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Dr Mal Horsburgh
BSc (Edinburgh) PhD (Glasgow)

Contact

M.J.Horsburgh@liverpool.ac.uk

+44 (0)151 795 4569

+44 (0)151 795 4569 Ext. 4569

Publications

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2024

OP-10 Recurrent microbial keratitis due to Staphylococcus aureus

Kaye, S., Glenn, M., Somerville, T., Simpson, D., Darby, A., & Horsburgh, M. (2024). OP-10 Recurrent microbial keratitis due to Staphylococcus aureus. In Oral Abstract Presentation (pp. A4.1-A4). BMJ Publishing Group Ltd. doi:10.1136/bmjophth-2024-bcm.11

DOI
10.1136/bmjophth-2024-bcm.11
Conference Paper

2023

2022

Comparative genomics of <i>Staphylococcus capitis</i> reveals determinants of speciation

DOI
10.1101/2022.02.11.480064
Preprint

2021

Long term nasopharyngeal colonization by <i>Staphylococcus aureus</i> determinants of adaptation

DOI
10.1101/2021.09.19.460983
Preprint

2020

Transcriptomic responses and survival mechanisms of staphylococci to the antimicrobial skin lipid sphingosine

DOI
10.1101/2020.09.15.297481
Preprint

Whole-Genome Sequence of Staphylococcus epidermidis Tu3298

Moran, J. C., & Horsburgh, M. J. (2020). Whole-Genome Sequence of Staphylococcus epidermidis Tu3298. Microbiology Resource Announcements, 4(2). doi:10.1128/genomeA.00112-16

DOI
10.1128/genomeA.00112-16
Journal article

2019

2018

Comparative Genomics of <i>Staphylococcus</i> Reveals Determinants of Speciation and Diversification of Antimicrobial Defense

DOI
10.1101/277400
Preprint

2017

2016

Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition

Moran, J. C., Crank, E. L., Ghabban, H. A., & Horsburgh, M. J. (n.d.). Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition. Journal of Visualized Experiments, (115). doi:10.3791/54437-v

DOI
10.3791/54437-v
Journal article

A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens

Gallagher, A. G., Alorabi, J. A., Wellings, D. A., Lace, R., Horsburgh, M. J., & Williams, R. L. (2016). A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens. Advanced Healthcare Materials, 5(16), 2013-2018. doi:10.1002/adhm.201600258

DOI
10.1002/adhm.201600258
Journal article

Staphylococcus aureus protects its immune‐evasion proteins against degradation by neutrophil serine proteases

Stapels, D. A. C., Kuipers, A., von Köckritz-Blickwede, M., Ruyken, M., Tromp, A., Horsburgh, M. J., . . . Rooijakkers, S. H. M. (2016). Staphylococcus aureus protects its immune‐evasion proteins against degradation by neutrophil serine proteases. Cellular Microbiology, 18(4), 536-545. doi:10.1111/cmi.12528

DOI
10.1111/cmi.12528
Journal article

2015

Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases

Wheeler, R., Turner, R. D., Bailey, R. G., Salamaga, B., Mesnage, S., Mohamad, S. A. S., . . . Foster, S. J. (2015). Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases. mBio, 6(4). doi:10.1128/mBio.00660-15

DOI
10.1128/mBio.00660-15
Journal article

The effects of spatial structure, frequency dependence and resistance evolution on the dynamics of toxin‐mediated microbial invasions

Libberton, B., Horsburgh, M. J., & Brockhurst, M. A. (2015). The effects of spatial structure, frequency dependence and resistance evolution on the dynamics of toxin‐mediated microbial invasions. Evolutionary Applications, 8(7), 738-750. doi:10.1111/eva.12284

DOI
10.1111/eva.12284
Journal article

2014

Evidence that intraspecific trait variation among nasal bacteria shapes the distribution of Staphylococcus aureus

Libberton, A., Coates, R., Brockhurst, M., & Horsburgh, M. (2014). Evidence that intraspecific trait variation among nasal bacteria shapes the distribution of Staphylococcus aureus. Infection and Immunity, 82(9), 3811-3815. doi:10.1128/IAI.02025-14

DOI
10.1128/IAI.02025-14
Journal article

<i>Staphylococcus aureus</i> protects immune evasion proteins from degradation by neutrophil serine proteases

