Publications
2022
Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle
Voronina, S., Chvanov, M., De Faveri, F., Mayer, U., Wileman, T., Criddle, D., & Tepikin, A. (2022). Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle. CELLS, 11(16). doi:10.3390/cells11162514
2021
Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1
Ouyang, Y., Wen, L., Armstrong, J. A., Chvanov, M., Latawiec, D., Cai, W., . . . Criddle, D. N. (2021). Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1. CELLS, 10(5). doi:10.3390/cells10051035
2020
The role of Ca2+ signalling in the physiology and pathophysiology of exocrine pancreas
Chvanov, M., Voronina, S., Criddle, D. N., & Tepikin, A. V. (2020). The role of Ca2+ signalling in the physiology and pathophysiology of exocrine pancreas. Current Opinion in Physiology, 17, 96-105. doi:10.1016/j.cophys.2020.07.013
Aqueous extraction from dachengqi formula granules reduces the severity of mouse acute pancreatitis via inhibition of pancreatic pro-inflammatory signalling pathways
Ma, X., Jin, T., Han, C., Shi, N., Liang, G., Wen, Y., . . . Xia, Q. (2020). Aqueous extraction from dachengqi formula granules reduces the severity of mouse acute pancreatitis via inhibition of pancreatic pro-inflammatory signalling pathways. JOURNAL OF ETHNOPHARMACOLOGY, 257. doi:10.1016/j.jep.2020.112861
LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells
De Faveri, F., Chvanov, M., Voronina, S., Moore, D., Pollock, L., Haynes, L., . . . Tepikin, A. (2020). LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells. Autophagy, 16(7), 1314-1331. doi:10.1080/15548627.2019.1679514
Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does not Reduce Severity of Experimental Acute Pancreatitis
Chvanov, M., Voronina, S., Zhang, X., Telnova, S., Chard, R., Ouyang, Y., . . . Tepikin, A. V. (2020). Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does not Reduce Severity of Experimental Acute Pancreatitis. CELLS, 9(6). doi:10.3390/cells9061407
2019
Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of <i>in vitro</i> and <i>in vivo</i> studies
Yao, L., Cheng, C., Yang, X., Han, C., Du, D., Liu, T., . . . Xia, Q. (2019). Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of <i>in vitro</i> and <i>in vivo</i> studies. PANCREATOLOGY, 19(2), 209-216. doi:10.1016/j.pan.2018.12.007
Dachengqi Decoction Aqueous Extracts Alleviate the Severity of Experimental Acute Pancreatitis Via Inhibition of Pancreatic Inflammatory Signaling Pathways
Ma, X., Jin, T., Han, C., Shi, N., Wen, Y., Jiang, K., . . . Xia, Q. (2019). Dachengqi Decoction Aqueous Extracts Alleviate the Severity of Experimental Acute Pancreatitis Via Inhibition of Pancreatic Inflammatory Signaling Pathways. In PANCREAS Vol. 48 (pp. 1483). Retrieved from https://www.webofscience.com/
Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine
Zhang, X., Jin, T., Shi, N., Yao, L., Yang, X., Han, C., . . . Sutton, R. (2019). Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine. FRONTIERS IN PHYSIOLOGY, 9. doi:10.3389/fphys.2018.01922
2018
Intracellular rupture, exocytosis and actin interaction of endocytic vacuoles in pancreatic acinar cells: initiating events in acute pancreatitis
Chvanov, M., De Faveri, F., Moore, D., Sherwood, M. W., Awais, M., Voronina, S., . . . Tepikin, A. V. (2018). Intracellular rupture, exocytosis and actin interaction of endocytic vacuoles in pancreatic acinar cells: initiating events in acute pancreatitis. JOURNAL OF PHYSIOLOGY, 596(13), 2547-2564. doi:10.1113/JP275879
Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift
Armstrong, J. A., Cash, N. J., Ouyang, Y., Morton, J. C., Chvanov, M., Latawiec, D., . . . Criddle, D. N. (2018). Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(21), 8032-8047. doi:10.1074/jbc.RA118.003200
TRO40303 Ameliorates Alcohol-Induced Pancreatitis Through Reduction of Fatty Acid Ethyl Ester-Induced Mitochondrial Injury and Necrotic Cell Death
