Publications
Selected publications
- Disruption of HIF1Α translational control attenuates the HIF-dependent hypoxic response and solid tumour formation<i>in vivo</i> (Preprint - 2022)
- Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling (Journal article - 2022)
- PERK/eIF2 alpha signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1 alpha translation (Journal article - 2018)
- Translating the Hypoxic Response-the Role of HIF Protein Translation in the Cellular Response to Low Oxygen. (Journal article - 2019)
- XIAP upregulates expression of HIF target genes by targeting HIF1 alpha for Lys(63)-linked polyubiquitination (Journal article - 2017)
- Regulation of gene expression by hypoxia (Journal article - 2008)
- UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease (Preprint - 2023)
2023
Oxygen-regulated post-translation modifications as master signalling pathway in cells.
Batie, M., Fasanya, T., Kenneth, N. S., & Rocha, S. (2023). Oxygen-regulated post-translation modifications as master signalling pathway in cells.. EMBO reports, e57849. doi:10.15252/embr.202357849
2022
Autophagy promotes cell survival by maintaining NAD levels
Kataura, T., Sedlackova, L., Otten, E. G., Kumari, R., Shapira, D., Scialo, F., . . . Korolchuk, V. I. (2022). Autophagy promotes cell survival by maintaining NAD levels. DEVELOPMENTAL CELL, 57(22), 2584-+. doi:10.1016/j.devcel.2022.10.008
Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
Hunter, J. E., Campbell, A. E., Butterworth, J. A., Sellier, H., Hannaway, N. L., Luli, S., . . . Perkins, N. D. (2022). Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance. BIOCHEMICAL JOURNAL, 479(19), 2087-2113. doi:10.1042/BCJ20220089
TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells.
Khazeem, M. M., Casement, J. W., Schlossmacher, G., Kenneth, N. S., Sumbung, N. K., Chan, J. Y. T., . . . Austin, C. A. (2022). TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells.. Molecular neurobiology, 59(10), 5987-6008. doi:10.1007/s12035-022-02949-6
Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase.
Russell, L. G., Davis, L. A. K., Hunter, J. E., Perkins, N. D., & Kenneth, N. S. (2022). Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase.. Scientific reports, 12(1), 7943. doi:10.1038/s41598-022-11438-8
Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling
Batie, M., Kenneth, N. S., & Rocha, S. (2022). Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling. The Biochemical journal, 479(3), 245-257. doi:10.1042/BCJ20210554
2021
PBRM1 Cooperates with YTHDF2 to Control HIF-1 alpha Protein Translation
Shmakova, A., Frost, M., Batie, M., Kenneth, N. S., & Rocha, S. (2021). PBRM1 Cooperates with YTHDF2 to Control HIF-1 alpha Protein Translation. CELLS, 10(6). doi:10.3390/cells10061425
2020
Autophagy promotes cell and organismal survival by maintaining NAD(H) pools
Sedlackova, L., Otten, E., Scialo, F., Shapira, D., Kataura, T., Carroll, B., . . . Korolchuk, V. (2020). Autophagy promotes cell and organismal survival by maintaining NAD(H) pools. doi:10.1101/2020.01.31.928424
2019
Translating the Hypoxic Response-the Role of HIF Protein Translation in the Cellular Response to Low Oxygen.
Ivanova, I. G., Park, C. V., & Kenneth, N. S. (2019). Translating the Hypoxic Response-the Role of HIF Protein Translation in the Cellular Response to Low Oxygen.. Cells, 8(2), E114. doi:10.3390/cells8020114
2018
Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN
Hunter, J., Butterworth, J., Sellier, H., Luli, S., Floudas, A., Moore, A., . . . Perkins, N. (2018). Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN. doi:10.1101/358291
PERK/eIF2 alpha signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1 alpha translation
Ivanova, I. G., Park, C. V., Yemm, A. I., & Kenneth, N. S. (2018). PERK/eIF2 alpha signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1 alpha translation. Nucleic Acids Research, 46(8), 3878-3890. doi:10.1093/nar/gky127
Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
Carroll, B., Otten, E. G., Manni, D., Stefanatos, R., Menzies, F. M., Smith, G. R., . . . Korolchuk, V. I. (2018). Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nature Communications, 9. doi:10.1038/s41467-017-02746-z
2017
XIAP upregulates expression of HIF target genes by targeting HIF1 alpha for Lys(63)-linked polyubiquitination
Park, C. V., Ivanova, I. G., & Kenneth, N. S. (2017). XIAP upregulates expression of HIF target genes by targeting HIF1 alpha for Lys(63)-linked polyubiquitination. Nucleic Acids Research, 45(16), 9336-9347. doi:10.1093/nar/gkx549
2014
Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways
Kenneth, N. S., Hucks, G. E. J., Kocab, A. J., McCollom, A. L., & Duckett, C. S. (2014). Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways. CELL CYCLE, 13(6), 1006-1014. doi:10.4161/cc.27922
2013
TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling
Kenneth, N. S., Mudie, S., Naron, S., & Rocha, S. (2013). TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling. BIOCHEMICAL JOURNAL, 449, 275-284. doi:10.1042/BJ20120625
2012
IAP proteins: regulators of cell migration and development
Kenneth, N. S., & Duckett, C. S. (2012). IAP proteins: regulators of cell migration and development. CURRENT OPINION IN CELL BIOLOGY, 24(6), 871-875. doi:10.1016/j.ceb.2012.11.004
IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function
IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function (2012). The EMBO journal, 31(11), 2660-2661. doi:10.1038/emboj.2012.135
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1
Kenneth, N. S., Younger, J. M., Hughes, E. D., Marcotte, D., Barker, P. A., Saunders, T. L., & Duckett, C. S. (2012). An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. BIOCHEMICAL JOURNAL, 443, 355-359. doi:10.1042/BJ20120249
Direct Regulation of tRNA and 5S rRNA Gene Transcription by Polo-like Kinase 1
Fairley, J. A., Mitchell, L. E., Berg, T., Kenneth, N. S., von Schubert, C., Sillje, H. H. W., . . . White, R. J. (2012). Direct Regulation of tRNA and 5S rRNA Gene Transcription by Polo-like Kinase 1. MOLECULAR CELL, 45(4), 541-552. doi:10.1016/j.molcel.2011.11.030
2011
Evolutionary Conserved Regulation of HIF-1β by NF-κB
van Uden, P., Kenneth, N. S., Webster, R., Mueller, H. A., Mudie, S., & Rocha, S. (2011). Evolutionary Conserved Regulation of HIF-1β by NF-κB. PLOS GENETICS, 7(1). doi:10.1371/journal.pgen.1001285
2010
Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection
Newton, I. P., Kenneth, N. S., Appleton, P. L., Naethke, I., & Rocha, S. (2010). Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection. MOLECULAR BIOLOGY OF THE CELL, 21(21), 3630-3638. doi:10.1091/mbc.E10-04-0312
IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function
Kenneth, N. S., Mudie, S., & Rocha, S. (2010). IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function. EMBO JOURNAL, 29(17), 2966-2978. doi:10.1038/emboj.2010.171
Mechanisms of RNA polymerase III transcriptional activation by c-Myc.
Kenneth, N. S. (2010). Mechanisms of RNA polymerase III transcriptional activation by c-Myc..
2009
SWI/SNF Regulates the Cellular Response to Hypoxia
Kenneth, N. S., Mudie, S., van Uden, P., & Rocha, S. (2009). SWI/SNF Regulates the Cellular Response to Hypoxia. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(7), 4123-4131. doi:10.1074/jbc.M808491200
Regulation by c-Myc of ncRNA expression
Kenneth, N. S., & White, R. J. (2009). Regulation by c-Myc of ncRNA expression. CURRENT OPINION IN GENETICS & DEVELOPMENT, 19(1), 38-43. doi:10.1016/j.gde.2008.11.012
2008
Regulation of gene expression by hypoxia
Kenneth, N. S., & Rocha, S. (2008). Regulation of gene expression by hypoxia. BIOCHEMICAL JOURNAL, 414, 19-29. doi:10.1042/BJ20081055
Regulation of hypoxia-inducible factor-1α by NF-κB
van Uden, P., Kenneth, N. S., & Rocha, S. (2008). Regulation of hypoxia-inducible factor-1α by NF-κB. BIOCHEMICAL JOURNAL, 412, 477-484. doi:10.1042/BJ20080476
Recruitment of RNA polymerase III <i>in vivo</i>
Kenneth, N. S., Marshall, L., & White, R. J. (2008). Recruitment of RNA polymerase III <i>in vivo</i>. NUCLEIC ACIDS RESEARCH, 36(11), 3757-3764. doi:10.1093/nar/gkn272
2007
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription
Kenneth, N. S., Ramsbottom, B. A., Gomez-Roman, N., Marshall, L., Cole, P. A., & White, R. J. (2007). TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(38), 14917-14922. doi:10.1073/pnas.0702909104
2006
Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes
Ernens, I., Goodfellow, S. J., Innes, F., Kenneth, N. S., Derblay, L. E., White, R. J., & Scott, P. H. (2006). Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. NUCLEIC ACIDS RESEARCH, 34(1), 286-294. doi:10.1093/nar/gkj402
Activation by c-Myc of transcription by RNA polymerases I, II and III
Gomez-Roman, N., Felton-Edkins, Z. A., Kenneth, N. S., Goodfellow, S. J., Athineos, D., Zhang, J. X., . . . White, R. J. (2006). Activation by c-Myc of transcription by RNA polymerases I, II and III. TRANSCRIPTION, 73, 141-154. doi:10.1042/bss0730141
2005
Human La is found at RNA polymerase III-transcribed genes <i>in vivo</i>
Fairley, J. A., Kantidakis, T., Kenneth, N. S., Intine, R. V., Maraia, R. J., & White, R. J. (2005). Human La is found at RNA polymerase III-transcribed genes <i>in vivo</i>. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(51), 18350-18355. doi:10.1073/pnas.0506415102
2003
Direct Regulation of RNA Polymerase III Transcription by RB, p53 and c-Myc
Felton-Edkins, Z. A., Kenneth, N. S., Brown, T. R. P., Daly, N. L., Gomez-Roman, N., Grandori, C., . . . White, R. J. (2003). Direct Regulation of RNA Polymerase III Transcription by RB, p53 and c-Myc. CELL CYCLE, 2(3), 181-184. doi:10.4161/cc.2.3.375