Research
Research Interest 1
The pathogenesis of invasive non-typhoidal salmonella infections in HIV.
Gut mucosal immunity in HIV
Research grants
Phase 2a Immunogenecity and Tolerability Study of a trivalent vaccine against invasive Salmonella Disease
GLAXOSMITHKLINE BIOLOGICALS S.A. (BELGIUM)
June 2023 - July 2025
Optimising Vaccination for iNTS disease in Africa (OptiVaNTS)
WELLCOME TRUST (UK)
September 2022 - August 2025
Enterics for Global Health – Shigella Surveillance in Malawi (Part B)
BILL & MELINDA GATES FOUNDATION (USA)
January 2021 - April 2025
Global Health Research Group in Gastrointestinal Infections: Facilitating the Introduction and Evaluation of Vaccines for Enteric Diseases in Children in Eastern and Southern sub-Saharan Africa
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
August 2022 - July 2025
Accelerating Access to Typhoid Conjugate Vaccines (TyVAC 2.0) (TyVAC 2.0)
BILL & MELINDA GATES FOUNDATION (USA)
January 2022 - August 2025
Vacc-iNTS SAiNTS project
WELLCOME TRUST (UK)
October 2020 - December 2024
Advancing a GMMA-based vaccine against invasive non-typhoidal salmonellosis through Phase I trial in Europe and sub-Saharan Africa (Vacc-iNTS)
EUROPEAN COMMISSION
October 2019 - July 2026
Impact of maternally derived antibodies and infant microbiota on the immunogenicity of rotavirus vaccines in African, Indian and European infants.
DEPARTMENT FOR BUSINESS, INNOVATION AND SKILLS (UK)
July 2015 - December 2018
Accelerating Availability and Access to Typhoid Conjugate Vaccines (TyVAC)
BILL & MELINDA GATES FOUNDATION (USA)
September 2017 - March 2022
Malawi as a Central African Endoscopy Training Centre
BRITISH SOCIETY OF GASTROENTEROLOGY (UK)
March 2016 - March 2020
Wellcome Trust Clinical PhD Programme 15/16
WELLCOME TRUST (UK)
September 2015 - January 2020
CRYPTPREV Prevalence of cryptosporidium in HIV-infected adults with diarrhea in Blantyre
BILL & MELINDA GATES FOUNDATION (USA)
May 2016 - October 2018
Field testing of diagnostics tool during typhoid outbreak in Malawi
BILL & MELINDA GATES FOUNDATION (USA)
October 2016 - December 2018
A strategic vision to drive the control of enteric fever through vaccination. (STRATSUP)
BILL & MELINDA GATES FOUNDATION (USA), WELLCOME TRUST (UK)
April 2015 - December 2020
Transcriptomic analysis of Salmonella Typhimurium ST313 Lineage 2A
MEDICAL RESEARCH FOUNDATION (UK)
February 2016 - October 2016
iNTS Knowledge Gaps in Transmission, Exposure and Diagnostics.
BILL & MELINDA GATES FOUNDATION (USA)
July 2015 - August 2017
Typhoid Diagnostics for Measuring Disease Burden
BILL & MELINDA GATES FOUNDATION (USA)
March 2016 - February 2017
Partnerships in gastrointestinal endoscopy training and practice - outreach to support district hospitals in Malawi
BRITISH SOCIETY OF GASTROENTEROLOGY (UK)
May 2011 - April 2013
Wellcome Trust Clinical PhD Programme - Philip Burgess
WELLCOME TRUST (UK)
August 2010 - July 2011
Wellcome Trust Clinical PhD Programme: James Scriven
WELLCOME TRUST (UK)
August 2010 - July 2011
Wellcome Trust Postdoctoral Veterinary Research.
WELLCOME TRUST (UK)
September 2014 - February 2015
Undergraduate medical student training in health research: Universities of Malawi and Liverpool
THE NUFFIELD FOUNDATION (UK)
January 2011 - February 2015
SAGE Endoscopy Training
SHIRE PHARMACEUTICALS LIMITED (UK)
August 2012 - July 2017
The impact of travel on antimicrobial resistance in the human gut microbiome – pilot work
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
April 2011 - July 2012
Developing and delivering a Foundation Course in Endoscopy for the Medical and Surgical trainee curricula of Malawi’s Medical School.
BRITISH SOCIETY OF GASTROENTEROLOGY (UK)
January 2014 - December 2015
Cellular responses to Salmonella vaccination
THE SIR JULES THORN CHARITABLE TRUST (UK)
October 2012 - March 2016
Health priorities in resource-limited settings.
WELLCOME TRUST (UK)
September 2014 - August 2015
Sustainable Partnerships in Gastrointestinal Endoscopy Training and Practice - Outreach to Support District Hospitals in Malawi
BRITISH COUNCIL (UK)
June 2011 - May 2012
Wellcome Trust Clinical PhD Programme.
WELLCOME TRUST (UK)
September 2012 - December 2013
The mechanism of recurrent non-typhi salmonella (NTS) bacteraemia in HIV-I infected Malawian adults.
WELLCOME TRUST (UK)
November 2000 - December 2005
Study of disease mechanisms in enteric fever to characterise innate and adaptive immunity in the mucosa and peripheral blood using controlled human infection
MEDICAL RESEARCH COUNCIL
January 2013 - August 2019
Clinical PhD Programme (14/15)
WELLCOME TRUST (UK)
September 2014 - August 2015
Understanding Mucosal Immunity to Typhoid.
THE TERESA ROSENBAUM GOLDEN CHARITABLE TRUST (THE ROSETREES TRUST) (UK)
May 2013 - June 2016
Development of a TTT-trained nurse educator network in Malawi
BRITISH SOCIETY OF GASTROENTEROLOGY (UK)
February 2013 - December 2015
Establishment of natural acquired nontyphoidal salmonella-specific B and T cell immunity in Malawian children
DEPARTMENT FOR INTERNATIONAL DEVELOPMENT (DFID) (UK)
May 2012 - April 2015
Wellcome Trust Clinical PhD Programme - Mathew Kelly
WELLCOME TRUST (UK)
August 2010 - August 2011
Health Priorities in the Developing World
WELLCOME TRUST (UK)
September 2013 - August 2014
Research collaborations
Dr Stephen Baker
The University of Oxford
Collaboration on antimicrobial resistance genes in the healthy gut microbiota
Dr Florence Niedergang
Universite Paris Descartes
Collaboration on intracellular Salmonella infections in HIV
Dr David Lynn
Teagasc (Irish Agriculture and Food Development Authority)
Collaboration on systems biology analysis of microarray and RNA Seq transcriptomic data, using InnateDB analysis platform
Prof Andreas Baumler
University of California, LA
Clinical consultant to NIH exploratory grant, aiming to study the mechanism of invasive non-typhoidal salmonella infections using a simian SIV model
Professor Brett Finlay
University of British Columbia, Vancouver, Canada
I am a collaborator on a Gates Grand Challenge programme held by Brett Finlay
Professor Bob Hancock
University of British Columbia, Vancouver, Canada
I collaborate with Professor Hancock on a Gates Grand Challenge programme
Prof Gordon Dougan
Wellcome Trust Sanger Institute
Study of host RNA responses to non-typhoidal salmonella infection in HIV, using RNA microarray. Molecular epidemiology of Salmonella in Africa
Jill Gilmour
Imperial College London
Mucosal immunology in HIV
Prof Robert Heyderman
Mucosal immunology in HIV, Host response to invasive salmonella disease
Dr CM Parry
Phenotyping of NTS isolates