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Calum Semple

Professor Calum Semple
OBE PhD FRCPCH FRCPE FFPH FHEA

Professor of Child Health and Outbreak Medicine, Consultant Respiratory Paediatrician at Alder Hey Children's Hospital
Clinical Infection, Microbiology & Immunology
Part of
Institute of Infection, Veterinary & Ecological Sciences
Faculty of Health and Life Sciences

Contact

M.G.Semple@liverpool.ac.uk

The International Severe Acute Respiratory and emerging Infection Consortium's Comprehensive Characterisation Collaboration (ISARIC4)

Publications

Selected publications

  1. Adeno-associated virus 2 infection in children with non-A-E hepatitis. (Journal article - 2023)
  2. Genomic investigations of unexplained acute hepatitis in children. (Journal article - 2023)
  3. Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. (Journal article - 2021)
  4. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article - 2020)
  5. Ebola virus antibody decay-stimulation in a high proportion of survivors (Journal article - 2021)
  6. Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea (Journal article - 2016)
  7. Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults (Journal article - 2022)
  8. Genetic mechanisms of critical illness in COVID-19. (Journal article - 2021)
  9. Mapping the human genetic architecture of COVID-19 (Journal article - 2021)
  10. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article - 2020)
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2024

Evaluation of the diagnostic accuracy and analytical sensitivity of the novel Xpert® Mpox (Cepheid®) and STANDARD™ M10 MPX/OPX (SD Biosensor) molecular point-of-care assays for the detection of Mpox virus in skin lesion swabs and upper-respiratory swab samples

DOI
10.1101/2024.09.09.24313234
Preprint

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.

Mesinovic, M., Wong, X. C., Rajahram, G. S., Citarella, B. W., Peariasamy, K. M., van Someren Greve, F., . . . ISARIC Characterisation Group. (2024). At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.. Scientific reports, 14(1), 16387. doi:10.1038/s41598-024-63212-7

DOI
10.1038/s41598-024-63212-7
Journal article

Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.

Elneima, O., Hurst, J. R., Echevarria, C., Quint, J. K., Walker, S., Siddiqui, S., . . . Heaney, L. G. (2024). Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.. ERJ open research, 10(4), 982-2023. doi:10.1183/23120541.00982-2023

DOI
10.1183/23120541.00982-2023
Journal article

Can self-testing be enhanced to hasten safe return of healthcare workers in pandemics? Random order, open label trial using two manufacturers’ SARS-CoV-2 lateral flow devices concurrently

DOI
10.21203/rs.3.rs-4483986/v1
Preprint

Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.

Turtle, L., Elliot, S., Drake, T. M., Thorpe, M., Khoury, E. G., Greenhalf, W., . . . ISARIC4C Investigators. (2024). Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.. The Lancet. Oncology, 25(5), 636-648. doi:10.1016/s1470-2045(24)00107-4

DOI
10.1016/s1470-2045(24)00107-4
Journal article

Post-Covid-19 condition (Long Covid) in children and young people 12 months after infection or reinfection with the Omicron variant: a prospective observational study.

Pinto Pereira, S. M., Nugawela, M. D., Stephenson, T., Foret-Bruno, P., Dalrymple, E., Xu, L., . . . Shafran, R. (2024). Post-Covid-19 condition (Long Covid) in children and young people 12 months after infection or reinfection with the Omicron variant: a prospective observational study.. Scientific reports, 14(1), 9957. doi:10.1038/s41598-024-60372-4

DOI
10.1038/s41598-024-60372-4
Journal article

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.

Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 15(1), 2918. doi:10.1038/s41467-024-47320-6

DOI
10.1038/s41467-024-47320-6
Journal article

Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".

Seylanova, N., Chernyavskaya, A., Degtyareva, N., Mursalova, A., Ajam, A., Xiao, L., . . . PC-COS Children Study Group. (2024). Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".. The European respiratory journal, 63(3), 2301761. doi:10.1183/13993003.01761-2023

DOI
10.1183/13993003.01761-2023
Journal article

Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.

Cho, S. -M., Premraj, L., Battaglini, D., Fanning, J. P., Suen, J., Bassi, G. L., . . . ISARIC Clinical Characterization Group. (2024). Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.. Brain communications, 6(2), fcae036. doi:10.1093/braincomms/fcae036

DOI
10.1093/braincomms/fcae036
Journal article

Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).

Pazukhina, E., Rumyantsev, M., Baimukhambetova, D., Bondarenko, E., Markina, N., El-Taravi, Y., . . . Sechenov StopCOVID Research Team. (2024). Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).. BMC medicine, 22(1), 48. doi:10.1186/s12916-023-03221-x

DOI
10.1186/s12916-023-03221-x
Journal article

Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.

RECOVERY Collaborative Group. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.. The Lancet. Child & adolescent health, S2352-4642(23)00316-4. doi:10.1016/s2352-4642(23)00316-4

DOI
10.1016/s2352-4642(23)00316-4
Journal article

Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.

Devine, K., Russell, C. D., Blanco, G. R., Walker, B. R., Homer, N. Z. M., Denham, S. G., . . . ISARIC4C Investigators and PHOSP-COVID Study Collaborative Group. (2024). Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.. Clinical endocrinology. doi:10.1111/cen.15012

DOI
10.1111/cen.15012
Journal article

COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region

Burnside, G., Cheyne, C. P., Leeming, G., Humann, M., Darby, A., Green, M. A., . . . Buchan, I. E. (2024). COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region. Journal of the Royal Society of Medicine. doi:10.1177/01410768231182389

DOI
10.1177/01410768231182389
Journal article

Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study.

Battaglini, D., White, N. M., Premraj, L., Wanjiru Citarella, B., Merson, L., Robba, C., . . . ISARIC Clinical Characterization Group. (2024). Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study.. Journal of neurology, 271(1), 79-86. doi:10.1007/s00415-023-12133-y

DOI
10.1007/s00415-023-12133-y
Journal article

2023

Long COVID research: an update from the PHOSP-COVID Scientific Summit.

Brightling, C. E., Evans, R. A., Singapuri, A., Smith, N., Wain, L. V., & PHOSP-COVID Collaborative Group. (2023). Long COVID research: an update from the PHOSP-COVID Scientific Summit.. The Lancet. Respiratory medicine, 11(11), e93-e94. doi:10.1016/s2213-2600(23)00341-7

DOI
10.1016/s2213-2600(23)00341-7
Journal article

Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: A prospective, multinational, observational study.

Reyes, L. F., Garcia-Gallo, E., Murthy, S., Fuentes, Y. V., Serrano, C. C., Ibáñez-Prada, E. D., . . . ISARIC Characterisation Group. (2023). Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: A prospective, multinational, observational study.. Journal of critical care, 77, 154318. doi:10.1016/j.jcrc.2023.154318

DOI
10.1016/j.jcrc.2023.154318
Journal article

Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19

Wainstein, M., Spyrison, N., Dai, D., Ghadimi, M., Chávez-Iñiguez, J. S., Rizo-Topete, L., . . . Zucman, D. (2023). Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19. Kidney International Reports, 8(8), 1514-1530. doi:10.1016/j.ekir.2023.05.015

DOI
10.1016/j.ekir.2023.05.015
Journal article

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.

