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2025

2024

Cost-benefit analysis of biomarker-driven early detection of pancreatic cancer in individuals with new-onset diabetes

Stefanova, I., Stott, M., Oldfield, L., Hanson, R., Greenhalf, W., Halloran, C., & Costello, E. (2024). Cost-benefit analysis of biomarker-driven early detection of pancreatic cancer in individuals with new-onset diabetes. Pancreatology, 24, e108-e109. doi:10.1016/j.pan.2024.05.279

DOI
10.1016/j.pan.2024.05.279
Journal article

HPB SO33 - Transcriptomic characterisation of the diabetogenic pancreatic ductal adenocarcinoma phenotype

Stott, M., Hasoon, M., Oldfield, L., Soul, J., Halloran, C., & Costello, E. (2024). HPB SO33 - Transcriptomic characterisation of the diabetogenic pancreatic ductal adenocarcinoma phenotype. British Journal of Surgery, 111(Supplement_9). doi:10.1093/bjs/znae271.266

DOI
10.1093/bjs/znae271.266
Journal article

Pancreatic and Biliary Tract Cancers

Ney, A., Osei‐Bordom, D. C., Garcia‐Sampedro, A., Acedo, P., Fusai, G. K., Stott, M., . . . Pereira, S. P. (2024). Pancreatic and Biliary Tract Cancers. In Unknown Book (pp. 291-320). Wiley. doi:10.1002/9781119756422.ch17

DOI
10.1002/9781119756422.ch17
Chapter

Abstract PR02: Deep proteomics identifies novel biomarker candidates and molecular pathways of pancreatic cancer-related diabetes

Oldfield, L., Johnson, E., Gutiérrez, E. C., Stott, M., Greenhalf, W., Halloran, C., & Costello, E. (2024). Abstract PR02: Deep proteomics identifies novel biomarker candidates and molecular pathways of pancreatic cancer-related diabetes. Cancer Research, 84(2_Supplement), PR02. doi:10.1158/1538-7445.panca2023-pr02

DOI
10.1158/1538-7445.panca2023-pr02
Journal article

Pancreatic and Biliary Tract Cancers: Risk Factors and Etiology, Screening, Surveillance, and Biomarkers of Detection and Prognosis

Ney, A., Osei-Bordom, D. C., Garcia-Sampedro, A., Acedo, P., Fusai, G. K., Stott, M., . . . Pereira, S. P. (2024). Pancreatic and Biliary Tract Cancers: Risk Factors and Etiology, Screening, Surveillance, and Biomarkers of Detection and Prognosis. In Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach (pp. 291-320). doi:10.1002/9781119756422.ch17

DOI
10.1002/9781119756422.ch17
Chapter

2023

Protein expression mapping reveals molecular mechanisms in pancreatic cancer-related diabetes

Oldfield, L., Stott, M., Greenhalf, W., Halloran, C., & Costello, E. (2023). Protein expression mapping reveals molecular mechanisms in pancreatic cancer-related diabetes. Pancreatology, 23, e153. doi:10.1016/j.pan.2023.06.793

DOI
10.1016/j.pan.2023.06.793
Journal article

9O Pancreatic cancer risk in individuals with newly diagnosed diabetes: Insights from the AMORIS cohort in Sweden

Zhang, Z., Carlsson, S., Hammar, N., Acedo Nunez, M. D. P., Brennan, P., Oldfield, L., . . . Santaolalla, A. (2023). 9O Pancreatic cancer risk in individuals with newly diagnosed diabetes: Insights from the AMORIS cohort in Sweden. ESMO Open, 8(1), 101655. doi:10.1016/j.esmoop.2023.101655

DOI
10.1016/j.esmoop.2023.101655
Journal article

2022

Pancreatic cancer-related diabetes mellitus: a clinical perspective

Stott, M., Oldfield, L., Evans, A., Halloran, C., & Costello, E. (2022). Pancreatic cancer-related diabetes mellitus: a clinical perspective. Pancreatology, 22, e63. doi:10.1016/j.pan.2022.06.164

