Publications
2023
The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesis
Barrera, L. N., Ridley, P. M., Bermejo-Rodriguez, C., Costello, E., & Perez-Mancera, P. A. (2023). The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesis. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 79(1), 193-204. doi:10.1007/s13105-022-00899-0
2021
Inclusion of cancer-associated fibroblasts in drug screening assays to evaluate pancreatic cancer resistance to therapeutic drugs
Brumskill, S., Barrera, L. N., Calcraft, P., Phillips, C., & Costello, E. (2021). Inclusion of cancer-associated fibroblasts in drug screening assays to evaluate pancreatic cancer resistance to therapeutic drugs. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY. doi:10.1007/s13105-021-00857-2
2020
Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers
Oldfield, L., Barrera, L., Williams, D., Evans, A. E., Neoptolemos, J., & Costello, E. (2020). Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers. In Molecular and Translational Medicine (pp. 73-82). Springer International Publishing. doi:10.1007/978-3-030-49476-6_4
Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties.
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2020). Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties.. Cancer Research, 80(13), 2861-2873. doi:10.1158/0008-5472.can-19-3534
2019
PDAC-associated fibroblasts are less responsive to an anti-fibrotic stimulus and more responsive to a positive regulator of fibroblast activation than normal activated fibroblasts
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F., Campbell, F., . . . Costello, E. (2019). PDAC-associated fibroblasts are less responsive to an anti-fibrotic stimulus and more responsive to a positive regulator of fibroblast activation than normal activated fibroblasts. Pancreatology, 19, S158. doi:10.1016/j.pan.2019.05.423
2018
S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes
Nedjadi, T., Evans, A., Sheikh, A., Barerra, L., Al-Ghamdi, S., Oldfield, L., . . . Costello, E. (2018). S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes. BMC CANCER, 18. doi:10.1186/s12885-018-5161-4
Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile
Barrera, L., Evans, A., Lane, B., Brumskill, S., Oldfield, F., Campbell, F., . . . Costello, E. (2018). Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile. Pancreatology, 18(4), S94. doi:10.1016/j.pan.2018.05.254
The efficacy of brusatol as a chemotherapeutic agent in pancreatic cancer and its relevance to potential chemoresistance conferred by Nrf2
Williams, D., Gayon, S., Barrera, L., Perez-Mancera, P., Copple, I., Goldring, C., . . . Costello, E. (2018). The efficacy of brusatol as a chemotherapeutic agent in pancreatic cancer and its relevance to potential chemoresistance conferred by Nrf2. Pancreatology, 18(4), S149. doi:10.1016/j.pan.2018.05.400
Development of Novel Diagnostic Pancreatic Tumor Biomarkers
Oldfield, L., Rao, R., Barrera, L. N., & Costello, E. (2018). Development of Novel Diagnostic Pancreatic Tumor Biomarkers. In Pancreatic Cancer (pp. 1241-1272). Springer New York. doi:10.1007/978-1-4939-7193-0_86
2017
Modelling the Tumour Microenvironment in Pancreatic Ductal Adenocarcinoma
Brumskill, S., Barrera, L., Campbell, F., Halloran, C., Neoptolemos, J., Sutton, R., . . . Costello, E. (2017). Modelling the Tumour Microenvironment in Pancreatic Ductal Adenocarcinoma. Pancreatology, 17(3), S4. doi:10.1016/j.pan.2017.05.011
2016
Circulating tenascin C levels distinguish pancreatic cancer from chronic pancreatitis and correlate with pancreatic stromal expression
Evans, A., Jenkinson, C., Barrera, L., Oldfield, F., Rimmer, N., Garner, E., . . . Costello, E. (2016). Circulating tenascin C levels distinguish pancreatic cancer from chronic pancreatitis and correlate with pancreatic stromal expression. Pancreatology, 16(3), S30-S31. doi:10.1016/j.pan.2016.05.105
Identification of novel signalling pathways dysregulated in pancreatic cancer-associated fibroblasts
Barrera, L., Lane, B., Brumskill, S., Oldfield, F., Lamond, R., Wilkinson, L., . . . Costello, E. (2016). Identification of novel signalling pathways dysregulated in pancreatic cancer-associated fibroblasts. Pancreatology, 16(3), S31. doi:10.1016/j.pan.2016.05.106
UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis
Abu-Alainin, W., Gana, T., Liloglou, L., Olayanju, A., Barrera Briceno, L., Ferguson, R., . . . Costello-Goldring, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. Journal of Pathology, 238(3), 423-433. doi:10.1002/path.4665
2015
Simultaneous integration of microRNA and mRNA expression in the analysis of quiescent and activated human fibroblasts in the diseased pancreas
Barrera, L., Lane, B., Brumskill, S., Oldfield, F., Nunes, Q., Campbell, F., . . . Costello, E. (2015). Simultaneous integration of microRNA and mRNA expression in the analysis of quiescent and activated human fibroblasts in the diseased pancreas. Pancreatology, 15(3), S19-S20. doi:10.1016/j.pan.2015.05.103
2014
Understanding life and death decisions in human leukaemias
MacEwan, D. J., Barrera, L. N., Keadsanti, S., Rushworth, S. A., Shah, N. M., Yuan, T., & Zaitseva, L. (2014). Understanding life and death decisions in human leukaemias. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 747-751. doi:10.1042/BST20140127
2013
Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro.