Jackson, C., Stewart, I., Plekhanova, T., Cunningham, P. S., Hazel, A. L., Al-Sheklly, B., . . . PHOSP-COVID, S. C. G. (2023). Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. LANCET RESPIRATORY MEDICINE, 11(8), 673-684. doi:10.1016/S2213-2600(23)00124-8

DOI
10.1016/s2213-2600(23)00124-8
Journal article

HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation

Yang, H., Sun, H., Brackenridge, S., Zhuang, X., Wing, P. A. C., Quastel, M., . . . McMichael, A. J. (2023). HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation. SCIENCE IMMUNOLOGY, 8(84). doi:10.1126/sciimmunol.abl8881

DOI
10.1126/sciimmunol.abl8881
Journal article

Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry

Griffee, M. J., Bozza, P. T., Reyes, L. F., Eddington, D. P., Rosenberger, D., Merson, L., . . . Zucman, D. (2023). Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry. Research and Practice in Thrombosis and Haemostasis, 7(5), 102142. doi:10.1016/j.rpth.2023.102142

DOI
10.1016/j.rpth.2023.102142
Journal article

Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

Zheng, B., Vivaldi, G., Daines, L., Leavy, O. C., Richardson, M., Elneima, O., . . . Zongo, O. (2023). Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls. The Lancet Regional Health - Europe, 29, 100635. doi:10.1016/j.lanepe.2023.100635

DOI
10.1016/j.lanepe.2023.100635
Journal article

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

McAuley, H. J. C., Evans, R. A., Bolton, C. E., Brightling, C. E., Chalmers, J. D., Docherty, A. B., . . . Zongo, O. (2023). Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. eClinicalMedicine, 57, 101896. doi:10.1016/j.eclinm.2023.101896

DOI
10.1016/j.eclinm.2023.101896
Journal article

Estimating distribution of length of stay in a multi-state model conditional on the pathway, with an application to patients hospitalised with Covid-19

Keogh, R. H., Diaz-Ordaz, K., Jewell, N. P., Semple, M. G., de Wreede, L. C., & Putter, H. (2023). Estimating distribution of length of stay in a multi-state model conditional on the pathway, with an application to patients hospitalised with Covid-19. Lifetime Data Analysis. doi:10.1007/s10985-022-09586-0

DOI
10.1007/s10985-022-09586-0
Journal article

Prevalence and Risk Factors of Post-COVID-19 Condition in Adults and Children at 6 and 12 Months After Hospital Discharge: A Prospective, Cohort Study in Moscow (Stop COVID)

Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., . . . Team, S. S. R. (n.d.). Prevalence and Risk Factors of Post-COVID-19 Condition in Adults and Children at 6 and 12 Months After Hospital Discharge: A Prospective, Cohort Study in Moscow (Stop COVID). SSRN Electronic Journal. doi:10.2139/ssrn.4020142

DOI
10.2139/ssrn.4020142
Journal article

The role of pandemic planning in the management of COVID-19 in England from an infection prevention and control perspective: results of a national survey.

Greene, C., Wilson, J., Griffin, H., Tingle, A., Cooper, T., Semple, M. G., . . . Loveday, H. (2023). The role of pandemic planning in the management of COVID-19 in England from an infection prevention and control perspective: results of a national survey.. Public health, 217, 89-94. doi:10.1016/j.puhe.2023.01.028

DOI
10.1016/j.puhe.2023.01.028
Journal article

Association of SARS-CoV-2 viral load distributions with individual demographics and suspected variant type: Results from the Liverpool Community Testing Pilot - England, 6 November 2020‒8 September 2021

Hughes, D., Cheyne, C., Ashton, M., Coffee, E., Crozier, A., Semple, M., . . . Garcia-Finana, M. (n.d.). Association of SARS-CoV-2 viral load distributions with individual demographics and suspected variant type: Results from the Liverpool Community Testing Pilot - England, 6 November 2020‒8 September 2021. Eurosurveillance. doi:10.2807/1560-7917.ES.2023.28.4.2200129

DOI
10.2807/1560-7917.ES.2023.28.4.2200129
Journal article

SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study

Parker, E., Thomas, J., Roper, K. J., Ijaz, S., Edwards, T., Marchesin, F., . . . Pollakis, G. (2023). SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1146702

DOI
10.3389/fimmu.2023.1146702
Journal article

2022

Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people

Green, M. A., Hungerford, D. J., Hughes, D. M., Garcia-Finana, M., Turtle, L., Cheyne, C., . . . Buchan, I. (2022). Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people. BMC INFECTIOUS DISEASES, 22(1). doi:10.1186/s12879-022-07878-2

DOI
10.1186/s12879-022-07878-2
Journal article

Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales

Swann, O. V., Lone, N. I., Harrison, E. M., Tomlinson, L. A., Walker, A. J., Seaborne, M. J., . . . Docherty, A. B. (2022). Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales. BMJ OPEN, 12(11). doi:10.1136/bmjopen-2022-063271

DOI
10.1136/bmjopen-2022-063271
Journal article

PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY

Marwali, E. M., Kekalih, A., Yuliarto, S., Wati, D. K., Rayhan, M., Valerie, I. C., . . . Dalton, H. (2022). PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY. In PEDIATRIC CRITICAL CARE MEDICINE Vol. 23. Retrieved from https://www.webofscience.com/

Conference Paper

Symptom‐based case definitions for COVID‐19: Time and geographical variations for detection at hospital admission among 260,000 patients

Baruch, J., Rojek, A., Kartsonaki, C., Vijayaraghavan, B. K. T., Gonçalves, B. P., Pritchard, M. G., . . . ISARIC Clinical Characterisation Group. (2022). Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.. Influenza and other respiratory viruses, 16(6), 1040-1050. doi:10.1111/irv.13039

DOI
10.1111/irv.13039
Journal article

Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study

Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531

DOI
10.1093/ofid/ofac531
Journal article

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Kotanidis, C. P., Xie, C., Alexander, D., Rodrigues, J. C. L., Burnham, K., Mentzer, A., . . . Antoniades, C. (2022). Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19. LANCET DIGITAL HEALTH, 4(10), E705-E716. doi:10.1016/S2589-7500(22)00132-7

DOI
10.1016/S2589-7500(22)00132-7
Journal article

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibanez-Prada, E. D., Rello, J., . . . Olliaro, P. L. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. CRITICAL CARE, 26(1). doi:10.1186/s13054-022-04155-1

DOI
10.1186/s13054-022-04155-1
Journal article

PREVENTION OF NEUROLOGICAL COMPLICATIONS DURING COVID-19: A RETROSPECTIVE ANALYSIS OF THE ISARIC4C NATIONAL COHORT

Grundmann, A., Hardwick, M., Wu, C. -H., Semple, M., Bohning, D., Pett, S., . . . Galea, I. (2022). PREVENTION OF NEUROLOGICAL COMPLICATIONS DURING COVID-19: A RETROSPECTIVE ANALYSIS OF THE ISARIC4C NATIONAL COHORT. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 93. doi:10.1136/jnnp-2022-abn2.22

