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Professor Lauren Walker
BSc (Hons) MBChB (Hons) PHD FHEA FBPhS FRCP

Professor of Clinical Pharmacology & Therapeutics and Internal Medicine
Pharmacology & Therapeutics

Contact

Lauren.Walker@liverpool.ac.uk

+44 (0)151 795 5407

Publications

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2024

Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee.

Hilmer, S. N., Schwartz, J., Petrovic, M., Walker, L. E., Thürmann, P., & Le Couteur, D. G. (2024). Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee.. Journal of the American Geriatrics Society, 72(9), 2942-2950. doi:10.1111/jgs.18826

DOI
10.1111/jgs.18826
Journal article

Incorporating Transgender and nonbinary Participants in Phase 1 Clinical Drug Trials: Current Knowledge Gaps and Considerations for Phase 1 Studies

DOI
10.22541/au.171126582.28610664/v1
Preprint

Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.

Asiimwe, I. G., Walker, L., Sofat, R., Jorgensen, A. L., Pirmohamed, M., & Multimorbidity Mechanism and Therapeutic Research Collaborative (MMTRC). (2024). Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.3229

DOI
10.1002/cpt.3229
Journal article

Adapting citizens’ jury methodology for use in Uganda: use of creative arts as a tool in deliberative, participatory research

Waitt, C., Nakyeyune, L., Ashaba, A., Ahebwa, S., Nakijoba, R., Asiimwe, S. P., . . . Walker, L. E. (n.d.). Adapting citizens’ jury methodology for use in Uganda: use of creative arts as a tool in deliberative, participatory research. International Journal of Social Research Methodology, 1-10. doi:10.1080/13645579.2024.2396371

DOI
10.1080/13645579.2024.2396371
Journal article

2023

Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide?

Walker, L. E., & Pirmohamed, M. (2023). Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide?. Drug and therapeutics bulletin, 61(6), 87-91. doi:10.1136/dtb.2022.000050

DOI
10.1136/dtb.2022.000050
Journal article

Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.

Fahmi, A., Wong, D., Walker, L., Buchan, I., Pirmohamed, M., Sharma, A., . . . van Staa, T. P. (2023). Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.. PloS one, 18(2), e0281466. doi:10.1371/journal.pone.0281466

DOI
10.1371/journal.pone.0281466
Journal article

Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study

Kuan, V., Denaxas, S., Patalay, P., Nitsch, D., Mathur, R., Gonzalez-Izquierdo, A., . . . MMTRC. (2023). Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study. LANCET DIGITAL HEALTH, 5(1), E16-E27. doi:10.1016/S2589-7500(22)00187-X

DOI
10.1016/S2589-7500(22)00187-X
Journal article

2022

Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial

Khoo, S. H., FitzGerald, R., Saunders, G., Middleton, C., Ahmad, S., Edwards, C. J., . . . Vyas, A. (2022). Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. The Lancet Infectious Diseases. doi:10.1016/s1473-3099(22)00644-2

DOI
10.1016/s1473-3099(22)00644-2
Journal article

Multispecialty multidisciplinary input into comorbidities along with treatment optimisation in heart failure reduces hospitalisation and clinic attendance

Essa, H., Walker, L., Mohee, K., Oguguo, C., Douglas, H., Kahn, M., . . . Sankaranarayanan, R. (2022). Multispecialty multidisciplinary input into comorbidities along with treatment optimisation in heart failure reduces hospitalisation and clinic attendance. OPEN HEART, 9(2). doi:10.1136/openhrt-2022-001979

DOI
10.1136/openhrt-2022-001979
Journal article

Sodium-glucose co-transporter-2 inhibitors in the non-diabetic heart failure patient

Essa, H., Walker, L., & Sankaranarayanan, R. (2022). Sodium-glucose co-transporter-2 inhibitors in the non-diabetic heart failure patient. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(6), 2566-2570. doi:10.1111/bcp.15085

DOI
10.1111/bcp.15085
Journal article

Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

FitzGerald, R., Dickinson, L., Else, L., Fletcher, T., Hale, C., Amara, A., . . . Khoo, S. (2022). Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. CLINICAL INFECTIOUS DISEASES. doi:10.1093/cid/ciac199

DOI
10.1093/cid/ciac199
Journal article

Triple antithrombotic therapy and dual therapy - What is the evidence base?

Essa, H., Sankaranarayanan, R., & Walker, L. (2022). Triple antithrombotic therapy and dual therapy - What is the evidence base?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15257

DOI
10.1111/bcp.15257
Journal article

The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity.

Walker, L. E., Abuzour, A. S., Bollegala, D., Clegg, A., Gabbay, M., Griffiths, A., . . . Buchan, I. (2022). The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity.. Journal of multimorbidity and comorbidity, 12, 26335565221145493. doi:10.1177/26335565221145493

DOI
10.1177/26335565221145493
Journal article

2021

Concise advice: Introducing a new clinically focused BJCP series on evidence-based (de)prescribing in challenging situations

Walker, L. E., & Cremers, S. (2021). Concise advice: Introducing a new clinically focused BJCP series on evidence-based (de)prescribing in challenging situations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4484-4487. doi:10.1111/bcp.15093

DOI
10.1111/bcp.15093
Journal article

Long-term bisphosphonate therapy and atypical femoral fracture: Can you have too much of a good thing?

