Publications
Selected publications
- Adeno-associated virus 2 infection in children with non-A-E hepatitis. (Journal article - 2023)
- Genomic investigations of unexplained acute hepatitis in children. (Journal article - 2023)
- Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. (Journal article - 2021)
- Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article - 2020)
- Ebola virus antibody decay-stimulation in a high proportion of survivors (Journal article - 2021)
- Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea (Journal article - 2016)
- Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults (Journal article - 2022)
- Genetic mechanisms of critical illness in COVID-19. (Journal article - 2021)
- Mapping the human genetic architecture of COVID-19 (Journal article - 2021)
- Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article - 2020)
2024
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.
Mesinovic, M., Wong, X. C., Rajahram, G. S., Citarella, B. W., Peariasamy, K. M., van Someren Greve, F., . . . ISARIC Characterisation Group. (2024). At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.. Scientific reports, 14(1), 16387. doi:10.1038/s41598-024-63212-7
Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.
Elneima, O., Hurst, J. R., Echevarria, C., Quint, J. K., Walker, S., Siddiqui, S., . . . Heaney, L. G. (2024). Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.. ERJ open research, 10(4), 982-2023. doi:10.1183/23120541.00982-2023
Stratified analyses refine association between TLR7 rare variants and severe COVID-19.
Boos, J., van der Made, C. I., Ramakrishnan, G., Coughlan, E., Asselta, R., Löscher, B. -S., . . . Ludwig, K. U. (2024). Stratified analyses refine association between TLR7 rare variants and severe COVID-19.. HGG advances, 5(4), 100323. doi:10.1016/j.xhgg.2024.100323
Can self-testing be enhanced to hasten safe return of healthcare workers in pandemics? Random order, open label trial using two manufacturers’ SARS-CoV-2 lateral flow devices concurrently
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms.
Citarella, B. W., Kartsonaki, C., Ibáñez-Prada, E. D., Gonçalves, B. P., Baruch, J., Escher, M., . . . ISARIC Clinical Characterisation Group. (2024). Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms.. Heliyon, 10(10), e29591. doi:10.1016/j.heliyon.2024.e29591
Long COVID and cardiovascular disease: a prospective cohort study.
Lawson, C. A., Moss, A. J., Arnold, J. R., Bagot, C., Banerjee, A., Berry, C., . . . PHOSP-COVID Study Collaborative Group. (2024). Long COVID and cardiovascular disease: a prospective cohort study.. Open heart, 11(1), e002662. doi:10.1136/openhrt-2024-002662
Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.
Turtle, L., Elliot, S., Drake, T. M., Thorpe, M., Khoury, E. G., Greenhalf, W., . . . ISARIC4C Investigators. (2024). Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.. The Lancet. Oncology, 25(5), 636-648. doi:10.1016/s1470-2045(24)00107-4
Post-Covid-19 condition (Long Covid) in children and young people 12 months after infection or reinfection with the Omicron variant: a prospective observational study.
Pinto Pereira, S. M., Nugawela, M. D., Stephenson, T., Foret-Bruno, P., Dalrymple, E., Xu, L., . . . Shafran, R. (2024). Post-Covid-19 condition (Long Covid) in children and young people 12 months after infection or reinfection with the Omicron variant: a prospective observational study.. Scientific reports, 14(1), 9957. doi:10.1038/s41598-024-60372-4
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
Liew, F., Efstathiou, C., Fontanella, S., Richardson, M., Saunders, R., Swieboda, D., . . . ISARIC investigators. (2024). Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.. Nature immunology, 25(4), 607-621. doi:10.1038/s41590-024-01778-0
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 15(1), 2918. doi:10.1038/s41467-024-47320-6
Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".
Seylanova, N., Chernyavskaya, A., Degtyareva, N., Mursalova, A., Ajam, A., Xiao, L., . . . PC-COS Children Study Group. (2024). Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".. The European respiratory journal, 63(3), 2301761. doi:10.1183/13993003.01761-2023
Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.
Cho, S. -M., Premraj, L., Battaglini, D., Fanning, J. P., Suen, J., Bassi, G. L., . . . ISARIC Clinical Characterization Group. (2024). Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.. Brain communications, 6(2), fcae036. doi:10.1093/braincomms/fcae036
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies.
Costigan, D., Fenn, J., Yen, S., Ilott, N., Bullers, S., Hale, J., . . . Thornton, E. E. (2024). A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies.. Mucosal immunology, 17(1), 111-123. doi:10.1016/j.mucimm.2023.11.005
Data Resource Profile: the Children and Young People with Long COVID (CLoCk) Study.
Nugawela, M. D., Pinto Pereira, S. M., Rojas, N. K., McOwat, K., Simmons, R., Dalrymple, E., . . . CLoCk Consortium. (2024). Data Resource Profile: the Children and Young People with Long COVID (CLoCk) Study.. International journal of epidemiology, 53(1), dyad158. doi:10.1093/ije/dyad158
Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).
Pazukhina, E., Rumyantsev, M., Baimukhambetova, D., Bondarenko, E., Markina, N., El-Taravi, Y., . . . Sechenov StopCOVID Research Team. (2024). Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).. BMC medicine, 22(1), 48. doi:10.1186/s12916-023-03221-x
Respiratory Syncytial Virus Maternal Vaccination in Infants below 6 Months of Age: Meta-Analysis of Safety, Immunogenicity, and Efficacy.
Mapindra, M. P., Mahindra, M. P., McNamara, P., Semple, M. G., Clark, H., & Madsen, J. (2024). Respiratory Syncytial Virus Maternal Vaccination in Infants below 6 Months of Age: Meta-Analysis of Safety, Immunogenicity, and Efficacy.. Neonatology, 121(3), 271-282. doi:10.1159/000536031
Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.. The Lancet. Child & adolescent health, S2352-4642(23)00316-4. doi:10.1016/s2352-4642(23)00316-4
Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.
Devine, K., Russell, C. D., Blanco, G. R., Walker, B. R., Homer, N. Z. M., Denham, S. G., . . . ISARIC4C Investigators and PHOSP-COVID Study Collaborative Group. (2024). Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.. Clinical endocrinology. doi:10.1111/cen.15012
Accelarated immune ageing is associated with COVID-19 disease severity.
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., . . . ISARIC4C investigators. (2024). Accelarated immune ageing is associated with COVID-19 disease severity.. Immunity & ageing : I & A, 21(1), 6. doi:10.1186/s12979-023-00406-z
Stakeholders' perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study.
Deja, E., Donohue, C., Semple, M. G., Woolfall, K., & BESS Investigators. (2024). Stakeholders' perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study.. BMJ open, 14(1), e077023. doi:10.1136/bmjopen-2023-077023
COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region
Burnside, G., Cheyne, C. P., Leeming, G., Humann, M., Darby, A., Green, M. A., . . . Buchan, I. E. (2024). COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region. Journal of the Royal Society of Medicine. doi:10.1177/01410768231182389
Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study.
Battaglini, D., White, N. M., Premraj, L., Wanjiru Citarella, B., Merson, L., Robba, C., . . . ISARIC Clinical Characterization Group. (2024). Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study.. Journal of neurology, 271(1), 79-86. doi:10.1007/s00415-023-12133-y
2023
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury.
Taquet, M., Skorniewska, Z., Zetterberg, H., Geddes, J. R., Mummery, C. J., Chalmers, J. D., . . . PHOSP-COVID Study Collaborative Group . (2024). Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury.. Brain communications, 6(1), fcad357. doi:10.1093/braincomms/fcad357
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.. The Journal of infectious diseases, 230(1), e17-e29. doi:10.1093/infdis/jiad590
Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L. -P., . . . Williams, N. (2023). Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology, 53(1). doi:10.1093/ije/dyad165
Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19.
Camirand-Lemyre, F., Merson, L., Tirupakuzhi Vijayaraghavan, B. K., Burrell, A. J. C., Citarella, B. W., Domingue, M. -P., . . . ISARIC Clinical Characterisation Group. (2023). Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19.. JAMA network open, 6(12), e2346502. doi:10.1001/jamanetworkopen.2023.46502
Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M. G., . . . Hiscox, J. A. (2023). Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome. Journal of Clinical Virology, 105620. doi:10.1016/j.jcv.2023.105620
Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.
Swets, M. C., Kerr, S., Scott-Brown, J., Brown, A. B., Gupta, R., Millar, J. E., . . . Baillie, J. K. (2023). Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.. Nature communications, 14(1), 7374. doi:10.1038/s41467-023-42205-6
A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves, B. P., Jassat, W., Baruch, J., Hashmi, M., Rojek, A., Dasgupta, A., . . . ISARIC Clinical Characterisation Group. (2023). A multi-country analysis of COVID-19 hospitalizations by vaccination status.. Med (New York, N.Y.), 4(11), 797-812.e2. doi:10.1016/j.medj.2023.08.005
Long COVID research: an update from the PHOSP-COVID Scientific Summit.
Brightling, C. E., Evans, R. A., Singapuri, A., Smith, N., Wain, L. V., & PHOSP-COVID Collaborative Group. (2023). Long COVID research: an update from the PHOSP-COVID Scientific Summit.. The Lancet. Respiratory medicine, 11(11), e93-e94. doi:10.1016/s2213-2600(23)00341-7
The CLoCk study: A retrospective exploration of loneliness in children and young people during the COVID-19 pandemic, in England.
McOwat, K., Pinto Pereira, S. M., Nugawela, M. D., Ladhani, S. N., Newlands, F., Stephenson, T., . . . Shafran, R. (2023). The CLoCk study: A retrospective exploration of loneliness in children and young people during the COVID-19 pandemic, in England.. PloS one, 18(11), e0294165. doi:10.1371/journal.pone.0294165
International Pediatric COVID-19 Severity Over the Course of the Pandemic
Zhu, Y., Almeida, F. J., Baillie, J. K., Bowen, A. C., Britton, P. N., Brizuela, M. E., . . . Short, K. R. (2023). International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA PEDIATRICS. doi:10.1001/jamapediatrics.2023.3117
Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: A prospective, multinational, observational study.
Reyes, L. F., Garcia-Gallo, E., Murthy, S., Fuentes, Y. V., Serrano, C. C., Ibáñez-Prada, E. D., . . . ISARIC Characterisation Group. (2023). Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: A prospective, multinational, observational study.. Journal of critical care, 77, 154318. doi:10.1016/j.jcrc.2023.154318
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
C-MORE/PHOSP-COVID Collaborative Group. (2023). Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.. The Lancet. Respiratory medicine, S2213-2600(23)00262-X. doi:10.1016/s2213-2600(23)00262-x
Liver injury in hospitalized patients with COVID-19: An International observational cohort study.
Tirupakuzhi Vijayaraghavan, B. K., Bishnu, S., Baruch, J., Citarella, B. W., Kartsonaki, C., Meeyai, A., . . . ISARIC Clinical Characterisation Group. (2023). Liver injury in hospitalized patients with COVID-19: An International observational cohort study.. PloS one, 18(9), e0277859. doi:10.1371/journal.pone.0277859
Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.
