Publications
2024
1348 Evaluation of a cancer vaccine targeting MAGED4B in preventing oral cancer development from oral epithelial dysplasia
Gan, C. P., Bang Lee, B. K., Lau, S. H., Kallarakkal, T. G., Zaini, Z. M., Zain, R. B., . . . Lim, K. P. (2024). 1348 Evaluation of a cancer vaccine targeting MAGED4B in preventing oral cancer development from oral epithelial dysplasia. In Regular and Young Investigator Award Abstracts (pp. A1507-A1509). BMJ Publishing Group Ltd. doi:10.1136/jitc-2024-sitc2024.1348
1434 Development of a cancer vaccine for head and neck cancer
Gan, C. P., Kok, S. Y., Bang Lee, B. K., Zainal, S., Zulaziz, N., Chai, S. J., . . . Lim, K. P. (2024). 1434 Development of a cancer vaccine for head and neck cancer. In Regular and Young Investigator Award Abstracts (pp. A1604). BMJ Publishing Group Ltd. doi:10.1136/jitc-2024-sitc2024.1434
Abstract B057: An optimized off-the shelf whole tumor cell vaccine activates T cells that recognize a diverse antigen repertoire with potential to provide meaningful clinical benefit to patients with NSCLC
Ferraro, B., Arndt, J., Tan, G., Yan, J., Bagarazzi, M. L., Savelyeva, N., & Ottensmeier, C. H. (2024). Abstract B057: An optimized off-the shelf whole tumor cell vaccine activates T cells that recognize a diverse antigen repertoire with potential to provide meaningful clinical benefit to patients with NSCLC. Cancer Immunology Research, 12(10_Supplement), B057. doi:10.1158/2326-6074.tumimm24-b057
2022
ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
Mellone, M., Piotrowska, K., Venturi, G., James, L., Bzura, A., Lopez, M. A., . . . Thomas, G. J. (2022). ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance. CANCER RESEARCH, 82(24), 4571-4585. doi:10.1158/0008-5472.CAN-22-0435
Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia
Gan, C. P., Lee, B. K. B., Lau, S. H., Kallarakkal, T. G., Zaini, Z. M., Lye, B. K. W., . . . Lim, K. P. (2022). Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.954567
Safety and Immunogenicity of Combined DNA-Polyethylenimine and Oral Bacterial Idiotypic Vaccine for Patients with B-Cell Non-Hodgkin Lymphoma: A Pilot Study
Meleshko, A., Piatrouskaya, N., Vashkevich, K., Lutskovich, D., Wang, C., Dormeshkin, D., . . . Katsin, M. (2022). Safety and Immunogenicity of Combined DNA-Polyethylenimine and Oral Bacterial Idiotypic Vaccine for Patients with B-Cell Non-Hodgkin Lymphoma: A Pilot Study. CANCERS, 14(14). doi:10.3390/cancers14143298
Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer.
McCann, K., von Witzleben, A., Thomas, J., Wang, C., Wood, O., Singh, D., . . . Ottensmeier, C. (2022). Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer.. Journal for immunotherapy of cancer, 10(3). doi:10.1136/jitc-2021-003821
2021
IMMUNE PROFILING REVEALS ENRICHMENT OF DISTINCT IMMUNE SIGNATURES IN HIGH-RISK ORAL POTENTIALLY MALIGNANT DISORDERS
Gan, C., Lee, B. K. B., Lau, S. H., Kallarakkal, T. G., Zaini, Z. M., Zain, R. B., . . . Lim, K. P. (2021). IMMUNE PROFILING REVEALS ENRICHMENT OF DISTINCT IMMUNE SIGNATURES IN HIGH-RISK ORAL POTENTIALLY MALIGNANT DISORDERS. In JOURNAL FOR IMMUNOTHERAPY OF CANCER Vol. 9 (pp. A957). doi:10.1136/jitc-2021-SITC2021.911
DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor
Wang, C., Zainal, N. S., Chai, S. J., Dickie, J., Gan, C. P., Zulaziz, N., . . . Lim, K. P. (2021). DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.763086
2020
Novel players: tissue-resident memory B cells
