Publications
2025
Biomarkers, omics and artificial intelligence for early detection of pancreatic cancer.
Murray, K., Oldfield, L., Stefanova, I., Gentiluomo, M., Aretini, P., O'Sullivan, R., . . . Costello, E. (2025). Biomarkers, omics and artificial intelligence for early detection of pancreatic cancer.. Seminars in cancer biology, 111, 76-88. doi:10.1016/j.semcancer.2025.02.009
2024
Cost-benefit analysis of biomarker-driven early detection of pancreatic cancer in individuals with new-onset diabetes
Stefanova, I., Stott, M., Oldfield, L., Hanson, R., Greenhalf, W., Halloran, C., & Costello, E. (2024). Cost-benefit analysis of biomarker-driven early detection of pancreatic cancer in individuals with new-onset diabetes. Pancreatology, 24, e108-e109. doi:10.1016/j.pan.2024.05.279
HPB SO33 - Transcriptomic characterisation of the diabetogenic pancreatic ductal adenocarcinoma phenotype
Stott, M., Hasoon, M., Oldfield, L., Soul, J., Halloran, C., & Costello, E. (2024). HPB SO33 - Transcriptomic characterisation of the diabetogenic pancreatic ductal adenocarcinoma phenotype. British Journal of Surgery, 111(Supplement_9). doi:10.1093/bjs/znae271.266
Pancreatic and Biliary Tract Cancers
Ney, A., Osei‐Bordom, D. C., Garcia‐Sampedro, A., Acedo, P., Fusai, G. K., Stott, M., . . . Pereira, S. P. (2024). Pancreatic and Biliary Tract Cancers. In Unknown Book (pp. 291-320). Wiley. doi:10.1002/9781119756422.ch17
Abstract PR02: Deep proteomics identifies novel biomarker candidates and molecular pathways of pancreatic cancer-related diabetes
Oldfield, L., Johnson, E., Gutiérrez, E. C., Stott, M., Greenhalf, W., Halloran, C., & Costello, E. (2024). Abstract PR02: Deep proteomics identifies novel biomarker candidates and molecular pathways of pancreatic cancer-related diabetes. Cancer Research, 84(2_Supplement), PR02. doi:10.1158/1538-7445.panca2023-pr02
Pancreatic and Biliary Tract Cancers: Risk Factors and Etiology, Screening, Surveillance, and Biomarkers of Detection and Prognosis
Ney, A., Osei-Bordom, D. C., Garcia-Sampedro, A., Acedo, P., Fusai, G. K., Stott, M., . . . Pereira, S. P. (2024). Pancreatic and Biliary Tract Cancers: Risk Factors and Etiology, Screening, Surveillance, and Biomarkers of Detection and Prognosis. In Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach (pp. 291-320). doi:10.1002/9781119756422.ch17
2023
Protein expression mapping reveals molecular mechanisms in pancreatic cancer-related diabetes
Oldfield, L., Stott, M., Greenhalf, W., Halloran, C., & Costello, E. (2023). Protein expression mapping reveals molecular mechanisms in pancreatic cancer-related diabetes. Pancreatology, 23, e153. doi:10.1016/j.pan.2023.06.793
9O Pancreatic cancer risk in individuals with newly diagnosed diabetes: Insights from the AMORIS cohort in Sweden
Zhang, Z., Carlsson, S., Hammar, N., Acedo Nunez, M. D. P., Brennan, P., Oldfield, L., . . . Santaolalla, A. (2023). 9O Pancreatic cancer risk in individuals with newly diagnosed diabetes: Insights from the AMORIS cohort in Sweden. ESMO Open, 8(1), 101655. doi:10.1016/j.esmoop.2023.101655
Where the metabolome meets the microbiome for pancreatic cancer detection.