DOI
10.1016/j.pan.2022.06.164
Journal article

United Kingdom Early Detection Initiative (UK-EDI): protocol for establishing a national multicentre cohort of individuals with new-onset diabetes for early detection of pancreatic cancer

Oldfield, L., Stott, M., Hanson, R., Jackson, R. J., Reynolds, W., Chandran-Gorner, V., . . . Costello, E. (2022). United Kingdom Early Detection Initiative (UK-EDI): protocol for establishing a national multicentre cohort of individuals with new-onset diabetes for early detection of pancreatic cancer. BMJ OPEN, 12(10). doi:10.1136/bmjopen-2022-068010

DOI
10.1136/bmjopen-2022-068010
Journal article

Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes

Oldfield, L., Evans, A., Rao, R. G., Jenkinson, C., Purewal, T., Psarelli, E. E., . . . Costello, E. (2022). Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes. EBIOMEDICINE, 75. doi:10.1016/j.ebiom.2021.103802

DOI
10.1016/j.ebiom.2021.103802
Journal article

2021

Preoperative diabetes mellitus in patients undergoing pancreatic surgery

Stott, M., Crosby, B., Oldfield, L., Rao, R., Halloran, C. M., & Costello, E. (2021). Preoperative diabetes mellitus in patients undergoing pancreatic surgery. Pancreatology, 21, S53. doi:10.1016/j.pan.2021.05.143

DOI
10.1016/j.pan.2021.05.143
Journal article

Recruitment pathways in the UK early detection initiative (UK-EDI) for pancreatic cancer study

Stott, M., Hanson, R., Oldfield, L., Greenhalf, W., Van Der Meer, R., Allison, L., . . . Costello, E. (2021). Recruitment pathways in the UK early detection initiative (UK-EDI) for pancreatic cancer study. Pancreatology, 21, S109. doi:10.1016/j.pan.2021.05.291

DOI
10.1016/j.pan.2021.05.291
Journal article

2020

Detecting pancreatic cancer in individuals with new-onset diabetes mellitus: why and how?

Oldfield, L., Rao, R., Purewal, T., Greenhalf, W., Halloran, C., & Costello, E. (2020). Detecting pancreatic cancer in individuals with new-onset diabetes mellitus: why and how?. Pancreatology, 20(8), e2-e3. doi:10.1016/j.pan.2018.10.016

DOI
10.1016/j.pan.2018.10.016
Journal article

UK–EDI: Detecting Pancreatic Cancer with DM

Oldfield, L., Rao, R. G., Jenkinson, C., Evans, A., Purewal, T., Psarelli, E. E., . . . Costello, E. (2020). UK–EDI: Detecting Pancreatic Cancer with DM. Pancreatology, 20(8), e14. doi:10.1016/j.pan.2020.10.003

DOI
10.1016/j.pan.2020.10.003
Journal article

Prevalence of diabetes mellitus among individuals undergoing pancreatic surgery

Crosby, B., Oldfield, L., Rao, R., Evans, A., Ghaneh, P., Hale, J., . . . Costello, E. (2020). Prevalence of diabetes mellitus among individuals undergoing pancreatic surgery. Pancreatology, 20, S101. doi:10.1016/j.pan.2020.07.172

DOI
10.1016/j.pan.2020.07.172
Journal article

The holding temperature of blood during a delay to processing can affect serum and plasma protein concentrations.

Small, B., Ashworth, M., Oldfield, L., Greenhalf, W., Halloran, C., & Costello-Goldring, E. (2020). The holding temperature of blood during a delay to processing can affect serum and plasma protein concentrations.. Pancreatology, 20, S120. doi:10.1016/j.pan.2020.07.217

DOI
10.1016/j.pan.2020.07.217
Journal article

UK Early Detection Initiative (UK-EDI) for Pancreatic Cancer

Oldfield, L., Hanson, R., Greenhalf, W., Meer R., V. D., Alison, L., Christiansen, P., . . . Costello, E. (2020). UK Early Detection Initiative (UK-EDI) for Pancreatic Cancer. Pancreatology, 20, S120-S121. doi:10.1016/j.pan.2020.07.218