Javed, M. A., Wen, L., Awais, M., Latawiec, D., Huang, W., Chvanov, M., . . . Sutton, R. (2018). TRO40303 Ameliorates Alcohol-Induced Pancreatitis Through Reduction of Fatty Acid Ethyl Ester-Induced Mitochondrial Injury and Necrotic Cell Death. PANCREAS, 47(1), 18-24. doi:10.1097/MPA.0000000000000953
2017
Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis
Szatmary, P., Liu, T., Abrams, S. T., Voronina, S., Wen, L., Chvanov, M., . . . Sutton, R. (2017). Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. PANCREATOLOGY, 17(6), 884-892. doi:10.1016/j.pan.2017.10.002
Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release
Huang, W., Cane, M. C., Mukherjee, R., Szatmary, P., Zhang, X., Elliott, V., . . . Sutton, R. (2017). Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release. Gut, 66(2), 301-313. doi:10.1136/gutjnl-2015-309363
2015
Novel Lipophilic Probe for Detecting Near-Membrane Reactive Oxygen Species Responses and Its Application for Studies of Pancreatic Acinar Cells: Effects of Pyocyanin and L-Ornithine
Chvanov, M., Huang, W., Jin, T., Wen, L., Armstrong, J., Elliot, V., . . . Tepikin, A. (2015). Novel Lipophilic Probe for Detecting Near-Membrane Reactive Oxygen Species Responses and Its Application for Studies of Pancreatic Acinar Cells: Effects of Pyocyanin and L-Ornithine. Antioxidants & Redox Signaling, 22(6), 451-464. doi:10.1089/ars.2013.5589
The role of Ca2+influx in endocytic vacuole formation in pancreatic acinar cells
Voronina, S., Collier, D., Chvanov, M., Middlehurst, B., Beckett, A., Prior, I., . . . Tepikin, A. V. (2015). The role of Ca2+influx in endocytic vacuole formation in pancreatic acinar cells. Biochemical Journal, 465(3), 405-412. doi:10.1042/BJ20140398
2014
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis
Huang, W., Booth, D., Cane, M. C., Chvanov, M., Javed, M. A., Elliott, V., . . . Criddle, D. (2014). Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis. Gut, 63(8), 1313-1324. doi:10.1136/gutjnl-2012-304058
Effects of a Mitochondrial-Targeted Antioxidant Mitoquinone (MitoQ) in Murine Experimental Acute Pancreatitis (AP)
Huang, W., Cash, N., Wen, L., Szatmary, P., Armstrong, J., Chvanov, M., . . . Criddle, D. N. (2014). Effects of a Mitochondrial-Targeted Antioxidant Mitoquinone (MitoQ) in Murine Experimental Acute Pancreatitis (AP). PANCREAS, 43(8), 1367. Retrieved from https://www.webofscience.com/
2013
Fatty Acid Ethyl Ester Synthase Inhibition Ameliorates Ethanol-Induced Ca<SUP>2+</SUP>-Dependent Mitochondrial Dysfunction and Acute Pancreatitis
Huang, W., Booth, D. M., Cane, M. C., Chvanov, M., Javed, M. A., Elliot, V. L., . . . Criddle, D. N. (2013). Fatty Acid Ethyl Ester Synthase Inhibition Ameliorates Ethanol-Induced Ca<SUP>2+</SUP>-Dependent Mitochondrial Dysfunction and Acute Pancreatitis. PANCREAS, 42(8), 1355. Retrieved from https://www.webofscience.com/
Inhibition of Pancreatitis-Associated Cell Death Using a Human Pancreatic Acinar Cell Model
Javed, M. A., Mukherjee, R., Wen, L., Huang, W., Chvanov, M., Awais, M., . . . Sutton, R. (2013). Inhibition of Pancreatitis-Associated Cell Death Using a Human Pancreatic Acinar Cell Model. In PANCREAS Vol. 42 (pp. 1356). Retrieved from https://www.webofscience.com/
L-Histidine- but not L-Arginine-Induced Acute Pancreatitis Involves Cyclophilin D-Dependent Opening of Mitochondrial Permeability Transition Pore
Huang, W., Chvanov, M., Wen, L., Javed, M. A., Jin, T., Tepikin, A. V., . . . Sutton, R. (2013). L-Histidine- but not L-Arginine-Induced Acute Pancreatitis Involves Cyclophilin D-Dependent Opening of Mitochondrial Permeability Transition Pore. In PANCREAS Vol. 42 (pp. 1355). Retrieved from https://www.webofscience.com/
TRO40303 Reduces Mitochondrial Injury and Ameliorates Experimental AP
Javed, M. A., Wen, L., Awais, M., Chvanov, M., Ghaneh, P., Halloran, C., . . . Sutton, R. (2013). TRO40303 Reduces Mitochondrial Injury and Ameliorates Experimental AP. In PANCREAS Vol. 42 (pp. 1356). Retrieved from https://www.webofscience.com/
