Publications
2024
Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case.
Tatham, L., Kipar, A., Sharp, J., Kijak, E., Herriott, J., Neary, M., . . . Owen, A. (2024). Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case.. Microbiology spectrum, 12(8), e0391623. doi:10.1128/spectrum.03916-23
Sotrovimab Lacks Efficacy in Treatment of Syrian Golden Hamsters Infected With SARS-CoV-2 BQ.1.1
Tatham, L., Sharp, J., Neary, M., Herriott, J., Kijak, E., Gallardo-Toledo, E., . . . Owen, A. (2024). Sotrovimab Lacks Efficacy in Treatment of Syrian Golden Hamsters Infected With SARS-CoV-2 BQ.1.1. Poster session presented at the meeting of The 31st Conference on Retroviruses and Opportunistic Infections (CROI 2024). Denver, US.
2023
Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters.
Box, H. J., Sharp, J., Pennington, S. H., Kijak, E., Tatham, L., Caygill, C. H., . . . Owen, A. (2023). Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters.. The Journal of antimicrobial chemotherapy, dkad362. doi:10.1093/jac/dkad362
Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters.
Gallardo-Toledo, E., Neary, M., Sharp, J., Herriott, J., Kijak, E., Bramwell, C., . . . Owen, A. (2023). Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters.. Viruses, 15(11), 2161. doi:10.3390/v15112161
Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters
Neary, M., Sharp, J., Gallardo-Toledo, E., Herriott, J., Kijak, E., Bramwell, C., . . . Owen, A. (2023). Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters. VIRUSES-BASEL, 15(8). doi:10.3390/v15081744
Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research
Neary, M., Arshad, U., Tatham, L., Pertinez, H., Box, H., Rajoli, R. K. R., . . . Owen, A. (2023). Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1228. doi:10.1016/j.jchromb.2023.123823
Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations.
Curley, P., Hobson, J. J., Liptrott, N. J., Makarov, E., Al-Khouja, A., Tatham, L., . . . Owen, A. (2023). Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations.. Pharmaceutics, 15(7), 1835. doi:10.3390/pharmaceutics15071835
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2
Gaynor, K. U. U., Vaysburd, M., Harman, M. A. J., Albecka, A., Jeffrey, P., Beswick, P., . . . James, L. C. C. (2023). Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-39158-1
Layer by layer self-assembly for coating a nanosuspension to modify drug release and stability for oral delivery
Elbaz, N. M., Tatham, L. M., Owen, A., Rannard, S., & McDonald, T. O. (2023). Layer by layer self-assembly for coating a nanosuspension to modify drug release and stability for oral delivery. Food Hydrocolloids, 108908. doi:10.1016/j.foodhyd.2023.108908
Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case.
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Brevini, T., Maes, M., Webb, G. J., John, B. V., Fuchs, C. D., Buescher, G., . . . Sampaziotis, F. (2023). FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. NATURE, 615(7950), 134-+. doi:10.1038/s41586-022-05594-0
2022
Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays.
2021
Redispersible nanosuspensions as a plausible oral delivery system for curcumin
Elbaz, N. M., Tatham, L. M., Owen, A., Rannard, S., & McDonald, T. O. (2021). Redispersible nanosuspensions as a plausible oral delivery system for curcumin. Food Hydrocolloids, 121, 107005. doi:10.1016/j.foodhyd.2021.107005
Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection
Hobson, J. J., Savage, A. C., Dwyer, A., Unsworth, C., Massam, J., Arshad, U., . . . Rannard, S. (n.d.). Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. Nanoscale. doi:10.1039/d1nr00309g
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis
Rajoli, R. K. R., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2021). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 2078-2088. doi:10.1111/bcp.14619
Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection
Hobson, J., Savage, A., Dwyer, A., Unsworth, C., Arshad, U., Pertinez, H., . . . Rannard, S. (2021). Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. doi:10.26434/chemrxiv.13587035
Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection
Hobson, J., Savage, A., Dwyer, A., Unsworth, C., Arshad, U., Pertinez, H., . . . Rannard, S. (2021). Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. doi:10.26434/chemrxiv.13587035.v1
2020
Optimization of the Synthetic Parameters of Lipid Polymer Hybrid Nanoparticles Dual Loaded with Darunavir and Ritonavir for the Treatment of HIV
Elkateb, H., Tatham, L. M., Cauldbeck, H., Niezabitowska, E., Owen, A., Rannard, S., & McDonald, T. (n.d.). Optimization of the Synthetic Parameters of Lipid Polymer Hybrid Nanoparticles Dual Loaded with Darunavir and Ritonavir for the Treatment of HIV. International Journal of Pharmaceutics, 119794. doi:10.1016/j.ijpharm.2020.119794
Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.