Savelyeva, N., & Ottensmeier, C. H. (2020). Novel players: tissue-resident memory B cells. BLOOD, 136(24), 2722-2723. doi:10.1182/blood.2020007890
HNSCC: Tumour Antigens and Their Targeting by Immunotherapy
von Witzleben, A., Wang, C., Laban, S., Savelyeva, N., & Ottensmeier, C. H. (2020). HNSCC: Tumour Antigens and Their Targeting by Immunotherapy. CELLS, 9(9). doi:10.3390/cells9092103
NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors
Ford, K., Hanley, C. J., Mellone, M., Szyndralewiez, C., Heitz, F., Wiesel, P., . . . Thomas, G. J. (2020). NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors. CANCER RESEARCH, 80(9), 1846-1860. doi:10.1158/0008-5472.CAN-19-3158
2019
Abstract 1466: Combination immunotherapy successfully control tumor growth in a transgenic mouse model
Lim, K. P., Zainal, S., Zulaziz, N., Gan, C. P., Chai, S. J., Lye, B. K. W., . . . Cheong, S. C. (2019). Abstract 1466: Combination immunotherapy successfully control tumor growth in a transgenic mouse model. In Clinical Research (Excluding Clinical Trials) (pp. 1466). American Association for Cancer Research. doi:10.1158/1538-7445.sabcs18-1466
Combination immunotherapy successfully control tumor growth in a transgenic mouse model
Lim, K. P., Zainal, S., Zulaziz, N., Gan, C. P., Chai, S. J., Lye, B. K. W., . . . Cheong, S. C. (2019). Combination immunotherapy successfully control tumor growth in a transgenic mouse model. In CANCER RESEARCH Vol. 79. doi:10.1158/1538-7445.AM2019-1466
Plant viral particle vaccine induces a potent antitumor response through induction of antigen-specific T-cells and overcoming an immunosuppressive tumor microenvironment
Wang, C., Wang, Y., Allen, A. J., Jobsri, J., Thomas, G. J., Ottensmeier, C. H., & Savelyeva, N. (2019). Plant viral particle vaccine induces a potent antitumor response through induction of antigen-specific T-cells and overcoming an immunosuppressive tumor microenvironment. In CANCER IMMUNOLOGY RESEARCH Vol. 7. doi:10.1158/2326-6074.CRICIMTEATIAACR18-B139
2018
Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model
Allen, A., Wang, C., Caproni, L. J., Sugiyarto, G., Harden, E., Douglas, L. R., . . . Savelyeva, N. (2018). Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model. CANCER IMMUNOLOGY IMMUNOTHERAPY, 67(4), 627-638. doi:10.1007/s00262-017-2111-y
Targeting Head and Neck Cancer by Vaccination
Wang, C., Dickie, J., Sutavani, R. V., Pointer, C., Thomas, G. J., & Savelyeva, N. (2018). Targeting Head and Neck Cancer by Vaccination. FRONTIERS IN IMMUNOLOGY, 9. doi:10.3389/fimmu.2018.00830
2017
Cancer Vaccines Preface
Savelyeva, N., & Ottensmeier, C. (2017). Cancer Vaccines Preface. In CANCER VACCINES (Vol. 405, pp. V-VI). Retrieved from https://www.webofscience.com/
Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination
Savelyeva, N., Allen, A., Chotprakaikiat, W., Harden, E., Jobsri, J., Godeseth, R., . . . Ottensmeier, C. (2017). Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination. CANCER VACCINES, 405, 123-143. doi:10.1007/82_2016_500
2016
Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors
Wood, O., Woo, J., Seumois, G., Savelyeva, N., McCann, K. J., Singh, D., . . . Consortium, S. P. A. R. C. (2016). Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors. Oncotarget, 7(35), 56781-56797. doi:10.18632/oncotarget.10788
IL-4 enhances expression and function of surface IgM in CLL cells
Aguilar-Hernandez, M. M., Blunt, M. D., Dobson, R., Yeomans, A., Thirdborough, S., Larrayoz, M., . . . Steele, A. J. (2016). IL-4 enhances expression and function of surface IgM in CLL cells. BLOOD, 127(24), 3015-3025. doi:10.1182/blood-2015-11-682906
