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Dr Nicola Harman
BSc MSc PhD

Contact

N.Harman@liverpool.ac.uk

+44 (0)151 795 8771

Publications

Selected publications

  1. Patient-reported outcomes for people with diabetes: what and how to measure? A narrative review (Journal article - 2023)
  2. Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes (Journal article - 2020)
  3. Core outcome sets through the healthcare ecosystem: the case of type 2 diabetes updates mellitus (Journal article - 2020)
  4. Selecting Core Outcomes for Randomised Effectiveness Trials in Type 2 Diabetes (SCORE-IT) - a Patient and Healthcare Professional Consensus on a Core Outcome Set for Type 2 Diabetes (Journal article - 2019)
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2024

Trial participants' self-reported understanding of randomisation phrases in participation information leaflets can be high, but acceptability of some descriptions is low, especially those linked to gambling and luck.

Shiely, F., Murphy, E., Gilles, K., Hood, K., O'Sullivan, L., Harman, N., . . . Treweek, S. (2024). Trial participants' self-reported understanding of randomisation phrases in participation information leaflets can be high, but acceptability of some descriptions is low, especially those linked to gambling and luck.. Trials, 25(1), 391. doi:10.1186/s13063-024-08217-3

DOI
10.1186/s13063-024-08217-3
Journal article

2023

Core outcome measurement instruments for use in clinical and research settings for adults with post-COVID-19 condition: an international Delphi consensus study.

Gorst, S. L., Seylanova, N., Dodd, S. R., Harman, N. L., O'Hara, M., Terwee, C. B., . . . PC-COS study group. (2023). Core outcome measurement instruments for use in clinical and research settings for adults with post-COVID-19 condition: an international Delphi consensus study.. The Lancet. Respiratory medicine, S2213-2600(23)00370-3. doi:10.1016/s2213-2600(23)00370-3

DOI
10.1016/s2213-2600(23)00370-3
Journal article

A Core Outcome Measurement Set (COMS) for Research and Clinical Practice in Post COVID-19 Condition (Long COVID) in Adults: An International Delphi Consensus Study

DOI
10.2139/ssrn.4317875
Preprint

2022

IDENTIFYING A CORE OUTCOME SET FOR PULMONARY SARCOIDOSIS RESEARCH - THE FOUNDATION FOR SARCOIDOSIS RESEARCH - SARCOIDOSIS CLINICAL OUTCOMES TASKFORCE (SCOUT)

Harman, N. L., Gorst, S. L., Williamson, P. R., Barnathan, E. S., Baughman, R. P., Judson, M. A., . . . Culver, D. A. (2022). IDENTIFYING A CORE OUTCOME SET FOR PULMONARY SARCOIDOSIS RESEARCH - THE FOUNDATION FOR SARCOIDOSIS RESEARCH - SARCOIDOSIS CLINICAL OUTCOMES TASKFORCE (SCOUT). SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 39(3). doi:10.36141/svdld.v39i3.12319

DOI
10.36141/svdld.v39i3.12319
Journal article

A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study

Munblit, D., Nicholson, T., Akrami, A., Apfelbacher, C., Chen, J., De Groote, W., . . . Williamson, P. R. (2022). A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study. LANCET RESPIRATORY MEDICINE, 10(7), 715-724. doi:10.1016/S2213-2600(22)00169-2

DOI
10.1016/S2213-2600(22)00169-2
Journal article

2021

SCOUT - SARCOIDOSIS OUTCOMES TASKFORCE. A SYSTEMATIC REVIEW OF OUTCOMES TO INFORM THE DEVELOPMENT OF A CORE OUTCOME SET FOR PULMONARY SARCOIDOSIS

Harman, N. L., Gorst, S. L., Williamson, P. R., Barnathan, E. S., Baughman, R. P., Judson, M. A., . . . Culver, D. A. (2021). SCOUT - SARCOIDOSIS OUTCOMES TASKFORCE. A SYSTEMATIC REVIEW OF OUTCOMES TO INFORM THE DEVELOPMENT OF A CORE OUTCOME SET FOR PULMONARY SARCOIDOSIS. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 38(3). doi:10.36141/svdld.v38i3.10737