Roper, K. J., Thomas, J., Albalawi, W., Maddocks, E., Dobson, S., Alshehri, A., . . . Pollakis, G. (2023). Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.. Scientific reports, 13(1), 15014. doi:10.1038/s41598-023-41928-2
A second update on mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative. (2023). A second update on mapping the human genetic architecture of COVID-19.. Nature, 621(7977), E7-E26. doi:10.1038/s41586-023-06355-3
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
Wainstein, M., Spyrison, N., Dai, D., Ghadimi, M., Chávez-Iñiguez, J. S., Rizo-Topete, L., . . . Zucman, D. (2023). Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19. Kidney International Reports, 8(8), 1514-1530. doi:10.1016/j.ekir.2023.05.015
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.
Jackson, C., Stewart, I., Plekhanova, T., Cunningham, P. S., Hazel, A. L., Al-Sheklly, B., . . . PHOSP-COVID, S. C. G. (2023). Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. LANCET RESPIRATORY MEDICINE, 11(8), 673-684. doi:10.1016/S2213-2600(23)00124-8
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023)
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023). NATURE. doi:10.1038/s41586-023-06383-z
Symptom Profiles of Children and Young People 12 Months after SARS-CoV-2 Testing: A National Matched Cohort Study (The CLoCk Study)
Pereira, S. M. P. M., Nugawela, M. D. D., McOwat, K., Dalrymple, E., Xu, L., Ladhani, S. N. N., . . . Stephenson, T. (2023). Symptom Profiles of Children and Young People 12 Months after SARS-CoV-2 Testing: A National Matched Cohort Study (The CLoCk Study). Children, 10(7). doi:10.3390/children10071227
HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation
Yang, H., Sun, H., Brackenridge, S., Zhuang, X., Wing, P. A. C., Quastel, M., . . . McMichael, A. J. (2023). HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation. SCIENCE IMMUNOLOGY, 8(84). doi:10.1126/sciimmunol.abl8881
Patient emergency health-care use before hospital admission for COVID-19 and long-term outcomes in Scotland: a national cohort study.
Docherty, A. B., Farrell, J., Thorpe, M., Egan, C., Dunn, S., Norman, L., . . . Lone, N. I. (2023). Patient emergency health-care use before hospital admission for COVID-19 and long-term outcomes in Scotland: a national cohort study.. The Lancet. Digital health, 5(7), e446-e457. doi:10.1016/s2589-7500(23)00051-1
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
Griffee, M. J., Bozza, P. T., Reyes, L. F., Eddington, D. P., Rosenberger, D., Merson, L., . . . Zucman, D. (2023). Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry. Research and Practice in Thrombosis and Haemostasis, 7(5), 102142. doi:10.1016/j.rpth.2023.102142
Enrichment of Sars-Cov-2 and Seasonal Coronavirus Sequence from Nasopharyngeal Swabs Whilst Maintaining the Background Context of the Microbiome
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M., . . . Hiscox, J. (2023). Enrichment of Sars-Cov-2 and Seasonal Coronavirus Sequence from Nasopharyngeal Swabs Whilst Maintaining the Background Context of the Microbiome. doi:10.2139/ssrn.4484216
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls
Zheng, B., Vivaldi, G., Daines, L., Leavy, O. C., Richardson, M., Elneima, O., . . . Zongo, O. (2023). Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls. The Lancet Regional Health - Europe, 29, 100635. doi:10.1016/j.lanepe.2023.100635
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. NATURE, 617(7962), 764-+. doi:10.1038/s41586-023-06034-3
Long COVID in Children and Young after Infection or Reinfection with the Omicron Variant: A Prospective Observational Study.
Pinto Pereira, S. M., Mensah, A., Nugawela, M. D., Stephenson, T., Ladhani, S. N., Dalrymple, E., . . . Shafran, R. (2023). Long COVID in Children and Young after Infection or Reinfection with the Omicron Variant: A Prospective Observational Study.. The Journal of pediatrics, 259, 113463. doi:10.1016/j.jpeds.2023.113463
Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial
Pauley, E., Drake, T. M., Griffith, D. M., Sigfrid, L., Lone, N. I., Harrison, E. M., . . . Docherty, A. B. (2023). Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial. JOURNAL OF THE INTENSIVE CARE SOCIETY, 24(2), 162-169. doi:10.1177/17511437211052226
Neurological manifestations of COVID-19 in adults and children.
Cho, S. -M., White, N., Premraj, L., Battaglini, D., Fanning, J., Suen, J., . . . ISARIC Clinical Characterisation Group. (2023). Neurological manifestations of COVID-19 in adults and children.. Brain : a journal of neurology, 146(4), 1648-1661. doi:10.1093/brain/awac332
Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.
Shah, N., Xue, B., Xu, Z., Yang, H., Marwali, E., Dalton, H., . . . ISARIC Clinical Characterisation Group. (2023). Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.. Artificial organs. doi:10.1111/aor.14542
Occupational inequalities in the prevalence of COVID-19: A longitudinal observational study of England, August 2020 to January 2021
Green, M., & Semple, M. (2023). Occupational inequalities in the prevalence of COVID-19: A longitudinal observational study of England, August 2020 to January 2021. PLoS One.
Adeno-associated virus 2 infection in children with non-A-E hepatitis.
Ho, A., Orton, R., Tayler, R., Asamaphan, P., Herder, V., Davis, C., . . . Thomson, E. C. (2023). Adeno-associated virus 2 infection in children with non-A-E hepatitis.. Nature. doi:10.1038/s41586-023-05948-2
Genomic investigations of unexplained acute hepatitis in children.
Morfopoulou, S., Buddle, S., Montaguth, O. E. T., Atkinson, L., Guerra-Assunção, J. A., Marjaneh, M. M., . . . Breuer, J. (2023). Genomic investigations of unexplained acute hepatitis in children.. Nature. doi:10.1038/s41586-023-06003-w
Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID-19 Study.
Stewart, I., Jacob, J., George, P. M., Molyneaux, P. L., Porter, J. C., Allen, R. J., . . . Jenkins, G. R. (2023). Residual Lung Abnormalities after COVID-19 Hospitalization Interim Analysis of the UKILD Post-COVID-19 Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207(6), 693-703. doi:10.1164/rccm.202203-0564OC
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study
McAuley, H. J. C., Evans, R. A., Bolton, C. E., Brightling, C. E., Chalmers, J. D., Docherty, A. B., . . . Zongo, O. (2023). Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. eClinicalMedicine, 57, 101896. doi:10.1016/j.eclinm.2023.101896
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.
Kartsonaki, C., Baillie, J. K., Barrio, N. G., Baruch, J., Beane, A., Blumberg, L., . . . ISARIC Clinical Characterisation Group. (2023). Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.. International journal of epidemiology, dyad012. doi:10.1093/ije/dyad012
Prevention of Neurological Complications During COVID-19: Protocol for a Retrospective Analysis of the ISARIC4C National Cohort
Grundmann, A., Hardwick, M., Wu, C. -H., Semple, M. G., Böhning, D., Pett, S., . . . Galea, I. (n.d.). Prevention of Neurological Complications During COVID-19: Protocol for a Retrospective Analysis of the ISARIC4C National Cohort. SSRN Electronic Journal. doi:10.2139/ssrn.4037376
Estimating distribution of length of stay in a multi-state model conditional on the pathway, with an application to patients hospitalised with Covid-19
Keogh, R. H., Diaz-Ordaz, K., Jewell, N. P., Semple, M. G., de Wreede, L. C., & Putter, H. (2023). Estimating distribution of length of stay in a multi-state model conditional on the pathway, with an application to patients hospitalised with Covid-19. Lifetime Data Analysis. doi:10.1007/s10985-022-09586-0
Prevalence and Risk Factors of Post-COVID-19 Condition in Adults and Children at 6 and 12 Months After Hospital Discharge: A Prospective, Cohort Study in Moscow (Stop COVID)
Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., . . . Team, S. S. R. (n.d.). Prevalence and Risk Factors of Post-COVID-19 Condition in Adults and Children at 6 and 12 Months After Hospital Discharge: A Prospective, Cohort Study in Moscow (Stop COVID). SSRN Electronic Journal. doi:10.2139/ssrn.4020142
The role of pandemic planning in the management of COVID-19 in England from an infection prevention and control perspective: results of a national survey.
Greene, C., Wilson, J., Griffin, H., Tingle, A., Cooper, T., Semple, M. G., . . . Loveday, H. (2023). The role of pandemic planning in the management of COVID-19 in England from an infection prevention and control perspective: results of a national survey.. Public health, 217, 89-94. doi:10.1016/j.puhe.2023.01.028
Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.
Turtle, L., Thorpe, M., Drake, T. M., Swets, M., Palmieri, C., Russell, C. D., . . . Docherty, A. B. (2023). Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.. PLoS medicine, 20(1), e1004086. doi:10.1371/journal.pmed.1004086
Association of SARS-CoV-2 viral load distributions with individual demographics and suspected variant type: Results from the Liverpool Community Testing Pilot - England, 6 November 2020‒8 September 2021
Hughes, D., Cheyne, C., Ashton, M., Coffee, E., Crozier, A., Semple, M., . . . Garcia-Finana, M. (n.d.). Association of SARS-CoV-2 viral load distributions with individual demographics and suspected variant type: Results from the Liverpool Community Testing Pilot - England, 6 November 2020‒8 September 2021. Eurosurveillance. doi:10.2807/1560-7917.ES.2023.28.4.2200129
SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study
Parker, E., Thomas, J., Roper, K. J., Ijaz, S., Edwards, T., Marchesin, F., . . . Pollakis, G. (2023). SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1146702
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402
The early use of Antibiotics for At-risk children with InfluEnza in Primary Care (the ARCHIE programme)
Wang, K., Tonner, S., Semple, M. G., Wolstenholme, J., Perera, R., & Harnden, A. (2023). The early use of Antibiotics for At-risk children with InfluEnza in Primary Care (the ARCHIE programme). Programme Grants for Applied Research, 1-57. doi:10.3310/wdfr7331
2022
CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic.
