Publications
Selected publications
- A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance (Journal article - 2024)
- Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function (Journal article - 2023)
- 3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration. (Journal article - 2023)
- Adhesion and growth factor receptor crosstalk mechanisms controlling cell migration. (Journal article - 2019)
- Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch (Journal article - 2017)
- Emerging properties of adhesion complexes: what are they and what do they do? (Journal article - 2015)
- Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling (Journal article - 2013)
- Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion (Journal article - 2011)
- Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal (Journal article - 2019)
2024
A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance
Maldonado, H., Dreger, M., Bedgood, L., Kyriakou, T., Wolanska, K., Rigby, M., . . . Morgan, M. (n.d.). A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance. Science Advances. Retrieved from https://doi.org/10.1126/sciadv.adk9944
[Tissue injury targeting peptide accelerates wound healing] Kudosvammaan hakeutuva peptidi kiihdyttää vamman paranemista
Maldonado, H., Savage, B., Barker, H., May, U., Vähätupa, M., Badiani, R., . . . Järvinen, T. (2024). [Tissue injury targeting peptide accelerates wound healing] Kudosvammaan hakeutuva peptidi kiihdyttää vamman paranemista. Duodecim Medical Journal, 140(3). Retrieved from https://www.duodecimlehti.fi/xmedia/duo/duo18037.pdf
2023
3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration.
Newman, D., Young, L. E., Waring, T., Brown, L., Wolanska, K. I., MacDonald, E., . . . Zech, T. (2023). 3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration.. Cell reports, 42(12), 113554. doi:10.1016/j.celrep.2023.113554
Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function
Maldonado, H., Savage, B. D., Barker, H. R., May, U., Vähätupa, M., Badiani, R. K., . . . Järvinen*, T. A. H. (2023). Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function. Nature Communications.
2022
Galectin-3 Is a Natural Binding Ligand of MCAM (CD146, MUC18) in Melanoma Cells and Their Interaction Promotes Melanoma Progression
Pang, Y., Maxwell, E., Sindrewicz-Goral, P., Shapanis, A., Li, S., Morgan, M., & Yu, L. -G. (n.d.). Galectin-3 Is a Natural Binding Ligand of MCAM (CD146, MUC18) in Melanoma Cells and Their Interaction Promotes Melanoma Progression. Biomolecules, 12(10), 1451. doi:10.3390/biom12101451
2019
Adhesion and growth factor receptor crosstalk mechanisms controlling cell migration.
Thomas, J. R., Paul, N. R., & Morgan, M. R. (2019). Adhesion and growth factor receptor crosstalk mechanisms controlling cell migration. MECHANISMS OF CELL MIGRATION, 63(5), 553-567. doi:10.1042/EBC20190025
Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal
Hill, C. J., Fleming, J. R., Mousavinejad, M., Nicholson, R., Tzokov, S. B., Bullough, P. A., . . . Murray, P. (2019). Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal. Advanced Materials, 31(17). doi:10.1002/adma.201807521
2018
Eps8 is a convergence point integrating EGFR and integrin trafficking and crosstalk
Paul, N., Thomas, J., Maldonado, H., Wolanska, K., Koper, E., Humphries, J., . . . Morgan, M. (2018). Eps8 is a convergence point integrating EGFR and integrin trafficking and crosstalk. doi:10.1101/405043
Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Thomas, J., Moore, K., Sproat, C., Maldonado-Lorca, H., Mo, S., Haider, S., . . . Morgan, M. (2018). Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion. doi:10.1101/407908
2017
Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signaling and cross-talk with TGFβ
Borland, S. J., Morris, T. G., Borland, S. C., Morgan, M. R., Francis, S. E., Merry, C. L. R., & Canfield, A. E. (2017). Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signaling and cross-talk with TGFβ. Cardiovascular Research, 113(13), 1639-1652. doi:10.1093/cvr/cvx178
Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch
Tod, J., Hanley, C. J., Morgan, M. R., Rucka, M., Mellows, T., Lopez, M. -A., . . . Thomas, G. J. (2017). Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch. The Journal of Pathology, 243(1), 37-50. doi:10.1002/path.4923
2016
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
Mana, G., Clapero, F., Panieri, E., Panero, V., Böttcher, R. T., Tseng, H. -Y., . . . Valdembri, V. (2016). PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nature Communications, 7. doi:10.1038/ncomms13546
2015
Emerging properties of adhesion complexes: what are they and what do they do?