DOI
10.1136/jnnp-2022-abn2.22
Conference Paper

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Evans, R. A., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J. C., Shikotra, A., . . . Brightling, C. E. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. LANCET RESPIRATORY MEDICINE, 10(8), 761-775. doi:10.1016/S2213-2600(22)00127-8

DOI
10.1016/S2213-2600(22)00127-8
Journal article

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

Ijaz, S., Dicks, S., Jegatheesan, K., Parker, E., Katsanovskaja, K., Vink, E., . . . Tedder, R. S. (2022). Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients. JOURNAL OF INFECTION, 85(2), 152-160. doi:10.1016/j.jinf.2022.05.033

DOI
10.1016/j.jinf.2022.05.033
Journal article

Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., . . . Munblit, D. (2022). Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID). BMC MEDICINE, 20(1). doi:10.1186/s12916-022-02448-4

DOI
10.1186/s12916-022-02448-4
Journal article

Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages

Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages. MSPHERE, 7(3). doi:10.1128/msphere.00913-21

DOI
10.1128/msphere.00913-21
Journal article

A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study

Munblit, D., Nicholson, T., Akrami, A., Apfelbacher, C., Chen, J., De Groote, W., . . . Williamson, P. R. (2022). A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study. LANCET RESPIRATORY MEDICINE, 10(7), 715-724. doi:10.1016/S2213-2600(22)00169-2

DOI
10.1016/S2213-2600(22)00169-2
Journal article

CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic (Preprint)

DOI
10.2196/preprints.40035
Preprint

Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers

Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Donovan-Banfield, I., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers. GIGASCIENCE, 11. doi:10.1093/gigascience/giac045

DOI
10.1093/gigascience/giac045
Journal article

Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

Stewart, A., Sinclair, E., Ng, J. C. -F., O'Hare, J. S., Page, A., Serangeli, I., . . . Dunn-Walters, D. K. (2022). Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.807104

DOI
10.3389/fimmu.2022.807104
Journal article

Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179

DOI
10.1093/ofid/ofac179
Journal article

Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol.

Wainstein, M., MacDonald, S., Fryer, D., Young, K., Balan, V., Begum, H., . . . ISARIC Clinical Characterisation Group. (2022). Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol.. PLoS medicine, 19(4), e1003969. doi:10.1371/journal.pmed.1003969

DOI
10.1371/journal.pmed.1003969
Journal article

SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses

Swets, M. C., Russell, C. D., Harrison, E. M., Docherty, A. B., Lone, N., Girvan, M., . . . Baillie, J. K. (2022). SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses. LANCET, 399(10334), 1463-1464. doi:10.1016/S0140-6736(22)00383-X

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Quality of life, healthcare use and costs in 'at-risk' children after early antibiotic treatment versus placebo for influenza- like illness: within-trial descriptive economic analyses of the ARCHIE randomised controlled trial

Rombach, I., Wang, K., Tonner, S., Grabey, J., Harnden, A., & Wolstenholme, J. (2022). Quality of life, healthcare use and costs in 'at-risk' children after early antibiotic treatment versus placebo for influenza- like illness: within-trial descriptive economic analyses of the ARCHIE randomised controlled trial. BMJ OPEN, 12(4). doi:10.1136/bmjopen-2021-049373

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10.1136/bmjopen-2021-049373
Journal article

Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility.

Rosadas, C., Khan, M., Parker, E., Marchesin, F., Katsanovskaja, K., Sureda-Vives, M., . . . Tedder, R. S. (2022). Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. JOURNAL OF VIROLOGICAL METHODS, 302. doi:10.1016/j.jviromet.2022.114475

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Journal article

Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study.

Stephenson, T., Pinto Pereira, S. M., Shafran, R., de Stavola, B. L., Rojas, N., McOwat, K., . . . Ladhani, S. N. (2022). Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study.. The Lancet. Child & adolescent health, 6(4), 230-239. doi:10.1016/s2352-4642(22)00022-0

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10.1016/s2352-4642(22)00022-0
Journal article

Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service

Egan, C., Turtle, L., Thorpe, M., Harrison, E. M., Semple, M. G., & Docherty, A. B. (2022). Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service. ANAESTHESIA. doi:10.1111/anae.15677

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Journal article

Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study.

Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., . . . Munblit, D. (2022). Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. EUROPEAN RESPIRATORY JOURNAL, 59(2). doi:10.1183/13993003.01341-2021

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Journal article

Neurological Presentations and In-Hospital Complications of COVID-19 in Adults and Children: A Large Prospective Multicentre Observational Study from the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC)

DOI
10.2139/ssrn.4047877
Preprint

Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629

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2021

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.

Fallerini, C., Picchiotti, N., Baldassarri, M., Zguro, K., Daga, S., Fava, F., . . . Furini, S. (2021). Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.. Human genetics, 141(1), 147-173. doi:10.1007/s00439-021-02397-7

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Journal article

The value of open-source clinical science in pandemic response: lessons from ISARIC

The value of open-source clinical science in pandemic response: lessons from ISARIC (2021). LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-X

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10.1016/S1473-3099(21)00565-X
Journal article

EXPRESSION OF THE SARS-COV-2 RECEPTORS ACE2 AND TMPRSS2 IN THE RESPIRATORY TRACT OF CHILDREN AND ADULTS

Nuttall, A. G., Hedrich, C., Semple, C., Losty, P., Shukla, R., McPartland, J., . . . McNamara, P. (2021). EXPRESSION OF THE SARS-COV-2 RECEPTORS ACE2 AND TMPRSS2 IN THE RESPIRATORY TRACT OF CHILDREN AND ADULTS. In THORAX Vol. 76 (pp. A39). doi:10.1136/thorax-2021-BTSabstracts.63

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Conference Paper

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.

Evans, R. A., McAuley, H., Harrison, E. M., Shikotra, A., Singapuri, A., Sereno, M., . . . Brightling, C. E. (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(11), 1275-1287. doi:10.1016/S2213-2600(21)00383-0

DOI
10.1016/s2213-2600(21)00383-0
Journal article

Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic

Cushnan, D., Berka, R., Bertolli, O., Williams, P., Schofield, D., Joshi, I., . . . Collaborative, N. C. C. I. D. (2021). Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic. DIGITAL HEALTH, 7. doi:10.1177/20552076211048654

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Journal article

1370 Is the liverpool respiratory symptom questionnaire (LRSQ) an acceptable tool to use in longitudinal cohort studies?

Naylor, C., Stead, J., Lane, S., McNamara, P., Southern, K., & Semple, M. (2021). 1370 Is the liverpool respiratory symptom questionnaire (LRSQ) an acceptable tool to use in longitudinal cohort studies?. In Abstracts (pp. A342.1-A342). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2021-rcpch.594

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10.1136/archdischild-2021-rcpch.594
Conference Paper

