Publications
2023
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture.
International League Against Epilepsy Consortium on Complex Epilepsies. (2023). GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture.. Nature genetics, 55(9), 1471-1482. doi:10.1038/s41588-023-01485-w
Statins as an antiepileptogenic or disease-modifying treatment? A survey of what UK patients and significant others think about repurposing and trialing them for epilepsy
Noble, A., Dixon, P., Roper, L., Marson, T., & Mirza, N. (2023). Statins as an antiepileptogenic or disease-modifying treatment? A survey of what UK patients and significant others think about repurposing and trialing them for epilepsy. EPILEPSY & BEHAVIOR, 138. doi:10.1016/j.yebeh.2022.108991
2022
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies
Taweel, B., Marson, A. G., & Mirza, N. (2022). A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies. EPILEPSIA, 63(12), 3125-3133. doi:10.1111/epi.17429
Statins as antiepileptogenic drugs: Analyzing the evidence and identifying the most promising statin
Hufthy, Y., Bharadwaj, M., Gupta, S., Hussain, D., Joseph, P. J. S., Khan, A., . . . Mirza, N. (2022). Statins as antiepileptogenic drugs: Analyzing the evidence and identifying the most promising statin. EPILEPSIA, 63(8), 1889-1898. doi:10.1111/epi.17303
Seizure-Associated Genes Acrosss Species database offers insights into epilepsy genes, pathways, and treatments
Gracie, L., Rostami-Hochaghan, D., Taweel, B., & Mirza, N. (2022). Seizure-Associated Genes Acrosss Species database offers insights into epilepsy genes, pathways, and treatments. EPILEPSIA, 63(9), 2403-2412. doi:10.1111/epi.17352
Widening prospective and current medical students' participation in research
Gracie, L., Rostami-Hochaghan, D., Taweel, B., & Mirza, N. (2022). Widening prospective and current medical students' participation in research. MEDICAL EDUCATION. doi:10.1111/medu.14779
2021
Using common genetic variants to find drugs for common epilepsies
Mirza, N., Stevelink, R., Taweel, B., Koeleman, B. P. C., Marson, A. G., Abou-Khalil, B., . . . Zimprich, F. (2021). Using common genetic variants to find drugs for common epilepsies. Brain Communications, 3(4). doi:10.1093/braincomms/fcab287
2020
Is NIPA1-associated hereditary spastic paraplegia always 'pure'? Further evidence of motor neurone disease and epilepsy as rare manifestations
Tanti, M., Cairns, D., Mirza, N., McCann, E., & Young, C. (2020). Is NIPA1-associated hereditary spastic paraplegia always 'pure'? Further evidence of motor neurone disease and epilepsy as rare manifestations. NEUROGENETICS, 21(4), 305-308. doi:10.1007/s10048-020-00619-0
2018
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
The International League Against Epilepsy Consortium on Complex Epilepsies. (2018). Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nature Communications, 9. doi:10.1038/s41467-018-07524-z
New uses for old drugs
Pantziarka, P., Pirmohamed, M., & Mirza, N. (2018). New uses for old drugs. BMJ-BRITISH MEDICAL JOURNAL, 361. doi:10.1136/bmj.k2701
The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy
Sivapalarajah, S., Krishnakumar, M., Bickerstaffe, H., Chan, Y., Clarkson, J., Hampden-Martin, A., . . . Mirza, N. (2018). The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy. Epilepsia, 59(2), 492-501. doi:10.1111/epi.13994
2017
Genetic regulation of gene expression in the epileptic human hippocampus
Mirza, N., Appleton, R., Burn, S., du Plessis, D., Duncan, R., Farah, J. O., . . . Pirmohamed, M. (2017). Genetic regulation of gene expression in the epileptic human hippocampus. HUMAN MOLECULAR GENETICS, 26(9), 1759-1769. doi:10.1093/hmg/ddx061
Identifying new antiepileptic drugs through genomics-based drug repurposing
Mirza, N., Sills, G. J., Pirmohamed, M., & Marson, A. G. (2017). Identifying new antiepileptic drugs through genomics-based drug repurposing. HUMAN MOLECULAR GENETICS, 26(3), 527-537. doi:10.1093/hmg/ddw410
2016
An integrative <i>in silico</i> system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters
Mirza, N., Vasieva, O., Appleton, R., Burn, S., Carr, D., Crooks, D., . . . Pirmohamed, M. (2016). An integrative <i>in silico</i> system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters. EPILEPSIA, 57(9), 1467-1474. doi:10.1111/epi.13473
2015
Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality
Mirza, N., Appleton, R., Burn, S., Carr, D. F., Crooks, D., du Plessis, D., . . . Pirmohamed, M. (2015). Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality. Human Molecular Genetics, 24(15), 4306-4316. doi:10.1093/hmg/ddv163
Personalized medicine approaches in epilepsy
Walker, L. E., Mirza, N., Yip, V. L. M., Marson, A. G., & Pirmohamed, M. (2015). Personalized medicine approaches in epilepsy. JOURNAL OF INTERNAL MEDICINE, 277(2), 218-234. doi:10.1111/joim.12322
2014
Pharmacoresistance in Epilepsy: An Integrative Genetic & Genomic Analysis
Mirza, N. (2014). Pharmacoresistance in Epilepsy: An Integrative Genetic & Genomic Analysis. (PhD Thesis, University of Liverpool).
2011
Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery
Mirza, N., Vasieva, O., Marson, A. G., & Pirmohamed, M. (2011). Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery. HUMAN MOLECULAR GENETICS, 20(22), 4381-4394. doi:10.1093/hmg/ddr365
Metabolic acidosis with topiramate and zonisamide
Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide. Pharmacogenetics and Genomics, 21(5), 297-302. doi:10.1097/fpc.0b013e3283441b95
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors
Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. PHARMACOGENETICS AND GENOMICS, 21(5), 297-302. doi:10.1097/FPC.0b013e3283441b95
2009
Effect of topiramate on acid-base balance: extent, mechanism and effects
Mirza, N., Marson, A. G., & Pirmohamed, M. (2009). Effect of topiramate on acid-base balance: extent, mechanism and effects. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(5), 655-661. doi:10.1111/j.1365-2125.2009.03521.x