Oldfield, L., & Costello, E. (2023). Where the metabolome meets the microbiome for pancreatic cancer detection.. Cell reports. Medicine, 4(9), 101011. doi:10.1016/j.xcrm.2023.101011
2022
Pancreatic cancer-related diabetes mellitus: a clinical perspective
Stott, M., Oldfield, L., Evans, A., Halloran, C., & Costello, E. (2022). Pancreatic cancer-related diabetes mellitus: a clinical perspective. Pancreatology, 22, e63. doi:10.1016/j.pan.2022.06.164
United Kingdom Early Detection Initiative (UK-EDI): protocol for establishing a national multicentre cohort of individuals with new-onset diabetes for early detection of pancreatic cancer
Oldfield, L., Stott, M., Hanson, R., Jackson, R. J., Reynolds, W., Chandran-Gorner, V., . . . Costello, E. (2022). United Kingdom Early Detection Initiative (UK-EDI): protocol for establishing a national multicentre cohort of individuals with new-onset diabetes for early detection of pancreatic cancer. BMJ OPEN, 12(10). doi:10.1136/bmjopen-2022-068010
Recent advances in understanding pancreatic cancer
Stott, M. C., Oldfield, L., Hale, J., Costello, E., & Halloran, C. M. (n.d.). Recent advances in understanding pancreatic cancer. Faculty Reviews, 11. doi:10.12703/r/11-10
Recent advances in understanding pancreatic cancer.
Stott, M. C., Oldfield, L., Hale, J., Costello, E., & Halloran, C. M. (2022). Recent advances in understanding pancreatic cancer.. Faculty reviews, 11, 9. doi:10.12703/r/11-9
Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes
Oldfield, L., Evans, A., Rao, R. G., Jenkinson, C., Purewal, T., Psarelli, E. E., . . . Costello, E. (2022). Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes. EBIOMEDICINE, 75. doi:10.1016/j.ebiom.2021.103802
2021
Preoperative diabetes mellitus in patients undergoing pancreatic surgery
Stott, M., Crosby, B., Oldfield, L., Rao, R., Halloran, C. M., & Costello, E. (2021). Preoperative diabetes mellitus in patients undergoing pancreatic surgery. Pancreatology, 21, S53. doi:10.1016/j.pan.2021.05.143
Recruitment pathways in the UK early detection initiative (UK-EDI) for pancreatic cancer study
Stott, M., Hanson, R., Oldfield, L., Greenhalf, W., Van Der Meer, R., Allison, L., . . . Costello, E. (2021). Recruitment pathways in the UK early detection initiative (UK-EDI) for pancreatic cancer study. Pancreatology, 21, S109. doi:10.1016/j.pan.2021.05.291
The holding temperature of blood during a delay to processing can affect serum and plasma protein measurements
Ashworth, M., Small, B., Oldfield, L., Evans, A., Greenhalf, W., Halloran, C., & Costello, E. (2021). The holding temperature of blood during a delay to processing can affect serum and plasma protein measurements. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-85052-5
2020
Detecting pancreatic cancer in individuals with new-onset diabetes mellitus: why and how?
Oldfield, L., Rao, R., Purewal, T., Greenhalf, W., Halloran, C., & Costello, E. (2020). Detecting pancreatic cancer in individuals with new-onset diabetes mellitus: why and how?. Pancreatology, 20(8), e2-e3. doi:10.1016/j.pan.2018.10.016
UK–EDI: Detecting Pancreatic Cancer with DM
Oldfield, L., Rao, R. G., Jenkinson, C., Evans, A., Purewal, T., Psarelli, E. E., . . . Costello, E. (2020). UK–EDI: Detecting Pancreatic Cancer with DM. Pancreatology, 20(8), e14. doi:10.1016/j.pan.2020.10.003
Prevalence of diabetes mellitus among individuals undergoing pancreatic surgery
Crosby, B., Oldfield, L., Rao, R., Evans, A., Ghaneh, P., Hale, J., . . . Costello, E. (2020). Prevalence of diabetes mellitus among individuals undergoing pancreatic surgery. Pancreatology, 20, S101. doi:10.1016/j.pan.2020.07.172
The holding temperature of blood during a delay to processing can affect serum and plasma protein concentrations.
