Publications
2024
Abstract B057: An optimized off-the shelf whole tumor cell vaccine activates T cells that recognize a diverse antigen repertoire with potential to provide meaningful clinical benefit to patients with NSCLC
Ferraro, B., Arndt, J., Tan, G., Yan, J., Bagarazzi, M. L., Savelyeva, N., & Ottensmeier, C. H. (2024). Abstract B057: An optimized off-the shelf whole tumor cell vaccine activates T cells that recognize a diverse antigen repertoire with potential to provide meaningful clinical benefit to patients with NSCLC. Cancer Immunology Research, 12(10_Supplement), B057. doi:10.1158/2326-6074.tumimm24-b057
2022
ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
Mellone, M., Piotrowska, K., Venturi, G., James, L., Bzura, A., Lopez, M. A., . . . Thomas, G. J. (2022). ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance. CANCER RESEARCH, 82(24), 4571-4585. doi:10.1158/0008-5472.CAN-22-0435
Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia
Gan, C. P., Lee, B. K. B., Lau, S. H., Kallarakkal, T. G., Zaini, Z. M., Lye, B. K. W., . . . Lim, K. P. (2022). Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.954567
Safety and Immunogenicity of Combined DNA-Polyethylenimine and Oral Bacterial Idiotypic Vaccine for Patients with B-Cell Non-Hodgkin Lymphoma: A Pilot Study
Meleshko, A., Piatrouskaya, N., Vashkevich, K., Lutskovich, D., Wang, C., Dormeshkin, D., . . . Katsin, M. (2022). Safety and Immunogenicity of Combined DNA-Polyethylenimine and Oral Bacterial Idiotypic Vaccine for Patients with B-Cell Non-Hodgkin Lymphoma: A Pilot Study. CANCERS, 14(14). doi:10.3390/cancers14143298
Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer.
McCann, K., von Witzleben, A., Thomas, J., Wang, C., Wood, O., Singh, D., . . . Ottensmeier, C. (2022). Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer.. Journal for immunotherapy of cancer, 10(3). doi:10.1136/jitc-2021-003821
2021
IMMUNE PROFILING REVEALS ENRICHMENT OF DISTINCT IMMUNE SIGNATURES IN HIGH-RISK ORAL POTENTIALLY MALIGNANT DISORDERS
Gan, C., Lee, B. K. B., Lau, S. H., Kallarakkal, T. G., Zaini, Z. M., Zain, R. B., . . . Lim, K. P. (2021). IMMUNE PROFILING REVEALS ENRICHMENT OF DISTINCT IMMUNE SIGNATURES IN HIGH-RISK ORAL POTENTIALLY MALIGNANT DISORDERS. In JOURNAL FOR IMMUNOTHERAPY OF CANCER Vol. 9 (pp. A957). doi:10.1136/jitc-2021-SITC2021.911
DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor
Wang, C., Zainal, N. S., Chai, S. J., Dickie, J., Gan, C. P., Zulaziz, N., . . . Lim, K. P. (2021). DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.763086
2020
Novel players: tissue-resident memory B cells
Savelyeva, N., & Ottensmeier, C. H. (2020). Novel players: tissue-resident memory B cells. BLOOD, 136(24), 2722-2723. doi:10.1182/blood.2020007890
HNSCC: Tumour Antigens and Their Targeting by Immunotherapy
von Witzleben, A., Wang, C., Laban, S., Savelyeva, N., & Ottensmeier, C. H. (2020). HNSCC: Tumour Antigens and Their Targeting by Immunotherapy. CELLS, 9(9). doi:10.3390/cells9092103
NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors
Ford, K., Hanley, C. J., Mellone, M., Szyndralewiez, C., Heitz, F., Wiesel, P., . . . Thomas, G. J. (2020). NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors. CANCER RESEARCH, 80(9), 1846-1860. doi:10.1158/0008-5472.CAN-19-3158
2019
Abstract 1466: Combination immunotherapy successfully control tumor growth in a transgenic mouse model
Lim, K. P., Zainal, S., Zulaziz, N., Gan, C. P., Chai, S. J., Lye, B. K. W., . . . Cheong, S. C. (2019). Abstract 1466: Combination immunotherapy successfully control tumor growth in a transgenic mouse model. In Clinical Research (Excluding Clinical Trials) (pp. 1466). American Association for Cancer Research. doi:10.1158/1538-7445.sabcs18-1466
Combination immunotherapy successfully control tumor growth in a transgenic mouse model
Lim, K. P., Zainal, S., Zulaziz, N., Gan, C. P., Chai, S. J., Lye, B. K. W., . . . Cheong, S. C. (2019). Combination immunotherapy successfully control tumor growth in a transgenic mouse model. In CANCER RESEARCH Vol. 79. doi:10.1158/1538-7445.AM2019-1466
Plant viral particle vaccine induces a potent antitumor response through induction of antigen-specific T-cells and overcoming an immunosuppressive tumor microenvironment
Wang, C., Wang, Y., Allen, A. J., Jobsri, J., Thomas, G. J., Ottensmeier, C. H., & Savelyeva, N. (2019). Plant viral particle vaccine induces a potent antitumor response through induction of antigen-specific T-cells and overcoming an immunosuppressive tumor microenvironment. In CANCER IMMUNOLOGY RESEARCH Vol. 7. doi:10.1158/2326-6074.CRICIMTEATIAACR18-B139
2018
Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model
Allen, A., Wang, C., Caproni, L. J., Sugiyarto, G., Harden, E., Douglas, L. R., . . . Savelyeva, N. (2018). Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model. CANCER IMMUNOLOGY IMMUNOTHERAPY, 67(4), 627-638. doi:10.1007/s00262-017-2111-y
