Publications
2024
Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria.
Norman, B. P., Sutherland, H., Wilson, P. J. M., Rutland, D. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2024). Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria.. Journal of inherited metabolic disease, 47(4), 664-673. doi:10.1002/jimd.12728
Identification of novel bone-resorption markers by osteoclasts<i>in vitro</i>and<i>in vivo</i>
2023
Skeletal progenitor LRP1-mediated endocytosis is critical for synovial joint formation and bone growth
2022
Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria
Norman, B. P., Davison, A. S., Hickton, B., Ross, G. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2022). Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100927
Growth and retreat of the last British–Irish Ice Sheet, 31 000 to 15 000 years ago: the BRITICE-CHRONO reconstruction
Clark, C. D., Ely, J. C., Hindmarsh, R. C. A., Bradley, S., Ignéczi, A., Fabel, D., . . . Wilson, P. (2022). Growth and retreat of the last British–Irish Ice Sheet, 31 000 to 15 000 years ago: the BRITICE-CHRONO reconstruction. Boreas, n/a(n/a). doi:10.1111/bor.12594
Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism
Norman, B. P., Davison, A. S., Hughes, J. H., Sutherland, H., Wilson, P. J. M., Berry, N. G., . . . Gallagher, J. A. (2022). Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism. GENES & DISEASES, 9(4), 1129-1142. doi:10.1016/j.gendis.2021.02.007
2021
Exploring controls of the early and stepped deglaciation on the western margin of the British Irish Ice Sheet
Benetti, S., Chiverrell, R. C., Cofaigh, C. O., Burke, M., Medialdea, A., Small, D., . . . Weilbach, K. (2021). Exploring controls of the early and stepped deglaciation on the western margin of the British Irish Ice Sheet. JOURNAL OF QUATERNARY SCIENCE, 36(5), 833-870. doi:10.1002/jqs.3315
Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation.
Wilson, P. J. M., Ranganath, L. R., Bou-Gharios, G., Gallagher, J. A., & Hughes, J. H. (2021). Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation.. JIMD reports, 58(1), 52-60. doi:10.1002/jmd2.12184
Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Wilson, P. J. M., Ranganath, L. R., . . . Gallagher, J. A. (n.d.). Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces. Calcified Tissue International. doi:10.1007/s00223-020-00764-6
2020
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., . . . Howson, J. M. M. (2020). Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. NATURE GENETICS, 52(12), 1314-1332. doi:10.1038/s41588-020-00713-x
Co-infection in critically ill patients with COVID-19: An observational cohort study from England
Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism
Norman, B. P., Davison, A. S., Hughes, J. H., Sutherland, H., Wilson, P. J., Berry, N. G., . . . Gallagher, J. A. (n.d.). Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism. biorxiv. doi:10.1101/2020.04.16.044347
Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria
Hughes, J. H., Wilson, P. J. M., Sutherland, H., Judd, S., Hughes, A. T., Milan, A. M., . . . Gallagher, J. A. (2020). Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(2), 259-268. doi:10.1002/jimd.12172
Reversal of ochronotic pigmentation in alkaptonuria following nitisinone therapy: Analysis of data from the United Kingdom National Alkaptonuria Centre.
Ranganath, L. R., Milan, A. M., Hughes, A. T., Khedr, M., Davison, A. S., Wilson, P. J., . . . Gallagher, J. A. (2020). Reversal of ochronotic pigmentation in alkaptonuria following nitisinone therapy: Analysis of data from the United Kingdom National Alkaptonuria Centre.. JIMD reports, 55(1), 75-87. doi:10.1002/jmd2.12137
2019
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria
Hughes, J. H., Liu, K., Plagge, A., Wilson, P. J. M., Sutherland, H., Norman, B. P., . . . Bou-Gharios, G. (2019). Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human Molecular Genetics, 28(23), 3928-3939. doi:10.1093/hmg/ddz234
EXTRACELLULAR CHEMICAL PROFILING BY LC-QTOF-MS IDENTIFIES NOVEL BONE RESORPTION MARKERS FOR MONITORING PROGRESSION OF OSTEOARTHROPATHY IN THE RARE DISEASE ALKAPTONURIA
Norman, B. P., Dillon, J. P., Wilson, P. J., Davison, A. S., Milan, A. M., Ross, G. R., . . . Gallagher, J. A. (2019). EXTRACELLULAR CHEMICAL PROFILING BY LC-QTOF-MS IDENTIFIES NOVEL BONE RESORPTION MARKERS FOR MONITORING PROGRESSION OF OSTEOARTHROPATHY IN THE RARE DISEASE ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S181-S182). doi:10.1016/j.joca.2019.02.274
2018
DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Norman, B. P., Ying, C. W., Sutherland, H., Wilson, P. J., Roberts, N. B., Duer, M. J., . . . Gallagher, J. A. (2018). DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S99). doi:10.1016/j.joca.2018.02.214
GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA
Hughes, J. H., Liu, K., Sutherland, H., Wilson, P. J., Hughes, A. T., Milan, A. M., . . . Bou-Gharios, G. (2018). GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S89-S90). doi:10.1016/j.joca.2018.02.194
2017
URINE METABOLOMICS USING LIQUID CHROMATOGRAPHY QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY INDICATES COMMON MARKERS OF DISEASE IN ALKAPTONURIA AND IDIOPATHIC OSTEOARTHRITIS IN HUMAN