286 BE FIT study: biomarkers rElated to weight and lifestyle in young adults

Fairhurst, K., Semple, M. G., Kemp, G. J., & Cuthbertson, D. J. (2021). 286 BE FIT study: biomarkers rElated to weight and lifestyle in young adults. In Abstracts (pp. A10-A11). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2021-rcpch.17

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Conference Paper

Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital

Wright, J., Achana, F., Diwakar, L., Semple, M. G., Carroll, W. D., Baillie, K., . . . Kemp, T. S. (2021). Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 111, 333-335. doi:10.1016/j.ijid.2021.08.022

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Journal article

Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)

Wild, J. M., Porter, J. C., Molyneaux, P. L., George, P. M., Stewart, I., Allen, R. J., . . . Jenkins, R. G. (2021). Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID). BMJ Open Respiratory Research, 8(1), e001049. doi:10.1136/bmjresp-2021-001049

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Journal article

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (vol 374, n2244, 2021)

Hippisley-Cox, J., Coupland, C. A., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., . . . Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (vol 374, n2244, 2021). BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n2300

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Journal article

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

Sigfrid, L., Drake, T. M., Pauley, E., Jesudason, E. C., Olliaro, P., Lim, W. S., . . . Scott, J. T. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. LANCET REGIONAL HEALTH-EUROPE, 8. doi:10.1016/j.lanepe.2021.100186

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Journal article

Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK

Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In ANNALS OF ONCOLOGY Vol. 32 (pp. S1337). doi:10.1016/j.annonc.2021.08.2141

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Conference Paper

Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK

Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In Annals of oncology : official journal of the European Society for Medical Oncology Vol. 32 (pp. S1337).

Conference Paper

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study.

Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2

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Journal article

Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort

Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06466-0

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10.1186/s12879-021-06466-0
Journal article

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study

Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/

Journal article

Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study

Garcia-Finana, M., Hughes, D. M., Cheyne, C. P., Burnside, G., Stockbridge, M., Fowler, T. A., . . . Buchan, I. (2021). Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n1637

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Journal article

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2

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10.1016/S2213-2600(21)00175-2
Journal article

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study

Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1

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Journal article

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178

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10.1002/oby.23178
Journal article

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8

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10.1016/S2213-2600(21)00013-8
Journal article

Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19

Mina, M. J., Peto, T. E., Garcia-Finana, M., Semple, M. G., & Buchan, I. E. (2021). Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19. LANCET, 397(10283), 1425-1427. doi:10.1016/S0140-6736(21)00425-6

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10.1016/S0140-6736(21)00425-6
Journal article

Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study

Davies, N. G., Barnard, R. C., Jarvis, C. I., Russell, T. W., Semple, M. G., Jit, M., & Edmunds, W. J. (2021). Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study. LANCET INFECTIOUS DISEASES, 21(4), 482-492. doi:10.1016/S1473-3099(20)30984-1

DOI
10.1016/S1473-3099(20)30984-1
Journal article

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study

Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2

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Journal article

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020.

Flood, J., Shingleton, J., Bennett, E., Walker, B., Amin-Chowdhury, Z., Oligbu, G., . . . Ladhani, S. N. (2021). Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. LANCET REGIONAL HEALTH-EUROPE, 3. doi:10.1016/j.lanepe.2021.100075

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10.1016/j.lanepe.2021.100075
Journal article

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

Sigfrid, L., Drake, T., Pauley, E., Jesudason, E., Olliaro, P., Lim, W. S., . . . ISARIC4C investigators. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2021.03.18.21253888

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10.1101/2021.03.18.21253888
Journal article

What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol.

Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J., . . . Scott, J. T. (2021). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol.. BMJ Open, 11(3), e043887. doi:10.1136/bmjopen-2020-043887

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Journal article

Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans

Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Salguero, J., . . . Hiscox, J. (2021). Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans. doi:10.1101/2021.03.03.433753

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Journal article

A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process

Harwood, R., Allin, B., Jones, C. E., Whittaker, E., Ramnarayan, P., Ramanan, A. V., . . . Kenny, S. (2021). A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. LANCET CHILD & ADOLESCENT HEALTH, 5(2), 133-141. doi:10.1016/S2352-4642(20)30304-7

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Journal article

2020

Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study

Docherty, A., Mulholland, R., Lone, N., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . for ISARIC4C investigators. (2020). Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study. doi:10.1101/2020.12.19.20248559

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Journal article

Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.

Geretti, A. M., Stockdale, A. J., Kelly, S. H., Cevik, M., Collins, S., Waters, L., . . . Semple, M. G. (2020). Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. doi:10.1093/cid/ciaa1605

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10.1093/cid/ciaa1605
Journal article

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020.

Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685

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Journal article

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study

Clift, A. K., Coupland, C. A. C., Keogh, R. H., Diaz-Ordaz, K., Williamson, E., Harrison, E. M., . . . Hippisley-Cox, J. (2020). Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ-BRITISH MEDICAL JOURNAL, 371. doi:10.1136/bmj.m3731

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Journal article

Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism

Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164

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10.3390/v12101164
Journal article

G154(P) User service evaluation of the regional paediatric bronchoscopy service focusing on satisfaction: ‘do we pass the friends and family test?’

Semple, M. G., & Haigh, A. C. (2020). G154(P) User service evaluation of the regional paediatric bronchoscopy service focusing on satisfaction: ‘do we pass the friends and family test?’. In Quality improvement and patient safety (pp. A52.2-A53). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.125

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Conference Paper

G169 Are children at risk of severe influenza and its complications receiving protection from seasonal flu?

Gokulakrishnan, D., Khaliq, R., & Semple, M. G. (2020). G169 Are children at risk of severe influenza and its complications receiving protection from seasonal flu?. In British association of child and adolescent public health (pp. A59.1-A59). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.140

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10.1136/archdischild-2020-rcpch.140
Conference Paper

G301(P) Diagnosing hereditary haemorrhagic telangiectasia in children: a service evaluation project

Anderson, E. R., & Semple, M. G. (2020). G301(P) Diagnosing hereditary haemorrhagic telangiectasia in children: a service evaluation project. In Down syndrome medical interest group, british association of community child health and british paediatric respiratory society (pp. A110.2-A110). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.262

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10.1136/archdischild-2020-rcpch.262
Conference Paper

G303(P) Parent and patient perceived side effects of paediatric flexible bronchoscopy

Semple, M. G., & Bamforth, J. H. (2020). G303(P) Parent and patient perceived side effects of paediatric flexible bronchoscopy. In Down syndrome medical interest group, british association of community child health and british paediatric respiratory society (pp. A111.2-A111). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.264

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10.1136/archdischild-2020-rcpch.264
Conference Paper

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.

Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339

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Journal article

The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK

Hepworth, C., Mingaud, N., Davies, S., Lawrence, P., Lilley, A., Gait, L., . . . Semple, M. (2020). The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK. In EUROPEAN RESPIRATORY JOURNAL Vol. 56. doi:10.1183/13993003.congress-2020.2878

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Conference Paper

Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium

Palmieri, C., Turtle, L., Docherty, A., Harrison, E., Drake, T., Greenhalf, B., . . . Semple, M. G. (2020). Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium. In ANNALS OF ONCOLOGY Vol. 31 (pp. S992). doi:10.1016/j.annonc.2020.08.1735

DOI
10.1016/j.annonc.2020.08.1735
Conference Paper

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249

DOI
10.1136/bmj.m3249
Journal article

Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study

Geretti, A. M., Stockdale, A., Kelly, S., Cevik, M., Collins, S., Waters, L., . . . Group, C. H. A. S. E. S. (2020). Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study. doi:10.2139/ssrn.3666248

DOI
10.2139/ssrn.3666248
Journal article

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Folegatti, P. M., Ewer, K. J., Aley, P. K., Angus, B., Becker, S., Belij-Rammerstorfer, S., . . . Pollard, A. J. (2020). Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. LANCET, 396(10249), 467-478. doi:10.1016/S0140-6736(20)31604-4

DOI
10.1016/s0140-6736(20)31604-4
Journal article

Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: prospective observational study

Geretti, A., Stockdale, A., Kelly, S., Villa, G., Turtle, L., Semple, M., & Sabin, C. (2020). Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 23, 13-14. Retrieved from https://www.webofscience.com/

DOI
10.1101/2020.08.07.20170449
Journal article

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

Knight, S., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T., . . . Harrison, E. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. doi:10.1101/2020.07.30.20165464

DOI
10.1101/2020.07.30.20165464
Journal article

A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process

Harwood, R., Allin, B., Jones, C., Whittaker, E., Ramnarayan, P., Ramanan, A., . . . Kenny, S. (2020). A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process. doi:10.1101/2020.07.17.20156075

DOI
10.1101/2020.07.17.20156075
Journal article

Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study

Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . Semple, M. (2020). Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study. doi:10.1101/2020.07.14.20153320

DOI
10.1101/2020.07.14.20153320
Journal article

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]

Adams, E. R., Ainsworth, M., Anand, R., Andersson, M. I., Auckland, K., Baillie, J. K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]. Wellcome Open Research, 5. doi:10.12688/wellcomeopenres.15927.1

DOI
10.12688/wellcomeopenres.15927.1
Journal article

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.

Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., . . . ISARIC4C investigators. (2020). Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.. BMJ (Clinical research ed.), 369. doi:10.1136/bmj.m1985

DOI
10.1136/bmj.m1985
Journal article

COVID-19 infection in children

Sinha, I. P., Harwood, R., Semple, M. G., Hawcutt, D. B., Thursfield, R., Narayan, O., . . . Southern, K. W. (2020). COVID-19 infection in children. LANCET RESPIRATORY MEDICINE, 8(5), 446-447. Retrieved from https://www.webofscience.com/

Journal article

2019

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018)

Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Griffiths, M. J. (2019). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018). NATURE IMMUNOLOGY, 20(3), 373. doi:10.1038/s41590-019-0328-y

DOI
10.1038/s41590-019-0328-y
Journal article

2018

Visual Disability in Ebola Survivors

Steptoe, P. J., Beare, N. A. V., Fornah, A. D., Momorie, F., Komba, P., Vandy, M., & Semple, M. G. (2018). Visual Disability in Ebola Survivors. CLINICAL INFECTIOUS DISEASES, 66(8), 1318-1319. doi:10.1093/cid/cix979

DOI
10.1093/cid/cix979
Journal article

G447 The cross-sectional and longitudinal assessment of the effects of nursery attendance and breastfeeding on respiratory symptoms and their impact on quality of life in the first 22 months of life- results from the liverpool baby breathing study

Stead, J., Semple, M., Griffith, B., Pickles, R., Patel, S., & Barclay, J. (2018). G447 The cross-sectional and longitudinal assessment of the effects of nursery attendance and breastfeeding on respiratory symptoms and their impact on quality of life in the first 22 months of life- results from the liverpool baby breathing study. In British Paediatric Respiratory Society and British Society for Paediatric and Adolescent Rheumatology (pp. A182.2-A184). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.436

DOI
10.1136/archdischild-2018-rcpch.436
Conference Paper

G453(P) A survey of paediatric bronchoscopy decontamination practice in uk regional centres

Letch, E. G., Batchelor, E. G. L., & Semple, M. G. (2018). G453(P) A survey of paediatric bronchoscopy decontamination practice in uk regional centres. In British Paediatric Respiratory Society and British Society for Paediatric and Adolescent Rheumatology (pp. A185.2-A187). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.442

DOI
10.1136/archdischild-2018-rcpch.442
Conference Paper

G58(P) Are children at risk of severe influenza receiving seasonal influenza vaccine? an audit of outpatient clinics at alder hey children’s hospital

Lythgoe, C. N., Baxter, M. R., Cooke, R. P. D., & Semple, M. G. (2018). G58(P) Are children at risk of severe influenza receiving seasonal influenza vaccine? an audit of outpatient clinics at alder hey children’s hospital. In British Paediatric Allergy, Immunity and Infection Group (pp. A23.3-A24). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.56

DOI
10.1136/archdischild-2018-rcpch.56
Conference Paper

Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (<i>Ophthalmology</i>. 2017;124:170-177)

Steptoe, P. J., Scott, J. T., Sahr, F., Vandy, M., Harding, S. P., Beare, N. A. V., & Semple, M. G. (2018). Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (<i>Ophthalmology</i>. 2017;124:170-177). OPHTHALMOLOGY, 125(3), E19. doi:10.1016/j.ophtha.2017.09.009

DOI
10.1016/j.ophtha.2017.09.009
Journal article

2017

Reply to Lee and colleagues-Viral posterior uveitis.

Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues-Viral posterior uveitis.. Survey of ophthalmology, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002

DOI
10.1016/j.survophthal.2017.06.002
Journal article

Ocular Complications in Survivors of the Ebola Outbreak in Guinea

Steptoe, P. J., Scott, J. T., Harding, S. P., Beare, N. A. V., Semple, M. G., Vandy, M. J., & Sahr, F. (2017). Ocular Complications in Survivors of the Ebola Outbreak in Guinea. AMERICAN JOURNAL OF OPHTHALMOLOGY, 181, 180. doi:10.1016/j.ajo.2017.05.029

DOI
10.1016/j.ajo.2017.05.029
Journal article

Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus

Semple, M. G., & Scott, J. T. (2017). Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus. The Lancet Infectious Diseases, 17(6), 645-653. doi:10.1016/S1473-3099(17)30111-1

DOI
10.1016/S1473-3099(17)30111-1
Journal article

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza

Cole, S. L., Dunning, J., Kok, W. L., Benam, K. H., Benlahrech, A., Repapi, E., . . . Ho, L. -P. (2017). M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI INSIGHT, 2(7). doi:10.1172/jci.insight.91868

DOI
10.1172/jci.insight.91868
Journal article

2016

Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea

Delamou, A., Haba, N. Y., Mari-Saez, A., Gallian, P., Ronse, M., Jacobs, J., . . . van Griensven, J. (2016). Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea.. The American journal of tropical medicine and hygiene, 95(3), 647-653. doi:10.4269/ajtmh.15-0890

