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2024

Data from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Data from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.c.7451265.v1

DOI
10.1158/0008-5472.c.7451265.v1
Other

Data from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Data from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.c.7451265

DOI
10.1158/0008-5472.c.7451265
Other

Figure S1 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S1 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024180

DOI
10.1158/0008-5472.27024180
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Figure S1 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S1 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024180.v1

DOI
10.1158/0008-5472.27024180.v1
Other

Figure S10 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S10 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024177.v1

DOI
10.1158/0008-5472.27024177.v1
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Figure S10 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S10 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024177

DOI
10.1158/0008-5472.27024177
Other

Figure S11 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S11 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024174

DOI
10.1158/0008-5472.27024174
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Figure S11 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S11 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024174.v1

DOI
10.1158/0008-5472.27024174.v1
Other

Figure S12 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S12 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024171

DOI
10.1158/0008-5472.27024171
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Figure S12 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S12 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024171.v1

DOI
10.1158/0008-5472.27024171.v1
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Figure S2 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S2 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024168.v1

DOI
10.1158/0008-5472.27024168.v1
Other

Figure S2 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S2 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024168

DOI
10.1158/0008-5472.27024168
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Figure S3 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S3 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024162

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10.1158/0008-5472.27024162
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Figure S3 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S3 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024162.v1

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10.1158/0008-5472.27024162.v1
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Figure S4 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S4 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024159.v1

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10.1158/0008-5472.27024159.v1
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Figure S4 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S4 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024159

DOI
10.1158/0008-5472.27024159
Other

Figure S5 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S5 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024156.v1

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10.1158/0008-5472.27024156.v1
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Figure S5 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S5 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024156

DOI
10.1158/0008-5472.27024156
Other

Figure S6 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S6 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024153.v1

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10.1158/0008-5472.27024153.v1
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Figure S6 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S6 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024153

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10.1158/0008-5472.27024153
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Figure S7 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S7 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024150

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10.1158/0008-5472.27024150
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Figure S7 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S7 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024150.v1

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10.1158/0008-5472.27024150.v1
Other

Figure S8 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S8 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024147

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10.1158/0008-5472.27024147
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Figure S8 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S8 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024147.v1

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10.1158/0008-5472.27024147.v1
Other

Figure S9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024144.v1

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10.1158/0008-5472.27024144.v1
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Figure S9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Figure S9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024144

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10.1158/0008-5472.27024144
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Supplemental material from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Supplemental material from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024141.v1

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10.1158/0008-5472.27024141.v1
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Supplemental material from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Supplemental material from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024141

DOI
10.1158/0008-5472.27024141
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Supplementary Tables 1-9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Supplementary Tables 1-9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024138

DOI
10.1158/0008-5472.27024138
Other

Supplementary Tables 1-9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Supplementary Tables 1-9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.27024138.v1

DOI
10.1158/0008-5472.27024138.v1
Other

Chemotherapy Assessment in Advanced Multicellular 3D Models of Pancreatic Cancer: Unravelling the Importance of Spatiotemporal Mimicry of the Tumor Microenvironment

Gupta, P., Bermejo-Rodriguez, C., Kocher, H., Pérez-Mancera, P. A., & Velliou, E. G. (2024). Chemotherapy Assessment in Advanced Multicellular 3D Models of Pancreatic Cancer: Unravelling the Importance of Spatiotemporal Mimicry of the Tumor Microenvironment. Advanced Biology. doi:10.1002/adbi.202300580

DOI
10.1002/adbi.202300580
Journal article

2023

2022

Abstract C084: Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer

Caligiuri, G., Thalappillil, J. S., Shakiba, M., Nadella, S., Hinds, J., Courtois, E., . . . Tuveson, D. A. (2022). Abstract C084: Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer. Cancer Research, 82(22_Supplement), C084. doi:10.1158/1538-7445.panca22-c084

DOI
10.1158/1538-7445.panca22-c084
Journal article

Abstract 3647: Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer

Thalappillil, J. S., Caligiuri, G., Nadella, S., Alagesan, B., Yordanov, G. N., Shakiba, M., . . . Tuveson, D. A. (2022). Abstract 3647: Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer. Cancer Research, 82(12_Supplement), 3647. doi:10.1158/1538-7445.am2022-3647

DOI
10.1158/1538-7445.am2022-3647
Journal article

Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer.

Caligiuri, G., Thalappillil, J. S., Shakiba, M., Nadella, S., Hinds, J., Courtois, E., . . . Tuveson, D. A. (2022). Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer.. In CANCER RESEARCH Vol. 82 (pp. 168). Retrieved from https://www.webofscience.com/

Conference Paper

Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer

Thalappillil, J. S., Caligiuri, G., Nadella, S., Alagesan, B., Yordanov, G. N., Shakiba, M., . . . Tuveson, D. A. (2022). Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer. In CANCER RESEARCH Vol. 82. Retrieved from https://www.webofscience.com/

Conference Paper

2020

ON THE DEVELOPMENT OF A BIOINSPIRED, BIOMIMETIC PANCREATIC CANCER MODEL: ENGINEERING A HYBRID SCAFFOLD ASSISTED IN VITRO MULTICELLULAR MODEL OF PANCREATIC CANCER