Small, B., Ashworth, M., Oldfield, L., Greenhalf, W., Halloran, C., & Costello-Goldring, E. (2020). The holding temperature of blood during a delay to processing can affect serum and plasma protein concentrations.. Pancreatology, 20, S120. doi:10.1016/j.pan.2020.07.217
UK Early Detection Initiative (UK-EDI) for Pancreatic Cancer
Oldfield, L., Hanson, R., Greenhalf, W., Meer R., V. D., Alison, L., Christiansen, P., . . . Costello, E. (2020). UK Early Detection Initiative (UK-EDI) for Pancreatic Cancer. Pancreatology, 20, S120-S121. doi:10.1016/j.pan.2020.07.218
Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers
Oldfield, L., Barrera, L., Williams, D., Evans, A. E., Neoptolemos, J., & Costello, E. (2020). Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers. In Molecular and Translational Medicine (pp. 73-82). Springer International Publishing. doi:10.1007/978-3-030-49476-6_4
Early detection of pancreatic cancer
Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., . . . Costello, E. (2020). Early detection of pancreatic cancer. The Lancet Gastroenterology and Hepatology, 5(7), 698-710. doi:10.1016/S2468-1253(19)30416-9
2019
Galectin-1 is a novel therapeutic target and diagnostic/prognostic biomarker for pancreatic cancer
Navarro, P., Martínez-Bosch, N., Orozco, C. A., Barranco, L. E., Guerrero, P. E., Vinaixa, J., . . . Rabinovich, G. A. (2019). Galectin-1 is a novel therapeutic target and diagnostic/prognostic biomarker for pancreatic cancer. Pancreatology, 19, S186. doi:10.1016/j.pan.2019.07.020
Blood levels of adiponectin and IL-1Ra could facilitate earlier detection of PDAC by distinguishing individuals with type 3c diabetes from those with type 2 diabetes
Oldfield, L., Rao, R., Purewal, T., Greenhalf, W., Halloran, C., & Costello, E. (2019). Blood levels of adiponectin and IL-1Ra could facilitate earlier detection of PDAC by distinguishing individuals with type 3c diabetes from those with type 2 diabetes. Pancreatology, 19, S3. doi:10.1016/j.pan.2019.05.004
2018
S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes
Nedjadi, T., Evans, A., Sheikh, A., Barerra, L., Al-Ghamdi, S., Oldfield, L., . . . Costello, E. (2018). S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes. BMC CANCER, 18. doi:10.1186/s12885-018-5161-4
Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.
Martinez-Bosch, N., Barranco, L. E., Orozco, C. A., Moreno, M., Visa, L., Iglesias, M., . . . Navarro, P. (2018). Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.. Oncotarget, 9(68), 32984-32996. doi:10.18632/oncotarget.26034
Towards earlier detection of PDAC: Validation of a biomarker panel for the identification of type 3c diabetes among individuals newly diagnosed with type 2 diabetes
Oldfield, L., Rao, R., Purewal, T., Neoptolemos, J. P., Greenhalf, W., Halloran, C., & Costello, E. (2018). Towards earlier detection of PDAC: Validation of a biomarker panel for the identification of type 3c diabetes among individuals newly diagnosed with type 2 diabetes. Pancreatology, 18(4), S72. doi:10.1016/j.pan.2018.05.194
Development of Novel Diagnostic Pancreatic Tumor Biomarkers
Oldfield, L., Rao, R., Barrera, L. N., & Costello, E. (2018). Development of Novel Diagnostic Pancreatic Tumor Biomarkers. In Pancreatic Cancer (pp. 1241-1272). Springer New York. doi:10.1007/978-1-4939-7193-0_86
Pancreatic ductal adenocarcinoma is associated with high prevalence of pancretogenic diabetes mellitus in individuals with potentially resectable disease.
