Research
Skeletal muscle redox regulation and ageing
Molecular and cellular physiology of oxidative stress and adaptation: Influences of nutrition, disease and ageing. Muscle group
The effects of microgravity on skeletal muscle and responses to exercise.
CIMA centre
Research grants
Investigating mitochondrial dynamics and ER-mitochondrial communication in RPE in ageing and macular disease
MACULAR DISEASE SOCIETY (UK)
September 2021 - August 2024
Bench fees for Ufuk Ersoy / 201443759
TURKISH EMBASSY (LONDON)
February 2021 - January 2025
HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE)
UK RESEARCH AND INNOVATION
April 2021 - April 2025
Close regulation of peroxiredoxin oxidation is essential for maintenance of muscle mass and function in the elderly.
MEDICAL RESEARCH COUNCIL
December 2021 - November 2024
University of Liverpool Translational Institutional Partnership (TRAP)
WELLCOME TRUST (UK)
February 2021 - February 2024
Mitochondria as a key regulator of muscle loss in microgravity and during ageing on earth (MicroAge II)
SCIENCE AND TECHNOLOGY FACILITIES COUNCIL
October 2020 - March 2021
Mitochondrial hydrogen peroxide as the mediator of skeletal muscle loss under microgravity and during ageing on earth
UK SPACE AGENCY (UK)
October 2021 - September 2022
PROSPER
RESEARCH ENGLAND (UK)
April 2021 - September 2023
Aquaporins: A hole in our understanding of ROS signalling
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
September 2019 - November 2022
Microgravity as a model for accelerated skeletal muscle ageing
UK SPACE AGENCY (UK)
November 2018 - May 2022
CIMA Centre Renewal
MEDICAL RESEARCH COUNCIL, VERSUS ARTHRITIS (UK)
June 2017 - May 2028
Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice
NATIONAL INSTITUTES OF HEALTH (USA)
September 2016 - April 2022
Disruption of redox relays in the age-related failure of muscle responses to contractile activity
MEDICAL RESEARCH COUNCIL
March 2017 - September 2021
2014 allocation - Wellcome ISSF non clinical fellowships
WELLCOME TRUST (UK)
May 2015 - October 2018
Gene editing of Age related Macular Degeneration risk factor in retinal pigment epithelial cells: could modulation of proteolytic control lead to new therapeutic interventions for Age related Macular Degeneration?
MACULAR DISEASE SOCIETY (UK)
November 2016 - November 2019
Microgravity as a model for accelerated skeletal muscle ageing
UK SPACE AGENCY (UK)
October 2017 - April 2018
Paraneoplastic neurological syndromes (PNS). Strengthening the European Network.
EUROPEAN COMMISSION
January 2006 - June 2009
Denervation of small numbers of fibres during ageing leads to dysregulation of ROS and functional changes in whole skeletal muscles
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
April 2013 - March 2016
Site-specific failure of redox homeostasis as a cause of age-related loss of skeletal muscle mass and function
MEDICAL RESEARCH COUNCIL
May 2008 - May 2011
University of Liverpool Institutional Discipline Bridging.
MEDICAL RESEARCH COUNCIL
October 2003 - October 2006
CIMA centre capital equipment
MEDICAL RESEARCH COUNCIL
April 2014 - May 2017
The role of copper and zinc in osteoporosis.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
February 1997 - July 2001
Ageing-Related Skeletal Muscle Weakness: Mechanisms of Prevention by Stress Proteins.
RESEARCH INTO AGEING
October 2001 - September 2006
Molecular mechanisms of preservation of muscle with age by HSP70.
EUROPEAN COMMISSION
August 2002 - July 2004
Examination of the effect of antioxidant supplementation on the ability of cells from the elderly to respond to stress.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
August 2001 - July 2002
European research on functional effects of dietary antioxydants (EUROFEDA).
EUROPEAN COMMISSION
January 2000 - December 2002
Centre of Excellence in musculoskeletal ageing research (MRC CIMA)
MEDICAL RESEARCH COUNCIL
June 2012 - December 2017
Value in People Award 2005.
WELLCOME TRUST (UK)
October 2005 - September 2009
Correction of marginal dietary selenium intake and cancer risk in the UK.
WORLD CANCER RESEARCH FUND (UK)
October 2002 - April 2006
Capacity building award in integrative mammalian biology
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
January 2007 - October 2015
Insulin resistance mediates age-related loss of muscle mass and function
RESEARCH INTO AGEING
February 2007 - February 2010
Modulation of aberrant mitochondrial and cytokine production in muscles of patients with CFS by polyphenols
MEDICAL RESEARCH COUNCIL, THE ME ASSOCIATION (UK)
September 2012 - April 2016
Functional markers of selenium status in man (AN0545).
MINISTRY AGRIC/FISHERIES/FOOD
April 1998 - March 2001
Angiotensin 11 blockade in the proximal renal tubular cell : mechanisms of injury, metabolism and renoprotection.
