerj.preprints.652
Preprint

Draft genome sequences of the type strains of <i>Shigella flexneri</i> held at Public Health England: comparison of classical phenotypic and novel molecular assays with whole genome sequence

Ashton, P. M., Baker, K. S., Gentle, A., Wooldridge, D. J., Thomson, N. R., Dallman, T. J., & Jenkins, C. (2014). Draft genome sequences of the type strains of <i>Shigella flexneri</i> held at Public Health England: comparison of classical phenotypic and novel molecular assays with whole genome sequence. GUT PATHOGENS, 6. doi:10.1186/1757-4749-6-7

DOI
10.1186/1757-4749-6-7
Journal article

Evaluating the use of multilocus variable number tandem repeat analysis of Shiga toxin-producing Escherichia coli O157 as a routine public health tool in England.

Byrne, L., Elson, R., Dallman, T. J., Perry, N., Ashton, P., Wain, J., . . . Jenkins, C. (2014). Evaluating the use of multilocus variable number tandem repeat analysis of Shiga toxin-producing Escherichia coli O157 as a routine public health tool in England.. PloS one, 9(1), e85901. doi:10.1371/journal.pone.0085901

DOI
10.1371/journal.pone.0085901
Journal article