Stapels, D. A. C., Kuipers, A., Horsburgh, M. J., de Haas, C. J. C., van Strijp, J. A. G., van Kessel, K. P. M., & Rooijakkers, S. H. M. (2014). <i>Staphylococcus aureus</i> protects immune evasion proteins from degradation by neutrophil serine proteases. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 28. Retrieved from https://www.webofscience.com/

Journal article

Create new genus with 3 new species in the family Siphoviridae, order Caudovirales

Adriaenssens, E. M. H., Kropinski, A., Lavigne, R., & Horsburgh, M. (n.d.). Create new genus with 3 new species in the family Siphoviridae, order Caudovirales (2013.005a-dB.A.v3.Phifllikevirus). Retrieved from http://www.ictvonline.org/proposals-14/2013.005a-dB.A.v3.Phifllikevirus.pdf

Report

Enterococcal bacteriophages and genome defense

Duerkop, B. A., Palmer, K. L., & Horsburgh, M. J. (2014). Enterococcal bacteriophages and genome defense. In D. B. Clewell, N. Shankar, Y. Ike, & M. Gilmore (Eds.), Enterococci: From Commensals to Leading Causes of Drug Resistant Infection (pp. 1). Bethesda: National Center for Biotechnology Information (US). Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK190419/

Chapter

Staphylococci: colonizers and pathogens of human skin

Coates, R., Moran, J., & Horsburgh, M. J. (2014). Staphylococci: colonizers and pathogens of human skin. FUTURE MICROBIOLOGY, 9(1), 75-91. doi:10.2217/fmb.13.145

DOI
10.2217/fmb.13.145
Journal article

2013

Mannitol Utilisation is Required for Protection of <i>Staphylococcus aureus</i> from Human Skin Antimicrobial Fatty Acids

Kenny, J. G., Moran, J., Kolar, S. L., Ulanov, A., Li, Z., Shaw, L. N., . . . Horsburgh, M. J. (2013). Mannitol Utilisation is Required for Protection of <i>Staphylococcus aureus</i> from Human Skin Antimicrobial Fatty Acids. PLOS ONE, 8(7). doi:10.1371/journal.pone.0067698

DOI
10.1371/journal.pone.0067698
Journal article

Recurrent Bacterial Keratitis

Kaye, R., Kaye, A., Sueke, H., Neal, T., Winstanley, C., Horsburgh, M., & Kaye, S. (2013). Recurrent Bacterial Keratitis. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(6), 4136-4139. doi:10.1167/iovs.13-12130

DOI
10.1167/iovs.13-12130
Journal article

<i>lukSF-PV</i> in <i>Staphylococcus</i> <i>aureus</i> Keratitis Isolates and Association With Clinical Outcome

Sueke, H., Shankar, J., Neal, T., Winstanley, C., Tuft, S., Coates, R., . . . Kaye, S. (2013). <i>lukSF-PV</i> in <i>Staphylococcus</i> <i>aureus</i> Keratitis Isolates and Association With Clinical Outcome. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(5), 3410-3416. doi:10.1167/iovs.12-11276

DOI
10.1167/iovs.12-11276
Journal article

2012

Genotypic analysis of UK keratitis-associated Pseudomonas aeruginosa suggests adaptation to environmental water as a key component in the development of eye infections

Shankar, J., Sueke, H., Wiehlmann, L., Horsburgh, M. J., Tuft, S., Neal, T. J., . . . Winstanley, C. (2012). Genotypic analysis of UK keratitis-associated Pseudomonas aeruginosa suggests adaptation to environmental water as a key component in the development of eye infections. FEMS MICROBIOLOGY LETTERS, 334(2), 79-86. doi:10.1111/j.1574-6968.2012.02621.x

DOI
10.1111/j.1574-6968.2012.02621.x
Journal article

SalB Inactivation Modulates Culture Supernatant Exoproteins and Affects Autolysis and Viability in <i>Enterococcus faecalis</i> OG1RF

Shankar, J., Walker, R. G., Wilkinson, M. C., Ward, D., & Horsburgh, M. J. (2012). SalB Inactivation Modulates Culture Supernatant Exoproteins and Affects Autolysis and Viability in <i>Enterococcus faecalis</i> OG1RF. JOURNAL OF BACTERIOLOGY, 194(14), 3569-3578. doi:10.1128/JB.00376-12

DOI
10.1128/JB.00376-12
Journal article

<i>Staphylococcus aureus</i> Virulence Is Enhanced by Secreted Factors That Block Innate Immune Defenses

