Publications
Selected publications
- Predicting physiologically-relevant oxygen concentrations in precision-cut liver slices using mathematical modelling (Journal article - 2022)
- Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome (Journal article - 2015)
- Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver (Journal article - 2010)
- Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management. (Journal article - 2025)
- The importance of preclinical models in cholangiocarcinoma (Journal article - 2024)
- Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS). (Journal article - 2024)
2025
Comparing methods of human precision cut tissue slice culture - tissue slice viability and functional markers data
McGreevy, O., Gilbert, T., & Randle, L. (n.d.). Comparing methods of human precision cut tissue slice culture - tissue slice viability and functional markers data. Liverpool: University of Liverpool.
Comparing methods of human precision cut tissue slice culture - tissue slice viability and functional markers data
McGreevy, O., Gilbert, T., & Randle, L. (n.d.). Comparing methods of human precision cut tissue slice culture - tissue slice viability and functional markers data. Liverpool: University of Liverpool.
Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management.
Gilbert, T. M., Randle, L., Quinn, M., McGreevy, O., O'leary, L., Young, R., . . . Palmer, D. H. (2025). Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management.. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 51(2), 108352. doi:10.1016/j.ejso.2024.108352
2024
The importance of preclinical models in cholangiocarcinoma
McGreevy, O., Bosakhar, M., Gilbert, T., Quinn, M., Fenwick, S., Malik, H., . . . Randle, L. (2024). The importance of preclinical models in cholangiocarcinoma. European Journal of Surgical Oncology, 108304. doi:10.1016/j.ejso.2024.108304
Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS).
Gilbert, T., Randle, L., Diaz-neito, R., Jones, R., Fenwick, S., Goldring, C., & Malik, H. (2024). Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS).. European Journal of Surgical Oncology, 50(2), 107758. doi:10.1016/j.ejso.2023.107758
2023
Developing a Patient-derived Model of Cholangiocarcinoma Using Precision Cut Tissue Slices (PCTS)
Gilbert, T., Randle, L., Diaz-Nieto, R., Jones, R., Fenwick, S., Goldring, C., & Malik, H. (2023). Developing a Patient-derived Model of Cholangiocarcinoma Using Precision Cut Tissue Slices (PCTS). HPB, 25, S513-S514. doi:10.1016/j.hpb.2023.07.659
2022
Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS)
Gilbert, T., Randle, L., Diaz-Nieto, R., Jones, R., Fenwick, S., Goldring, C., & Malik, H. (2022). Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS). In BRITISH JOURNAL OF SURGERY Vol. 109. doi:10.1093/bjs/znac404.020
Predicting physiologically-relevant oxygen concentrations in precision-cut liver slices using mathematical modelling
Chidlow, S. J., Randle, L. E., & Kelly, R. A. (2022). Predicting physiologically-relevant oxygen concentrations in precision-cut liver slices using mathematical modelling. PLOS ONE, 17(11). doi:10.1371/journal.pone.0275788
2018
Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture
Kelly, R. A., Leedale, J. A., Harrell, A., Beard, D. A., Randle, L. E., Chadwick, A. E., & Webb, S. D. (2018). Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS One, 13(11). doi:10.1371/journal.pone.0207803
Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials
del Casino, A., Lukinovic, V., Bhatt, R., Randle, L. E., Dascombe, M. J., Fennell, B. J., . . . Ismail, F. M. D. (2018). Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials. CHEMISTRYSELECT, 3(26), 7572-7580. doi:10.1002/slct.201801723
2017
Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines
Fielding, A. J., Lukinovic, V., Evans, P. G., Alizadeh-Shekalgourabi, S., Bisby, R. H., Drew, M. G. B., . . . Ismail, F. M. D. (2017). Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines. CHEMISTRY-A EUROPEAN JOURNAL, 23(28), 6811-6828. doi:10.1002/chem.201605099
2015
Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome
Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., . . . Park, B. K. (2015). Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. SCIENTIFIC REPORTS, 5. doi:10.1038/srep16423
2013
The Generation, Detection, and Effects of Reactive Drug Metabolites
Stachulski, A. V., Baillie, T. A., Kevin Park, B., Scott Obach, R., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. Medicinal Research Reviews, 33(5), 985-1080. doi:10.1002/med.21273
2010
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. JOURNAL OF PROTEOMICS, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018
2008
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system
Copple, I. M., Goldring, C. E., Jenkins, R. E., Chia, A. J. L., Randle, L. E., Hayes, J. D., . . . Park, B. K. (2008). The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. HEPATOLOGY, 48(4), 1292-1301. doi:10.1002/hep.22472
α1-adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice
Randle, L. E., Sathish, J. G., Kitteringham, N. R., Macdonald, I., Williams, D. P., & Park, B. K. (2008). α1-adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. BRITISH JOURNAL OF PHARMACOLOGY, 153(4), 820-830. doi:10.1038/sj.bjp.0707620
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice
Randle, L. E., Goldring, C. E. P., Benson, C. A., Metcalfe, P. N., Kitteringham, N. R., Park, B. K., & Williams, D. P. (2008). Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. TOXICOLOGY, 243(3), 249-260. doi:10.1016/j.tox.2007.10.011
2007
The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore
Williams, D. P., Antoine, D. J., Butler, P. J., Jones, R., Randle, L., Payne, A., . . . Park, B. K. (2007). The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore. The Journal of Pharmacology and Experimental Therapeutics, 322(3), 1208-1220. doi:10.1124/jpet.107.125302
The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore
Williams, D. P., Antoine, D. J., Butler, P. J., Jones, R., Randle, L., Payne, A., . . . Park, B. K. (2007). The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 322(3), 1208-1220. doi:10.1124/jpet.107.125302
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice
Randle, L. E., Goldring, C. E. P., Benson, C., Metcalfe, P., Kitteringham, N. R., Park, B. K., & Williams, D. P. (2007). Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. Toxicology, E-pub, 14.
2006
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005
2005
'Pharmacological and physiological protective mechanisms in chemical-induced hepatotoxicity.'
Randle, L. E. (2005). 'Pharmacological and physiological protective mechanisms in chemical-induced hepatotoxicity.'. (PhD Thesis, The University of Liverpool).
2004
Activation of hepatic Nrf2 <i>in vivo</i> by acetaminophen in CD-1 mice
Goldring, C. E. P., Kitteringham, N. R., Elsby, R., Randle, L. E., Clement, Y. N., Williams, D. P., . . . Park, B. K. (2004). Activation of hepatic Nrf2 <i>in vivo</i> by acetaminophen in CD-1 mice. HEPATOLOGY, 39(5), 1267-1276. doi:10.1002/hep.20183
2003
Isoquine and related amodiaquine analogues: A new generation of improved 4-aminoquinoline antimalarials
O'Neill, P. M., Mukhtar, A., Stocks, P. A., Randle, L. E., Hindley, S., Ward, S. A., . . . Park, B. K. (2003). Isoquine and related amodiaquine analogues: A new generation of improved 4-aminoquinoline antimalarials. JOURNAL OF MEDICINAL CHEMISTRY, 46(23), 4933-4945. doi:10.1021/jm030796n
Transcription factor regulation and gene expression in response to the antipsychotic, clozapine
Williams, D. P., O'Donnell, C., Randle, L. E., Goldring, C. E. P., Garcia-Allen, C., Johnston, G., . . . Park, B. K. (2003). Transcription factor regulation and gene expression in response to the antipsychotic, clozapine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(4), 446. Retrieved from https://www.webofscience.com/