DOI
10.4269/ajtmh.15-0890
Journal article

Post-Ebola Syndrome, Sierra Leone

Scott, J., Sesay, F., Massaquoi, T., Idriss, B., Sahr, F., & Semple, M. G. (2016). Post-Ebola Syndrome, Sierra Leone. Emerging Infectious Diseases, 22(4), 641-646. doi:10.3201/eid2204.151302

DOI
10.3201/eid2204.151302
Journal article

Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak

Edwards, T., Semple, M. G., De Weggheleire, A., Claeys, Y., De Crop, M., Menten, J., . . . van Griensven, J. (2016). Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak. CLINICAL TRIALS, 13(1), 13-21. doi:10.1177/1740774515621056

DOI
10.1177/1740774515621056
Journal article

Stemming the tide of hospital admissions for bronchiolitis

Cheung, C. R., & Semple, M. G. (2016). Stemming the tide of hospital admissions for bronchiolitis. ARCHIVES OF DISEASE IN CHILDHOOD, 101(2), 118-119. doi:10.1136/archdischild-2015-309452

DOI
10.1136/archdischild-2015-309452
Journal article

2015

DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION?

Shorthouse, L., & Semple, M. G. (2015). DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION?. In THORAX Vol. 70 (pp. A120). doi:10.1136/thoraxjnl-2015-207770.226

DOI
10.1136/thoraxjnl-2015-207770.226
Conference Paper

Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study

Venkatesan, S., Myles, P. R., McCann, G., Kousoulis, A. A., Hashmi, M., Belatri, R., . . . Semple, M. G. (2015). Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study. Health Technology Assessment, 19(89), 1-132. doi:10.3310/hta19890

DOI
10.3310/hta19890
Journal article

Evaluation and refinement of pandemic inFLUenza Community Assessment Tools

Semple, M. (n.d.). Evaluation and refinement of pandemic inFLUenza Community Assessment Tools. doi:10.1186/isrctn87130712

DOI
10.1186/isrctn87130712
Dataset

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

Habibi, M. S., Jozwik, A., Makris, S., Dunning, J., Paras, A., The Mechanisms of Severe Acute Influenza Consortium Investigators., . . . Chiu, C. (2015). Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191(9), 1040-1049. doi:10.1164/rccm.201412-2256OC

DOI
10.1164/rccm.201412-2256OC
Journal article

JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT

Brown, L. E., Sampath, S., Ryan, F., Cleary, G., McCann, L., Pain, C., . . . Baildam, E. (2015). JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT. In RHEUMATOLOGY Vol. 54 (pp. 11). doi:10.1093/rheumatology/keu508

DOI
10.1093/rheumatology/keu508
Conference Paper

Convalescent plasma for early Ebola virus disease in Sierra Leone

Winters, V., & Semple, C. (n.d.). Convalescent plasma for early Ebola virus disease in Sierra Leone. doi:10.1186/isrctn13990511

DOI
10.1186/isrctn13990511
Dataset

2014

2013

An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic

Semple, M. G., Myles, P. R., Nicholson, K. G., Lim, W. S., Read, R. C., Taylor, B. L., . . . Nguyen-Van-Tam, J. S. (2013). An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic. PLOS ONE, 8(9). doi:10.1371/journal.pone.0075384

DOI
10.1371/journal.pone.0075384
Journal article

Differences between asthmatics and nonasthmatics hospitalised with influenza A infection

Myles, P., Nguyen-Van-Tam, J. S., Semple, M. G., Brett, S. J., Bannister, B., Read, R. C., . . . Lim, W. S. (2013). Differences between asthmatics and nonasthmatics hospitalised with influenza A infection. EUROPEAN RESPIRATORY JOURNAL, 41(4), 824-831. doi:10.1183/09031936.00015512

DOI
10.1183/09031936.00015512
Journal article

Population variation in admission rates and duration of inpatient stay for bronchiolitis in England

Cheung, C. R., Smith, H., Thurland, K., Duncan, H., & Semple, M. G. (2013). Population variation in admission rates and duration of inpatient stay for bronchiolitis in England. ARCHIVES OF DISEASE IN CHILDHOOD, 98(1), 57-59. doi:10.1136/archdischild-2012-302277

DOI
10.1136/archdischild-2012-302277
Journal article

2012

The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection

Dolan, G. P., Myles, P. R., Brett, S. J., Enstone, J. E., Read, R. C., Openshaw, P. J. M., . . . Nguyen-Van-Tam, J. S. (2012). The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection. PLOS ONE, 7(8). doi:10.1371/journal.pone.0041638

DOI
10.1371/journal.pone.0041638
Journal article

Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis

Semple, M. G., Flanagan, B., & Smyth, R. L. (2012). Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis. In A15. AIRWAY RESPONSES TO RESPIRATORY VIRAL INFECTION (pp. A1026). American Thoracic Society. doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026

DOI
10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026
Conference Paper

Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data

Myles, P. R., Nguyen-Van-Tam, J. S., Lim, W. S., Nicholson, K. G., Brett, S. J., Enstone, J. E., . . . Semple, M. G. (2012). Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data. PLOS ONE, 7(4). doi:10.1371/journal.pone.0034428

DOI
10.1371/journal.pone.0034428
Journal article

IFITM3 restricts the morbidity and mortality associated with influenza

Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., . . . Kellam, P. (2012). IFITM3 restricts the morbidity and mortality associated with influenza. NATURE, 484(7395), 519-U146. doi:10.1038/nature10921

DOI
10.1038/nature10921
Journal article

Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK

Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., Gadd, E. M., Read, R. C., . . . Nguyen-Van-Tam, J. S. (2012). Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK. THORAX, 67(8), 709-717. doi:10.1136/thoraxjnl-2011-200266

DOI
10.1136/thoraxjnl-2011-200266
Journal article

Problems of the Respiratory System: Rate of admissions and mean length of stay for bronchiolitis in children under 2 years of age by PCT in England, Maps 20 & 21

Semple, M. G., Cheung, R., Duncan, H., Smith, H., Chaplin, S., & Ridler, C. (2012). Problems of the Respiratory System: Rate of admissions and mean length of stay for bronchiolitis in children under 2 years of age by PCT in England, Maps 20 & 21. In R. Cheung, & R. Cheung (Eds.), NHS Atlas of variation in healthcare for children and young people. (pp. 58-61, 74). London: NHS Right Care Department of Health. Retrieved from http://www.rightcare.nhs.uk/index.php/nhs-atlas/

Chapter

Suction versus no suction for chest drain management

van Miert, C., Dwan, K., Hill, R., Hoenig, M. R., Gruen, R. L., & Semple, M. G. (n.d.). Suction versus no suction for chest drain management. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd009939

DOI
10.1002/14651858.cd009939
Journal article

2011

The increasing importance of innate antimicrobials response

Lim, W. S., Bewick, T., Myles, P., Greenwood, S., Nguyen-Van-Tam, J. S., Brett, S., . . . Nicholson, K. G. (2011). The increasing importance of innate antimicrobials response. THORAX, 66(12), 1091. doi:10.1136/thoraxjnl-2011-200600