Gupta, P., Pérez-Mancera, P. A., Kocher, H., Nisbet, A., Schettino, G., & Velliou, E. G. (2020). ON THE DEVELOPMENT OF A BIOINSPIRED, BIOMIMETIC PANCREATIC CANCER MODEL: ENGINEERING A HYBRID SCAFFOLD ASSISTED IN VITRO MULTICELLULAR MODEL OF PANCREATIC CANCER. Pancreatology, 20(8), e21. doi:10.1016/j.pan.2020.10.023

DOI
10.1016/j.pan.2020.10.023
Journal article

A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma-Toward a Better Mimicry of the <i>in vivo</i> Tumor Microenvironment

Gupta, P., Perez-Mancera, P. A., Kocher, H., Nisbet, A., Schettino, G., & Velliou, E. G. (2020). A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma-Toward a Better Mimicry of the <i>in vivo</i> Tumor Microenvironment. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 8. doi:10.3389/fbioe.2020.00290

DOI
10.3389/fbioe.2020.00290
Journal article

A second site <i>Kras<SUP>G12D</SUP></i> mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis.

Wong, J. C., Perez-Mancera, P. A., Kim, J., Jen, K. -Y., Kogan, S. C., Firestone, A. J., . . . Shannon, K. (2020). A second site <i>Kras<SUP>G12D</SUP></i> mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis.. In MOLECULAR CANCER RESEARCH Vol. 18 (pp. 43). Retrieved from https://www.webofscience.com/

Conference Paper

2019

PDAC-associated fibroblasts are less responsive to an anti-fibrotic stimulus and more responsive to a positive regulator of fibroblast activation than normal activated fibroblasts

Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F., Campbell, F., . . . Costello, E. (2019). PDAC-associated fibroblasts are less responsive to an anti-fibrotic stimulus and more responsive to a positive regulator of fibroblast activation than normal activated fibroblasts. Pancreatology, 19, S158. doi:10.1016/j.pan.2019.05.423

DOI
10.1016/j.pan.2019.05.423
Journal article

2018

Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile

Barrera, L., Evans, A., Lane, B., Brumskill, S., Oldfield, F., Campbell, F., . . . Costello, E. (2018). Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile. Pancreatology, 18(4), S94. doi:10.1016/j.pan.2018.05.254

DOI
10.1016/j.pan.2018.05.254
Journal article

The efficacy of brusatol as a chemotherapeutic agent in pancreatic cancer and its relevance to potential chemoresistance conferred by Nrf2

Williams, D., Gayon, S., Barrera, L., Perez-Mancera, P., Copple, I., Goldring, C., . . . Costello, E. (2018). The efficacy of brusatol as a chemotherapeutic agent in pancreatic cancer and its relevance to potential chemoresistance conferred by Nrf2. Pancreatology, 18(4), S149. doi:10.1016/j.pan.2018.05.400

DOI
10.1016/j.pan.2018.05.400
Journal article

Mouse Models of Pancreatic Exocrine Cancer

Pérez-Mancera, P. A. (2018). Mouse Models of Pancreatic Exocrine Cancer. In Pancreatic Cancer (pp. 509-538). Springer New York. doi:10.1007/978-1-4939-7193-0_77

DOI
10.1007/978-1-4939-7193-0_77
Chapter

2017

Generation of Mouse Models of Cancer Using Transposon‐Mediated Approaches

Bermejo‐Rodríguez, C., & Pérez‐Mancera, P. A. (n.d.). Generation of Mouse Models of Cancer Using Transposon‐Mediated Approaches. In Unknown Book (pp. 1-11). Wiley. doi:10.1002/9780470015902.a0026891

DOI
10.1002/9780470015902.a0026891
Chapter

Mouse Models of Pancreatic Exocrine Cancer

Pérez-Mancera, P. A. (2017). Mouse Models of Pancreatic Exocrine Cancer. In Pancreatic Cancer (pp. 1-30). Springer New York. doi:10.1007/978-1-4939-6631-8_77-1

DOI
10.1007/978-1-4939-6631-8_77-1
Chapter

2016

Identification of novel signalling pathways dysregulated in pancreatic cancer-associated fibroblasts

Barrera, L., Lane, B., Brumskill, S., Oldfield, F., Lamond, R., Wilkinson, L., . . . Costello, E. (2016). Identification of novel signalling pathways dysregulated in pancreatic cancer-associated fibroblasts. Pancreatology, 16(3), S31. doi:10.1016/j.pan.2016.05.106

DOI
10.1016/j.pan.2016.05.106
Journal article

2015

Use of DNA transposons for functional genetic screens in mouse models of cancer

Bermejo-Rodriguez, C., & Perez-Mancera, P. A. (2015). Use of DNA transposons for functional genetic screens in mouse models of cancer. CURRENT OPINION IN BIOTECHNOLOGY, 35, 103-110. doi:10.1016/j.copbio.2015.05.005

DOI
10.1016/j.copbio.2015.05.005
Journal article

2014

Cancer Cell Signaling

Ayyanathan, K. (Ed.) (n.d.). Cancer Cell Signaling. In . Apple Academic Press. doi:10.1201/b17138

DOI
10.1201/b17138
Chapter

Inside and out: the activities of senescence in cancer

Perez-Mancera, P. A., Young, A. R. J., & Narita, M. (2014). Inside and out: the activities of senescence in cancer. NATURE REVIEWS CANCER, 14(8), 547-558. doi:10.1038/nrc3773

DOI
10.1038/nrc3773
Journal article