A plant-expressed conjugate vaccine breaks CD4<SUP>+</SUP> tolerance and induces potent immunity against metastatic Her2<SUP>+</SUP> breast cancer
Chotprakaikiat, W., Allen, A., Bui-Minh, D., Harden, E., Jobsri, J., Cavallo, F., . . . Savelyeva, N. (2016). A plant-expressed conjugate vaccine breaks CD4<SUP>+</SUP> tolerance and induces potent immunity against metastatic Her2<SUP>+</SUP> breast cancer. ONCOIMMUNOLOGY, 5(6). doi:10.1080/2162402X.2016.1166323
Response to vaccination via tumour draining lymph nodes does not demonstrate a tumour suppressive effect in patients with breast cancer: A peri-surgical window study
Layfield, D., Clarke, J., Savelyeva, N., Cutress, R., & Ottensmeier, C. (2016). Response to vaccination via tumour draining lymph nodes does not demonstrate a tumour suppressive effect in patients with breast cancer: A peri-surgical window study. European Journal of Surgical Oncology (EJSO), 42(5), S43. doi:10.1016/j.ejso.2016.02.169
2015
Vaccine based immunotherapy as a strategy to bypass drug resistance in multiple myeloma
Wang, C., Gourzones, C., Weston-Bell, N., Rice, J., Zojer, N., Vacca, A., . . . Sahota, S. S. (2015). Vaccine based immunotherapy as a strategy to bypass drug resistance in multiple myeloma. Clinical Lymphoma Myeloma and Leukemia, 15, e285-e286. doi:10.1016/j.clml.2015.07.586
Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody
Jobsri, J., Allen, A., Rajagopal, D., Shipton, M., Kanyuka, K., Lomonossoff, G. P., . . . Savelyeva, N. (2015). Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody. PLOS ONE, 10(2). doi:10.1371/journal.pone.0118096
2013
Chapter 15 Genetic Vaccines against Cancer Design, Testing and Clinical Performance
Stevenson, F. K., di Genova, G., Ottensmeier, C. H., & Savelyeva, N. (2013). Chapter 15 Genetic Vaccines against Cancer Design, Testing and Clinical Performance. In Cancer Immunotherapy (pp. 223-239). Elsevier. doi:10.1016/b978-0-12-394296-8.00015-4
Genetic Vaccines against Cancer
Stevenson, F. K., di Genova, G., Ottensmeier, C. H., & Savelyeva, N. (2013). Genetic Vaccines against Cancer. In Cancer Immunotherapy (pp. 223-239). Elsevier. doi:10.1016/b978-0-12-394296-8.00015-4
2009
Defining Multiple Myeloma as a Target for DNA Fusion Gene Vaccines
Sahota, S. S., Zojer, N., Babbage, G., Joseph-Pietras, D., Weston-Bell, N., Vanderkerken, K., . . . Ottensmeier, C. H. (2009). Defining Multiple Myeloma as a Target for DNA Fusion Gene Vaccines. In CLINICAL LYMPHOMA & MYELOMA Vol. 9 (pp. S23-S24). doi:10.1016/S1557-9190(11)70813-7
2007
Cancer Vaccines
Stevenson, F. K., Genova, G. D., Ottensmeier, C., & Savelyeva, N. (2007). Cancer Vaccines. In Cancer Immunotherapy (pp. 183-204). Elsevier. doi:10.1016/b978-012372551-6/50075-4
Cancer Vaccines
Stevenson, F. K., di Genova, G., Ottensmeier, C., & Savelyeva, N. (2007). Cancer Vaccines. In Cancer Immunotherapy: Immune Suppression and Tumor Growth (pp. 183-204). doi:10.1016/B978-012372551-6/50075-4
Chapter 11 Cancer Vaccines
Stevenson, F. K., di Genova, G., Ottensmeier, C., & Savelyeva, N. (2007). Chapter 11 Cancer Vaccines. In Cancer Immunotherapy (pp. 183-204). Elsevier. doi:10.1016/b978-012372551-6/50075-4
2004
DNA vaccines to attack cancer
Stevenson, F. K., Ottensmeier, C. H., Johnson, P., Zhu, D. L., Buchan, S. L., McCann, K. J., . . . Rice, J. (2004). DNA vaccines to attack cancer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 14646-14652. doi:10.1073/pnas.0404896101