DOI
10.1016/j.pan.2020.07.218
Journal article

Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers

Oldfield, L., Barrera, L., Williams, D., Evans, A. E., Neoptolemos, J., & Costello, E. (2020). Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers. In Molecular and Translational Medicine (pp. 73-82). Springer International Publishing. doi:10.1007/978-3-030-49476-6_4

DOI
10.1007/978-3-030-49476-6_4
Chapter

Early detection of pancreatic cancer

Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., . . . Costello, E. (2020). Early detection of pancreatic cancer. The Lancet Gastroenterology and Hepatology, 5(7), 698-710. doi:10.1016/S2468-1253(19)30416-9

DOI
10.1016/S2468-1253(19)30416-9
Journal article

2019

Galectin-1 is a novel therapeutic target and diagnostic/prognostic biomarker for pancreatic cancer

Navarro, P., Martínez-Bosch, N., Orozco, C. A., Barranco, L. E., Guerrero, P. E., Vinaixa, J., . . . Rabinovich, G. A. (2019). Galectin-1 is a novel therapeutic target and diagnostic/prognostic biomarker for pancreatic cancer. Pancreatology, 19, S186. doi:10.1016/j.pan.2019.07.020

DOI
10.1016/j.pan.2019.07.020
Journal article

Blood levels of adiponectin and IL-1Ra could facilitate earlier detection of PDAC by distinguishing individuals with type 3c diabetes from those with type 2 diabetes

Oldfield, L., Rao, R., Purewal, T., Greenhalf, W., Halloran, C., & Costello, E. (2019). Blood levels of adiponectin and IL-1Ra could facilitate earlier detection of PDAC by distinguishing individuals with type 3c diabetes from those with type 2 diabetes. Pancreatology, 19, S3. doi:10.1016/j.pan.2019.05.004

DOI
10.1016/j.pan.2019.05.004
Journal article

2018

Towards earlier detection of PDAC: Validation of a biomarker panel for the identification of type 3c diabetes among individuals newly diagnosed with type 2 diabetes

Oldfield, L., Rao, R., Purewal, T., Neoptolemos, J. P., Greenhalf, W., Halloran, C., & Costello, E. (2018). Towards earlier detection of PDAC: Validation of a biomarker panel for the identification of type 3c diabetes among individuals newly diagnosed with type 2 diabetes. Pancreatology, 18(4), S72. doi:10.1016/j.pan.2018.05.194

DOI
10.1016/j.pan.2018.05.194
Journal article

Development of Novel Diagnostic Pancreatic Tumor Biomarkers

Oldfield, L., Rao, R., Barrera, L. N., & Costello, E. (2018). Development of Novel Diagnostic Pancreatic Tumor Biomarkers. In Pancreatic Cancer (pp. 1241-1272). Springer New York. doi:10.1007/978-1-4939-7193-0_86

DOI
10.1007/978-1-4939-7193-0_86
Chapter

Pancreatic ductal adenocarcinoma is associated with high prevalence of pancretogenic diabetes mellitus in individuals with potentially resectable disease.

Rao, R. G., Oldfield, L., Evans, A., Greenhalf, W., Halloran, C., & Costello, E. (2018). Pancreatic ductal adenocarcinoma is associated with high prevalence of pancretogenic diabetes mellitus in individuals with potentially resectable disease.. In BRITISH JOURNAL OF SURGERY Vol. 105 (pp. 82). Retrieved from https://www.webofscience.com/

Conference Paper

2017

The Prevalence of Diabetes Mellitus is Significantly Higher for Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma Compared to Surgery for Other Pancreatic Pathologies

Rao, R. G., Costello, E., Halloran, C. M., Oldfield, L., Greenhalf, W., Ghaneh, P., . . . Mann, K. (2017). The Prevalence of Diabetes Mellitus is Significantly Higher for Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma Compared to Surgery for Other Pancreatic Pathologies. In PANCREAS Vol. 46 (pp. 1403-1404). Retrieved from https://www.webofscience.com/

