Publications
2024
Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017.
Kovacs, D., Mambule, I., Read, J. M., Kiran, A., Chilombe, M., Bvumbwe, T., . . . Ho, A. (2024). Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017.. The Journal of infectious diseases, 230(2), e363-e373. doi:10.1093/infdis/jiad587
Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction.
Kalizang'oma, A., Swarthout, T. D., Mwalukomo, T. S., Kamng'ona, A., Brown, C., Msefula, J., . . . Heyderman, R. S. (2024). Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction.. The Journal of infectious diseases, 230(1), e189-e198. doi:10.1093/infdis/jiae040
Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction.
Kalizang'oma, A., Swarthout, T. D., Mwalukomo, T. S., Kamng'ona, A., Brown, C., Msefula, J., . . . Heyderman, R. S. (2024). Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction.. The Journal of infectious diseases, jiae040. doi:10.1093/infdis/jiae040
2023
A Survey of the UK Pharmacy Profession's Educational Needs on Pharmacogenomics
Rollinson, V., French, N., Turner, R., & Pirmohamed, M. (2023). A Survey of the UK Pharmacy Profession's Educational Needs on Pharmacogenomics. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2023. doi:10.1155/2023/2388845
2021
The application of cytokeratin-18 as a biomarker for drug-induced liver injury
Korver, S., Bowen, J., Pearson, K., Gonzalez, R. J., French, N., Park, K., . . . Goldring, C. (2021). The application of cytokeratin-18 as a biomarker for drug-induced liver injury. ARCHIVES OF TOXICOLOGY, 95(11), 3435-3448. doi:10.1007/s00204-021-03121-0
Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models
Jones, S. W., Penman, S. L., French, N. S., Park, B. K., & Chadwick, A. E. (2021). Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models. Toxicology in Vitro, 105096. doi:10.1016/j.tiv.2021.105096
2018
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity
Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030
Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017)
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020
2017
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
Scarfe, L., Brillant, N., Kumar, J. D., Ali, N., Alrumayh, A., Amali, M., . . . Park, B. K. (2017). Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. NPJ REGENERATIVE MEDICINE, 2. doi:10.1038/s41536-017-0029-9
Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells
Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. doi:10.1093/toxsci/kfx069
Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development
Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4
Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.. Journal of Immunology, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209
Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury
Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218
New Approaches to Investigate Drug-Induced Hypersensitivity
Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333
2016
Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury
Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393
Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients
Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253
2015
Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation
Naisbitt, D., Yang, E. L., Alhaidari, M., Berry, N., Lawrenson, A. S., Farrell, J., . . . Park, B. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867
Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409
The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death.
Kamalian, L., Chadwick, A., Bayliss, M., French, N., Monshouwer, M., Snoeys, J., & Park, B. K. (2015). The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death.. Toxicology in Vitro, 29(4), 732-740. doi:10.1016/j.tiv.2015.02.011
Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
Garner, R. C., Park, K. B., French, N. S., Earnshaw, C., Schipani, A., Selby, A. M., . . . Turner, M. A. (2015). Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis. British Journal Of Clinical Pharmacology, 80(1), 157-167. doi:10.1111/bcp.12597
Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin
Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. Chemical Research in Toxicology, 28(1), 51-58. doi:10.1021/tx500285k
2014
Abacavir forms novel cross-linking abacavir protein adducts in patients
Meng, X., Lawrenson, A., Berry, N., Maggs, J., French, N., Back, D., . . . Park, K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Clinical and translational allergy, 4(Suppl 3), P38. doi:10.1186/2045-7022-4-s3-p38
Antigen exposure required for T cell activation
Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-s3-p115
Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury
Usui, T., Saide, K., Meng, X., Whitaker, P., Peckham, D., French, N., . . . Park, K. (2014). Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury. Clinical and translational allergy, 4(Suppl 3), P116. doi:10.1186/2045-7022-4-s3-p116
Abacavir forms novel cross-linking abacavir protein adducts in patients
Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Chemical Research in Toxicology, 27(04), 524-535. doi:10.1021/tx400406p
2013
Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients
Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107
Challenges and approaches for the development of safer immunomodulatory biologics
Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974
Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury
Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077
2012
<i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers
Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). <i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350
Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis
El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900
HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury
Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.
