Publications
2024
Incorporating transgender and nonbinary participants in phase 1 clinical drug trials: Current knowledge gaps and considerations.
Walker, L. E., Stackpoole, M., Hodge, D., & FitzGerald, R. (2024). Incorporating transgender and nonbinary participants in phase 1 clinical drug trials: Current knowledge gaps and considerations.. British journal of clinical pharmacology. doi:10.1111/bcp.16073
Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee.
Hilmer, S. N., Schwartz, J., Petrovic, M., Walker, L. E., Thürmann, P., & Le Couteur, D. G. (2024). Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee.. Journal of the American Geriatrics Society, 72(9), 2942-2950. doi:10.1111/jgs.18826
Antipsychotic management in general practice: serial cross-sectional study (2011-2020)
Incorporating Transgender and nonbinary Participants in Phase 1 Clinical Drug Trials: Current Knowledge Gaps and Considerations for Phase 1 Studies
Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.
Asiimwe, I. G., Walker, L., Sofat, R., Jorgensen, A. L., Pirmohamed, M., & Multimorbidity Mechanism and Therapeutic Research Collaborative (MMTRC). (2024). Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.3229
The status of drug evaluation in older adults in the United Kingdom: Bridging the representation gap.
Walker, L. E., & Pirmohamed, M. (2024). The status of drug evaluation in older adults in the United Kingdom: Bridging the representation gap.. Journal of the American Geriatrics Society. doi:10.1111/jgs.18817
Public Attitudes Towards Access to Health Data for Research Purposes Through Citizens' Jury in Uganda.
Walker, L. E., Nakyeyune, L., Ashaba, A., Ahebwa, S., Nakijoba, R., Asiimwe, S. P., . . . Waitt, C. (2024). Public Attitudes Towards Access to Health Data for Research Purposes Through Citizens' Jury in Uganda.. Studies in health technology and informatics, 310, 129-133. doi:10.3233/shti230941
Adapting citizens’ jury methodology for use in Uganda: use of creative arts as a tool in deliberative, participatory research
Waitt, C., Nakyeyune, L., Ashaba, A., Ahebwa, S., Nakijoba, R., Asiimwe, S. P., . . . Walker, L. E. (n.d.). Adapting citizens’ jury methodology for use in Uganda: use of creative arts as a tool in deliberative, participatory research. International Journal of Social Research Methodology, 1-10. doi:10.1080/13645579.2024.2396371
2023
Immunomodulatory interventions for focal epilepsy.
Panebianco, M., Walker, L., & Marson, A. G. (2023). Immunomodulatory interventions for focal epilepsy.. The Cochrane database of systematic reviews, 10, CD009945. doi:10.1002/14651858.cd009945.pub3
Interventions for reducing anticholinergic medication burden in older adults-a systematic review and meta-analysis
Braithwaite, E., Todd, O. M., Atkin, A., Hulatt, R., Tadrous, R., Alldred, D. P., . . . Clegg, A. (2023). Interventions for reducing anticholinergic medication burden in older adults-a systematic review and meta-analysis. AGE AND AGEING, 52(9). doi:10.1093/ageing/afad176
Development and validation of an LC-MS/MS method for quantification of favipiravir in human plasma
Challenger, E., Penchala, S. D., Hale, C., Fitzgerald, R., Walker, L., Reynolds, H., . . . Else, L. (2023). Development and validation of an LC-MS/MS method for quantification of favipiravir in human plasma. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 233. doi:10.1016/j.jpba.2023.115436
Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide?
Walker, L. E., & Pirmohamed, M. (2023). Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide?. Drug and therapeutics bulletin, 61(6), 87-91. doi:10.1136/dtb.2022.000050
Cardiovascular risk estimation in rural psychiatric inpatient populations: Cross-sectional preliminary study.