MERSEY KIDNEY FIRST (UK)
January 2001 - December 2007
YEAR 1 (part2) Wellcome Trust ISSF Non-Clinical Fellowships
WELLCOME TRUST (UK)
October 2012 - March 2023
Liverpool Imaging Partnership: Molecular physiology and drug response
MEDICAL RESEARCH COUNCIL
February 2013 - February 2017
Hydrogen peroxide generation regulates proximal tubular cell responses to excessive protein exposure.
MERSEY KIDNEY FIRST (UK)
January 2006 - December 2008
Free radical generation by skeletal muscle: signals for adaptation to contractile activity?
WELLCOME TRUST (UK)
February 2001 - February 2004
Selenium, immune status and viral handling.
FOOD STANDARDS AGENCY (UK)
January 2005 - September 2010
New non-angiotensinII type 1 receptor-mediated mechanisms of inducing oxidative stress and modulating stress-related gene expression in renal proximal tubular cells implications for transplant patients with chronic allograft nephropathy.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)
March 2007 - May 2007
The role of heat shock proteins in ageing-related loss of muscle function.
RESEARCH INTO AGEING
April 1998 - April 2001
A PCR based technique for cloning the sites of oxidative DNA damage and measuring the 'in vivo' protective effects of dietary antioxidants.
MINISTRY AGRIC/FISHERIES/FOOD
April 1998 - May 2001
Liverpool BioAFM: an integrated optical and atomic force microscope for research across the life sciences
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
January 2015 - January 2016
Glutathione Metabolism in Muscle and Kidney in Severe Systemic Inflammation.
WELLCOME TRUST (UK)
August 1998 - September 2001
Admin. and Secretarial Support to the NWCRF Sci.Comte.
NORTH WEST CANCER RESEARCH FUND
January 1990 - December 2019
Protein overload, oxidative metabolism and the proximal tubules.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
April 2004 - November 2007
Extracellular Reactive Oxygen Species as Propagators of Tissue Ageing.
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
July 2002 - February 2006
Generation of reactive oxygen species by skeletal muscle mitochondria as a target for interventions to prevent age-related loss of muscle mass and function
MEDICAL RESEARCH COUNCIL
September 2011 - November 2013
Cystatin C in age-related macular degeneration: mechanism of action and consequences on cellular processes.
RESEARCH INTO AGEING
October 2010 - December 2013
Cross-Linked Actin Networks (CLANs). Are they a morphological fingerprint of trabecular meshwork cell malfunction in glaucoma that may be targeted as a new treatment direction?
THE GUIDE DOGS FOR THE BLIND ASSOCIATION (UK)
April 2006 - March 2009
Translational research into Frailty for the benefit of Older People
THE DOWAGER COUNTESS ELEANOR PEEL TRUST (UK)
February 2009 - April 2012
Novel renal proximal tubular pathways of injury: Angiotensin II induces fibrosis via Angiiotensin II receptors other than type I.
MERSEY KIDNEY FIRST (UK)
May 2007 - December 2010
Assessment of individual variability in functional responses to selenium.
FOOD STANDARDS AGENCY (UK)
October 2001 - March 2003
Fluorescence Light Sheet Microscopy for Live 3D and 4D imaging
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
January 2014 - June 2014
YEAR 1 Wellcome Trust ISSF Non-Clinical Fellowships
WELLCOME TRUST (UK)
October 2011 - May 2018
Ageing-related muscle dysfunction: A failure of adaptation to oxidative stress?
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
November 1998 - November 2001
Wellcome VIP - Pearson
WELLCOME TRUST (UK)
May 2011 - August 2011
A failure of neuroprotective redox signalling from skeletal muscle to motor neurons leads to loss of motor units with ageing
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
September 2011 - August 2014
Dietary polyphenols as modulators of redox signalling pathways to reduce chronio inflammation in the elderly
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
April 2011 - January 2015
The effects of dietary selenium supplementation on depression in older subjects.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)
November 2003 - July 2006
Nitric oxide-superoxide interactions in the regulation of skeletal muscle adaptations and damage following contractile activity.
WELLCOME TRUST (UK)
January 2004 - October 2009
Motor unit remodelling contributes to the age-related loss of skeletal muscle fibres
MEDICAL RESEARCH COUNCIL
June 2015 - June 2018
Wellcome VIP Award - Victoria Kearns
WELLCOME TRUST (UK)
July 2011 - September 2011
Research collaborations
Dr Jose Vina
CHOKO-AGE
University of Valencia
Joint intervention study with Dr Francesco Galli
Dr Francesco Galli
CHOKO-AGE
University of Perugia
Joint EU intervention study of high polyphenol +/- vitamin E in sarcopenic patients
Dr. Arlan Richardson/Dr. Holly Van Remmen
University of Oklahoma Health Science Center, USA
NIH-funded research into skeletal muscle aging
Dr Susan Brooks
University of Michigan
NIH-funded research into skeletal muscle aging