Targeting Head and Neck Cancer by Vaccination
Wang, C., Dickie, J., Sutavani, R. V., Pointer, C., Thomas, G. J., & Savelyeva, N. (2018). Targeting Head and Neck Cancer by Vaccination. FRONTIERS IN IMMUNOLOGY, 9. doi:10.3389/fimmu.2018.00830
2017
Cancer Vaccines Preface
Savelyeva, N., & Ottensmeier, C. (2017). Cancer Vaccines Preface. In CANCER VACCINES (Vol. 405, pp. V-VI). Retrieved from https://www.webofscience.com/
Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination
Savelyeva, N., Allen, A., Chotprakaikiat, W., Harden, E., Jobsri, J., Godeseth, R., . . . Ottensmeier, C. (2017). Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination. CANCER VACCINES, 405, 123-143. doi:10.1007/82_2016_500
2016
Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors
Wood, O., Woo, J., Seumois, G., Savelyeva, N., McCann, K. J., Singh, D., . . . Consortium, S. P. A. R. C. (2016). Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors. Oncotarget, 7(35), 56781-56797. doi:10.18632/oncotarget.10788
IL-4 enhances expression and function of surface IgM in CLL cells
Aguilar-Hernandez, M. M., Blunt, M. D., Dobson, R., Yeomans, A., Thirdborough, S., Larrayoz, M., . . . Steele, A. J. (2016). IL-4 enhances expression and function of surface IgM in CLL cells. BLOOD, 127(24), 3015-3025. doi:10.1182/blood-2015-11-682906
A plant-expressed conjugate vaccine breaks CD4<SUP>+</SUP> tolerance and induces potent immunity against metastatic Her2<SUP>+</SUP> breast cancer
Chotprakaikiat, W., Allen, A., Bui-Minh, D., Harden, E., Jobsri, J., Cavallo, F., . . . Savelyeva, N. (2016). A plant-expressed conjugate vaccine breaks CD4<SUP>+</SUP> tolerance and induces potent immunity against metastatic Her2<SUP>+</SUP> breast cancer. ONCOIMMUNOLOGY, 5(6). doi:10.1080/2162402X.2016.1166323
Response to vaccination via tumour draining lymph nodes does not demonstrate a tumour suppressive effect in patients with breast cancer: A peri-surgical window study
Layfield, D., Clarke, J., Savelyeva, N., Cutress, R., & Ottensmeier, C. (2016). Response to vaccination via tumour draining lymph nodes does not demonstrate a tumour suppressive effect in patients with breast cancer: A peri-surgical window study. European Journal of Surgical Oncology (EJSO), 42(5), S43. doi:10.1016/j.ejso.2016.02.169
2015
Vaccine based immunotherapy as a strategy to bypass drug resistance in multiple myeloma
Wang, C., Gourzones, C., Weston-Bell, N., Rice, J., Zojer, N., Vacca, A., . . . Sahota, S. S. (2015). Vaccine based immunotherapy as a strategy to bypass drug resistance in multiple myeloma. Clinical Lymphoma Myeloma and Leukemia, 15, e285-e286. doi:10.1016/j.clml.2015.07.586
Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody
Jobsri, J., Allen, A., Rajagopal, D., Shipton, M., Kanyuka, K., Lomonossoff, G. P., . . . Savelyeva, N. (2015). Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody. PLOS ONE, 10(2). doi:10.1371/journal.pone.0118096
2013
Chapter 15 Genetic Vaccines against Cancer Design, Testing and Clinical Performance
Stevenson, F. K., di Genova, G., Ottensmeier, C. H., & Savelyeva, N. (2013). Chapter 15 Genetic Vaccines against Cancer Design, Testing and Clinical Performance. In Cancer Immunotherapy (pp. 223-239). Elsevier. doi:10.1016/b978-0-12-394296-8.00015-4
Genetic Vaccines against Cancer
Stevenson, F. K., di Genova, G., Ottensmeier, C. H., & Savelyeva, N. (2013). Genetic Vaccines against Cancer. In Cancer Immunotherapy (pp. 223-239). Elsevier. doi:10.1016/b978-0-12-394296-8.00015-4
2009
Defining Multiple Myeloma as a Target for DNA Fusion Gene Vaccines
Sahota, S. S., Zojer, N., Babbage, G., Joseph-Pietras, D., Weston-Bell, N., Vanderkerken, K., . . . Ottensmeier, C. H. (2009). Defining Multiple Myeloma as a Target for DNA Fusion Gene Vaccines. In CLINICAL LYMPHOMA & MYELOMA Vol. 9 (pp. S23-S24). doi:10.1016/S1557-9190(11)70813-7
2007
Cancer Vaccines
Stevenson, F. K., Genova, G. D., Ottensmeier, C., & Savelyeva, N. (2007). Cancer Vaccines. In Cancer Immunotherapy (pp. 183-204). Elsevier. doi:10.1016/b978-012372551-6/50075-4
Cancer Vaccines
Stevenson, F. K., di Genova, G., Ottensmeier, C., & Savelyeva, N. (2007). Cancer Vaccines. In Cancer Immunotherapy: Immune Suppression and Tumor Growth (pp. 183-204). doi:10.1016/B978-012372551-6/50075-4
Chapter 11 Cancer Vaccines
Stevenson, F. K., di Genova, G., Ottensmeier, C., & Savelyeva, N. (2007). Chapter 11 Cancer Vaccines. In Cancer Immunotherapy (pp. 183-204). Elsevier. doi:10.1016/b978-012372551-6/50075-4
2004
DNA vaccines to attack cancer
Stevenson, F. K., Ottensmeier, C. H., Johnson, P., Zhu, D. L., Buchan, S. L., McCann, K. J., . . . Rice, J. (2004). DNA vaccines to attack cancer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 14646-14652. doi:10.1073/pnas.0404896101