Publications
Selected publications
- Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells (Journal article - 2021)
- Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages (Journal article - 2017)
2022
Salt-inducible kinase 2 regulates fibrosis during bleomycin- induced lung injury
van Gijsel-Bonnello, M., Darling, N. J., Tanaka, T., Di Carmine, S., Marchesi, F., Thomson, S., . . . Arthur, J. S. C. (2022). Salt-inducible kinase 2 regulates fibrosis during bleomycin- induced lung injury. JOURNAL OF BIOLOGICAL CHEMISTRY, 298(12). doi:10.1016/j.jbc.2022.102644
2021
Salt inducible kinases 2 and 3 are required for thymic T cell development
Nefla, M., Darling, N. J., Bonnello, M. V. G., Cohen, P., & Arthur, J. S. C. (2021). Salt inducible kinases 2 and 3 are required for thymic T cell development. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-00986-0
Salt-inducible kinase (SIK) inhibition is protective in a mouse model of asthma
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases
Mokhtar, A. M. B. A., Ahmed, S. B. M., Darling, N. J., Harris, M., Mott, H. R., & Owen, D. (2021). A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases. BIOCHEMISTRY, 60(19), 1533-1551. doi:10.1021/acs.biochem.1c00120
Nuts and bolts of the salt-inducible kinases (SIKs)
Darling, N. J., & Cohen, P. (2021). Nuts and bolts of the salt-inducible kinases (SIKs). BIOCHEMICAL JOURNAL, 478(7), 1377-1397. doi:10.1042/BCJ20200502
Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells
Darling, N. J., Arthur, J. S. C., & Cohen, P. (2021). Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 296. doi:10.1016/j.jbc.2021.100428
2020
Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses
Hutchinson, L. D., Darling, N. J., Nicolaou, S., Gori, I., Squair, D. R., Cohen, P., . . . Sapkota, G. P. (2020). Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses. CELL DEATH & DISEASE, 11(1). doi:10.1038/s41419-020-2241-6
2017
ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death
Darling, N. J., Balmanno, K., & Cook, S. J. (2017). ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death. PLOS ONE, 12(9). doi:10.1371/journal.pone.0184907
Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages
Darling, N. J., Toth, R., Arthur, J. S. C., & Clark, K. (2017). Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. BIOCHEMICAL JOURNAL, 474, 521-537. doi:10.1042/BCJ20160646
2014
The role of MAPK signalling pathways in the response to endoplasmic reticulum stress
Darling, N. J., & Cook, S. J. (2014). The role of MAPK signalling pathways in the response to endoplasmic reticulum stress. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1843(10), 2150-2163. doi:10.1016/j.bbamcr.2014.01.009