Research
Dr. Masoud Isanejad is an expert in clinical and precision nutrition, specializing in the prevention and treatment of sarcopenia and frailty, particularly in individuals living with cardiometabolic multimorbidity (CMM).
Sarcopenia, characterized by muscle mass and strength loss, encompasses both primary sarcopenia (age-related) and secondary sarcopenia, which is exacerbated by factors such as malignancy or organ failure alongside aging. Employing metabotyping, an integration of multi-omics analyses, including metabolites and lipids in tissues or biofluids, Dr. Isanejad gains profound insights into disease mechanisms and identifies novel targets for clinical interventions.
Dr. Isanejad's unique skills lie in developing epidemiological and clinical studies to comprehensively understand the pathophysiology of sarcopenia within diseases like heart failure. Additionally, he excels at identifying affordable and scalable lifestyle interventions, particularly nutrition-based approaches, to mitigate and prevent sarcopenia and frailty. Furthermore, my research is part of a broader project known as "MuscleGaIN: Enhancing the Muscle-Gut Axis through Nutrition." This overarching project aims to develop innovative nutritional interventions to counteract conditions like sarcopenia and frailty, with a specific focus on targeting gut and metabolic phenotypes as potential avenues for improvement.
Despite significant therapeutic advances, heart failure (HF) remains a leading cause of morbidity and mortality, with a 5-year mortality rate of approximately 50%, rivalling or exceeding that of many cancers. A significant portion of the elderly population grapples with cardiometabolic multimorbidities (CMM), such as hypertension, diabetes, and cardiovascular diseases (CVD), including coronary heart disease (CHD) and cerebrovascular diseases. This population is at an elevated risk of sarcopenia and frailty, resulting in declining physical function, muscle strength, and muscle mass. Dr. Isanejad's research aims to:
1. Investigate secondary sarcopenia mechanisms through biomarker analysis and deep phenotyping of associated conditions (utilizing imaging, blood metabolite, and clinical data).
2. Analyze risk factors and epidemiology of these conditions using extensive data analysis.
3. Design and execute clinical trials, with a specific focus on nutrition as a standalone or complex intervention, aiming to integrate these into NHS-based strategies to enhance patients' quality of life and mitigate associated risks with CMM, secondary sarcopenia, and frailty.
4. Explore physiological pathways through which diet and nutrients impact heart and muscle physiology.
Dr. Isanejad is actively involved in various projects, including leading roles as Principal Investigator (PI) and a collaborative role as Co-Investigator (Co-I), focusing on biomarkers, metabotyping, and interventions to tackle protein-energy malnutrition in the elderly.
His diverse skill set comprises:
- Metabolomics interpretation relating to nutrition and muscle metabolism.
- Expertise in clinical nutrition and precision nutrition.
- Proficiency in metabotyping (Metabolic phenotyping).
- Strong aptitude in large data analysis.
- In-depth knowledge of Public Health Nutrition, with a particular focus on addressing food insecurity through data-driven approaches and engaging various stakeholders in collaboration with the Centre of Excellence for Sustainable Food Systems.
Population based studies to investigate the risk factors associated with musculoskeletal deterioration, frailty, sarcopenia and falls
Intervention to prevent and reverse frailty in older people
Implication of technological advancement to enable older people live longer and independent at home
Research grants
Bench fees for Beyza Gulsah Altinpinar (201609083)
TURKISH MINISTRY OF NATIONAL EDUCATION
June 2023 - May 2027
HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE)
UK RESEARCH AND INNOVATION
April 2021 - April 2025
Research collaborations
Stuart Phillips
Professor
Department Of Kinesiology, McMaster University
Nutrition, Exercise, and Health Research
Professor Lyn Stefen
Associate Professor, Division of Epidemiology and Community Health
University of Miennesota
Nutritional epidemiology and the epidemiology of the cardiovascular disease. Specific research projects include studies of dietary intake and cardiovascular disease and its risk factors in adults. Recent projects include the study of dietary intake (diet patterns, added sugar, processed foods), biomarkers (metabolomics, fatty acids), adipose tissue depots, and cardiovascular disease.
Professor Francesco Galli
CHOKO-AGE
Department of Pharmaceutical Sciences, Unicersity of Perugina
Choko-age is a scientific European project that aims to tackle the age- dependent malnutrition and the metabolic decline of tissues through combining the health-promoting effects of nutrition and physical exercise
Professor Malcolm Jackson
CHOKO-AGE
Choko-age is a scientific European project that aims to tackle the age- dependent malnutrition and the metabolic decline of tissues by combining the health-promoting effects of nutrition and physical exercise https://chokoage.eu/
Professor Heikki Kröger, Dr Arja Erkkilä, Dr Joonas Sirola, Dr Toni Rikkonen
Research Team
Kuopio Musculoskeletal Research Unit, University of Eastern Finland
Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study - a population-based prospective cohort study- started in 1989 – was originally aimed to investigate factors associated with bone mineral density, bone loss, falls and fractures in a target population of 14 220 peri- and postmenopausal women. Later the scope was broadened and especially the 25-year follow-up enquiry in 2014 focused on physical, psychological and social factors related to healthy aging and mortality. The unique long-term design of the study allows identification of risk and protective factors for several somatic and mental health outcomes (including some non-skeletal chronic health disorders, functional capacity and subjective wellbeing). Merging the OSTPRE questionnaire data with data from National health registers enables the validation of self-reports and broadens the scope for other important health disorders. http://www.uef.fi/en/web/kmru/ostpre