DOI
10.36141/svdld.v38i3.10737
Journal article

A review of the Cochrane COVID-19 Study Register reveals inconsistency in the choice and measurement of SARS-CoV-2 infection outcomes in prevention trials

Dodd, S., Gorst, S., Avery, K., Harman, N., Macefield, R., Williamson, P., . . . COS-COVID-P Steering Committee. (2021). A review of the Cochrane COVID-19 Study Register reveals inconsistency in the choice and measurement of SARS-CoV-2 infection outcomes in prevention trials. doi:10.12688/f1000research.52491.1

DOI
10.12688/f1000research.52491.1
Journal article

2020

Collaborating in response to COVID-19: editorial and methods initiatives across Cochrane

Collaborating in response to COVID-19: editorial and methods initiatives across Cochrane (n.d.). . Wiley. doi:10.1002/14651858.cd202002

DOI
10.1002/14651858.cd202002
Report

Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes

Harman, N., Williamson, P., Sanz-Moreno, A., Papoutsopoulou, S., Lloyd, K. A., Ameen-Ali, K. E., & Macleod, M. (2020). Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes. Journal of Translational Medicine. doi:10.1186/s12967-020-02649-6

DOI
10.1186/s12967-020-02649-6
Journal article

2019

Selecting Core Outcomes for Randomised Effectiveness Trials in Type 2 Diabetes (SCORE-IT) - a Patient and Healthcare Professional Consensus on a Core Outcome Set for Type 2 Diabetes

Harman, N., Wilding, J., Curry, D., Harris, J., Logue, J., Pemberton, R. J., . . . Team, S. C. O. R. E. -I. T. S. (2019). Selecting Core Outcomes for Randomised Effectiveness Trials in Type 2 Diabetes (SCORE-IT) - a Patient and Healthcare Professional Consensus on a Core Outcome Set for Type 2 Diabetes. BMJ Open Diabetes Research and Care.

Journal article

Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial

Gregory, J. W., Townson, J., Channon, S., Cohen, D., Longo, M., Davies, J., . . . Lowes, L. (2019). Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial. BMJ Open, 9(12), e032317. doi:10.1136/bmjopen-2019-032317

DOI
10.1136/bmjopen-2019-032317
Journal article

Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age

Shaw, W., Semb, G., Lohmander, A., Persson, C., Willadsen, E., Clayton-Smith, J., . . . Williamson, P. (2019). Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age. BMJ OPEN, 9(7). doi:10.1136/bmjopen-2019-029780

DOI
10.1136/bmjopen-2019-029780
Journal article

Agreeing outcomes that matter to patients - co-production of an animation to explain core outcome sets

Bagley, H., Gorst, S., Humphreys, R., Craven, R., Vial, C., Williamson, P. R., . . . Gargon, E. (2019). Agreeing outcomes that matter to patients - co-production of an animation to explain core outcome sets. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Conference Paper

MOUSE - Mapping OUtcomes measured in pre-clinical Studies against randomised phase 3/4 Effectiveness trials. Do core outcome sets developed for phase3/4 effectiveness trials translate to pre-clinical research?

Harman, N. L., Sanz-Moreno, A., Ameen-Ali, K. E., Papoutsopoulou, S., Lloyd, K., Garcia-Finana, M., . . . Williamson, P. R. (2019). MOUSE - Mapping OUtcomes measured in pre-clinical Studies against randomised phase 3/4 Effectiveness trials. Do core outcome sets developed for phase3/4 effectiveness trials translate to pre-clinical research?. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Conference Paper

2018

Choosing important health outcomes for comparative effectiveness research: An updated systematic review and involvement of low and middle income countries

Davis, K., Gorst, S. L., Harman, N., Smith, V., Gargon, E., Altman, D. G., . . . Williamson, P. R. (2018). Choosing important health outcomes for comparative effectiveness research: An updated systematic review and involvement of low and middle income countries. PLOS ONE, 13(2). doi:10.1371/journal.pone.0190695

DOI
10.1371/journal.pone.0190695
Journal article

2017

The COMET Handbook: version 1.0

Williamson, P., Altman, D. G., Bagley, H., Barnes, K. L., Blazeby, J. M., Brookes, S. T., . . . Young, B. (2017). The COMET Handbook: version 1.0. Trials, 18(Suppl 3), 50 pages. doi:10.1186/s13063-017-1978-4

DOI
10.1186/s13063-017-1978-4
Journal article

How can incentives be designed and used to improve recruitment and retention in ways that are effective, efficient and ethical?