Jongerius, I., von Kockritz-Blickwede, M., Horsburgh, M. J., Ruyken, M., Nizet, V., & Rooijakkers, S. H. M. (2012). <i>Staphylococcus aureus</i> Virulence Is Enhanced by Secreted Factors That Block Innate Immune Defenses. JOURNAL OF INNATE IMMUNITY, 4(3), 301-311. doi:10.1159/000334604

DOI
10.1159/000334604
Journal article

The <i>Enterococcus faecalis</i> Exoproteome: Identification and Temporal Regulation by Fsr

Shankar, J., Walker, R. G., Ward, D., & Horsburgh, M. J. (2012). The <i>Enterococcus faecalis</i> Exoproteome: Identification and Temporal Regulation by Fsr. PLOS ONE, 7(3). doi:10.1371/journal.pone.0033450

DOI
10.1371/journal.pone.0033450
Journal article

New Developments in Antibacterial Chemotherapy for Bacterial Keratitis

Sueke, H., Shankar, J., Neal, T. J., Horsburgh, M., Gilbert, R., & Kaye, S. B. (2013). New Developments in Antibacterial Chemotherapy for Bacterial Keratitis. In Corneal Disease (pp. 19-35). Springer Berlin Heidelberg. doi:10.1007/978-3-642-28747-3_2

DOI
10.1007/978-3-642-28747-3_2
Chapter

2010

Comparative Genomics and Transduction Potential of <i>Enterococcus faecalis</i> Temperate Bacteriophages

Yasmin, A., Kenny, J. G., Shankar, J., Darby, A. C., Hall, N., Edwards, C., & Horsburgh, M. J. (2010). Comparative Genomics and Transduction Potential of <i>Enterococcus faecalis</i> Temperate Bacteriophages. JOURNAL OF BACTERIOLOGY, 192(4), 1122-1130. doi:10.1128/JB.01293-09

DOI
10.1128/JB.01293-09
Journal article

2009

The <i>Staphylococcus aureus</i> Response to Unsaturated Long Chain Free Fatty Acids: Survival Mechanisms and Virulence Implications

Kenny, J. G., Ward, D., Josefsson, E., Jonsson, I. -M., Hinds, J., Rees, H. H., . . . Horsburgh, M. J. (2009). The <i>Staphylococcus aureus</i> Response to Unsaturated Long Chain Free Fatty Acids: Survival Mechanisms and Virulence Implications. PLOS ONE, 4(2). doi:10.1371/journal.pone.0004344

DOI
10.1371/journal.pone.0004344
Journal article

Label-free Rapid AC Electrokinetic Test for S aureus

Bakewell, D. J. G., Horsburgh, M. J., Pradhan, R. S., & Morgan, H. (2009). Label-free Rapid AC Electrokinetic Test for S aureus. In Logothetdis (Ed.), Sixth International Conference on Nanosciences and Nanotechnologies (pp. 188). Thessaloniki: Galonis.

Conference Paper

2008

The Response of Staphylococcus aureus to Environmental Stimuli

Horsburgh, M. J. (2008). The Response of Staphylococcus aureus to Environmental Stimuli. In J. A. Lindsay (Ed.), Staphylococcus Molecular genetics (pp. 185-206). Norfolk, England: Caister Academic Press. Retrieved from http://books.google.com/

Chapter

2007

Characterization of IsaA and SceD, two putative lytic transglycosylases of <i>Staphylococcus aureus</i>

Stapleton, M. R., Horsburgh, M. J., Hayhurst, E. J., Wright, L., Jonsson, I. -M., Tarkowski, A., . . . Foster, S. J. (2007). Characterization of IsaA and SceD, two putative lytic transglycosylases of <i>Staphylococcus aureus</i>. JOURNAL OF BACTERIOLOGY, 189(20), 7316-7325. doi:10.1128/JB.00734-07

DOI
10.1128/JB.00734-07
Journal article

SigM-Responsive genes of <i>Bacillus subtilis</i> and their promoters

Jervis, A. J., Thackray, P. D., Houston, C. W., Horsburgh, M. J., & Moir, A. (2007). SigM-Responsive genes of <i>Bacillus subtilis</i> and their promoters. JOURNAL OF BACTERIOLOGY, 189(12), 4534-4538. doi:10.1128/JB.00130-07

DOI
10.1128/JB.00130-07
Journal article

2006

Opinion -: The evolution and maintenance of virulence in <i>Staphylococcus aureus</i>:: a role for host-to-host transmission?