DOI
10.1136/thoraxjnl-2011-200600
Journal article

Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study

Semple, M. G., Taylor-Robinson, D. C., Lane, S., & Smyth, R. L. (2011). Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study. PLOS ONE, 6(7). doi:10.1371/journal.pone.0022425

DOI
10.1371/journal.pone.0022425
Journal article

Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease

Brett, S. J., Myles, P., Lim, W. S., Enstone, J. E., Bannister, B., Semple, M. G., . . . Openshaw, P. J. M. (2011). Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease. PLOS ONE, 6(4). doi:10.1371/journal.pone.0018120

DOI
10.1371/journal.pone.0018120
Journal article

Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009-2010

Enstone, J. E., Myles, P. R., Openshaw, P. J. M., Gadd, E. M., Lim, W. S., Semple, M. G., . . . Nguyen-Van-Tam, J. S. (2011). Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009-2010. EMERGING INFECTIOUS DISEASES, 17(4), 592-598. doi:10.3201/eid1704.101679

DOI
10.3201/eid1704.101679
Journal article

Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults

Bewick, T., Myles, P., Greenwood, S., Nguyen-Van-Tam, J. S., Brett, S. J., Semple, M. G., . . . Lim, W. S. (2011). Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults. THORAX, 66(3), 247-252. doi:10.1136/thx.2010.151522

DOI
10.1136/thx.2010.151522
Journal article

2010

Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009)

Nguyen-Van-Tam, J. S., Openshaw, P. J. M., Hashim, A., Gadd, E. M., Lim, W. S., Semple, M. G., . . . Nicholson, K. G. (2010). Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). THORAX, 65(7), 645-651. doi:10.1136/thx.2010.135210

DOI
10.1136/thx.2010.135210
Journal article

Paediatric practice note for the management of critically ill children with pandemic (H1N1) 2009 Influenza.

Semple, M. G., Thomson, G., Taylor, D. J., Lister, P., Hackett, S., Faust, S. N., . . . Wilkinson, K. (2010). Paediatric practice note for the management of critically ill children with pandemic (H1N1) 2009 Influenza.. Royal College of Paediatrics and Child Health Swine FLu Policy.

Journal article

2009

Evidence That RSV Directly Infects Neutrophils in the Airways and Blood of Infants with Severe Bronchiolitis

Halfhide, C. P., Brearey, S., Howarth, D., Semple, M. G., Kipar, A., Hunt, J. A., . . . Smyth, R. L. (2009). Evidence That RSV Directly Infects Neutrophils in the Airways and Blood of Infants with Severe Bronchiolitis. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 179. Retrieved from https://www.webofscience.com/

Conference Paper

Medikidz Explain Swine Flu

Semple, M. G., & McCauley, J. (Eds.) (2009). Medikidz Explain Swine Flu. London: Medikidz.

Book

Pandemic H1N1 2009 Influenza: Clinical Management Guidelines for Adults and Children

Semple, M. G., Lim, W. S., Reid, R. C., & al, E. (2009). Pandemic H1N1 2009 Influenza: Clinical Management Guidelines for Adults and Children. Delphi, Department of Health., 25. Retrieved from http://www.dh.gov.uk/

Journal article

Pandemic H1N1 2009 influenza: clinical management guidelines for pregnancy

Lim, B. H., Semple, M. G., Lim, W. S., & al, E. (2009). Pandemic H1N1 2009 influenza: clinical management guidelines for pregnancy. Delphi, Department of Health., 27. Retrieved from http://www.dh.gov.uk/

Journal article

Pandemic flu:Managing Demand and Capacity in Health Care Organisations.

Wilson, L., Bannister, B., & Semple, M. G. (2009). Pandemic flu:Managing Demand and Capacity in Health Care Organisations.. London: HMG UK. Retrieved from http://www.dh.gov.uk/

Report

Swine flu clinical package

Semple, M. G., & Bannister, B. (2009). Swine flu clinical package. London: HMG UK. Retrieved from http://www.dh.gov.uk/

Report

2008

Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK

Hopkins, M. J., Redmond, C., Shaw, J. M., Hart, I. J., Hart, C. A., Smyth, R. L., & Semple, M. G. (2008). Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK. JOURNAL OF CLINICAL VIROLOGY, 42(3), 273-279. doi:10.1016/j.jcv.2008.03.011

DOI
10.1016/j.jcv.2008.03.011
Journal article

2007

CD8<SUP>+</SUP> T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections

Heidema, J., Lukens, M. V., van Maren, W. W. C., van Dijk, M. E. A., Otten, H. G., van Vught, A. J., . . . van Bleek, G. M. (2007). CD8<SUP>+</SUP> T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections. JOURNAL OF IMMUNOLOGY, 179(12), 8410-8417. doi:10.4049/jimmunol.179.12.8410

DOI
10.4049/jimmunol.179.12.8410
Journal article

Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free

Semple, M. G., Booth, J. A., & Ebrahimi, B. (2007). Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free. JOURNAL OF CLINICAL VIROLOGY, 40(3), 241-244. doi:10.1016/j.jcv.2007.08.019

DOI
10.1016/j.jcv.2007.08.019
Journal article

Severe Respiratory Syncytial Virus Bronchiolitis in Infants Is Associated with Reduced Airway Interferon Gamma and Substance P

Semple, M. G., Dankert, H. M., Ebrahimi, B., Correia, J. B., Booth, J. A., Stewart, J. P., . . . Hart, C. A. (2007). Severe Respiratory Syncytial Virus Bronchiolitis in Infants Is Associated with Reduced Airway Interferon Gamma and Substance P. PLOS ONE, 2(10). doi:10.1371/journal.pone.0001038

DOI
10.1371/journal.pone.0001038
Journal article

Pathophysiology. Lessons from humanrespiratory syncytial virus bronchiolitisand acute wheezing episodes in infants

Semple, M., & Smyth, R. (2007). Pathophysiology. Lessons from humanrespiratory syncytial virus bronchiolitisand acute wheezing episodes in infants. In Exacerbations of Asthma (pp. 187-202). CRC Press. doi:10.1201/b14633-14

DOI
10.1201/b14633-14
Chapter

CD8+ T cell responses in bronchoalveolar lavage fluid and PBMC of infants with severe primary respiratory syncytial virus infections.

Heidema, J., Lukens, M. V., van Maren, W. W. C., van Dijk, M. E. A., Otten, H. G., van Vught, A. J., . . . van Bleek, G. M. (2007). CD8+ T cell responses in bronchoalveolar lavage fluid and PBMC of infants with severe primary respiratory syncytial virus infections.. Journal of Immunology, 179(12), 8410-8417. Retrieved from http://www.jimmunol.org/cgi/content/full/179/12/8410

Journal article

2005

Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis

Semple, M. G., Cowell, A., Dove, W., Greensill, J., McNamara, P. S., Halfhide, C., . . . Hart, C. A. (2005). Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis. JOURNAL OF INFECTIOUS DISEASES, 191(3), 382-386. doi:10.1086/426457

DOI
10.1086/426457
Journal article

Interleukin 9 concentrations in infants with Respiratory Syncytial Virus Bronchiolitis.