2011
Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury
Lewis, P. J. S., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury. HEPATOLOGY, 54(5), 1767-1776. doi:10.1002/hep.24538
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871
Assessing the Safety of Stem Cell Therapeutics
Goldring, C. E. P., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, B. K. (2011). Assessing the Safety of Stem Cell Therapeutics. Cell Stem Cell, 9(2), 176. doi:10.1016/j.stem.2011.06.006
Assessing the Safety of Stem Cell Therapeutics
Goldring, C. E. P., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, B. K. (2011). Assessing the Safety of Stem Cell Therapeutics. CELL STEM CELL, 8(6), 618-628. doi:10.1016/j.stem.2011.05.012
2001
Context-dependent Pax-5 repression of a PU.1/NF-κB regulated reporter gene in B lineage cells
Linderson, Y., French, N. S., Neurath, M. F., & Pettersson, S. (2001). Context-dependent Pax-5 repression of a PU.1/NF-κB regulated reporter gene in B lineage cells. GENE, 262(1-2), 107-114. doi:10.1016/S0378-1119(00)00546-1
2000
Microbe-host interactions in the alimentary tract: the gateway to understanding inflammatory bowel disease
French, N., & Pettersson, S. (2000). Microbe-host interactions in the alimentary tract: the gateway to understanding inflammatory bowel disease. GUT, 47(2), 162-163. doi:10.1136/gut.47.2.162
1999
Novel <i>Salmonella typhimurium</i> properties in host-parasite interactions
Borg, S., Björkman, J., Eriksson, S., Syk, A., Andersson, D. I., Schesser, K., . . . French, N. S. (1999). Novel <i>Salmonella typhimurium</i> properties in host-parasite interactions. IMMUNOLOGY LETTERS, 68(2-3), 247-249. doi:10.1016/S0165-2478(99)00073-5
1997
Structure and functional properties of mouse VL30 retrotransposons
French, N. S., & Norton, J. D. (1997). Structure and functional properties of mouse VL30 retrotransposons. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1352(1), 33-47. doi:10.1016/S0167-4781(97)00009-2
1996
Suppression of tumorigenicity in Ras-transformed fibroblasts by alpha 2(1) collagen
Travers, H., French, N. S., & Norton, J. D. (1996). Suppression of tumorigenicity in Ras-transformed fibroblasts by alpha 2(1) collagen. CELL GROWTH & DIFFERENTIATION, 7(10), 1353-1360. Retrieved from https://www.webofscience.com/
1995
CONSTRUCTION OF A RETROVIRAL VECTOR INCORPORATING MOUSE VL30 RETROTRANSPOSON-DERIVED, TRANSCRIPTIONAL REGULATORY SEQUENCES
FRENCH, N. S., & NORTON, J. D. (1995). CONSTRUCTION OF A RETROVIRAL VECTOR INCORPORATING MOUSE VL30 RETROTRANSPOSON-DERIVED, TRANSCRIPTIONAL REGULATORY SEQUENCES. ANALYTICAL BIOCHEMISTRY, 228(2), 354-355. doi:10.1006/abio.1995.1364
1994
ANALYSIS OF RETROTRANSPOSON FAMILIES IN GENOMIC DNA BY 2-DIMENSIONAL RESTRICTION MAPPING - DETECTION OF VL30 INSERTIONS IN MOUSE THYMIC LYMPHOMA
FRENCH, N. S., & NORTON, J. D. (1994). ANALYSIS OF RETROTRANSPOSON FAMILIES IN GENOMIC DNA BY 2-DIMENSIONAL RESTRICTION MAPPING - DETECTION OF VL30 INSERTIONS IN MOUSE THYMIC LYMPHOMA. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1219(2), 484-492. doi:10.1016/0167-4781(94)90075-2