Bower, P., Parkinson, B., Fichera, E., Meacock, R., Sutton, M., Treweek, S., . . . Shorter, G. (2017). How can incentives be designed and used to improve recruitment and retention in ways that are effective, efficient and ethical?. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Conference Paper

Online resource for recruitment research in clinical trials research (ORRCA)

Kearney, A., Harman, N. L., Bacon, N., Daykin, A., Heawood, A. J., Lane, A., . . . Bower, P. (2017). Online resource for recruitment research in clinical trials research (ORRCA). In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Conference Paper

2016

2015

Developing a toolkit for patient and public involvement in a clinical trials unit

Bagley, H., Harman, N., Woolfall, K., Young, B., Short, H., Hickey, H., & Williamson, P. (2015). Developing a toolkit for patient and public involvement in a clinical trials unit. TRIALS, 16. doi:10.1186/1745-6215-16-S2-O92

DOI
10.1186/1745-6215-16-S2-O92
Journal article

Development of an online resource for recruitment research in clinical trials (ORRCA)

Harman, N., Treweek, S., Clarke, M., Williamson, P., Bower, P., & Gamble, C. (2015). Development of an online resource for recruitment research in clinical trials (ORRCA). TRIALS, 16. doi:10.1186/1745-6215-16-S2-P98

DOI
10.1186/1745-6215-16-S2-P98
Journal article

Exploring the role and functionality of trial steering committees

Harman, N., Conroy, E., Lewis, S., Murray, G., Norrie, J., Sydes, M., . . . Gamble, C. (2015). Exploring the role and functionality of trial steering committees. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P189

DOI
10.1186/1745-6215-16-S2-P189
Conference Paper

Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature

Conroy, E. J., Arch, B., Lewis, S., Lane, A., Sydes, M. R., Norrie, J., . . . Gamble, C. (2015). Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature. In Trials Vol. 16. Springer Science and Business Media LLC. doi:10.1186/1745-6215-16-s2-p177

DOI
10.1186/1745-6215-16-s2-p177
Conference Paper

Trial Steering Committees in randomised controlled trials: A survey of registered clinical trials units to establish current practice and experiences

Conroy, E. J., Harman, N. L., Lane, J. A., Lewis, S. C., Murray, G., Norrie, J., . . . Gamble, C. (2015). Trial Steering Committees in randomised controlled trials: A survey of registered clinical trials units to establish current practice and experiences. CLINICAL TRIALS, 12(6), 664-676. doi:10.1177/1740774515589959

DOI
10.1177/1740774515589959
Journal article

The management of Otitis Media with Effusion in children with cleft palate (mOMEnt): a feasibility study and economic evaluation

Bruce, I., Harman, N., Williamson, P., Tierney, S., Callery, P., Mohiuddin, S., . . . O'Brien, K. (2015). The management of Otitis Media with Effusion in children with cleft palate (mOMEnt): a feasibility study and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 19(68), 1-+. doi:10.3310/hta19680

DOI
10.3310/hta19680
Journal article

The Importance of Integration of Stakeholder Views in Core Outcome Set Development: Otitis Media with Effusion in Children with Cleft Palate

Harman, N. L., Bruce, I. A., Kirkham, J. J., Tierney, S., Callery, P., O'Brien, K., . . . Williamson, P. R. (2015). The Importance of Integration of Stakeholder Views in Core Outcome Set Development: Otitis Media with Effusion in Children with Cleft Palate. PLOS ONE, 10(6). doi:10.1371/journal.pone.0129514

DOI
10.1371/journal.pone.0129514
Journal article

Otitis Media With Effusion: Experiences of Children With Cleft Palate and Their Parents

Tierney, S., O'Brien, K., Harman, N. L., Sharma, R. K., Madden, C., & Callery, P. (2015). Otitis Media With Effusion: Experiences of Children With Cleft Palate and Their Parents. CLEFT PALATE-CRANIOFACIAL JOURNAL, 52(1), 23-30. doi:10.1597/13-139