Barrera, L. N., Johnson, I. T., Bao, Y., Cassidy, A., & Belshaw, N. J. (2013). Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro.. European journal of nutrition, 52(4), 1327-1341. doi:10.1007/s00394-012-0442-1
Isolation of pancreatic stellate cells for future analysis of microRNA
Barrera, L., Oldfield, F., Nunes, Q., Campbell, F., Lane, B., Andrews, T., . . . Costello, E. (2013). Isolation of pancreatic stellate cells for future analysis of microRNA. Pancreatology, 13(3), S58. doi:10.1016/j.pan.2013.04.205
BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB
Rushworth, S. A., Bowles, K. M., Barrera, L. N., Murray, M. Y., Zaitseva, L., & MacEwan, D. J. (2013). BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB. CELLULAR SIGNALLING, 25(1), 106-112. doi:10.1016/j.cellsig.2012.09.008
2012
TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.
Barrera, L. N., Cassidy, A., Wang, W., Wei, T., Belshaw, N. J., Johnson, I. T., . . . Bao, Y. (2012). TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.. Biochimica et biophysica acta, 1823(10), 1914-1924. doi:10.1016/j.bbamcr.2012.07.007
Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes.
Li, D., Wang, W., Shan, Y., Barrera, L. N., Howie, A. F., Beckett, G. J., . . . Bao, Y. (2012). Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes.. Food chemistry, 133(2), 300-307. doi:10.1016/j.foodchem.2012.01.026
Bortezomib induces heme oxygenase-1 expression in multiple myeloma
Barrera, L. N., Rushworth, S. A., Bowles, K. M., & MacEwan, D. J. (2012). Bortezomib induces heme oxygenase-1 expression in multiple myeloma. CELL CYCLE, 11(12), 2248-2252. doi:10.4161/cc.20343
Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention.
Barrera, L. N., Cassidy, A., Johnson, I. T., Bao, Y., & Belshaw, N. J. (2012). Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention.. The Proceedings of the Nutrition Society, 71(2), 237-245. doi:10.1017/s002966511200016x
Understanding the role of miRNA in regulating NF-κB in blood cancer.
Rushworth, S. A., Murray, M. Y., Barrera, L. N., Heasman, S. -A., Zaitseva, L., & Macewan, D. J. (2012). Understanding the role of miRNA in regulating NF-κB in blood cancer.. American journal of cancer research, 2(1), 65-74.
2011
Custom design of a GeXP multiplexed assay used to assess expression profiles of inflammatory gene targets in normal colon, polyp, and tumor tissue.
Drew, J. E., Mayer, C. -D., Farquharson, A. J., Young, P., & Barrera, L. N. (2011). Custom design of a GeXP multiplexed assay used to assess expression profiles of inflammatory gene targets in normal colon, polyp, and tumor tissue.. The Journal of molecular diagnostics : JMD, 13(2), 233-242. doi:10.1016/j.jmoldx.2010.10.001
2008
S1996 Role of Chronic Inflammation in Sporadic Colorectal Neoplasia
McLean, M. H., Drew, J. E., Mayer, C. D., Farquharson, A., Barrera, L. N., Fyfe, N., . . . El-Omar, E. (2008). S1996 Role of Chronic Inflammation in Sporadic Colorectal Neoplasia. Gastroenterology, 134(4). doi:10.1016/s0016-5085(08)61366-9
2007
Insulin, leptin, and adiponectin receptors in colon: regulation relative to differing body adiposity independent of diet and in response to dimethylhydrazine.
Drew, J. E., Farquharson, A. J., Padidar, S., Duthie, G. G., Mercer, J. G., Arthur, J. R., . . . Barrera, L. N. (2007). Insulin, leptin, and adiponectin receptors in colon: regulation relative to differing body adiposity independent of diet and in response to dimethylhydrazine.. American journal of physiology. Gastrointestinal and liver physiology, 293(4), G682-G691. doi:10.1152/ajpgi.00231.2007
2006
Complex regulation of mucosal pentraxin (Mptx) revealed by discrete micro-anatomical locations in colon.
Drew, J. E., Farquharson, A. J., Keijer, J., & Barrera, L. N. (2006). Complex regulation of mucosal pentraxin (Mptx) revealed by discrete micro-anatomical locations in colon.. Biochimica et biophysica acta, 1762(9), 844-848. doi:10.1016/j.bbadis.2006.07.011