Woodall, A., Prosser, A., Griffiths, M., Shooter, B., Garfitt, J., Walker, L., & Buchan, I. (2023). Cardiovascular risk estimation in rural psychiatric inpatient populations: Cross-sectional preliminary study.. Psychiatry research communications, 3(1), 100103. doi:10.1016/j.psycom.2023.100103
Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.
Fahmi, A., Wong, D., Walker, L., Buchan, I., Pirmohamed, M., Sharma, A., . . . van Staa, T. P. (2023). Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.. PloS one, 18(2), e0281466. doi:10.1371/journal.pone.0281466
Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study
Kuan, V., Denaxas, S., Patalay, P., Nitsch, D., Mathur, R., Gonzalez-Izquierdo, A., . . . MMTRC. (2023). Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study. LANCET DIGITAL HEALTH, 5(1), E16-E27. doi:10.1016/S2589-7500(22)00187-X
2022
Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial
Donovan-Banfield, I., Penrice-Randal, R., Goldswain, H., Rzeszutek, A. M., Pilgrim, J., Bullock, K., . . . Fletcher, T. (2022). Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34839-9
Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial
Khoo, S. H., FitzGerald, R., Saunders, G., Middleton, C., Ahmad, S., Edwards, C. J., . . . Vyas, A. (2022). Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. The Lancet Infectious Diseases. doi:10.1016/s1473-3099(22)00644-2
Multispecialty multidisciplinary input into comorbidities along with treatment optimisation in heart failure reduces hospitalisation and clinic attendance
Essa, H., Walker, L., Mohee, K., Oguguo, C., Douglas, H., Kahn, M., . . . Sankaranarayanan, R. (2022). Multispecialty multidisciplinary input into comorbidities along with treatment optimisation in heart failure reduces hospitalisation and clinic attendance. OPEN HEART, 9(2). doi:10.1136/openhrt-2022-001979
Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions
Osanlou, R., Walker, L., Hughes, D. A., Burnside, G., & Pirmohamed, M. (2022). Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions. BMJ OPEN, 12(7). doi:10.1136/bmjopen-2021-055551
Paediatric polypharmacy and deprescribing: the views of UK healthcare professionals
Moss, J. G., Young, D., Rashed, A. N., Walker, L. E., & Hawcutt, D. B. (2023). Paediatric polypharmacy and deprescribing: the views of UK healthcare professionals. ARCHIVES OF DISEASE IN CHILDHOOD, 108(1), 72-73. doi:10.1136/archdischild-2022-323827
Sodium-glucose co-transporter-2 inhibitors in the non-diabetic heart failure patient
Essa, H., Walker, L., & Sankaranarayanan, R. (2022). Sodium-glucose co-transporter-2 inhibitors in the non-diabetic heart failure patient. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(6), 2566-2570. doi:10.1111/bcp.15085
A European cross-sectional survey to investigate how involved doctors training in clinical pharmacology are in drug concentration monitoring
Green, T. J., Walker, L. E., & Turner, R. M. (2022). A European cross-sectional survey to investigate how involved doctors training in clinical pharmacology are in drug concentration monitoring. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1007/s00228-022-03316-z
Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection
FitzGerald, R., Dickinson, L., Else, L., Fletcher, T., Hale, C., Amara, A., . . . Khoo, S. (2022). Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. CLINICAL INFECTIOUS DISEASES. doi:10.1093/cid/ciac199
An Open Label, Adaptive, Phase 1 Trial of High-Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS-CoV-2
Walker, L. E., FitzGerald, R., Saunders, G., Lyon, R., Fisher, M., Martin, K., . . . Fletcher, T. E. (2022). An Open Label, Adaptive, Phase 1 Trial of High-Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS-CoV-2. CLINICAL PHARMACOLOGY & THERAPEUTICS, 111(3), 585-594. doi:10.1002/cpt.2463
Triple antithrombotic therapy and dual therapy - What is the evidence base?
Essa, H., Sankaranarayanan, R., & Walker, L. (2022). Triple antithrombotic therapy and dual therapy - What is the evidence base?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15257
Polypharmacy in Older People With Heart Failure: Roles of the Geriatrician and Pharmacist.