DOI
10.1597/13-139
Journal article

Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature

Conroy, E. J., Arch, B., Lewis, S., Lane, A., Sydes, M. R., Norrie, J., . . . Gamble, C. (2015). Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature. Poster session presented at the meeting of Unknown Conference. Retrieved from https://www.webofscience.com/

DOI
10.1186/1745-6215-16-S2-P177
Poster

2014

The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents

Hobkirk, J. P., King, R. F., Davies, I., Harman, N., Gately, P., Pemberton, P., . . . Carroll, S. (2014). The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents. PEDIATRIC OBESITY, 9(3), 209-217. doi:10.1111/j.2047-6310.2013.00165.x

DOI
10.1111/j.2047-6310.2013.00165.x
Journal article

2013

Risks and benefits of ventilation tubes and hearing aids from the perspective of parents of children with cleft palate

Tierney, S., O'Brien, K., Harman, N. L., Madden, C., Sharma, R. K., & Callery, P. (2013). Risks and benefits of ventilation tubes and hearing aids from the perspective of parents of children with cleft palate. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 77(10), 1742-1748. doi:10.1016/j.ijporl.2013.08.006

DOI
10.1016/j.ijporl.2013.08.006
Journal article

The Predictive Ability of Triglycerides and Waist (Hypertriglyceridemic Waist) in Assessing Metabolic Triad Change in Obese Children and Adolescents

Hobkirk, J. P., King, R. F., Gately, P., Pemberton, P., Smith, A., Barth, J. H., . . . Carroll, S. (2013). The Predictive Ability of Triglycerides and Waist (Hypertriglyceridemic Waist) in Assessing Metabolic Triad Change in Obese Children and Adolescents. METABOLIC SYNDROME AND RELATED DISORDERS, 11(5), 336-342. doi:10.1089/met.2012.0152

DOI
10.1089/met.2012.0152
Journal article

Separation of the principal HDL subclasses by iodixanol ultracentrifugation

Harman, N. L., Griffin, B. A., & Davies, I. G. (2013). Separation of the principal HDL subclasses by iodixanol ultracentrifugation. JOURNAL OF LIPID RESEARCH, 54(8), 2273-2281. doi:10.1194/jlr.D037432

DOI
10.1194/jlr.D037432
Journal article

MOMENT - Management of Otitis Media with Effusion in Cleft Palate: protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey

Harman, N. L., Bruce, I. A., Callery, P., Tierney, S., Sharif, M. O., O'Brien, K., & Williamson, P. R. (2013). MOMENT - Management of Otitis Media with Effusion in Cleft Palate: protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. TRIALS, 14. doi:10.1186/1745-6215-14-70

DOI
10.1186/1745-6215-14-70
Journal article

Trial steering committees for randomised controlled trials: updating and redeveloping guidance and terms of reference informed by current practice and experience

Conroy, E. J., Lewis, S., Lane, A., Sydes, M. R., Norrie, J., Murray, G., . . . Gamble, C. (2013). Trial steering committees for randomised controlled trials: updating and redeveloping guidance and terms of reference informed by current practice and experience. In Trials Vol. 14 (pp. P128). doi:10.1186/1745-6215-14-s1-p128

DOI
10.1186/1745-6215-14-s1-p128
Conference Paper

2012

(19) The hypertriglyceridemic waist and the metabolic triad: a weight loss study in clinically obese children

Hobkirk, J. P., Pemberton, P., Smith, A., Harman, N., Davies, I. G., & Carroll, S. (2012). (19) The hypertriglyceridemic waist and the metabolic triad: a weight loss study in clinically obese children. Atherosclerosis, 223(2), 532. doi:10.1016/j.atherosclerosis.2012.06.043

DOI
10.1016/j.atherosclerosis.2012.06.043
Journal article

2011

Interaction of <i>PPARG</i> Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk

AlSaleh, A., O'Dell, S. D., Frost, G. S., Griffin, B. A., Lovegrove, J. A., Jebb, S. A., & Sanders, T. A. B. (2011). Interaction of <i>PPARG</i> Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk. JOURNAL OF LIPID RESEARCH, 52(12), 2298-2303. doi:10.1194/jlr.P019281