Walker, L. E., & Cooper, C. (2021). Long-term bisphosphonate therapy and atypical femoral fracture: Can you have too much of a good thing?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4877-4879. doi:10.1111/bcp.15110

DOI
10.1111/bcp.15110
Journal article

The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite β-d-N4-hydroxycytidine in human plasma and saliva

Amara, A., Penchala, S. D., Else, L., Hale, C., FitzGerald, R., Walker, L., . . . Khoo, S. (2021). The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite β-d-N4-hydroxycytidine in human plasma and saliva. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 206. doi:10.1016/j.jpba.2021.114356

DOI
10.1016/j.jpba.2021.114356
Journal article

Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

Khoo, S. H., Fitzgerald, R., Fletcher, T., Ewings, S., Jaki, T., Lyon, R., . . . Griffiths, G. (2021). Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 76(12), 3286-3295. doi:10.1093/jac/dkab318

DOI
10.1093/jac/dkab318
Journal article

AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter

Griffiths, G. O., FitzGerald, R., Jaki, T., Corkhill, A., Reynolds, H., Ewings, S., . . . Khoo, S. (2021). AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter. TRIALS, 22(1). doi:10.1186/s13063-021-05458-4

DOI
10.1186/s13063-021-05458-4
Journal article

2020

AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial

Griffiths, G., Fitzgerald, R., Jaki, T., Corkhill, A., Marwood, E., Reynolds, H., . . . Khoo, S. (2020). AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial. TRIALS, 21(1). doi:10.1186/s13063-020-04473-1

DOI
10.1186/s13063-020-04473-1
Journal article

2019

Strategies to safely reduce polypharmacy in older people: a systematic review of barriers and facilitators to effective intervention

Hill, R. A., Walker, L., Osanlou, O., Williams, N., & Khedmati Morasae, E. (2019). Strategies to safely reduce polypharmacy in older people: a systematic review of barriers and facilitators to effective intervention. Retrieved from http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019121848

Other

2018

WITHDRAWN: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.

Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A. L., Park, B. K., . . . Antoine, D. J. (2018). WITHDRAWN: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.. Journal of hepatology, S0168-8278(18)32042-7. doi:10.1016/j.jhep.2018.04.024

DOI
10.1016/j.jhep.2018.04.024
Journal article

2017

Stroke Pharmacogenetics

Walker, L. E., Stewart, A., & Pirmohamed, S. M. (2017). Stroke Pharmacogenetics. In P. Sharma, & J. F. Meschia (Eds.), Stroke Genetics (pp. 327-410). Springer. doi:10.1007/978-3-319-56210-0_17

DOI
10.1007/978-3-319-56210-0_17
Chapter

2016

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease

Walker, L., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2016). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003

DOI
10.1080/1354750X.2016.1265003
Journal article

2015

Personalized medicine approaches in epilepsy

Walker, L. E., Mirza, N., Yip, V. L. M., Marson, A. G., & Pirmohamed, M. (2015). Personalized medicine approaches in epilepsy. JOURNAL OF INTERNAL MEDICINE, 277(2), 218-234. doi:10.1111/joim.12322

DOI
10.1111/joim.12322
Journal article

2014

Adverse Drug Reactions

Walker, L., Yip, V., & Pirmohamed, M. (2014). Adverse Drug Reactions. In Handbook of Pharmacogenomics and Stratified Medicine (pp. 405-435). Elsevier. doi:10.1016/b978-0-12-386882-4.00020-7

DOI
10.1016/b978-0-12-386882-4.00020-7
Chapter

2013

Immunomodulatory interventions for focal epilepsy syndromes

Walker, L., Pirmohamed, M., & Marson, A. G. (2013). Immunomodulatory interventions for focal epilepsy syndromes. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (6). doi:10.1002/14651858.CD009945.pub2

DOI
10.1002/14651858.CD009945.pub2
Journal article

Stroke Pharmacogenetics

Walker, L. E., Stewart, A., & Pirmohamed, M. (2013). Stroke Pharmacogenetics. In Stroke Genetics (pp. 223-297). Springer London. doi:10.1007/978-0-85729-209-4_14

DOI
10.1007/978-0-85729-209-4_14
Chapter

2012

Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?

Walker, L., & Sills, G. J. (2012). Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?. EPILEPSY CURRENTS, 12(1), 8-12. doi:10.5698/1535-7511-12.1.8

DOI
10.5698/1535-7511-12.1.8
Journal article

2011

'Septrin psychosis' among renal transplant patients with <i>Pneumocystis jirovecii</i> pneumonia

Walker, L. E., Thomas, S., McBride, C., Howse, M., Turtle, L. C. W., Vivancos, R., . . . Beadsworth, M. B. J. (2011). 'Septrin psychosis' among renal transplant patients with <i>Pneumocystis jirovecii</i> pneumonia. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 66(5), 1117-1119. doi:10.1093/jac/dkr050

DOI
10.1093/jac/dkr050
Journal article

2009

Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin

Ganguli, A., Walker, L., FitzGerald, R. J., & Pirmohamed, M. (2009). Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin. ANNALS OF PHARMACOTHERAPY, 43(9), 1528-1531. doi:10.1345/aph.1L542

DOI
10.1345/aph.1L542
Journal article

SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer

Moss, A. C., Jacobson, G. M., Walker, L. E., Blake, N. W., Marshall, E., & Coulson, J. M. (2009). SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer. CLINICAL CANCER RESEARCH, 15(1), 274-283. doi:10.1158/1078-0432.CCR-08-1163

DOI
10.1158/1078-0432.CCR-08-1163
Journal article