Arshad, U., Pertinez, H., Box, H., Tatham, L., Rajoli, R. K., Curley, P., . . . Owen, A. (2020). Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.1909
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.
Rajoli, R. K., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2020). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.. medRxiv : the preprint server for health sciences. doi:10.1101/2020.05.01.20087130
Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate plasma and target site concentrations derived from their established human pharmacokinetics
Arshad, U., Pertinez, H., Box, H., Tatham, L., Rajoli, R. K. R., Curley, P., . . . Owen, A. (2020). Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate plasma and target site concentrations derived from their established human pharmacokinetics. doi:10.1101/2020.04.16.20068379
2019
Long-Acting Injectable Statins-Is It Time for a Paradigm Shift?
Tatham, L. M., Liptrott, N. J., Rannard, S. P., & Owen, A. (2019). Long-Acting Injectable Statins-Is It Time for a Paradigm Shift?. MOLECULES, 24(15). doi:10.3390/molecules24152685
Improving maraviroc oral bioavailability by formation of solid drug nanoparticles
Savage, A. C., Tatham, L. M., Siccardi, M., Scott, T., Vourvahis, M., Clark, A., . . . Owen, A. (2019). Improving maraviroc oral bioavailability by formation of solid drug nanoparticles. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 138, 30-36. doi:10.1016/j.ejpb.2018.05.015
Towards a Maraviroc long-acting injectable nanoformulation
Tatham, L. M., Savage, A. C., Dwyer, A., Siccardi, M., Scott, T., Vourvahis, M., . . . Owen, A. (2019). Towards a Maraviroc long-acting injectable nanoformulation. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 138, 92-98. doi:10.1016/j.ejpb.2018.04.009
2018
Direct synthesis of nanoparticles with spatial heterogeneity for tailored cellular interactions
Hern, F. Y., Tatham, L., Owen, A., & Rannard, S. (2018). Direct synthesis of nanoparticles with spatial heterogeneity for tailored cellular interactions. In 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond Vol. 256. Boston, MA.
Maraviroc solid drug nanoparticles with improved oral pharmacokinetics
Tatham, L., Savage, A. C., Dwyer, A. B., Siccardi, M., Scott, T., Vourvahis, M., . . . Owen, A. (2018). Maraviroc solid drug nanoparticles with improved oral pharmacokinetics. In CROI. Boston MA.
Towards a Long-Acting Injectable (LAI) Formulation For Maraviroc
Tatham, L., Dwyer, A. B., Savage, A. C., Siccardi, M., Scott, T., Vourvahis, M., . . . Owen, A. (2018). Towards a Long-Acting Injectable (LAI) Formulation For Maraviroc. In CROI. Boston MA.
Preclinical evaluation of reduced dose darunavir/ritonavir nanoparticle formulation.
Box, H., Sharp, J., Neary, M. G., Moss, D., Tatham, L., Savage, A., . . . Owen, A. (n.d.). Preclinical evaluation of reduced dose darunavir/ritonavir nanoparticle formulation.. In CROI. Boston, MA, USA.
Long-acting injectable atovaquone nanomedicines for malaria prophylaxis
Bakshi, R. P., Tatham, L. M., Savage, A. C., Tripathi, A. K., Mlambo, G., Ippolito, M. M., . . . Shapiro, T. A. (2018). Long-acting injectable atovaquone nanomedicines for malaria prophylaxis. Nature Communications, 9. doi:10.1038/s41467-017-02603-z
Direct synthesis of nanoparticles with spatial heterogeneity for tailored cellular interactions
Hern, F., Tatham, L., Owen, A., & Rannard, S. (2018). Direct synthesis of nanoparticles with spatial heterogeneity for tailored cellular interactions. Retrieved from https://www.webofscience.com/
LONG-ACTING INJECTABLE ATOVAQUONE NANOMEDICINES FOR MALARIA PROPHYLAXIS
Bakshi, R., Tatham, L., Savage, A., Tripathi, A., Mlambo, G., Ippolito, M., . . . Shapiro, T. (2018). LONG-ACTING INJECTABLE ATOVAQUONE NANOMEDICINES FOR MALARIA PROPHYLAXIS. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 99 (pp. 94). Retrieved from https://www.webofscience.com/
2017
Maraviroc Solid Drug Nanoparticles with Improved Oral Pharmacokinetics
Tatham, L., Savage, A., Rannard, S., & Owen, A. (2017). Maraviroc Solid Drug Nanoparticles with Improved Oral Pharmacokinetics. In British Society for Nanomedicine. Queens University Belfast.