Stefil, M., Dixon, M., Bahar, J., Saied, S., Mashida, K., Heron, O., . . . Sankaranarayanan, R. (2022). Polypharmacy in Older People With Heart Failure: Roles of the Geriatrician and Pharmacist.. Cardiac failure review, 8, e34. doi:10.15420/cfr.2022.14
The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity.
Walker, L. E., Abuzour, A. S., Bollegala, D., Clegg, A., Gabbay, M., Griffiths, A., . . . Buchan, I. (2022). The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity.. Journal of multimorbidity and comorbidity, 12, 26335565221145493. doi:10.1177/26335565221145493
2021
Concise advice: Introducing a new clinically focused BJCP series on evidence-based (de)prescribing in challenging situations
Walker, L. E., & Cremers, S. (2021). Concise advice: Introducing a new clinically focused BJCP series on evidence-based (de)prescribing in challenging situations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4484-4487. doi:10.1111/bcp.15093
Long-term bisphosphonate therapy and atypical femoral fracture: Can you have too much of a good thing?
Walker, L. E., & Cooper, C. (2021). Long-term bisphosphonate therapy and atypical femoral fracture: Can you have too much of a good thing?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4877-4879. doi:10.1111/bcp.15110
The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite β-d-N4-hydroxycytidine in human plasma and saliva
Amara, A., Penchala, S. D., Else, L., Hale, C., FitzGerald, R., Walker, L., . . . Khoo, S. (2021). The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite β-d-N4-hydroxycytidine in human plasma and saliva. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 206. doi:10.1016/j.jpba.2021.114356
Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study
Khoo, S. H., Fitzgerald, R., Fletcher, T., Ewings, S., Jaki, T., Lyon, R., . . . Griffiths, G. (2021). Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 76(12), 3286-3295. doi:10.1093/jac/dkab318
High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study
Walker, L. E., Sills, G. J., Jorgensen, A., Alapirtti, T., Peltola, J., Brodie, M. J., . . . Pirmohamed, M. (2021). High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study. EPILEPSIA. doi:10.1111/epi.17116
AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter
Griffiths, G. O., FitzGerald, R., Jaki, T., Corkhill, A., Reynolds, H., Ewings, S., . . . Khoo, S. (2021). AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter. TRIALS, 22(1). doi:10.1186/s13063-021-05458-4
Avoiding harm from overprescribing: What are the challenges and how do we overcome them?
Walker, L. E., & Mangoni, A. A. (2021). Avoiding harm from overprescribing: What are the challenges and how do we overcome them?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(1), 6-8. doi:10.1111/bcp.14696
Sequential Association Rule Mining Revisited: A Study Directed at Relational Pattern Mining for Multi-morbidity
Vincent-Paulraj, A., Burnside, G., Coenen, F., Pirmohamed, M., & Walker, L. (2021). Sequential Association Rule Mining Revisited: A Study Directed at Relational Pattern Mining for Multi-morbidity. In ARTIFICIAL INTELLIGENCE XXXVIII Vol. 13101 (pp. 241-253). doi:10.1007/978-3-030-91100-3_20
2020
Barriers and facilitators to deprescribing in primary care: a systematic review
Doherty, A. J., Boland, P., Reed, J., Clegg, A. J., Stephani, A., Williams, N. H., . . . Walker, L. (2020). Barriers and facilitators to deprescribing in primary care: a systematic review. BJGP Open, 4(3), 0. doi:10.3399/bjgpopen20X101096
AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial
Griffiths, G., Fitzgerald, R., Jaki, T., Corkhill, A., Marwood, E., Reynolds, H., . . . Khoo, S. (2020). AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial. TRIALS, 21(1). doi:10.1186/s13063-020-04473-1
2019
Strategies to safely reduce polypharmacy in older people: a systematic review of barriers and facilitators to effective intervention
Hill, R. A., Walker, L., Osanlou, O., Williams, N., & Khedmati Morasae, E. (2019). Strategies to safely reduce polypharmacy in older people: a systematic review of barriers and facilitators to effective intervention. Retrieved from http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019121848
2018
WITHDRAWN: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.
Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A. L., Park, B. K., . . . Antoine, D. J. (2018). WITHDRAWN: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.. Journal of hepatology, S0168-8278(18)32042-7. doi:10.1016/j.jhep.2018.04.024
2017
Prospective clinical trials to investigate clinical and molecular biomarkers
Auvin, S., Walker, L. E., Gallentine, W., Jozwiak, S., Tombini, M., & Sills, G. J. (2017). Prospective clinical trials to investigate clinical and molecular biomarkers. EPILEPSIA, 58(S3), 20-26. doi:10.1111/epi.13782
Stroke Pharmacogenetics
Walker, L. E., Stewart, A., & Pirmohamed, S. M. (2017). Stroke Pharmacogenetics. In P. Sharma, & J. F. Meschia (Eds.), Stroke Genetics (pp. 327-410). Springer. doi:10.1007/978-3-319-56210-0_17
2016
A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease
Walker, L., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2016). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003
WONOEP appraisal: Molecular and cellular biomarkers for epilepsy
Walker, L. E., Janigro, D., Heinemann, U., Riikonen, R., Bernard, C., & Patel, M. (2016). WONOEP appraisal: Molecular and cellular biomarkers for epilepsy. EPILEPSIA, 57(9), 1354-1362. doi:10.1111/epi.13460
2015
Personalized medicine approaches in epilepsy
Walker, L. E., Mirza, N., Yip, V. L. M., Marson, A. G., & Pirmohamed, M. (2015). Personalized medicine approaches in epilepsy. JOURNAL OF INTERNAL MEDICINE, 277(2), 218-234. doi:10.1111/joim.12322
2014
Adverse Drug Reactions
Walker, L., Yip, V., & Pirmohamed, M. (2014). Adverse Drug Reactions. In Handbook of Pharmacogenomics and Stratified Medicine (pp. 405-435). Elsevier. doi:10.1016/b978-0-12-386882-4.00020-7
2013
Immunomodulatory interventions for focal epilepsy syndromes
Walker, L., Pirmohamed, M., & Marson, A. G. (2013). Immunomodulatory interventions for focal epilepsy syndromes. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (6). doi:10.1002/14651858.CD009945.pub2
Stroke Pharmacogenetics
Walker, L. E., Stewart, A., & Pirmohamed, M. (2013). Stroke Pharmacogenetics. In Stroke Genetics (pp. 223-297). Springer London. doi:10.1007/978-0-85729-209-4_14
2012
Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?
Walker, L., & Sills, G. J. (2012). Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?. EPILEPSY CURRENTS, 12(1), 8-12. doi:10.5698/1535-7511-12.1.8
2011
'Septrin psychosis' among renal transplant patients with <i>Pneumocystis jirovecii</i> pneumonia
Walker, L. E., Thomas, S., McBride, C., Howse, M., Turtle, L. C. W., Vivancos, R., . . . Beadsworth, M. B. J. (2011). 'Septrin psychosis' among renal transplant patients with <i>Pneumocystis jirovecii</i> pneumonia. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 66(5), 1117-1119. doi:10.1093/jac/dkr050
2009
Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin
Ganguli, A., Walker, L., FitzGerald, R. J., & Pirmohamed, M. (2009). Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin. ANNALS OF PHARMACOTHERAPY, 43(9), 1528-1531. doi:10.1345/aph.1L542
SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer
Moss, A. C., Jacobson, G. M., Walker, L. E., Blake, N. W., Marshall, E., & Coulson, J. M. (2009). SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer. CLINICAL CANCER RESEARCH, 15(1), 274-283. doi:10.1158/1078-0432.CCR-08-1163