Norman, B., Davison, A., Wilson, P., Ross, G., Milan, A., Roberts, N., . . . Gallagher, J. (2017). URINE METABOLOMICS USING LIQUID CHROMATOGRAPHY QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY INDICATES COMMON MARKERS OF DISEASE IN ALKAPTONURIA AND IDIOPATHIC OSTEOARTHRITIS IN HUMAN. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S97-S98). doi:10.1016/j.joca.2017.02.156
Defining the properties of an array of -NH2- modified substrates for the induction of a mature osteoblast/osteocyte phenotype from a primary human osteoblast population using controlled nanotopography and surface chemistry
Fawcett, S. A., Curran, J. M., Chen, R., Rhodes, N. P., Murphy, M. F., Wilson, P., . . . Hunt, J. A. (2017). Defining the properties of an array of -NH2- modified substrates for the induction of a mature osteoblast/osteocyte phenotype from a primary human osteoblast population using controlled nanotopography and surface chemistry. Calcified Tissue International, 100(1), 95-106. doi:10.1007/s00223-016-0202-y
2016
c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines
Pacheco-Pantoja, E. L., Dillon, J. P., Wilson, P. J. M., Fraser, W. D., & Gallagher, J. A. (2016). c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines. Purinergic Signalling, 12(4), 647-651. doi:10.1007/s11302-016-9526-3
Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury
Varley, I., Greeves, J. P., Sale, C., Friedman, E., Moran, D. S., Yanovich, R., . . . Gallagher, J. A. (2016). Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury. PURINERGIC SIGNALLING, 12(01), 103-113. doi:10.1007/s11302-016-9495-6
2015
Adipocytic Templating of Bone Matrix Deposition in Osteoarthropathies
Taylor, A., Platt, C., Wilson, P., Ranganath, L., Gallagher, J., & Boyde, A. (2015). Adipocytic Templating of Bone Matrix Deposition in Osteoarthropathies. In FASEB JOURNAL Vol. 29. Retrieved from https://www.webofscience.com/
Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice
Keenan, C. M., Preston, A. J., Sutherland, H., Wilson, P. J., Psarelli, E. E., Cox, T. F., . . . Gallagher, J. A. (2015). Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice. JIMD REPORTS, VOL 24, 24, 45-50. doi:10.1007/8904_2015_437
2012
Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition
Taylor, A. M., Preston, A. J., Paulk, N. K., Sutherland, H., Keenan, C. M., Wilson, P. J. M., . . . Jarvis, J. C. (2012). Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition. OSTEOARTHRITIS AND CARTILAGE, 20(8), 880-886. doi:10.1016/j.joca.2012.04.013
Association of polymorphisms in the P2X7 receptor gene with stress fracture risk in military recruits
Greeves⁎, J., Fraser, W., Friedman, E., Wilson, P., Dillon, J., Gartland, A., & Gallagher, J. (2012). Association of polymorphisms in the P2X7 receptor gene with stress fracture risk in military recruits. Bone, 50, S108. doi:10.1016/j.bone.2012.02.329
2011
Receptors and effects of gut hormones in three osteoblastic cell lines.
Pacheco-Pantoja, E. L., Ranganath, L. R., Gallagher, J. A., Wilson, P. J. M., & Fraser, W. D. (2011). Receptors and effects of gut hormones in three osteoblastic cell lines.. BMC physiology, 11, 12. doi:10.1186/1472-6793-11-12
Advanced ochronosis of articular cartilage in aku provides an extreme model of focal unloading of bone due to stress shielding
Taylor, A. M., Boyde, A., Wilson, P. J., Davidson, J. S., Jarvis, J. C., Hunt, J., . . . Gallagher, J. A. (2011). Advanced ochronosis of articular cartilage in aku provides an extreme model of focal unloading of bone due to stress shielding. BONE, 48, S173-S174. doi:10.1016/j.bone.2011.03.397
2010
257 ELUCIDATING THE MECHANISM OF OSTEOARTHROPATHY IN ALKAPTONURIA: LESSONS FOR OSTEOARTHRITIS
Taylor, A. M., Boyde, A., Wlodarski, B., Davidson, J. S., Wilson, P. J., Jarvis, J. C., . . . Gallagher, J. A. (2010). 257 ELUCIDATING THE MECHANISM OF OSTEOARTHROPATHY IN ALKAPTONURIA: LESSONS FOR OSTEOARTHRITIS. Osteoarthritis and Cartilage, 18, S116-S117. doi:10.1016/s1063-4584(10)60284-1
Deposition of ochronotic pigment in articular cartilage in alkaptonuria is initiated near the tidemark and progresses to the articular surface
Taylor, A. M., Wlodarski, B., Wilson, P. J., Jarvis, J., Ranganath, L. R., Boyde, A., & Gallagher, J. A. (2010). Deposition of ochronotic pigment in articular cartilage in alkaptonuria is initiated near the tidemark and progresses to the articular surface. Bone, 47, S79. doi:10.1016/j.bone.2010.04.156
Time course and mechanisms of the synergistic activation of osteoblastic cells by extracelluar ATP and PTH
Bond, A. P., Wilson, P. J. M., Dillon, J. P., & Gallagher, J. A. (2010). Time course and mechanisms of the synergistic activation of osteoblastic cells by extracelluar ATP and PTH. Bone, 47, S117. doi:10.1016/j.bone.2010.04.252
Type VI collagen plays a major role in adhesion of osteoblastic cells
Wilson, P. J., Dillon, J. P., Gallagher, J. A., & Waring-Green, V. J. (2010). Type VI collagen plays a major role in adhesion of osteoblastic cells. Bone, 47, S135-S136. doi:10.1016/j.bone.2010.04.304
2006
Expression of collagen VI in bone and osteosarcoma cell lines reveals its role in the development of bone matrix
Wilson, P. J. M., Wagstaff, S. C., Wlodarski, B. W., Dillon, J. P., Fraser, W. D., & Gallagher, J. A. (2006). Expression of collagen VI in bone and osteosarcoma cell lines reveals its role in the development of bone matrix. Bone, 38(3), 21. doi:10.1016/j.bone.2006.01.100