Jefferson, E., Cole, C., Mumtaz, S., Cox, S., Giles, T. C., Adejumo, S., . . . Quinlan, P. (2022). A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study. JOURNAL OF MEDICAL INTERNET RESEARCH, 24(12). doi:10.2196/40035
Corticosteroid treatment in influenza virus and SARS-CoV-2 co-infected patients
Swets, M. C., Russell, C., Harrison, E., Docherty, A., Lone, N., Girvan, M., . . . Baillie, K. (2022). 260. Corticosteroid treatment in influenza virus and SARS-CoV-2 co-infected patients. Open Forum Infectious Diseases, 9(Supplement_2). doi:10.1093/ofid/ofac492.338
Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people
Green, M. A., Hungerford, D. J., Hughes, D. M., Garcia-Finana, M., Turtle, L., Cheyne, C., . . . Buchan, I. (2022). Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people. BMC INFECTIOUS DISEASES, 22(1). doi:10.1186/s12879-022-07878-2
Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales
Swann, O. V., Lone, N. I., Harrison, E. M., Tomlinson, L. A., Walker, A. J., Seaborne, M. J., . . . Docherty, A. B. (2022). Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales. BMJ OPEN, 12(11). doi:10.1136/bmjopen-2022-063271
PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY
Marwali, E. M., Kekalih, A., Yuliarto, S., Wati, D. K., Rayhan, M., Valerie, I. C., . . . Dalton, H. (2022). PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY. In PEDIATRIC CRITICAL CARE MEDICINE Vol. 23. Retrieved from https://www.webofscience.com/
Symptom‐based case definitions for COVID‐19: Time and geographical variations for detection at hospital admission among 260,000 patients
Baruch, J., Rojek, A., Kartsonaki, C., Vijayaraghavan, B. K. T., Gonçalves, B. P., Pritchard, M. G., . . . ISARIC Clinical Characterisation Group. (2022). Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.. Influenza and other respiratory viruses, 16(6), 1040-1050. doi:10.1111/irv.13039
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
Marwali, E. M., Kekalih, A., Yuliarto, S., Wati, D. K., Rayhan, M., Valerie, I. C., . . . Dalton, H. J. (2022). Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity. BMJ PAEDIATRICS OPEN, 6(1). doi:10.1136/bmjpo-2022-001657
Plasma steroid concentrations reflect disease severity during acute illness but not recovery after hospitalisation with COVID-19
Devine, K., Walker, B. R., Homer, N. Z. M., Openshaw, P. J. M., Kenneth, B. J., Andrew, R., . . . Reynolds, R. M. (n.d.). Plasma steroid concentrations reflect disease severity during acute illness but not recovery after hospitalisation with COVID-19. Endocrine Abstracts. doi:10.1530/endoabs.86.oc4.3
Fewer COVID-19 Neurological Complications with Dexamethasone and Remdesivir.
Grundmann, A., Wu, C. -H., Hardwick, M., Baillie, J. K., Openshaw, P. J. M., Semple, M. G., . . . ISARIC4C investigators. (2022). Fewer COVID-19 Neurological Complications with Dexamethasone and Remdesivir.. Annals of neurology. doi:10.1002/ana.26536
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Clonal hematopoiesis is not significantly associated with COVID-19 disease severity
Zhou, Y., Shalhoub, R., Rogers, S. N., Yu, S., Gu, M., Fabre, M. A., . . . Vassiliou, G. S. (2022). Clonal hematopoiesis is not significantly associated with COVID-19 disease severity. BLOOD, 140(14), 1650-1656. doi:10.1182/blood.2022015721
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
Goncalves, B. P., Hall, M., Jassat, W., Balan, V., Murthy, S., Kartsonaki, C., . . . Olliaro, P. L. (2022). An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients. ELIFE, 11. doi:10.7554/eLife.80556
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
Kotanidis, C. P., Xie, C., Alexander, D., Rodrigues, J. C. L., Burnham, K., Mentzer, A., . . . Antoniades, C. (2022). Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19. LANCET DIGITAL HEALTH, 4(10), E705-E716. doi:10.1016/S2589-7500(22)00132-7
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
Evaluation of <i>S</i>/<i>F</i><sub>94</sub> as a proxy for COVID-19 severity
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibanez-Prada, E. D., Rello, J., . . . Olliaro, P. L. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. CRITICAL CARE, 26(1). doi:10.1186/s13054-022-04155-1
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257
PREVENTION OF NEUROLOGICAL COMPLICATIONS DURING COVID-19: A RETROSPECTIVE ANALYSIS OF THE ISARIC4C NATIONAL COHORT
Grundmann, A., Hardwick, M., Wu, C. -H., Semple, M., Bohning, D., Pett, S., . . . Galea, I. (2022). PREVENTION OF NEUROLOGICAL COMPLICATIONS DURING COVID-19: A RETROSPECTIVE ANALYSIS OF THE ISARIC4C NATIONAL COHORT. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 93. doi:10.1136/jnnp-2022-abn2.22
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
Evans, R. A., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J. C., Shikotra, A., . . . Brightling, C. E. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. LANCET RESPIRATORY MEDICINE, 10(8), 761-775. doi:10.1016/S2213-2600(22)00127-8
Clinical features and management of human monkeypox: a retrospective observational study in the UK
Adler, H., Gould, S., Hine, P., Snell, L. B., Wong, W., Houlihan, C. F., . . . Price, N. M. (2022). Clinical features and management of human monkeypox: a retrospective observational study in the UK. LANCET INFECTIOUS DISEASES, 22(8), 1153-1162. doi:10.1016/S1473-3099(22)00228-6
Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients
Ijaz, S., Dicks, S., Jegatheesan, K., Parker, E., Katsanovskaja, K., Vink, E., . . . Tedder, R. S. (2022). Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients. JOURNAL OF INFECTION, 85(2), 152-160. doi:10.1016/j.jinf.2022.05.033
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
Garcia-Gallo, E., Merson, L., Kennon, K., Kelly, S., Citarella, B. W., Fryer, D. V., . . . Reyes, L. F. (2022). ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01534-9
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses
McNaughton, A. L., Paton, R. S., Edmans, M., Youngs, J., Wellens, J., Phalora, P., . . . Thompson, C. P. (2022). Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses. JCI INSIGHT, 7(13). doi:10.1172/jci.insight.156372
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum
Tuekprakhon, A., Nutalai, R., Dijokaite-Guraliuc, A., Zhou, D., Ginn, H. M., Selvaraj, M., . . . Screaton, G. R. (2022). Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum. CELL, 185(14), 2422-+. doi:10.1016/j.cell.2022.06.005
Whole genome sequencing reveals host factors underlying critical Covid-19.
Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., . . . Baillie, J. K. (2022). Whole-genome sequencing reveals host factors underlying critical COVID-19. NATURE, 607(7917), 97-+. doi:10.1038/s41586-022-04576-6
Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)
Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., . . . Munblit, D. (2022). Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID). BMC MEDICINE, 20(1). doi:10.1186/s12916-022-02448-4
Long COVID (post-COVID-19 condition) in children: a modified Delphi process
Stephenson, T., Allin, B., Nugawela, M. D., Rojas, N., Dalrymple, E., Pereira, S. P., . . . Shafran, R. (2022). Long COVID (post-COVID-19 condition) in children: a modified Delphi process. ARCHIVES OF DISEASE IN CHILDHOOD, 107(7), 674-680. doi:10.1136/archdischild-2021-323624
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages
Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages. MSPHERE, 7(3). doi:10.1128/msphere.00913-21
The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020
Knight, G. M., Thi, M. P., Stimson, J., Funk, S., Jafari, Y., Pople, D., . . . Robotham, J. V. (2022). The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020. BMC INFECTIOUS DISEASES, 22(1). doi:10.1186/s12879-022-07490-4
A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study
Munblit, D., Nicholson, T., Akrami, A., Apfelbacher, C., Chen, J., De Groote, W., . . . Williamson, P. R. (2022). A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study. LANCET RESPIRATORY MEDICINE, 10(7), 715-724. doi:10.1016/S2213-2600(22)00169-2
CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic (Preprint)
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Donovan-Banfield, I., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers. GIGASCIENCE, 11. doi:10.1093/gigascience/giac045
<SUP>1</SUP>H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization
Correia, G. D. S., Takis, P. G., Sands, C. J., Kowalka, A. M., Tan, T., Turtle, L., . . . Lewis, M. R. (2022). <SUP>1</SUP>H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization. ANALYTICAL CHEMISTRY, 94(19), 6919-6923. doi:10.1021/acs.analchem.2c00466
Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus
Stewart, A., Sinclair, E., Ng, J. C. -F., O'Hare, J. S., Page, A., Serangeli, I., . . . Dunn-Walters, D. K. (2022). Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.807104
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, J. K. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3
Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves
Swann, O. V., Pollock, L., Holden, K. A., Munro, A. P. S., Bennett, A., Williams, T. C., . . . Investigators, I. (2022). Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves. PEDIATRIC RESEARCH. doi:10.1038/s41390-022-02052-5
Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol.
Wainstein, M., MacDonald, S., Fryer, D., Young, K., Balan, V., Begum, H., . . . ISARIC Clinical Characterisation Group. (2022). Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol.. PLoS medicine, 19(4), e1003969. doi:10.1371/journal.pmed.1003969
SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses
Swets, M. C., Russell, C. D., Harrison, E. M., Docherty, A. B., Lone, N., Girvan, M., . . . Baillie, J. K. (2022). SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses. LANCET, 399(10334), 1463-1464. doi:10.1016/S0140-6736(22)00383-X
Quality of life, healthcare use and costs in 'at-risk' children after early antibiotic treatment versus placebo for influenza- like illness: within-trial descriptive economic analyses of the ARCHIE randomised controlled trial
Rombach, I., Wang, K., Tonner, S., Grabey, J., Harnden, A., & Wolstenholme, J. (2022). Quality of life, healthcare use and costs in 'at-risk' children after early antibiotic treatment versus placebo for influenza- like illness: within-trial descriptive economic analyses of the ARCHIE randomised controlled trial. BMJ OPEN, 12(4). doi:10.1136/bmjopen-2021-049373
Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility.
Rosadas, C., Khan, M., Parker, E., Marchesin, F., Katsanovskaja, K., Sureda-Vives, M., . . . Tedder, R. S. (2022). Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. JOURNAL OF VIROLOGICAL METHODS, 302. doi:10.1016/j.jviromet.2022.114475
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study.
Stephenson, T., Pinto Pereira, S. M., Shafran, R., de Stavola, B. L., Rojas, N., McOwat, K., . . . Ladhani, S. N. (2022). Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study.. The Lancet. Child & adolescent health, 6(4), 230-239. doi:10.1016/s2352-4642(22)00022-0
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults
Killingley, B., Mann, A. J., Kalinova, M., Boyers, A., Goonawardane, N., Zhou, J., . . . Chiu, C. (2022). Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults. NATURE MEDICINE. doi:10.1038/s41591-022-01780-9
Impact of Dexamethasone and Remdesivir on Neurological Complications during COVID-19
Grundmann, A., Wu, C. -H., Hardwick, M., Baillie, K., Openshaw, P., Semple, M., . . . Galea, I. (2022). Impact of Dexamethasone and Remdesivir on Neurological Complications during COVID-19. doi:10.2139/ssrn.4065552
Admission Blood Glucose Level and Its Association With Cardiovascular and Renal Complications in Patients Hospitalized With COVID-19.
Norris, T., Razieh, C., Yates, T., Zaccardi, F., Gillies, C. L., Chudasama, Y. V., . . . Khunti, K. (2022). Admission Blood Glucose Level and Its Association With Cardiovascular and Renal Complications in Patients Hospitalized With COVID-19.. Diabetes care. doi:10.2337/dc21-1709
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
Ahern, D. J., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., Angus, B., . . . Zurke, Y. -X. (2022). A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. CELL, 185(5), 916-+. doi:10.1016/j.cell.2022.01.012
Legacy of COVID-19 infection in children: long-COVID will have a lifelong health/economic impact.