Rao, R. G., Oldfield, L., Evans, A., Greenhalf, W., Halloran, C., & Costello, E. (2018). Pancreatic ductal adenocarcinoma is associated with high prevalence of pancretogenic diabetes mellitus in individuals with potentially resectable disease.. In BRITISH JOURNAL OF SURGERY Vol. 105 (pp. 82). Retrieved from https://www.webofscience.com/
2017
Detecting Pancreatic Cancer Earlier: Identifying Type 3c Diabetes in Individuals Newly Diagnosed With Type 2 Diabetes
Oldfield, L., Rao, R., Purewal, T., Neoptolemos, J. P., Halloran, C. M., Greenhalf, W., & Costello, E. (2017). Detecting Pancreatic Cancer Earlier: Identifying Type 3c Diabetes in Individuals Newly Diagnosed With Type 2 Diabetes. In PANCREAS Vol. 46 (pp. 1425). Retrieved from https://www.webofscience.com/
The Prevalence of Diabetes Mellitus is Significantly Higher for Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma Compared to Surgery for Other Pancreatic Pathologies
Rao, R. G., Costello, E., Halloran, C. M., Oldfield, L., Greenhalf, W., Ghaneh, P., . . . Mann, K. (2017). The Prevalence of Diabetes Mellitus is Significantly Higher for Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma Compared to Surgery for Other Pancreatic Pathologies. In PANCREAS Vol. 46 (pp. 1403-1404). Retrieved from https://www.webofscience.com/
Cytokines as potential biomarkers for distinguishing patients with pancreatic cancer and type 2 diabetes mellitus
Rao, R. G., Oldfield, L., Evans, A., Sivapalan, L., Schuler, P., Purewal, T., . . . Costello, E. (2017). Cytokines as potential biomarkers for distinguishing patients with pancreatic cancer and type 2 diabetes mellitus. Pancreatology, 17(3), S33. doi:10.1016/j.pan.2017.05.103
Development of Novel Diagnostic Pancreatic Tumor Biomarkers 2nd ed
Oldfield, L., Rao, R., Barrera, L. N., & Costello, E. (2017). Development of Novel Diagnostic Pancreatic Tumor Biomarkers 2nd ed. In Pancreatic Cancer (pp. 1-32). Springer New York. doi:10.1007/978-1-4939-6631-8_86-1
2016
Targeting individuals with new-onset diabetes for early detection of pancreatic cancer in this high risk group
Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J. P., Greenhalf, W., & Costello, E. (2016). Targeting individuals with new-onset diabetes for early detection of pancreatic cancer in this high risk group. Pancreatology, 16(3), S19. doi:10.1016/j.pan.2016.05.069
Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus
Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R., O'Brien, D., . . . Costello-Goldring, E. (2016). Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus. Clinical Cancer Research, 22(7), 1734-1743. doi:10.1158/1078-0432.ccr-15-0879
Exploring the Protein Profile of Pancreatic Cancer-Associated Diabetes
Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J. P., Greenhalf, W., & Costello, E. (2016). Exploring the Protein Profile of Pancreatic Cancer-Associated Diabetes. PANCREAS, 45(10), 1531-1532. Retrieved from https://www.webofscience.com/
2015
Decreased serum thrombospondin-1 levels in pancreatic ductal adenocarcinoma patients: an early indicator of disease or diabetes mellitus development?
Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., O'Brien, D., Apostolidou, S., . . . Costello, E. (2015). Decreased serum thrombospondin-1 levels in pancreatic ductal adenocarcinoma patients: an early indicator of disease or diabetes mellitus development?. Pancreatology, 15(3), S28. doi:10.1016/j.pan.2015.05.129
Potential biomarkers of pancreatic ductal adenocarcinoma (PDAC)-associated diabetes
Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J., Greenhalf, W., & Costello, E. (2015). Potential biomarkers of pancreatic ductal adenocarcinoma (PDAC)-associated diabetes. Pancreatology, 15(3), S30. doi:10.1016/j.pan.2015.05.136
Potential Biomarkers of Pancreatic Ductal Adenocarcinoma-Associated Diabetes
Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J. P., Greenhalf, W., & Costello, E. (2015). Potential Biomarkers of Pancreatic Ductal Adenocarcinoma-Associated Diabetes. PANCREAS, 44(8), 1404-1405. Retrieved from https://www.webofscience.com/
2007
Comparative analysis of gamma-hydroxybutyrate and gamma-hydroxyvalerate using GC/MS and HPLC
Mercer, J. W., Oldfield, L. S., Hoffman, K. N., Shakleya, D. M., & Bell, S. C. (2007). Comparative analysis of gamma-hydroxybutyrate and gamma-hydroxyvalerate using GC/MS and HPLC. JOURNAL OF FORENSIC SCIENCES, 52(2), 383-388. doi:10.1111/j.1556-4029.2007.00392.x