Publications
2024
Molecular basis of the biogenesis of a protein organelle for ethanolamine utilization
2023
A mathematical model integrates diverging PXY and MP interactions in cambium development
Bagdassarian, K. S., Etchells, J. P., & Savage, N. S. (2023). A mathematical model integrates diverging PXY and MP interactions in cambium development. IN SILICO PLANTS, 5(1). doi:10.1093/insilicoplants/diad003
2022
2021
Describing the movement of molecules in reduced-dimension models
Savage, N. (2021). Describing the movement of molecules in reduced-dimension models. Communications Biology. doi:10.1038/s42003-021-02200-3
Specifying patterns in 3D: epidermal patterning of roots (https://www.flipsnack.com/LeverhulmeTrust/leverhulme-trust-newsletter-may-2021-dcjepj14ot/full-view.html)
Savage, N., & Bishopp, A. (2021). Specifying patterns in 3D: epidermal patterning of roots (https://www.flipsnack.com/LeverhulmeTrust/leverhulme-trust-newsletter-may-2021-dcjepj14ot/full-view.html). Retrieved from https://www.flipsnack.com/
2020
Describing the movement of molecules in reduced-dimension models
2016
Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast
Woods, B., Lai, H., Wu, C. -F., Zyla, T. R., Savage, N. S., & Lew, D. J. (2016). Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast. Current Biology, 26(16), 2114-2126. doi:10.1016/j.cub.2016.06.047
2015
The Importance of Statistical Measure when Describing Phenotype
Hajne, J. (2015, December 4). The Importance of Statistical Measure when Describing Phenotype. (PhD Thesis, University of Liverpool).
Superresolution microscopy reveals a dynamic picture of cell polarity maintenance during directional growth
Ishitsuka, Y., Savage, N., Yiming, L., Bergs, A., Grun, N., Kolher, D., . . . Takeshita, N. (2015). Superresolution microscopy reveals a dynamic picture of cell polarity maintenance during directional growth. Science advances, 1(10). doi:10.1126/sciadv.1500947
Role of competition between polarity sites in establishing a unique front
Wu, C. -F., Chiou, J. -G., Minakova, M., Woods, B., Tsygankov, D., Zyla, T., . . . Lew, D. (2015). Role of competition between polarity sites in establishing a unique front. eLIFE, 4, 33 pages. doi:10.7554/eLife.11611
2014
UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity
Wang, Z., Linden, L. M., Naegeli, K. M., Ziel, J. W., Chi, Q., Hagedorn, E. J., . . . Sherwood, D. R. (2014). UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. Journal of Cell Biology, 206(5), 619-633. doi:10.1083/jcb.201405026
Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit
Kuo, C. -C., Savage, N. S., Chen, H., Wu, C. -F., Zyla, T. R., & Lew, D. J. (2014). Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit. Current Biology, 24(7), 753-759. doi:10.1016/j.cub.2014.02.024
2013
Interaction between bud-site selection and polarity-establishment machineries in budding yeast.
Wu, C. -F., Savage, N. S., & Lew, D. J. (2013). Interaction between bud-site selection and polarity-establishment machineries in budding yeast.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368(1629), 20130006. doi:10.1098/rstb.2013.0006
Positional signaling and expression of ENHANCER OF TRY AND CPC1 are tuned to increase root hair density in response to phosphate deficiency in Arabidopsis thaliana.
Savage, N., Yang, T. J. W., Chen, C. Y., Lin, K. -L., Monk, N. A. M., & Schmidt, W. (2013). Positional signaling and expression of ENHANCER OF TRY AND CPC1 are tuned to increase root hair density in response to phosphate deficiency in Arabidopsis thaliana.. PloS one, 8(10), e75452. doi:10.1371/journal.pone.0075452
Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis.
Okada, S., Leda, M., Hanna, J., Savage, N. S., Bi, E., & Goryachev, A. B. (2013). Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis.. Developmental cell, 26(2), 148-161. doi:10.1016/j.devcel.2013.06.015
Tracking shallow chemical gradients by actin-driven wandering of the polarization site.
Dyer, J. M., Savage, N. S., Jin, M., Zyla, T. R., Elston, T. C., & Lew, D. J. (2013). Tracking shallow chemical gradients by actin-driven wandering of the polarization site.. Current biology : CB, 23(1), 32-41. doi:10.1016/j.cub.2012.11.014
2012
Mechanistic mathematical model of polarity in yeast.
Savage, N. S., Layton, A. T., & Lew, D. J. (2012). Mechanistic mathematical model of polarity in yeast.. Molecular biology of the cell, 23(10), 1998-2013. doi:10.1091/mbc.e11-10-0837
2011
Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment.
Layton, A. T., Savage, N. S., Howell, A. S., Carroll, S. Y., Drubin, D. G., & Lew, D. J. (2011). Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment.. Current biology : CB, 21(3), 184-194. doi:10.1016/j.cub.2011.01.012
2009
Singularity in polarization: rewiring yeast cells to make two buds.
Howell, A. S., Savage, N. S., Johnson, S. A., Bose, I., Wagner, A. W., Zyla, T. R., . . . Lew, D. J. (2009). Singularity in polarization: rewiring yeast cells to make two buds.. Cell, 139(4), 731-743. doi:10.1016/j.cell.2009.10.024
2008
A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis.
Savage, N. S., Walker, T., Wieckowski, Y., Schiefelbein, J., Dolan, L., & Monk, N. A. M. (2008). A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis.. PLoS biology, 6(9), e235. doi:10.1371/journal.pbio.0060235
From priming to plasticity: the changing fate of rhizodermic cells.
Savage, N. S., & Schmidt, W. (2008). From priming to plasticity: the changing fate of rhizodermic cells.. BioEssays : news and reviews in molecular, cellular and developmental biology, 30(1), 75-81. doi:10.1002/bies.20693
2005
The Effects of State Dependent and State Independent Probabilistic Updating on Boolean Network Dynamics.
Savage, N. (2005, January 3). The Effects of State Dependent and State Independent Probabilistic Updating on Boolean Network Dynamics.. (University of Manchester).
2004
Traffic Reduction in Randomly Generated Information Networks
Savage, N. (2004). Traffic Reduction in Randomly Generated Information Networks. In 16th International Symposium on Mathematical Theory of Networks and Systems, MTNS 2004. Leuven.