Munblit, D., Simpson, F., Mabbitt, J., Dunn-Galvin, A., Semple, C., & Warner, J. O. (2022). Legacy of COVID-19 infection in children: long-COVID will have a lifelong health/economic impact. ARCHIVES OF DISEASE IN CHILDHOOD, 107(3). doi:10.1136/archdischild-2021-321882
SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures
Winslow, R. L., Zhou, J., Windle, E. F., Nur, I., Lall, R., Ji, C., . . . Green, C. A. (2022). SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures. THORAX, 77(3), 259-267. doi:10.1136/thoraxjnl-2021-218035
Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service
Egan, C., Turtle, L., Thorpe, M., Harrison, E. M., Semple, M. G., & Docherty, A. B. (2022). Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service. ANAESTHESIA. doi:10.1111/anae.15677
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study.
Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., . . . Munblit, D. (2022). Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. EUROPEAN RESPIRATORY JOURNAL, 59(2). doi:10.1183/13993003.01341-2021
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge
Killingley, B., Mann, A., Kalinova, M., Boyers, A., Goonawardane, N., Zhou, J., . . . Chiu, C. (2022). Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge. doi:10.21203/rs.3.rs-1121993/v1
Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303
Neurological Presentations and In-Hospital Complications of COVID-19 in Adults and Children: A Large Prospective Multicentre Observational Study from the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC)
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629
Validation of the russian version of the 4C Mortality Score and prediction of outcomes of severe COVID-19
Vechorko, V. I., Averkov, O. V., Suponeva, N. A., Piradov, M. A., Zimin, A. A., Yusupova, J. G., . . . Harrison, E. M. (2022). Validation of the russian version of the 4C Mortality Score and prediction of outcomes of severe COVID-19. Infectious diseases: News, Opinions, Training, 11(1), 57-63. doi:10.33029/2305-3496-2022-11-1-57-63
2021
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2021). Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. bioRxiv. doi:10.1101/2021.12.03.471045
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-x
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Fallerini, C., Picchiotti, N., Baldassarri, M., Zguro, K., Daga, S., Fava, F., . . . Furini, S. (2021). Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.. Human genetics, 141(1), 147-173. doi:10.1007/s00439-021-02397-7
The value of open-source clinical science in pandemic response: lessons from ISARIC
The value of open-source clinical science in pandemic response: lessons from ISARIC (2021). LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-X
Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort.
Hall, M. D., Baruch, J., Carson, G., Citarella, B. W., Dagens, A., Dankwa, E. A., . . . Olliaro, P. L. (2021). Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. ELIFE, 10. doi:10.7554/eLife.70970
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353
Hereditary haemorrhagic telangiectasia: development of a regional life-course collaborative clinical care pathway
Anderson, E., Green, R., Swift, A., & Semple, M. G. (2021). Hereditary haemorrhagic telangiectasia: development of a regional life-course collaborative clinical care pathway. BRITISH JOURNAL OF HOSPITAL MEDICINE, 82(11). doi:10.12968/hmed.2020.0537
Comment on: Dark without pressure retinal changes in a paediatric age group
Steptoe, P. J., Beare, N. A. V., & Semple, M. G. (2021). Comment on: Dark without pressure retinal changes in a paediatric age group. EYE, 35(11), 3163-3164. doi:10.1038/s41433-020-01252-9
EXPRESSION OF THE SARS-COV-2 RECEPTORS ACE2 AND TMPRSS2 IN THE RESPIRATORY TRACT OF CHILDREN AND ADULTS
Nuttall, A. G., Hedrich, C., Semple, C., Losty, P., Shukla, R., McPartland, J., . . . McNamara, P. (2021). EXPRESSION OF THE SARS-COV-2 RECEPTORS ACE2 AND TMPRSS2 IN THE RESPIRATORY TRACT OF CHILDREN AND ADULTS. In THORAX Vol. 76 (pp. A39). doi:10.1136/thorax-2021-BTSabstracts.63
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.
Evans, R. A., McAuley, H., Harrison, E. M., Shikotra, A., Singapuri, A., Sereno, M., . . . Brightling, C. E. (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(11), 1275-1287. doi:10.1016/S2213-2600(21)00383-0
Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic
Cushnan, D., Berka, R., Bertolli, O., Williams, P., Schofield, D., Joshi, I., . . . Collaborative, N. C. C. I. D. (2021). Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic. DIGITAL HEALTH, 7. doi:10.1177/20552076211048654
A prenylated dsRNA sensor protects against severe COVID-19
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435
Plasma steroid profiles in patients hospitalised with COVID-19 - an ISARIC/WHO CCP-UK cohort study
Devine, K., Russell, C. D., Moore, S. C., Thwaites, R. S., Hardwick, H. E., Oosthuyzen, W., . . . Reynolds, R. M. (n.d.). Plasma steroid profiles in patients hospitalised with COVID-19 - an ISARIC/WHO CCP-UK cohort study. Endocrine Abstracts. doi:10.1530/endoabs.77.p1
1370 Is the liverpool respiratory symptom questionnaire (LRSQ) an acceptable tool to use in longitudinal cohort studies?
Naylor, C., Stead, J., Lane, S., McNamara, P., Southern, K., & Semple, M. (2021). 1370 Is the liverpool respiratory symptom questionnaire (LRSQ) an acceptable tool to use in longitudinal cohort studies?. In Abstracts (pp. A342.1-A342). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2021-rcpch.594
286 BE FIT study: biomarkers rElated to weight and lifestyle in young adults
Fairhurst, K., Semple, M. G., Kemp, G. J., & Cuthbertson, D. J. (2021). 286 BE FIT study: biomarkers rElated to weight and lifestyle in young adults. In Abstracts (pp. A10-A11). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2021-rcpch.17
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Zucman, D. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5
Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital
Wright, J., Achana, F., Diwakar, L., Semple, M. G., Carroll, W. D., Baillie, K., . . . Kemp, T. S. (2021). Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 111, 333-335. doi:10.1016/j.ijid.2021.08.022
The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial
Wang, K., Semple, M. G., Moore, M., Hay, A. D., Tonner, S., Galal, U., . . . Harnden, A. (2021). The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial. EUROPEAN RESPIRATORY JOURNAL, 58(4). doi:10.1183/13993003.02819-2020
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)
Wild, J. M., Porter, J. C., Molyneaux, P. L., George, P. M., Stewart, I., Allen, R. J., . . . Jenkins, R. G. (2021). Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID). BMJ Open Respiratory Research, 8(1), e001049. doi:10.1136/bmjresp-2021-001049
Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (vol 374, n2244, 2021)
Hippisley-Cox, J., Coupland, C. A., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., . . . Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (vol 374, n2244, 2021). BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n2300
Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave.
Read, J. M., Green, C. A., Harrison, E. M., Docherty, A. B., Funk, S., Harrison, J., . . . Semple, M. G. (2021). Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. LANCET, 398(10305), 1037-1038. doi:10.1016/S0140-6736(21)01786-4
Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study
Hippisley-Cox, J., Coupland, C. A. C., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., . . . Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n2244
COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol.
Marciniak, S. J., Farrell, J., Rostron, A., Smith, I., Openshaw, P. J. M., Baillie, J. K., . . . Semple, M. G. (2021). COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol. EUROPEAN RESPIRATORY JOURNAL, 58(3). doi:10.1183/13993003.00929-2021
Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . Toh, C. -H. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492
Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19
Munblit, D., Bobkova, P., Spiridonova, E., Shikhaleva, A., Gamirova, A., Blyuss, O., . . . StopCO, S. (2021). Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19. CLINICAL AND EXPERIMENTAL ALLERGY, 51(9), 1107-1120. doi:10.1111/cea.13997
Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol
Sigfrid, L., Drake, T. M., Pauley, E., Jesudason, E. C., Olliaro, P., Lim, W. S., . . . Scott, J. T. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. LANCET REGIONAL HEALTH-EUROPE, 8. doi:10.1016/j.lanepe.2021.100186
Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK
Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In ANNALS OF ONCOLOGY Vol. 32 (pp. S1337). doi:10.1016/j.annonc.2021.08.2141
Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK
Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In Annals of oncology : official journal of the European Society for Medical Oncology Vol. 32 (pp. S1337).
Long COVID and the mental and physical health of children and young people: national matched cohort study protocol (the CLoCk study)
Stephenson, T., Shafran, R., De Stavola, B., Rojas, N., Aiano, F., Amin-Chowdhury, Z., . . . Members, C. C. (2021). Long COVID and the mental and physical health of children and young people: national matched cohort study protocol (the CLoCk study). BMJ OPEN, 11(8). doi:10.1136/bmjopen-2021-052838
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study.
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2
Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06466-0
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number.
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., ISARIC4C Investigators., . . . Hill, E. M. (2021). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number.. medRxiv. doi:10.1101/2020.08.04.20163782
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study
Garcia-Finana, M., Hughes, D. M., Cheyne, C. P., Burnside, G., Stockbridge, M., Fowler, T. A., . . . Buchan, I. (2021). Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n1637
SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures
Winslow, R. L., Zhou, J., Windle, E. F., Nur, I., Lall, R., Ji, C., . . . Green, C. A. (2021). SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures. doi:10.1101/2021.07.04.21259945
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1
Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8
Could expanding the covid-19 case definition improve the UK's pandemic response?
Crozier, A., Dunning, J., Rajan, S., Semple, M. G., & Buchan, I. E. (2021). Could expanding the covid-19 case definition improve the UK's pandemic response?. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n1625
Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-x
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium., Ahern, D., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., . . . Zurke, Y. -X. (2021). A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. doi:10.1101/2021.05.11.21256877
Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19
Mina, M. J., Peto, T. E., Garcia-Finana, M., Semple, M. G., & Buchan, I. E. (2021). Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19. LANCET, 397(10283), 1425-1427. doi:10.1016/S0140-6736(21)00425-6
Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study
Davies, N. G., Barnard, R. C., Jarvis, C. I., Russell, T. W., Semple, M. G., Jit, M., & Edmunds, W. J. (2021). Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study. LANCET INFECTIOUS DISEASES, 21(4), 482-492. doi:10.1016/S1473-3099(20)30984-1
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020.
Flood, J., Shingleton, J., Bennett, E., Walker, B., Amin-Chowdhury, Z., Oligbu, G., . . . Ladhani, S. N. (2021). Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. LANCET REGIONAL HEALTH-EUROPE, 3. doi:10.1016/j.lanepe.2021.100075
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y. A., Schimanski, L., . . . Joly, E. (2021). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-22045-y
Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol
Sigfrid, L., Drake, T., Pauley, E., Jesudason, E., Olliaro, P., Lim, W. S., . . . ISARIC4C investigators. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2021.03.18.21253888
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873
Performance of the Innova SARS-CoV-2 Antigen Rapid Lateral Flow Test in the Liverpool Asymptomatic Testing Pilot
García-Fiñana, M., Hughes, D. M., Cheyne, C., Burnside, G., Stockbridge, M., Fowler, T. A., . . . Buchan, I. (2021). Performance of the Innova SARS-CoV-2 Antigen Rapid Lateral Flow Test in the Liverpool Asymptomatic Testing Pilot. doi:10.2139/ssrn.3798558
What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol.
Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J., . . . Scott, J. T. (2021). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol.. BMJ Open, 11(3), e043887. doi:10.1136/bmjopen-2020-043887
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Thomson, E. C., Rosen, L. E., Shepherd, J. G., Spreafico, R., Filipe, A. D. S., Wojcechowskyj, J. A., . . . Snell, G. (2021). Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. CELL, 184(5), 1171-+. doi:10.1016/j.cell.2021.01.037
Genetic mechanisms of critical illness in COVID-19.
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y
Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Salguero, J., . . . Hiscox, J. (2021). Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans. doi:10.1101/2021.03.03.433753
Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps
De Luca, D., Cogo, P., Kneyber, M. C., Biban, P., Semple, M. G., Perez-Gil, J., . . . Rimensberger, P. C. (2021). Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps. CRITICAL CARE, 25(1). doi:10.1186/s13054-021-03489-6
Ebola virus antibody decay-stimulation in a high proportion of survivors
Adaken, C., Scott, J. T., Sharma, R., Gopal, R., Dicks, S., Niazi, S., . . . Pollakis, G. (2021). Ebola virus antibody decay-stimulation in a high proportion of survivors. NATURE, 590(7846), 468-+. doi:10.1038/s41586-020-03146-y
A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process
Harwood, R., Allin, B., Jones, C. E., Whittaker, E., Ramnarayan, P., Ramanan, A. V., . . . Kenny, S. (2021). A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. LANCET CHILD & ADOLESCENT HEALTH, 5(2), 133-141. doi:10.1016/S2352-4642(20)30304-7
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Garrod, G., Owen, S., Baillie, K., Baldwin, L., Brown, L., Byrne, R., . . . Adams, E. (2021). Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies. doi:10.12688/wellcomeopenres.16522.1
Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England
Leclerc, Q., Fuller, N., Keogh, R., Diaz-Ordaz, K., Sekula, R., Semple, M., . . . Knight, G. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England. doi:10.1101/2021.01.14.21249791
2020
Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study
Docherty, A., Mulholland, R., Lone, N., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . for ISARIC4C investigators. (2020). Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study. doi:10.1101/2020.12.19.20248559
Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison
Stoesser, N. (2020). Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison. LANCET INFECTIOUS DISEASES, 20(12), 1390-1400. doi:10.1016/S1473-3099(20)30634-4
COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study
ISARIC Clinical Characterisation Group. (2020). COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study.. medRxiv. doi:10.1101/2020.10.26.20219519
Short-term forecasts to inform the response to the Covid-19 epidemic in the UK
Funk, S., Abbott, S., Atkins, B. D., Baguelin, M., Baillie, J. K., Birrell, P., . . . ISARIC4C Investigators. (2020). Short-term forecasts to inform the response to the Covid-19 epidemic in the UK. doi:10.1101/2020.11.11.20220962
The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
Thomson, E., Rosen, L., Shepherd, J., Spreafico, R., da Silva Filipe, A., Wojcechowskyj, J., . . . Snell, G. (2020). The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity. doi:10.1101/2020.11.04.355842
Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Investigators, I. (2020). Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. NATURE IMMUNOLOGY, 21(11), 1336-1345. doi:10.1038/s41590-020-0782-6
Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.
Geretti, A. M., Stockdale, A. J., Kelly, S. H., Cevik, M., Collins, S., Waters, L., . . . Semple, M. G. (2020). Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. doi:10.1093/cid/ciaa1605
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020.
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685
Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study
Clift, A. K., Coupland, C. A. C., Keogh, R. H., Diaz-Ordaz, K., Williamson, E., Harrison, E. M., . . . Hippisley-Cox, J. (2020). Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ-BRITISH MEDICAL JOURNAL, 371. doi:10.1136/bmj.m3731
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y., Schimanski, L., . . . Joly, E. (2020). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. doi:10.21203/rs.3.rs-91353/v2
Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism
Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164
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Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19
Gupta, R., Harrison, E., Ho, A., Docherty, A., Knight, S., van Smeden, M., . . . Noursadeghi, M. (2020). Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19. doi:10.1101/2020.10.09.20209957
Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19
Thwaites, R., Sevilla Uruchurtu, A. S., Siggins, M., Liew, F., Russell, C., Moore, S., . . . Openshaw, P. J. M. (2020). Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19. doi:10.1101/2020.10.08.20209411
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus.
Andersson, M. I., Arancibia-Carcamo, C. V., Auckland, K., Baillie, J. K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus.. Wellcome open research, 5, 181. doi:10.12688/wellcomeopenres.16002.2
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y., Schimanski, L., . . . Joly, E. (2020). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. doi:10.1101/2020.10.02.20205831
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC
G154(P) User service evaluation of the regional paediatric bronchoscopy service focusing on satisfaction: ‘do we pass the friends and family test?’
Semple, M. G., & Haigh, A. C. (2020). G154(P) User service evaluation of the regional paediatric bronchoscopy service focusing on satisfaction: ‘do we pass the friends and family test?’. In Quality improvement and patient safety (pp. A52.2-A53). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.125
G169 Are children at risk of severe influenza and its complications receiving protection from seasonal flu?
Gokulakrishnan, D., Khaliq, R., & Semple, M. G. (2020). G169 Are children at risk of severe influenza and its complications receiving protection from seasonal flu?. In British association of child and adolescent public health (pp. A59.1-A59). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.140
G301(P) Diagnosing hereditary haemorrhagic telangiectasia in children: a service evaluation project
Anderson, E. R., & Semple, M. G. (2020). G301(P) Diagnosing hereditary haemorrhagic telangiectasia in children: a service evaluation project. In Down syndrome medical interest group, british association of community child health and british paediatric respiratory society (pp. A110.2-A110). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.262
G303(P) Parent and patient perceived side effects of paediatric flexible bronchoscopy
Semple, M. G., & Bamforth, J. H. (2020). G303(P) Parent and patient perceived side effects of paediatric flexible bronchoscopy. In Down syndrome medical interest group, british association of community child health and british paediatric respiratory society (pp. A111.2-A111). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.264
Genetic mechanisms of critical illness in Covid-19
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A., Rawlik, K., Parkinson, N., . . . Baillie, K. (2020). Genetic mechanisms of critical illness in Covid-19. doi:10.1101/2020.09.24.20200048
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339
Empowering children with asthma: a framework for clinical practice based on a qualitative literature review
Gait, L., Longworth, M., Brown, L., Worrall, V., Hepworth, C., Mingaud, N., . . . Sinha, I. (2020). Empowering children with asthma: a framework for clinical practice based on a qualitative literature review. In EUROPEAN RESPIRATORY JOURNAL Vol. 56. doi:10.1183/13993003.congress-2020.414
The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK
Hepworth, C., Mingaud, N., Davies, S., Lawrence, P., Lilley, A., Gait, L., . . . Semple, M. (2020). The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK. In EUROPEAN RESPIRATORY JOURNAL Vol. 56. doi:10.1183/13993003.congress-2020.2878
Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium
Palmieri, C., Turtle, L., Docherty, A., Harrison, E., Drake, T., Greenhalf, B., . . . Semple, M. G. (2020). Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium. In ANNALS OF ONCOLOGY Vol. 31 (pp. S992). doi:10.1016/j.annonc.2020.08.1735
What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study
Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J. H., . . . Scott, J. (2020). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study. doi:10.1101/2020.08.26.20180950
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249
Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study
Geretti, A. M., Stockdale, A., Kelly, S., Cevik, M., Collins, S., Waters, L., . . . Group, C. H. A. S. E. S. (2020). Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study. doi:10.2139/ssrn.3666248
Robust, reproducible clinical patterns in hospitalised patients with COVID-19
Millar, J., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, K. (2020). Robust, reproducible clinical patterns in hospitalised patients with COVID-19. doi:10.1101/2020.08.14.20168088
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
Folegatti, P. M., Ewer, K. J., Aley, P. K., Angus, B., Becker, S., Belij-Rammerstorfer, S., . . . Pollard, A. J. (2020). Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. LANCET, 396(10249), 467-478. doi:10.1016/S0140-6736(20)31604-4
Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: prospective observational study
Geretti, A., Stockdale, A., Kelly, S., Villa, G., Turtle, L., Semple, M., & Sabin, C. (2020). Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 23, 13-14. Retrieved from https://www.webofscience.com/
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score
Knight, S., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T., . . . Harrison, E. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. doi:10.1101/2020.07.30.20165464
Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database
Jacob, J., Alexander, D., Baillie, J. K., Berka, R., Bertolli, O., Blackwood, J., . . . Joshi, I. (2020). Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database. EUROPEAN RESPIRATORY JOURNAL, 56(2). doi:10.1183/13993003.01809-2020
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus
Andersson, M., Arancibia-Carcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. doi:10.12688/wellcomeopenres.16002.1
ISARIC Clinical Data Report 20 November 2020
ISARIC Clinical Characterisation Group., Baillie, K., Baruch, J., Beane, A., Blumberg, L., Bozza, F. A., . . . Merson, L. (2020). ISARIC COVID-19 Clinical Data Report: Final report January 2020 – January 2023. doi:10.1101/2020.07.17.20155218
A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process
Harwood, R., Allin, B., Jones, C., Whittaker, E., Ramnarayan, P., Ramanan, A., . . . Kenny, S. (2020). A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process. doi:10.1101/2020.07.17.20156075
Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . Semple, M. (2020). Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study. doi:10.1101/2020.07.14.20153320
Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.
Drake, T., Docherty, A., Harrison, E., Quint, J., Adamali, H., Adamali, H., . . . Jenkins, G. (2020). Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.. doi:10.1101/2020.07.15.20152967
Global outbreak research: harmony not hegemony
Global outbreak research: harmony not hegemony (2020). LANCET INFECTIOUS DISEASES, 20(7), 770-772. doi:10.1016/S1473-3099(20)30440-0
The UK hibernated pandemic influenza research portfolio: triggered for COVID-19
Simpson, C. R., Thomas, B. D., Challen, K., De Angelis, D., Fragaszy, E., Goodacre, S., . . . Knight, M. (2020). The UK hibernated pandemic influenza research portfolio: triggered for COVID-19. LANCET INFECTIOUS DISEASES, 20(7), 767-769. doi:10.1016/S1473-3099(20)30398-4
Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population
Hippisley-Cox, J., Clift, A., Coupland, C., Keogh, R., Diaz-Ordaz, K., Williamson, E., . . . Coggon, D. (2020). Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population. doi:10.1101/2020.06.28.20141986
Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients
Harrison, E., Docherty, A., Barr, B., Buchan, I., Carson, G., Drake, T., . . . Investigators, I. (2020). Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients. doi:10.2139/ssrn.3618215
Appropriate selection of convalescent plasma donors for COVID-19.