Semple, M. G., Dankert, H. M., Hart, C. A., & Smyth, R. L. (2005). Interleukin 9 concentrations in infants with Respiratory Syncytial Virus Bronchiolitis.. European Respiratory Journal, 26(49), 28. Retrieved from http://www.ersnet.org/ers/lr/browse/media.aspx?id_dossier=46084&id_fiche=211554

Journal article

Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trial.

A, S., & et.al., F. T. T. S. G. (2005). Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trial.. Lancet, 365(9459), 573-578. Retrieved from http://dx.doi.org/10.1016/S0140-6736(05)17906-9

Journal article

Reduced interferon-gamma concentration in infants with severe respiratory syncytial virus bronchiolitis

Dankert, H. M., Semple, M. G., Hart, C. A., & Smyth, R. L. (2005). Reduced interferon-gamma concentration in infants with severe respiratory syncytial virus bronchiolitis. European Respiratory Journal, 26(49), 27. Retrieved from http://www.ersnet.org/ers/lr/browse/media.aspx?id_dossier=46083&id_fiche=211552

Journal article

TLR expression and localisation in the airway cells of infants with severe bronchiolitis

Brearey, S. P., Flanagan, B. F., Hunt, J. A., Cummerson, J. A., McNamara, P. S., Semple, M. G., . . . Smyth, R. L. (2005). TLR expression and localisation in the airway cells of infants with severe bronchiolitis. In IMMUNOLOGY Vol. 116 (pp. 79). Retrieved from https://www.webofscience.com/

Conference Paper

2003

Left pulmonary artery sling presenting as unilateral echogenic lung on 20-week detailed antenatal ultrasound examination

Semple, M. G., Bricker, L., Shaw, B. N. J., & Pilling, D. W. (2003). Left pulmonary artery sling presenting as unilateral echogenic lung on 20-week detailed antenatal ultrasound examination. PEDIATRIC RADIOLOGY, 33(8), 567-569. doi:10.1007/s00247-003-0942-5

DOI
10.1007/s00247-003-0942-5
Journal article

Update on Cochrane data on paediatric respiratory diseases.

Semple, M. G., & Smyth, R. L. (2003). Update on Cochrane data on paediatric respiratory diseases.. Paediatric respiratory reviews, 4(3), 250-266. doi:10.1016/s1526-0542(03)00048-4

DOI
10.1016/s1526-0542(03)00048-4
Journal article

2002

Academic Mentoiring

Openshaw, P., Semple, M. G., & Smyth, R. L. (2002). Academic Mentoiring. London: Academy of Medical Sciences.

Report

1995

MORTALITY BEFORE AND AFTER HIV-INFECTION IN THE COMPLETE UK POPULATION OF HEMOPHILIACS

DARBY, S. C., EWART, D. W., GIANGRANDE, P. L. F., DOLIN, P. J., SPOONER, R. J. D., & RIZZA, C. R. (1995). MORTALITY BEFORE AND AFTER HIV-INFECTION IN THE COMPLETE UK POPULATION OF HEMOPHILIACS. NATURE, 377(6544), 79-82. doi:10.1038/377079a0

DOI
10.1038/377079a0
Journal article

HIV RESULTS IN THE FRAME - RESULTS CONFIRMED

NOWAK, M. A., BONHOEFFER, S., LOVEDAY, C., BALFE, P., SEMPLE, M., KAYE, S., . . . TEDDER, R. (1995). HIV RESULTS IN THE FRAME - RESULTS CONFIRMED. NATURE, 375(6528), 193. doi:10.1038/375193a0

DOI
10.1038/375193a0
Journal article

HIV-1 RNA SERUM-LOAD AND RESISTANT VIRAL GENOTYPES DURING EARLY ZIDOVUDINE THERAPY

LOVEDAY, C., KAYE, S., TENANTFLOWERS, M., SEMPLE, M., AYLIFFE, U., WELLER, I. V. D., & TEDDER, R. S. (1995). HIV-1 RNA SERUM-LOAD AND RESISTANT VIRAL GENOTYPES DURING EARLY ZIDOVUDINE THERAPY. LANCET, 345(8953), 820-824. doi:10.1016/S0140-6736(95)92963-0

DOI
10.1016/S0140-6736(95)92963-0
Journal article

HIV results in the frame. Results confirmed.

Nowak, M. A., Bonhoeffer, S., Loveday, C., Balfe, P., Semple, M., Kaye, S., . . . Tedder, R. (1995). HIV results in the frame. Results confirmed.. Nature, 375(6528), 193. doi:10.1038/375193a0

DOI
10.1038/375193a0
Journal article

1993

HIV-1 PLASMA VIREMIA QUANTIFICATION - A NONCULTURE MEASUREMENT NEEDED FOR THERAPEUTIC TRIALS

SEMPLE, M. G., KAYE, S., LOVEDAY, C., & TEDDER, R. S. (1993). HIV-1 PLASMA VIREMIA QUANTIFICATION - A NONCULTURE MEASUREMENT NEEDED FOR THERAPEUTIC TRIALS. JOURNAL OF VIROLOGICAL METHODS, 41(2), 167-179. doi:10.1016/0166-0934(93)90124-A

DOI
10.1016/0166-0934(93)90124-A
Journal article

1992

LACK OF SUPPRESSION BY RIBAVIRIN OF HIV VIREMIA

GILSON, R. J. C., SEMPLE, M., GILL, S. K., LOVEDAY, C., TEDDER, R. S., & WELLER, I. V. D. (1992). LACK OF SUPPRESSION BY RIBAVIRIN OF HIV VIREMIA. LANCET, 339(8809), 1605-1606. doi:10.1016/0140-6736(92)91867-8

DOI
10.1016/0140-6736(92)91867-8
Journal article

Quantitative viral assay

Semple, M. G., Tedder, R. S., Loveday, C., & Kaye, S. (1993, April 8). WO1993021339 A1, Quantitative viral assay. WO.

Patent

HIV, AIDS, AND ZIDOVUDINE

TEDDER, R. S., SEMPLE, M. G., TENANTFLOWERS, M., & LOVEDAY, C. (1992). HIV, AIDS, AND ZIDOVUDINE. LANCET, 339(8796), 805. doi:10.1016/0140-6736(92)91929-3

DOI
10.1016/0140-6736(92)91929-3
Journal article

1991

DIRECT MEASUREMENT OF VIREMIA IN PATIENTS INFECTED WITH HIV-1 AND ITS RELATIONSHIP TO DISEASE PROGRESSION AND ZIDOVUDINE THERAPY

SEMPLE, M., LOVEDAY, C., WELLER, I., & TEDDER, R. (1991). DIRECT MEASUREMENT OF VIREMIA IN PATIENTS INFECTED WITH HIV-1 AND ITS RELATIONSHIP TO DISEASE PROGRESSION AND ZIDOVUDINE THERAPY. JOURNAL OF MEDICAL VIROLOGY, 35(1), 38-45. doi:10.1002/jmv.1890350109

DOI
10.1002/jmv.1890350109
Journal article