Conference Paper

Cytokines as potential biomarkers for distinguishing patients with pancreatic cancer and type 2 diabetes mellitus

Rao, R. G., Oldfield, L., Evans, A., Sivapalan, L., Schuler, P., Purewal, T., . . . Costello, E. (2017). Cytokines as potential biomarkers for distinguishing patients with pancreatic cancer and type 2 diabetes mellitus. Pancreatology, 17(3), S33. doi:10.1016/j.pan.2017.05.103

DOI
10.1016/j.pan.2017.05.103
Journal article

Development of Novel Diagnostic Pancreatic Tumor Biomarkers 2nd ed

Oldfield, L., Rao, R., Barrera, L. N., & Costello, E. (2017). Development of Novel Diagnostic Pancreatic Tumor Biomarkers 2nd ed. In Pancreatic Cancer (pp. 1-32). Springer New York. doi:10.1007/978-1-4939-6631-8_86-1

DOI
10.1007/978-1-4939-6631-8_86-1
Chapter

2016

Targeting individuals with new-onset diabetes for early detection of pancreatic cancer in this high risk group

Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J. P., Greenhalf, W., & Costello, E. (2016). Targeting individuals with new-onset diabetes for early detection of pancreatic cancer in this high risk group. Pancreatology, 16(3), S19. doi:10.1016/j.pan.2016.05.069

DOI
10.1016/j.pan.2016.05.069
Journal article

Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus

Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R., O'Brien, D., . . . Costello-Goldring, E. (2016). Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus. Clinical Cancer Research, 22(7), 1734-1743. doi:10.1158/1078-0432.ccr-15-0879

DOI
10.1158/1078-0432.ccr-15-0879
Journal article

Exploring the Protein Profile of Pancreatic Cancer-Associated Diabetes

Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J. P., Greenhalf, W., & Costello, E. (2016). Exploring the Protein Profile of Pancreatic Cancer-Associated Diabetes. PANCREAS, 45(10), 1531-1532. Retrieved from https://www.webofscience.com/

Journal article

2015

Decreased serum thrombospondin-1 levels in pancreatic ductal adenocarcinoma patients: an early indicator of disease or diabetes mellitus development?

Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., O'Brien, D., Apostolidou, S., . . . Costello, E. (2015). Decreased serum thrombospondin-1 levels in pancreatic ductal adenocarcinoma patients: an early indicator of disease or diabetes mellitus development?. Pancreatology, 15(3), S28. doi:10.1016/j.pan.2015.05.129

DOI
10.1016/j.pan.2015.05.129
Journal article

Potential biomarkers of pancreatic ductal adenocarcinoma (PDAC)-associated diabetes

Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J., Greenhalf, W., & Costello, E. (2015). Potential biomarkers of pancreatic ductal adenocarcinoma (PDAC)-associated diabetes. Pancreatology, 15(3), S30. doi:10.1016/j.pan.2015.05.136

DOI
10.1016/j.pan.2015.05.136
Journal article

Potential Biomarkers of Pancreatic Ductal Adenocarcinoma-Associated Diabetes

Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J. P., Greenhalf, W., & Costello, E. (2015). Potential Biomarkers of Pancreatic Ductal Adenocarcinoma-Associated Diabetes. PANCREAS, 44(8), 1404-1405. Retrieved from https://www.webofscience.com/

Journal article

2007

Comparative analysis of gamma-hydroxybutyrate and gamma-hydroxyvalerate using GC/MS and HPLC

Mercer, J. W., Oldfield, L. S., Hoffman, K. N., Shakleya, D. M., & Bell, S. C. (2007). Comparative analysis of gamma-hydroxybutyrate and gamma-hydroxyvalerate using GC/MS and HPLC. JOURNAL OF FORENSIC SCIENCES, 52(2), 383-388. doi:10.1111/j.1556-4029.2007.00392.x

DOI
10.1111/j.1556-4029.2007.00392.x
Journal article