Tedder, R. S., & Semple, M. G. (2020). Appropriate selection of convalescent plasma donors for COVID-19.. Lancet Infectious Diseases. doi:10.1016/s1473-3099(20)30470-9
Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]
Adams, E. R., Ainsworth, M., Anand, R., Andersson, M. I., Auckland, K., Baillie, J. K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]. Wellcome Open Research, 5. doi:10.12688/wellcomeopenres.15927.1
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Dong, T. (2020). Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.. bioRxiv. doi:10.1101/2020.06.05.134551
SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus
Andersson, M., Arancibia-Cárcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus. doi:10.1101/2020.05.21.20105486
Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration.
Palmieri, C., Palmer, D., Openshaw, P. J., Baille, J. K., Semple, M. G., & Turtle, L. (2020). Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration.. ESMO Open, 5(3). doi:10.1136/esmoopen-2020-000825
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., . . . ISARIC4C investigators. (2020). Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.. BMJ (Clinical research ed.), 369. doi:10.1136/bmj.m1985
COVID-19 infection in children
Sinha, I. P., Harwood, R., Semple, M. G., Hawcutt, D. B., Thursfield, R., Narayan, O., . . . Southern, K. W. (2020). COVID-19 infection in children. LANCET RESPIRATORY MEDICINE, 8(5), 446-447. Retrieved from https://www.webofscience.com/
Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel
National COVID Testing Scientific Advisory Panel., Adams, E., Ainsworth, M., Anand, R., Andersson, M., Auckland, K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel. doi:10.1101/2020.04.15.20066407
Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors – a pilot study of the value of serology to determine population exposure
Thompson, C. P., Grayson, N., Paton, R. S., Bolton, J., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS coronavirus 2 to determine population exposure in Scottish blood donors between March and May 2020. doi:10.1101/2020.04.13.20060467
Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.
Liu, W., Zhang, Q., Chen, J., Xiang, R., Song, H., Shu, S., . . . Liu, Y. (2020). Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.. New England Journal of Medicine. doi:10.1056/NEJMc2003717
Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease
Steptoe, P. J., Momorie, F., Fornah, A. D., Komba, P., Emsley, E., Scott, J. T., . . . Semple, M. G. (n.d.). Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease. JAMA Ophthalmology. doi:10.1001/jamaophthalmol.2020.0173
Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
Moore, S., Penrice-Randal, R., Alruwaili, M., Dong, X., Pullan, S., Carter, D., . . . Hiscox, J. (2020). Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19. doi:10.1101/2020.03.05.20032011
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus
Andersson, M., Arancibia-Carcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. doi:10.12688/wellcomeopenres.16002.2
2019
A new regional multidisciplinary clinic for children with difficult asthma
Brown, L., Worrall, V., Lilley, A., Thursfield, R., Grime, C., Hepworth, C., . . . Sinha, I. (2019). A new regional multidisciplinary clinic for children with difficult asthma. In EUROPEAN RESPIRATORY JOURNAL Vol. 54. doi:10.1183/13993003.congress-2019.PA1269
Convalescent plasma therapy for persistent hepatitis E virus infection
Ankcorn, M., Gallacher, J., Ijaz, S., Taha, Y., Harvala, H., Maclennan, S., . . . McPherson, S. (2019). Convalescent plasma therapy for persistent hepatitis E virus infection. JOURNAL OF HEPATOLOGY, 71(2), 434-438. doi:10.1016/j.jhep.2019.04.008
The UK's pandemic influenza research portfolio: a model for future research on emerging infections
Simpson, C. R., Beever, D., Challen, K., De Angelis, D., Fragaszy, E., Goodacre, S., . . . Knight, M. (2019). The UK's pandemic influenza research portfolio: a model for future research on emerging infections. LANCET INFECTIOUS DISEASES, 19(8), E295-E300. doi:10.1016/S1473-3099(18)30786-2
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018)
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Griffiths, M. J. (2019). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018). NATURE IMMUNOLOGY, 20(3), 373. doi:10.1038/s41590-019-0328-y
Using research to prepare for outbreaks of severe acute respiratory infection
Mich, V., Pho, Y., Bory, S., Vann, M., Teav, B., Som, L., . . . Mahesh, V. (2019). Using research to prepare for outbreaks of severe acute respiratory infection. BMJ GLOBAL HEALTH, 4(1). doi:10.1136/bmjgh-2018-001061
2018
Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma
Cordell, R. L., Valkenburg, T. S. E., Pandya, H. C., Hawcutt, D. B., Semple, M. G., & Monks, P. S. (2018). Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma. JOURNAL OF ASTHMA, 55(11), 1205-1213. doi:10.1080/02770903.2017.1402341
Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone
Howlett, P. J., Walder, A. R., Lisk, D. R., Fitzgerald, F., Sevalie, S., Lado, M., . . . Scott, J. T. (2018). Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone. EMERGING INFECTIOUS DISEASES, 24(8), 1412-1421. doi:10.3201/eid2408.171367
Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease
Steptoe, P. J., Momorie, F., Fornah, A. D., Komba, S. P., Emsley, E., Scott, J. T., . . . Semple, M. G. (2018). Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease. JAMA Ophthalmology, 136(6), 689-693. doi:10.1001/jamaophthalmol.2018.1248
Optimising the dosing of intravenous theophylline in acute severe asthma in children
Saint, G. L., Semple, M., Sinha, I., & Hawcutt, D. B. (2018). Optimising the dosing of intravenous theophylline in acute severe asthma in children. Pediatric Drugs, 20(3), 209-214. doi:10.1007/s40272-017-0281-x
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Openshaw, P. J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19(06), 625-635. doi:10.1038/s41590-018-0111-5
Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial
Wang, K., Carver, T., Tonner, S., Semple, M. G., Hay, A. D., Moore, M., . . . Hamden, A. (2018). Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial. BMJ OPEN, 8(5). doi:10.1136/bmjopen-2017-021144
Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone
Tedder, R. S., Samuel, D., Dicks, S., Scott, J. T., Ijaz, S., Smith, C. C., . . . Semple, M. G. (2018). Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone. TRANSFUSION, 58(5), 1289-1298. doi:10.1111/trf.14580
Visual Disability in Ebola Survivors
Steptoe, P. J., Beare, N. A. V., Fornah, A. D., Momorie, F., Komba, P., Vandy, M., & Semple, M. G. (2018). Visual Disability in Ebola Survivors. CLINICAL INFECTIOUS DISEASES, 66(8), 1318-1319. doi:10.1093/cid/cix979
G447 The cross-sectional and longitudinal assessment of the effects of nursery attendance and breastfeeding on respiratory symptoms and their impact on quality of life in the first 22 months of life- results from the liverpool baby breathing study
Stead, J., Semple, M., Griffith, B., Pickles, R., Patel, S., & Barclay, J. (2018). G447 The cross-sectional and longitudinal assessment of the effects of nursery attendance and breastfeeding on respiratory symptoms and their impact on quality of life in the first 22 months of life- results from the liverpool baby breathing study. In British Paediatric Respiratory Society and British Society for Paediatric and Adolescent Rheumatology (pp. A182.2-A184). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.436
G453(P) A survey of paediatric bronchoscopy decontamination practice in uk regional centres
Letch, E. G., Batchelor, E. G. L., & Semple, M. G. (2018). G453(P) A survey of paediatric bronchoscopy decontamination practice in uk regional centres. In British Paediatric Respiratory Society and British Society for Paediatric and Adolescent Rheumatology (pp. A185.2-A187). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.442
G58(P) Are children at risk of severe influenza receiving seasonal influenza vaccine? an audit of outpatient clinics at alder hey children’s hospital
Lythgoe, C. N., Baxter, M. R., Cooke, R. P. D., & Semple, M. G. (2018). G58(P) Are children at risk of severe influenza receiving seasonal influenza vaccine? an audit of outpatient clinics at alder hey children’s hospital. In British Paediatric Allergy, Immunity and Infection Group (pp. A23.3-A24). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.56
Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (<i>Ophthalmology</i>. 2017;124:170-177)
Steptoe, P. J., Scott, J. T., Sahr, F., Vandy, M., Harding, S. P., Beare, N. A. V., & Semple, M. G. (2018). Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (<i>Ophthalmology</i>. 2017;124:170-177). OPHTHALMOLOGY, 125(3), E19. doi:10.1016/j.ophtha.2017.09.009
Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study.
Jagadesh, S., Sevalie, S., Fatoma, R., Sesay, F., Sahr, F., Faragher, B., . . . Scott, J. T. (2018). Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study.. Clinical Infectious Diseases, 66(1), 131-133. doi:10.1093/cid/cix705
2017
Reply to Lee and colleagues Viral posterior uveitis
Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues Viral posterior uveitis. SURVEY OF OPHTHALMOLOGY, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002
Reply to Lee and colleagues-Viral posterior uveitis.
Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues-Viral posterior uveitis.. Survey of ophthalmology, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002
WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus
Wilkinson, D. E., Hassall, M., Mattiuzzo, G., Stone, L., Atkinson, E., Hockley, J., . . . Minor, P. D. (2017). WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus. World Health Organization. Retrieved from http://www.who.int/
Ocular Complications in Survivors of the Ebola Outbreak in Guinea
Steptoe, P. J., Scott, J. T., Harding, S. P., Beare, N. A. V., Semple, M. G., Vandy, M. J., & Sahr, F. (2017). Ocular Complications in Survivors of the Ebola Outbreak in Guinea. AMERICAN JOURNAL OF OPHTHALMOLOGY, 181, 180. doi:10.1016/j.ajo.2017.05.029
Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016
Steptoe, P. J., Scott, J. T., Baxter, J. M., Parkes, C. K., Dwivedi, R., Czanner, G., . . . Semple, M. G. (2017). Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016. EMERGING INFECTIOUS DISEASES, 23(7), 1102-1109. doi:10.3201/eid2307.161608
Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus
Semple, M. G., & Scott, J. T. (2017). Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus. The Lancet Infectious Diseases, 17(6), 645-653. doi:10.1016/S1473-3099(17)30111-1
Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors
Steptoe, P. J., Beare, N. V., Scott, J. T., Vandy, M. J., Harrison-Williams, L., Momorie, F., . . . Semple, M. G. (2017). Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from https://www.webofscience.com/
SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16
Semple, M. G. (2017). SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16. In http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2017.195.1_MeetingAbstracts.A6854. Washington, DC.