Long acting injectable formulations of atovaquone for malaria prophylaxis
Savage, A., Tatham, L., Bakshi, R., Tripathi, A., Mlambo, G., Shapiro, T., . . . Rannard, S. (2017). Long acting injectable formulations of atovaquone for malaria prophylaxis. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from https://www.webofscience.com/
2016
Surface-Dependent Mechanism for Transcellular Permeation of Polymeric Nanoparticles Across Intestinal Monolayers
Tatham, L., Ford, J., Rogers, H., Rannard, S., & Owen, A. (2016). Surface-Dependent Mechanism for Transcellular Permeation of Polymeric Nanoparticles Across Intestinal Monolayers. In Controlled Release Society Annual Meeting & Exposition. Seattle, Washington.
Handbook of Immunological Properties of Engineered Nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (n.d.). Handbook of Immunological Properties of Engineered Nanomaterials. WORLD SCIENTIFIC. doi:10.1142/9677
2015
Formulation of Solid Drug Nanoparticles for the Improved Oral Bioavailability of Antiretroviral Drugs
Savage, A. C., Tatham, L. M., Owen, A., & Rannard, S. P. (2015). Formulation of Solid Drug Nanoparticles for the Improved Oral Bioavailability of Antiretroviral Drugs. Poster session presented at the meeting of British Society of Nanomedicine Young Researchers Meeting. University of Liverpool.
Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions
Liptrott, N. J., Giardiello, M., Hunter, J. W., Tatham, L., Tidbury, L. R., Siccardi, M., . . . Owen, A. (2015). Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions. NANOMEDICINE, 10(9), 1407-1421. doi:10.2217/NNM.14.77
Nanoformulation strategies for the enhanced oral bioavailability of antiretroviral therapeutics
Tatham, L. M., Rannard, S. P., & Owen, A. (2015). Nanoformulation strategies for the enhanced oral bioavailability of antiretroviral therapeutics. THERAPEUTIC DELIVERY, 6(4), 469-490. doi:10.4155/TDE.15.4
Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium
Hatton, F. L., Tatham, L. M., Tidbury, L. R., Chambon, P., He, T., Owen, A., & Rannard, S. P. (2015). Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium. CHEMICAL SCIENCE, 6(1), 326-334. doi:10.1039/c4sc02889a
pH-Responsive hyperbranched-polydendrons for drug delivery applications
Rogers, H., Tatham, L., Chambon, P., Owen, A., & Rannard, S. (2015). pH-Responsive hyperbranched-polydendrons for drug delivery applications. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 250. Retrieved from https://www.webofscience.com/
2014
Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions
Liptrott, N., Giardiello, M., Hunter, J. W., Tatham, L., Tidbury, L. R., Siccardi, M., . . . Owen, A. (2014). Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions. Nanomedicine (London).
Highlights of research at the University of Liverpool and activity of the British Society for Nanomedicine
Curley, P., Liptrott, N., Tatham, L., Siccardi, M., & Owen, A. (2014). Highlights of research at the University of Liverpool and activity of the British Society for Nanomedicine. Poster session presented at the meeting of 7th CLINAM Conference and Exhibition. Basel, Switzerland.
2013
High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against <i>Escherichia coli</i>
McDonald, T. O., Tatham, L. M., Southworth, F. Y., Giardiello, M., Martin, P., Liptrott, N. J., . . . Rannard, S. P. (2013). High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against <i>Escherichia coli</i>. JOURNAL OF MATERIALS CHEMISTRY B, 1(35), 4455-4465. doi:10.1039/c3tb20543f
High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli
McDonald, T. O., Tatham, L. M., Southworth, F. Y., Giardiello, M., Martin, P., Liptrott, N. J., . . . Rannard, S. P. (2013). High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli. Journal of Materials Chemistry B, 1(35), 4455. doi:10.1039/c3tb20543f