DOI
10.1194/jlr.P019281
Journal article

Variation in the FFAR1 Gene Modifies BMI, Body Composition and Beta-Cell Function in Overweight Subjects: An Exploratory Analysis

Walker, C. G., Goff, L., Bluck, L. J., Griffin, B. A., Jebb, S. A., Lovegrove, J. A., . . . Frost, G. S. (2011). Variation in the FFAR1 Gene Modifies BMI, Body Composition and Beta-Cell Function in Overweight Subjects: An Exploratory Analysis. PLOS ONE, 6(4). doi:10.1371/journal.pone.0019146

DOI
10.1371/journal.pone.0019146
Journal article

Delivering early care in diabetes evaluation (DECIDE): a protocol for a randomised controlled trial to assess hospital versus home management at diagnosis in childhood diabetes

Townson, J. K., Gregory, J. W., Cohen, D., Channon, S., Harman, N., Davies, J. H., . . . Lowes, L. (2011). Delivering early care in diabetes evaluation (DECIDE): a protocol for a randomised controlled trial to assess hospital versus home management at diagnosis in childhood diabetes. BMC PEDIATRICS, 11. doi:10.1186/1471-2431-11-7

DOI
10.1186/1471-2431-11-7
Journal article

PPARγ2 Gene Pro12Ala and PPARα Gene Leu162Val Single Nucleotide Polymorphisms Interact with Dietary Intake of Fat in Determination of Plasma Lipid Concentrations

AlSaleh, A., Frost, G. S., Griffin, B. A., Lovegrove, J. A., Jebb, S. A., Sanders, T. A. B., & O'Dell, S. D. (2011). PPARγ2 Gene Pro12Ala and PPARα Gene Leu162Val Single Nucleotide Polymorphisms Interact with Dietary Intake of Fat in Determination of Plasma Lipid Concentrations. JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS, 4(6), 354-366. doi:10.1159/000336362

DOI
10.1159/000336362
Journal article

2010

Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial

Jebb, S. A., Lovegrove, J. A., Griffin, B. A., Frost, G. S., Moore, C. S., Chatfield, M. D., . . . Sanders, T. A. B. (2010). Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial. AMERICAN JOURNAL OF CLINICAL NUTRITION, 92(4), 748-758. doi:10.3945/ajcn.2009.29096

DOI
10.3945/ajcn.2009.29096
Journal article

2009

INCREASED DIETARY CHOLESTEROL DOES NOT INCREASE PLASMA LOW DENSITY LIPOPROTEIN WHEN ACCOMPANIED BY WEIGHT LOSS

Harman, N. L., Leeds, A. R., & Griffin, B. A. (2009). INCREASED DIETARY CHOLESTEROL DOES NOT INCREASE PLASMA LOW DENSITY LIPOPROTEIN WHEN ACCOMPANIED BY WEIGHT LOSS. Atherosclerosis, 207(1), 307. doi:10.1016/j.atherosclerosis.2009.07.006

DOI
10.1016/j.atherosclerosis.2009.07.006
Journal article

2008

Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss

Harman, N. L., Leeds, A. R., & Griffin, B. A. (2008). Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss. European Journal of Nutrition, 47(7), 408. doi:10.1007/s00394-008-0746-3

DOI
10.1007/s00394-008-0746-3
Journal article

Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss

Harman, N. L., Leeds, A. R., & Griffin, B. A. (2008). Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss. EUROPEAN JOURNAL OF NUTRITION, 47(6), 287-293. doi:10.1007/s00394-008-0730-y

DOI
10.1007/s00394-008-0730-y
Journal article

2007

Separation of the principal HDL subclasses by iodixanol gradient ultracentrifugation

Harman, N. L., Davies, I. G., & Griffin, B. A. (2007). Separation of the principal HDL subclasses by iodixanol gradient ultracentrifugation. ATHEROSCLEROSIS, 194(1), 283-284. doi:10.1016/j.atherosclerosis.2007.04.038

DOI
10.1016/j.atherosclerosis.2007.04.038
Journal article