Ebola virus disease sequelae: a challenge that is not going away
Scott, J. T., & Semple, M. G. (2017). Ebola virus disease sequelae: a challenge that is not going away. LANCET INFECTIOUS DISEASES, 17(5), 470-471. doi:10.1016/S1473-3099(17)30027-0
M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza
Cole, S. L., Dunning, J., Kok, W. L., Benam, K. H., Benlahrech, A., Repapi, E., . . . Ho, L. -P. (2017). M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI INSIGHT, 2(7). doi:10.1172/jci.insight.91868
Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone
Howlett, P., Walder, A., Lisk, D., N'jai, A., Lado, M., Brown, C., . . . Scott, J. T. (2017). Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone. In LANCET Vol. 389 (pp. 48). doi:10.1016/S0140-6736(17)30444-0
2016
Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies
van Griensven, J., Edwards, T., & Baize, S. (2016). Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies. New England Journal of Medicine, 375(23), 2307-2309. doi:10.1056/NEJMc1609116
Electrolyte and metabolic disturbances in ebola patients during a clinical Trial, Guinea, 2015
van Griensven, J., Bah, E. I., Haba, N., Delamou, A., Camara, B. S., Olivier, K. J. -J., . . . De Weggheleire, A. (2016). Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015. EMERGING INFECTIOUS DISEASES, 22(12), 2120-2127. doi:10.3201/eid2212.161136
Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea
Delamou, A., Haba, N. Y., Mari-Saez, A., Gallian, P., Ronse, M., Jacobs, J., . . . van Griensven, J. (2016). Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea.. The American journal of tropical medicine and hygiene, 95(3), 647-653. doi:10.4269/ajtmh.15-0890
Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study
Ashdown, H. F., Raeisaenen, U., Wang, K., Ziebland, S., & Harnden, A. (2016). Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study. BMJ OPEN, 6(6). doi:10.1136/bmjopen-2016-011497
Post-Ebola Syndrome, Sierra Leone
Scott, J., Sesay, F., Massaquoi, T., Idriss, B., Sahr, F., & Semple, M. G. (2016). Post-Ebola Syndrome, Sierra Leone. Emerging Infectious Diseases, 22(4), 641-646. doi:10.3201/eid2204.151302
Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak
Edwards, T., Semple, M. G., De Weggheleire, A., Claeys, Y., De Crop, M., Menten, J., . . . van Griensven, J. (2016). Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak. CLINICAL TRIALS, 13(1), 13-21. doi:10.1177/1740774515621056
Stemming the tide of hospital admissions for bronchiolitis
Cheung, C. R., & Semple, M. G. (2016). Stemming the tide of hospital admissions for bronchiolitis. ARCHIVES OF DISEASE IN CHILDHOOD, 101(2), 118-119. doi:10.1136/archdischild-2015-309452
Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea
Semple, M. G. (2016). Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The New England Journal of Medicine, 374(1), 33-42. doi:10.1056/NEJMoa1511812
2015
DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION?
Shorthouse, L., & Semple, M. G. (2015). DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION?. In THORAX Vol. 70 (pp. A120). doi:10.1136/thoraxjnl-2015-207770.226
Ebola: Europe-Africa research collaborations
Horby, P. W., Endzt, H., Muyembe-Tamfum, J. -J., van Griensven, J., Gevao, S., Goossens, H., . . . Kennedy, S. (2015). Ebola: Europe-Africa research collaborations. LANCET INFECTIOUS DISEASES, 15(11), 1258-1259. doi:10.1016/S1473-3099(15)00375-8
Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study
Venkatesan, S., Myles, P. R., McCann, G., Kousoulis, A. A., Hashmi, M., Belatri, R., . . . Semple, M. G. (2015). Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study. Health Technology Assessment, 19(89), 1-132. doi:10.3310/hta19890
Evaluation and refinement of pandemic inFLUenza Community Assessment Tools
Semple, M. (n.d.). Evaluation and refinement of pandemic inFLUenza Community Assessment Tools. doi:10.1186/isrctn87130712
Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus
Habibi, M. S., Jozwik, A., Makris, S., Dunning, J., Paras, A., The Mechanisms of Severe Acute Influenza Consortium Investigators., . . . Chiu, C. (2015). Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191(9), 1040-1049. doi:10.1164/rccm.201412-2256OC
JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT
Brown, L. E., Sampath, S., Ryan, F., Cleary, G., McCann, L., Pain, C., . . . Baildam, E. (2015). JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT. In RHEUMATOLOGY Vol. 54 (pp. 11). doi:10.1093/rheumatology/keu508
Convalescent plasma for early Ebola virus disease in Sierra Leone
Winters, V., & Semple, C. (n.d.). Convalescent plasma for early Ebola virus disease in Sierra Leone. doi:10.1186/isrctn13990511
Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK
Nyland, G. A., McKenzie, B. C., Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., . . . Nguyen-Van-Tam, J. S. (2015). Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK. Epidemiology and Infection, 143(6), 1129-1138. doi:10.1017/S0950268814001873
2014
Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom
Elderfield, R. A., Watson, S. J., Godlee, A., Adamson, W. E., Thompson, C. I., Dunning, J., . . . Barclay, W. S. (2014). Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom. JOURNAL OF VIROLOGY, 88(22), 13269-13283. doi:10.1128/JVI.01636-14
Open source clinical science for emerging infections
Dunning, J. W., Merson, L., Rohde, G. G. U., Gao, Z., Semple, M. G., Dat, T., . . . Baillie, J. K. (2014). Open source clinical science for emerging infections. LANCET INFECTIOUS DISEASES, 14(1), 8-9. doi:10.1016/S1473-3099(13)70327-X
2013
An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic
Semple, M. G., Myles, P. R., Nicholson, K. G., Lim, W. S., Read, R. C., Taylor, B. L., . . . Nguyen-Van-Tam, J. S. (2013). An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic. PLOS ONE, 8(9). doi:10.1371/journal.pone.0075384
Design, development and initiation of the Liverpool Respiratory Birth Cohort Study
Pickles, R. (2013, July 1). Design, development and initiation of the Liverpool Respiratory Birth Cohort Study. (Master's Thesis, University of Liverpool).
Differences between asthmatics and nonasthmatics hospitalised with influenza A infection
Myles, P., Nguyen-Van-Tam, J. S., Semple, M. G., Brett, S. J., Bannister, B., Read, R. C., . . . Lim, W. S. (2013). Differences between asthmatics and nonasthmatics hospitalised with influenza A infection. EUROPEAN RESPIRATORY JOURNAL, 41(4), 824-831. doi:10.1183/09031936.00015512
Population variation in admission rates and duration of inpatient stay for bronchiolitis in England
Cheung, C. R., Smith, H., Thurland, K., Duncan, H., & Semple, M. G. (2013). Population variation in admission rates and duration of inpatient stay for bronchiolitis in England. ARCHIVES OF DISEASE IN CHILDHOOD, 98(1), 57-59. doi:10.1136/archdischild-2012-302277
2012
The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection
Dolan, G. P., Myles, P. R., Brett, S. J., Enstone, J. E., Read, R. C., Openshaw, P. J. M., . . . Nguyen-Van-Tam, J. S. (2012). The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection. PLOS ONE, 7(8). doi:10.1371/journal.pone.0041638
Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis
Semple, M. G., Flanagan, B., & Smyth, R. L. (2012). Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis. In A15. AIRWAY RESPONSES TO RESPIRATORY VIRAL INFECTION (pp. A1026). American Thoracic Society. doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026
Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data
Myles, P. R., Nguyen-Van-Tam, J. S., Lim, W. S., Nicholson, K. G., Brett, S. J., Enstone, J. E., . . . Semple, M. G. (2012). Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data. PLOS ONE, 7(4). doi:10.1371/journal.pone.0034428
IFITM3 restricts the morbidity and mortality associated with influenza
Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., . . . Kellam, P. (2012). IFITM3 restricts the morbidity and mortality associated with influenza. NATURE, 484(7395), 519-U146. doi:10.1038/nature10921
Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK
Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., Gadd, E. M., Read, R. C., . . . Nguyen-Van-Tam, J. S. (2012). Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK. THORAX, 67(8), 709-717. doi:10.1136/thoraxjnl-2011-200266
Problems of the Respiratory System: Rate of admissions and mean length of stay for bronchiolitis in children under 2 years of age by PCT in England, Maps 20 & 21
Semple, M. G., Cheung, R., Duncan, H., Smith, H., Chaplin, S., & Ridler, C. (2012). Problems of the Respiratory System: Rate of admissions and mean length of stay for bronchiolitis in children under 2 years of age by PCT in England, Maps 20 & 21. In R. Cheung, & R. Cheung (Eds.), NHS Atlas of variation in healthcare for children and young people. (pp. 58-61, 74). London: NHS Right Care Department of Health. Retrieved from http://www.rightcare.nhs.uk/index.php/nhs-atlas/
Suction versus no suction for chest drain management
van Miert, C., Dwan, K., Hill, R., Hoenig, M. R., Gruen, R. L., & Semple, M. G. (n.d.). Suction versus no suction for chest drain management. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd009939
2011
The increasing importance of innate antimicrobials response
Lim, W. S., Bewick, T., Myles, P., Greenwood, S., Nguyen-Van-Tam, J. S., Brett, S., . . . Nicholson, K. G. (2011). The increasing importance of innate antimicrobials response. THORAX, 66(12), 1091. doi:10.1136/thoraxjnl-2011-200600
Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study
Semple, M. G., Taylor-Robinson, D. C., Lane, S., & Smyth, R. L. (2011). Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study. PLOS ONE, 6(7). doi:10.1371/journal.pone.0022425
Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease
Brett, S. J., Myles, P., Lim, W. S., Enstone, J. E., Bannister, B., Semple, M. G., . . . Openshaw, P. J. M. (2011). Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease. PLOS ONE, 6(4). doi:10.1371/journal.pone.0018120
Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009-2010
Enstone, J. E., Myles, P. R., Openshaw, P. J. M., Gadd, E. M., Lim, W. S., Semple, M. G., . . . Nguyen-Van-Tam, J. S. (2011). Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009-2010. EMERGING INFECTIOUS DISEASES, 17(4), 592-598. doi:10.3201/eid1704.101679
Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults
Bewick, T., Myles, P., Greenwood, S., Nguyen-Van-Tam, J. S., Brett, S. J., Semple, M. G., . . . Lim, W. S. (2011). Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults. THORAX, 66(3), 247-252. doi:10.1136/thx.2010.151522
2010
Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009)
Nguyen-Van-Tam, J. S., Openshaw, P. J. M., Hashim, A., Gadd, E. M., Lim, W. S., Semple, M. G., . . . Nicholson, K. G. (2010). Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). THORAX, 65(7), 645-651. doi:10.1136/thx.2010.135210
Paediatric practice note for the management of critically ill children with pandemic (H1N1) 2009 Influenza.
Semple, M. G., Thomson, G., Taylor, D. J., Lister, P., Hackett, S., Faust, S. N., . . . Wilkinson, K. (2010). Paediatric practice note for the management of critically ill children with pandemic (H1N1) 2009 Influenza.. Royal College of Paediatrics and Child Health Swine FLu Policy.