Massey, R. C., Horsburgh, M. J., Lina, G., Hook, M., & Recker, M. (2006). Opinion -: The evolution and maintenance of virulence in <i>Staphylococcus aureus</i>:: a role for host-to-host transmission?. NATURE REVIEWS MICROBIOLOGY, 4(12), 953-958. doi:10.1038/nrmicro1551

DOI
10.1038/nrmicro1551
Journal article

Identification of in vivo-expressed antigens of <i>Staphylococcus aureus</i> and their use in vaccinations for protection against nasal carriage

Clarke, S. R., Brummell, K. J., Horsburgh, M. J., McDowell, P. W., Mohamad, S. A. S., Stapleton, M. R., . . . Foster, S. J. (2006). Identification of in vivo-expressed antigens of <i>Staphylococcus aureus</i> and their use in vaccinations for protection against nasal carriage. JOURNAL OF INFECTIOUS DISEASES, 193(8), 1098-1108. doi:10.1086/501471

DOI
10.1086/501471
Journal article

2004

PheP, a putative amino acid permease of <i>Staphylococcus aureus</i>, contributes to survival in vivo and during starvation

Horsburgh, M. J., Wiltshire, M. D., Crossley, H., Ingham, E., & Foster, S. J. (2004). PheP, a putative amino acid permease of <i>Staphylococcus aureus</i>, contributes to survival in vivo and during starvation. INFECTION AND IMMUNITY, 72(5), 3073-3076. doi:10.1128/IAI.72.5.3073-3076.2004

DOI
10.1128/IAI.72.5.3073-3076.2004
Journal article

2003

Role and regulation of the superoxide dismutases of <i>Staphylococcus aureus</i>

Karavolos, M. H., Horsburgh, M. J., Ingham, E., & Foster, S. J. (2003). Role and regulation of the superoxide dismutases of <i>Staphylococcus aureus</i>. MICROBIOLOGY-SGM, 149, 2749-2758. doi:10.1099/mic.0.26353-0

DOI
10.1099/mic.0.26353-0
Journal article

Selective roles for toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span

Sabroe, I., Prince, L. R., Jones, E. C., Horsburgh, M. J., Foster, S. J., Vogel, S. N., . . . Whyte, M. K. B. (2003). Selective roles for toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. JOURNAL OF IMMUNOLOGY, 170(10), 5268-5275. doi:10.4049/jimmunol.170.10.5268

DOI
10.4049/jimmunol.170.10.5268
Journal article

2002

Manganese: elemental defence for a life with oxygen?

Horsburgh, M. J., Wharton, S. J., Karavolos, M., & Foster, S. J. (2002). Manganese: elemental defence for a life with oxygen?. TRENDS IN MICROBIOLOGY, 10(11), 496-501. doi:10.1016/S0966-842X(02)02462-9

DOI
10.1016/S0966-842X(02)02462-9
Journal article

σ<SUP>B</SUP> modulates virulence determinant expression and stress resistance:: Characterization of a functional <i>rsbU</i> strain derived from <i>Staphylococcus aureus</i> 8325-4

Horsburgh, M. J., Aish, J. L., White, I. J., Shaw, L., Lithgow, J. K., & Foster, S. J. (2002). σ<SUP>B</SUP> modulates virulence determinant expression and stress resistance:: Characterization of a functional <i>rsbU</i> strain derived from <i>Staphylococcus aureus</i> 8325-4. JOURNAL OF BACTERIOLOGY, 184(19), 5457-5467. doi:10.1128/JB.184.19.5457-5467.2002

DOI
10.1128/JB.184.19.5457-5467.2002
Journal article

MntR modulates expression of the PerR regulon and superoxide resistance in <i>Staphylococcus aureus</i> through control of manganese uptake

Horsburgh, M. J., Wharton, S. J., Cox, A. G., Ingham, E., Peacock, S., & Foster, S. J. (2002). MntR modulates expression of the PerR regulon and superoxide resistance in <i>Staphylococcus aureus</i> through control of manganese uptake. MOLECULAR MICROBIOLOGY, 44(5), 1269-1286. doi:10.1046/j.1365-2958.2002.02944.x

DOI
10.1046/j.1365-2958.2002.02944.x
Journal article

2001

Transcriptional responses during outgrowth of <i>Bacillus subtilis</i> endospores