2010
Pharmacologically Directed Cell Disposal: Labeling Damaged Cells for Phagocytosis as a Strategy against Acute Pancreatitis
Chvanov, M., Petersen, O. H., & Tepikin, A. V. (2010). Pharmacologically Directed Cell Disposal: Labeling Damaged Cells for Phagocytosis as a Strategy against Acute Pancreatitis. MOLECULAR INTERVENTIONS, 10(2), 80-85. doi:10.1124/mi.10.2.9
2009
Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry
Walsh, C. M., Chvanov, M., Haynes, L. P., Petersen, O. H., Tepikin, A. V., & Burgoyne, R. D. (2010). Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. BIOCHEMICAL JOURNAL, 425, 159-168. doi:10.1042/BJ20090884
Modulation of calcium signalling by mitochondria
Walsh, C., Barrow, S., Voronina, S., Chvanov, M., Petersen, O. H., & Tepikin, A. (2009). Modulation of calcium signalling by mitochondria. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1787(11), 1374-1382. doi:10.1016/j.bbabio.2009.01.007
2008
ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP
Chvanov, M., Walsh, C. M., Haynes, L. P., Voronina, S. G., Lur, G., Gerasimenko, O. V., . . . Tepikin, A. V. (2008). ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 457(2), 505-517. doi:10.1007/s00424-008-0529-y
ATP depletion inhibits Ca<SUP>2+</SUP> release, influx and extrusion in pancreatic acinar cells but not pathological Ca<SUP>2+</SUP> responses induced by bile
Barrow, S. L., Voronina, S. G., Xavier, G. D. S., Chvanov, M. A., Longbottom, R. E., Gerasimenko, O. V., . . . Tepikin, A. V. (2008). ATP depletion inhibits Ca<SUP>2+</SUP> release, influx and extrusion in pancreatic acinar cells but not pathological Ca<SUP>2+</SUP> responses induced by bile. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 455(6), 1025-1039. doi:10.1007/s00424-007-0360-x
Direct activation of cytosolic Ca<SUP>2+</SUP> signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells
Murphy, J. A., Criddle, D. N., Sherwood, M., Chvanov, M., Mukherjee, R., McLaughlin, E., . . . Sutton, R. (2008). Direct activation of cytosolic Ca<SUP>2+</SUP> signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. GASTROENTEROLOGY, 135(2), 632-641. doi:10.1053/j.gastro.2008.05.026
2007
Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins
Baumgartner, H. K., Gerasimenko, J. V., Thorne, C., Ashurst, L. H., Barrow, S. L., Chvanov, M. A., . . . Gerasimenko, O. V. (2007). Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(1), G296-G307. doi:10.1152/ajpgi.00103.2007
Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins
Baumgartner, H. K., Gerasimenko, J. V., Thorne, C., Ashurst, L. H., Barrow, S. L., Chvanov, M. A., . . . Gerasimenko, O. V. (2007). Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 293(1), G296-G307. doi:10.1152/ajpgi.00103.2007
2006
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells
Criddle, D. N., Gillies, S., Baumgartner-Wilson, H. K., Jaffar, M., Chinje, E. C., Passmore, S., . . . Petersen, O. H. (2006). Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(52), 40485-40492. doi:10.1074/jbc.M607704200
Metabolic control of elastic properties of the inner mitochondrial membrane.
Chvanov, M. (2006). Metabolic control of elastic properties of the inner mitochondrial membrane.. The journal of physical chemistry. B, 110(45), 22903-22909. doi:10.1021/jp0638181
Calcium-dependent release of NO from intracellular <i>S</i>-nitrosothiols
Chvanov, M., Gerasimenko, O. V., Petersen, O. H., & Tepikin, A. V. (2006). Calcium-dependent release of NO from intracellular <i>S</i>-nitrosothiols. EMBO JOURNAL, 25(13), 3024-3032. doi:10.1038/sj.emboj.7601207
2005
Free radicals and the pancreatic acinar cells: role in physiology and pathology
Chvanov, M., Petersen, O. H., & Tepikin, A. (2005). Free radicals and the pancreatic acinar cells: role in physiology and pathology. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 360(1464), 2273-2284. doi:10.1098/rstb.2005.1757