2009
Evidence That RSV Directly Infects Neutrophils in the Airways and Blood of Infants with Severe Bronchiolitis
Halfhide, C. P., Brearey, S., Howarth, D., Semple, M. G., Kipar, A., Hunt, J. A., . . . Smyth, R. L. (2009). Evidence That RSV Directly Infects Neutrophils in the Airways and Blood of Infants with Severe Bronchiolitis. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 179. Retrieved from https://www.webofscience.com/
Medikidz Explain Swine Flu
Semple, M. G., & McCauley, J. (Eds.) (2009). Medikidz Explain Swine Flu. London: Medikidz.
Pandemic H1N1 2009 Influenza: Clinical Management Guidelines for Adults and Children
Semple, M. G., Lim, W. S., Reid, R. C., & al, E. (2009). Pandemic H1N1 2009 Influenza: Clinical Management Guidelines for Adults and Children. Delphi, Department of Health., 25. Retrieved from http://www.dh.gov.uk/
Pandemic H1N1 2009 influenza: clinical management guidelines for pregnancy
Lim, B. H., Semple, M. G., Lim, W. S., & al, E. (2009). Pandemic H1N1 2009 influenza: clinical management guidelines for pregnancy. Delphi, Department of Health., 27. Retrieved from http://www.dh.gov.uk/
Pandemic flu:Managing Demand and Capacity in Health Care Organisations.
Wilson, L., Bannister, B., & Semple, M. G. (2009). Pandemic flu:Managing Demand and Capacity in Health Care Organisations.. London: HMG UK. Retrieved from http://www.dh.gov.uk/
Swine flu clinical package
Semple, M. G., & Bannister, B. (2009). Swine flu clinical package. London: HMG UK. Retrieved from http://www.dh.gov.uk/
2008
Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK
Hopkins, M. J., Redmond, C., Shaw, J. M., Hart, I. J., Hart, C. A., Smyth, R. L., & Semple, M. G. (2008). Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK. JOURNAL OF CLINICAL VIROLOGY, 42(3), 273-279. doi:10.1016/j.jcv.2008.03.011
2007
CD8<SUP>+</SUP> T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections
Heidema, J., Lukens, M. V., van Maren, W. W. C., van Dijk, M. E. A., Otten, H. G., van Vught, A. J., . . . van Bleek, G. M. (2007). CD8<SUP>+</SUP> T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections. JOURNAL OF IMMUNOLOGY, 179(12), 8410-8417. doi:10.4049/jimmunol.179.12.8410
Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free
Semple, M. G., Booth, J. A., & Ebrahimi, B. (2007). Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free. JOURNAL OF CLINICAL VIROLOGY, 40(3), 241-244. doi:10.1016/j.jcv.2007.08.019
Severe Respiratory Syncytial Virus Bronchiolitis in Infants Is Associated with Reduced Airway Interferon Gamma and Substance P
Semple, M. G., Dankert, H. M., Ebrahimi, B., Correia, J. B., Booth, J. A., Stewart, J. P., . . . Hart, C. A. (2007). Severe Respiratory Syncytial Virus Bronchiolitis in Infants Is Associated with Reduced Airway Interferon Gamma and Substance P. PLOS ONE, 2(10). doi:10.1371/journal.pone.0001038
Pathophysiology. Lessons from humanrespiratory syncytial virus bronchiolitisand acute wheezing episodes in infants
Semple, M., & Smyth, R. (2007). Pathophysiology. Lessons from humanrespiratory syncytial virus bronchiolitisand acute wheezing episodes in infants. In Exacerbations of Asthma (pp. 187-202). CRC Press. doi:10.1201/b14633-14
CD8+ T cell responses in bronchoalveolar lavage fluid and PBMC of infants with severe primary respiratory syncytial virus infections.
Heidema, J., Lukens, M. V., van Maren, W. W. C., van Dijk, M. E. A., Otten, H. G., van Vught, A. J., . . . van Bleek, G. M. (2007). CD8+ T cell responses in bronchoalveolar lavage fluid and PBMC of infants with severe primary respiratory syncytial virus infections.. Journal of Immunology, 179(12), 8410-8417. Retrieved from http://www.jimmunol.org/cgi/content/full/179/12/8410
2005
Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis
Semple, M. G., Cowell, A., Dove, W., Greensill, J., McNamara, P. S., Halfhide, C., . . . Hart, C. A. (2005). Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis. JOURNAL OF INFECTIOUS DISEASES, 191(3), 382-386. doi:10.1086/426457
Interleukin 9 concentrations in infants with Respiratory Syncytial Virus Bronchiolitis.
Semple, M. G., Dankert, H. M., Hart, C. A., & Smyth, R. L. (2005). Interleukin 9 concentrations in infants with Respiratory Syncytial Virus Bronchiolitis.. European Respiratory Journal, 26(49), 28. Retrieved from http://www.ersnet.org/ers/lr/browse/media.aspx?id_dossier=46084&id_fiche=211554
Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trial.
A, S., & et.al., F. T. T. S. G. (2005). Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trial.. Lancet, 365(9459), 573-578. Retrieved from http://dx.doi.org/10.1016/S0140-6736(05)17906-9
Reduced interferon-gamma concentration in infants with severe respiratory syncytial virus bronchiolitis
Dankert, H. M., Semple, M. G., Hart, C. A., & Smyth, R. L. (2005). Reduced interferon-gamma concentration in infants with severe respiratory syncytial virus bronchiolitis. European Respiratory Journal, 26(49), 27. Retrieved from http://www.ersnet.org/ers/lr/browse/media.aspx?id_dossier=46083&id_fiche=211552
TLR expression and localisation in the airway cells of infants with severe bronchiolitis
Brearey, S. P., Flanagan, B. F., Hunt, J. A., Cummerson, J. A., McNamara, P. S., Semple, M. G., . . . Smyth, R. L. (2005). TLR expression and localisation in the airway cells of infants with severe bronchiolitis. In IMMUNOLOGY Vol. 116 (pp. 79). Retrieved from https://www.webofscience.com/
2003
Left pulmonary artery sling presenting as unilateral echogenic lung on 20-week detailed antenatal ultrasound examination
Semple, M. G., Bricker, L., Shaw, B. N. J., & Pilling, D. W. (2003). Left pulmonary artery sling presenting as unilateral echogenic lung on 20-week detailed antenatal ultrasound examination. PEDIATRIC RADIOLOGY, 33(8), 567-569. doi:10.1007/s00247-003-0942-5
Update on Cochrane data on paediatric respiratory diseases.
Semple, M. G., & Smyth, R. L. (2003). Update on Cochrane data on paediatric respiratory diseases.. Paediatric respiratory reviews, 4(3), 250-266. doi:10.1016/s1526-0542(03)00048-4
2002
Academic Mentoiring
Openshaw, P., Semple, M. G., & Smyth, R. L. (2002). Academic Mentoiring. London: Academy of Medical Sciences.
1995
MORTALITY BEFORE AND AFTER HIV-INFECTION IN THE COMPLETE UK POPULATION OF HEMOPHILIACS
DARBY, S. C., EWART, D. W., GIANGRANDE, P. L. F., DOLIN, P. J., SPOONER, R. J. D., & RIZZA, C. R. (1995). MORTALITY BEFORE AND AFTER HIV-INFECTION IN THE COMPLETE UK POPULATION OF HEMOPHILIACS. NATURE, 377(6544), 79-82. doi:10.1038/377079a0
HIV RESULTS IN THE FRAME - RESULTS CONFIRMED
NOWAK, M. A., BONHOEFFER, S., LOVEDAY, C., BALFE, P., SEMPLE, M., KAYE, S., . . . TEDDER, R. (1995). HIV RESULTS IN THE FRAME - RESULTS CONFIRMED. NATURE, 375(6528), 193. doi:10.1038/375193a0
HIV-1 RNA SERUM-LOAD AND RESISTANT VIRAL GENOTYPES DURING EARLY ZIDOVUDINE THERAPY
LOVEDAY, C., KAYE, S., TENANTFLOWERS, M., SEMPLE, M., AYLIFFE, U., WELLER, I. V. D., & TEDDER, R. S. (1995). HIV-1 RNA SERUM-LOAD AND RESISTANT VIRAL GENOTYPES DURING EARLY ZIDOVUDINE THERAPY. LANCET, 345(8953), 820-824. doi:10.1016/S0140-6736(95)92963-0
HIV results in the frame. Results confirmed.
Nowak, M. A., Bonhoeffer, S., Loveday, C., Balfe, P., Semple, M., Kaye, S., . . . Tedder, R. (1995). HIV results in the frame. Results confirmed.. Nature, 375(6528), 193. doi:10.1038/375193a0
1993
HIV-1 PLASMA VIREMIA QUANTIFICATION - A NONCULTURE MEASUREMENT NEEDED FOR THERAPEUTIC TRIALS
SEMPLE, M. G., KAYE, S., LOVEDAY, C., & TEDDER, R. S. (1993). HIV-1 PLASMA VIREMIA QUANTIFICATION - A NONCULTURE MEASUREMENT NEEDED FOR THERAPEUTIC TRIALS. JOURNAL OF VIROLOGICAL METHODS, 41(2), 167-179. doi:10.1016/0166-0934(93)90124-A
1992
LACK OF SUPPRESSION BY RIBAVIRIN OF HIV VIREMIA
GILSON, R. J. C., SEMPLE, M., GILL, S. K., LOVEDAY, C., TEDDER, R. S., & WELLER, I. V. D. (1992). LACK OF SUPPRESSION BY RIBAVIRIN OF HIV VIREMIA. LANCET, 339(8809), 1605-1606. doi:10.1016/0140-6736(92)91867-8
Quantitative viral assay
Semple, M. G., Tedder, R. S., Loveday, C., & Kaye, S. (1993, April 8). WO1993021339 A1, Quantitative viral assay. WO.
HIV, AIDS, AND ZIDOVUDINE
TEDDER, R. S., SEMPLE, M. G., TENANTFLOWERS, M., & LOVEDAY, C. (1992). HIV, AIDS, AND ZIDOVUDINE. LANCET, 339(8796), 805. doi:10.1016/0140-6736(92)91929-3
1991
DETECTION OF HIV-1 RNA IN FACTOR-VIII CONCENTRATE
SEMPLE, M. G., LOVEDAY, C., PRESTON, E., & TEDDER, R. S. (1991). DETECTION OF HIV-1 RNA IN FACTOR-VIII CONCENTRATE. AIDS, 5(5), 597-598. doi:10.1097/00002030-199105000-00021
DIRECT MEASUREMENT OF VIREMIA IN PATIENTS INFECTED WITH HIV-1 AND ITS RELATIONSHIP TO DISEASE PROGRESSION AND ZIDOVUDINE THERAPY
SEMPLE, M., LOVEDAY, C., WELLER, I., & TEDDER, R. (1991). DIRECT MEASUREMENT OF VIREMIA IN PATIENTS INFECTED WITH HIV-1 AND ITS RELATIONSHIP TO DISEASE PROGRESSION AND ZIDOVUDINE THERAPY. JOURNAL OF MEDICAL VIROLOGY, 35(1), 38-45. doi:10.1002/jmv.1890350109