Horsburgh, M. J., Thackray, P. D., & Moir, A. (2001). Transcriptional responses during outgrowth of <i>Bacillus subtilis</i> endospores. MICROBIOLOGY-SGM, 147, 2933-2941. doi:10.1099/00221287-147-11-2933

DOI
10.1099/00221287-147-11-2933
Journal article

The 1.2 Å structure of a novel quorum-sensing protein, <i>Bacillus subtilis</i> LuxS

Ruzheinikov, S. N., Das, S. K., Sedelnikova, S. E., Hartley, A., Foster, S. J., Horsburgh, M. J., . . . Baker, P. J. (2001). The 1.2 Å structure of a novel quorum-sensing protein, <i>Bacillus subtilis</i> LuxS. JOURNAL OF MOLECULAR BIOLOGY, 313(1), 111-122. doi:10.1006/jmbi.2001.5027

DOI
10.1006/jmbi.2001.5027
Journal article

Cloning, purification, crystallization and preliminary crystallographic analysis of <i>Bacillus subtili</i>s LuxS

Das, S. K., Sedelnikova, S. E., Baker, P. J., Ruzheinikov, S. N., Foster, S., Hartley, A., . . . Rice, D. W. (2001). Cloning, purification, crystallization and preliminary crystallographic analysis of <i>Bacillus subtili</i>s LuxS. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 57, 1324-1325. doi:10.1107/S0907444901011611

DOI
10.1107/S0907444901011611
Journal article

PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in <i>Staphylococcus aureus</i>

Horsburgh, M. J., Clements, M. O., Crossley, H., Ingham, E., & Foster, S. J. (2001). PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in <i>Staphylococcus aureus</i>. INFECTION AND IMMUNITY, 69(6), 3744-3754. doi:10.1128/IAI.69.6.3744-3754.2001

DOI
10.1128/IAI.69.6.3744-3754.2001
Journal article

In <i>Staphylococcus aureus</i>, Fur is an interactive regulator with PerR, contributes to virulence, and is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis

Horsburgh, M. J., Ingham, E., & Foster, S. J. (2001). In <i>Staphylococcus aureus</i>, Fur is an interactive regulator with PerR, contributes to virulence, and is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis. JOURNAL OF BACTERIOLOGY, 183(2), 468-475. doi:10.1128/JB.183.2.468-475.2001

DOI
10.1128/JB.183.2.468-475.2001
Journal article

The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS

Ruzheinikov, S. N., Das, S. K., Sedelnikova, S. E., Hartley, A., Foster, S. J., Horsburgh, M. J., . . . Baker, P. J. (2001). The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS. Journal of Molecular Biology, 313((1)), 111-122.

Journal article

1999

σ<SUP>M</SUP>, an ECF RNA polymerase sigma factor of <i>Bacillus subtilis</i> 168, is essential for growth and survival in high concentrations of salt

Horsburgh, M. J., & Moir, A. (1999). σ<SUP>M</SUP>, an ECF RNA polymerase sigma factor of <i>Bacillus subtilis</i> 168, is essential for growth and survival in high concentrations of salt. MOLECULAR MICROBIOLOGY, 32(1), 41-50. doi:10.1046/j.1365-2958.1999.01323.x

DOI
10.1046/j.1365-2958.1999.01323.x
Journal article

1997

Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase from Erwinia chrysanthemi

Krell, T., Coyle, J. E., Horsburgh, M. J., Coggins, J. R., & Lapthorn, A. J. (1997). Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase from Erwinia chrysanthemi. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 53, 612-614. doi:10.1107/S0907444997004319

DOI
10.1107/S0907444997004319
Journal article

1996

Localization of the active site of type II dehydroquinases - Identification of a common arginine-containing motif in the two classes of dehydroquinases

Krell, T., Horsburgh, M. J., Cooper, A., Kelly, S. M., & Coggins, J. R. (1996). Localization of the active site of type II dehydroquinases - Identification of a common arginine-containing motif in the two classes of dehydroquinases. JOURNAL OF BIOLOGICAL CHEMISTRY, 271(40), 24492-24497. doi:10.1074/jbc.271.40.24492

DOI
10.1074/jbc.271.40.24492
Journal article

Chorismate synthase from Staphylococcus aureus

Horsburgh, M. J., Foster, T. J., Barth, P. T., & Coggins, J. R. (1996). Chorismate synthase from Staphylococcus aureus. MICROBIOLOGY-UK, 142, 2943-2950. doi:10.1099/13500872-142-10-2943

DOI
10.1099/13500872-142-10-2943
Journal article