Humphries, J. D., Paul, N. R., Humphries, M. J., & Morgan, M. R. (2015). Emerging properties of adhesion complexes: what are they and what do they do?. TRENDS IN CELL BIOLOGY, 25(7), 388-397. doi:10.1016/j.tcb.2015.02.008
Fibronectin remodelling: cell-mediated regulation of the microenvironment
Wolanska, K. I., & Morgan, M. R. (2015). Fibronectin remodelling: cell-mediated regulation of the microenvironment. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 122-128. doi:10.1042/BST20140313
2013
Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway
Jacquemet, G., Morgan, M. R., Byron, A., Humphries, J. D., Choi, C. K., Chen, C. S., . . . Humphries, M. J. (2013). Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. JOURNAL OF CELL SCIENCE, 126(18), 4121-4135. doi:10.1242/jcs.121988
Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling
Morgan, M. R., Hamidi, H., Bass, M. D., Warwood, S., Ballestrem, C., & Humphries, M. J. (2013). Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling. DEVELOPMENTAL CELL, 24(5), 472-485. doi:10.1016/j.devcel.2013.01.027
2012
A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis (vol 21, pg 681, 2011)
Bass, M. D., Williamson, R. C., Nunan, R. D., Humphries, J. D., Byron, A., Morgan, M. R., . . . Humphries, M. J. (2012). A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis (vol 21, pg 681, 2011). DEVELOPMENTAL CELL, 23(5), 1081-1082. doi:10.1016/j.devcel.2012.10.021
2011
A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis
Bass, M. D., Williamson, R. C., Nunan, R. D., Humphries, J. D., Byron, A., Morgan, M. R., . . . Humphries, M. J. (2011). A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis. DEVELOPMENTAL CELL, 21(4), 681-693. doi:10.1016/j.devcel.2011.08.007
Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion
Morgan, M. R., Jazayeri, M., Ramsay, A. G., Thomas, G. J., Boulanger, M. J., Hart, I. R., & Marshall, J. F. (2011). Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion. ONCOGENE, 30(12), 1422-1435. doi:10.1038/onc.2010.535
2010
Adhesion signalling complexes
Byron, A., Morgan, M. R., & Humphries, M. J. (2010). Adhesion signalling complexes. CURRENT BIOLOGY, 20(24), R1063-R1067. doi:10.1016/j.cub.2010.10.059
2009
Giving off Mixed Signals-Distinct Functions of α<sub>5</sub>β<sub>1</sub> and α<sub>V</sub>β<sub>3</sub> Integrins in Regulating Cell Behaviour
Morgan, M. R., Byron, A., Humphries, M. J., & Bass, M. D. (2009). Giving off Mixed Signals-Distinct Functions of α<sub>5</sub>β<sub>1</sub> and α<sub>V</sub>β<sub>3</sub> Integrins in Regulating Cell Behaviour. IUBMB LIFE, 61(7), 731-738. doi:10.1002/iub.200
Syndecans Shed Their Reputation as Inert Molecules
Bass, M. D., Morgan, M. R., & Humphries, M. J. (2009). Syndecans Shed Their Reputation as Inert Molecules. SCIENCE SIGNALING, 2(64). doi:10.1126/scisignal.264pe18
Therapeutic Ultrasound Bypasses Canonical Syndecan-4 Signaling to Activate Rac1
Mahoney, C. M., Morgan, M. R., Harrison, A., Humphries, M. J., & Bass, M. D. (2009). Therapeutic Ultrasound Bypasses Canonical Syndecan-4 Signaling to Activate Rac1. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(13), 8889-8900. doi:10.1074/jbc.M804281200
2008
p190RhoGAP is the convergence point of adhesion signals from α<sub>5</sub>β<sub>1</sub> integrin and syndecan-4
Bass, M. D., Morgan, M. R., Roach, K. A., Settleman, J., Goryachev, A. B., & Humphries, M. J. (2008). p190RhoGAP is the convergence point of adhesion signals from α<sub>5</sub>β<sub>1</sub> integrin and syndecan-4. JOURNAL OF CELL BIOLOGY, 181(6), 1013-1026. doi:10.1083/jcb.200711129
2007
Synergistic control of cell adhesion by integrins and syndecans
Morgan, M. R., Humphries, M. J., & Bass, M. D. (2007). Synergistic control of cell adhesion by integrins and syndecans. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 8(12), 957-969. doi:10.1038/nrm2289
Sndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix
Bass, M. D., Roach, K. A., Morgan, M. R., Mostafavi-Pour, Z., Schoen, T., Muramatsu, T., . . . Humphries, M. J. (2007). Sndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. JOURNAL OF CELL BIOLOGY, 177(3), 527-538. doi:10.1083/jcb.200610076
Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation
Bass, M. D., Morgan, M. R., & Humphries, M. J. (2007). Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation. SOFT MATTER, 3(3), 372-376. doi:10.1039/b614610d
2005
Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading.
Humphries, M. J., Mostafavi-Pour, Z., Morgan, M. R., Deakin, N. O., Messent, A. J., & Bass, M. D. (2005). Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading.. In Novartis Foundation symposium Vol. 269 (pp. 178-230).
2004
The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9
Morgan, M. R., Thomas, G. J., Russell, A., Hart, I. R., & Marshall, J. F. (2004). The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(25), 26533-26539. doi:10.1074/jbc.M401736200
Modulation of the urokinase-type plasminogen activator receptor by the β6 integrin subunit
Dalvi, N., Thomas, G. J., Marshall, J. F., Morgan, M., Bass, R., Ellis, V., . . . Whawell, S. A. (2004). Modulation of the urokinase-type plasminogen activator receptor by the β6 integrin subunit. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 317(1), 92-99. doi:10.1016/j.bbrc.2004.02.178
Reduction of TSG101 protein has a negative impact on tumor cell growth
Zhu, G., Gilchrist, R., Borley, N., Chng, H. W., Morgan, M., Marshall, J. F., . . . Hart, I. R. (2004). Reduction of TSG101 protein has a negative impact on tumor cell growth. INTERNATIONAL JOURNAL OF CANCER, 109(4), 541-547. doi:10.1002/ijc.20014
Role of the β6 integrin cytoplasmic domain in carcinoma cell invasion
Morgan, M. (2004). Role of the β6 integrin cytoplasmic domain in carcinoma cell invasion. (PhD Thesis, University of London (Kings College)).
2002
Patent: Biologically Active Molecules
Morgan, M., Marshall, J. F., & Williams, G. (2002). Patent: Biologically Active Molecules.