Publications
2024
Phlorotannin rich<i>Ascophyllum nodosum</i>seaweed extract inhibits influenza infection
The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19
Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Cornish, K., Huo, J., Jones, L., Sharma, P., Thrush, J. W., Abdelkarim, S., . . . Owens, R. J. (2024). Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.. Open biology, 14(6), 230252. doi:10.1098/rsob.230252
The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.
Fernández, J. J., Marín, A., Rosales, R., Penrice-Randal, R., Mlcochova, P., Alvarez, Y., . . . Fernández, N. (2024). The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.. Biochimica et biophysica acta. Molecular basis of disease, 1870(5), 167193. doi:10.1016/j.bbadis.2024.167193
Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.
Clark, J. J., Penrice-Randal, R., Sharma, P., Dong, X., Pennington, S. H., Marriott, A. E., . . . Stewart, J. P. (2024). Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.. Viruses, 16(6), 863. doi:10.3390/v16060863
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 15(1), 2918. doi:10.1038/s41467-024-47320-6
Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression.
Zhuang, X., Gallo, G., Sharma, P., Ha, J., Magri, A., Borrmann, H., . . . McKeating, J. A. (2024). Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression.. iScience, 27(1), 108763. doi:10.1016/j.isci.2023.108763
2023
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4
Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression
Amino acids 1811-1960 of myosin heavy chain 9 is involved in murine gammaherpesvirus 68 infection
Han, X., Clark, J. J., Sharma, P., Bentley, E. G., Kipar, A., Alsayer, M., . . . Zhao, Q. (2023). Amino acids 1811-1960 of myosin heavy chain 9 is involved in murine gammaherpesvirus 68 infection. VIROLOGY, 587. doi:10.1016/j.virol.2023.109849
Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated<i>in vivo</i>
The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections
De Neck, S., Penrice-Randal, R., Clark, J. J., Sharma, P., Bentley, E. G., Kirby, A., . . . Kipar, A. (2023). The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections. Viruses, 15(8), 1637. doi:10.3390/v15081637
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2
Gaynor, K. U. U., Vaysburd, M., Harman, M. A. J., Albecka, A., Jeffrey, P., Beswick, P., . . . James, L. C. C. (2023). Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-39158-1
2022
Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse
Seehusen, F., Clark, J. J., Sharma, P., Bentley, E. G., Kirby, A., Subramaniam, K., . . . Kipar, A. (2022). Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse. VIRUSES-BASEL, 14(5). doi:10.3390/v14051020
2021
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
Huo, J., Mikolajek, H., Le Bas, A., Clark, J. J., Sharma, P., Kipar, A., . . . Moynie, L. (2021). A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25480-z
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
Salzer, R., Clark, J. J., Vaysburd, M., Chang, V. T., Albecka, A., Kiss, L., . . . Lowe, J. (2021). Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice. FEBS LETTERS, 595(18), 2323-2340. doi:10.1002/1873-3468.14171
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
Salzer, R., Clark, J., Vaysburd, M., Chang, V., Albecka, A., Kiss, L., . . . Löwe, J. (2021). Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice. doi:10.1101/2021.05.18.444622
Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus.
Wang, Y., Sharma, P., Jefferson, M., Zhang, W., Bone, B., Kipar, A., . . . Wileman, T. (2021). Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus.. The EMBO Journal, e105543. doi:10.15252/embj.2020105543
2020
Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism
Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164
2018
Bovine Neonatal Monocytes Display Phenotypic Differences Compared With Adults After Challenge With the Infectious Abortifacient Agent <i>Neospora caninum</i>
Sharma, P., Hartley, C. S., Haque, M., Coffey, T. J., Egan, S. A., & Flynn, R. J. (2018). Bovine Neonatal Monocytes Display Phenotypic Differences Compared With Adults After Challenge With the Infectious Abortifacient Agent <i>Neospora caninum</i>. FRONTIERS IN IMMUNOLOGY, 9. doi:10.3389/fimmu.2018.03011
2012
Comparative evaluation of real time PCR assay with conventional parasitological techniques for diagnosis of Trypanosoma evansi in cattle and buffaloes.
Sharma, P., Juyal, P. D., Singla, L. D., Chachra, D., & Pawar, H. (2012). Comparative evaluation of real time PCR assay with conventional parasitological techniques for diagnosis of Trypanosoma evansi in cattle and buffaloes.. Veterinary parasitology, 190(3-4), 375-382. doi:10.1016/j.vetpar.2012.07.005