Publications
2024
Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery.
Ali, M., Longet, S., Neale, I., Rongkard, P., Chowdhury, F. U. H., Hill, J., . . . Dunachie, S. J. (2024). Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery.. Clinical and experimental immunology, 218(1), 78-92. doi:10.1093/cei/uxae030
Identifying and reducing risks of neurological complications associated with vaccination.
Handunnetthi, L., Ramasamy, M. N., Turtle, L., & Hunt, D. P. J. (2024). Identifying and reducing risks of neurological complications associated with vaccination.. Nature reviews. Neurology, 20(9), 541-554. doi:10.1038/s41582-024-01000-7
Immunogenicity of COVID-19 vaccines in patients with follicular lymphoma receiving frontline chemoimmunotherapy.
Lim, Y. J., Ward, V., Brown, A., Phillips, E., Kronsteiner, B., Malone, T., . . . Pettitt, A. (2024). Immunogenicity of COVID-19 vaccines in patients with follicular lymphoma receiving frontline chemoimmunotherapy.. British journal of haematology, 205(2), 440-451. doi:10.1111/bjh.19562
HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.
Shafiqa, N., Aston, S., Howard, A., Turtle, L., Abrams, S., Young, B., . . . Wootton, D. G. (2024). HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.. BMJ open, 14(7), e088490. doi:10.1136/bmjopen-2024-088490
Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.
Clark, J. J., Penrice-Randal, R., Sharma, P., Dong, X., Pennington, S. H., Marriott, A. E., . . . Stewart, J. P. (2024). Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.. Viruses, 16(6), 863. doi:10.3390/v16060863
Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.
Turtle, L., Elliot, S., Drake, T. M., Thorpe, M., Khoury, E. G., Greenhalf, W., . . . ISARIC4C Investigators. (2024). Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.. The Lancet. Oncology, 25(5), 636-648. doi:10.1016/s1470-2045(24)00107-4
Diagnostic markers of acute encephalitis syndrome and COVID-associated multisystem inflammatory syndrome in children from Southern India.
Damodar, T., Dunai, C., Prabhu, N., Jose, M., Akhila, L., Kinhal, U. V., . . . Mani, R. S. (2024). Diagnostic markers of acute encephalitis syndrome and COVID-associated multisystem inflammatory syndrome in children from Southern India.. Journal of medical virology, 96(5), e29666. doi:10.1002/jmv.29666
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
Liew, F., Efstathiou, C., Fontanella, S., Richardson, M., Saunders, R., Swieboda, D., . . . ISARIC investigators. (2024). Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.. Nature immunology, 25(4), 607-621. doi:10.1038/s41590-024-01778-0
Accelarated immune ageing is associated with COVID-19 disease severity.
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., . . . ISARIC4C investigators. (2024). Accelarated immune ageing is associated with COVID-19 disease severity.. Immunity & ageing : I & A, 21(1), 6. doi:10.1186/s12979-023-00406-z
N<sup>1</sup>-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.
Mulroney, T. E., Pöyry, T., Yam-Puc, J. C., Rust, M., Harvey, R. F., Kalmar, L., . . . Willis, A. E. (2024). N<sup>1</sup>-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.. Nature, 625(7993), 189-194. doi:10.1038/s41586-023-06800-3
2023
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.. The Journal of infectious diseases, 230(1), e17-e29. doi:10.1093/infdis/jiad590
Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4
Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.
Abrams, S. T., Du, M., Shaw, R. J., Johnson, C., McGuinness, D., Schofield, J., . . . Toh, C. -H. (2023). Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00873-5. doi:10.1016/j.jtha.2023.12.008
Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.
Roper, K. J., Thomas, J., Albalawi, W., Maddocks, E., Dobson, S., Alshehri, A., . . . Pollakis, G. (2023). Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.. Scientific reports, 13(1), 15014. doi:10.1038/s41598-023-41928-2
A second update on mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative. (2023). A second update on mapping the human genetic architecture of COVID-19.. Nature, 621(7977), E7-E26. doi:10.1038/s41586-023-06355-3
CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study.
Neale, I., Ali, M., Kronsteiner, B., Longet, S., Abraham, P., Deeks, A. S., . . . PITCH Consortium. (2023). CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study.. mBio, e0121223. doi:10.1128/mbio.01212-23
Modified vaccinia Ankara-Bavarian Nordic vaccine against mpox in children
Turtle, L., & Subramaniam, K. (2023). Modified vaccinia Ankara-Bavarian Nordic vaccine against mpox in children. LANCET INFECTIOUS DISEASES, 23(9), 989-990. doi:10.1016/S1473-3099(23)00345-6
Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history.
Hornsby, H., Nicols, A. R., Longet, S., Liu, C., Tomic, A., Angyal, A., . . . de Silva, T. I. (2023). Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history.. Nature communications, 14(1), 5065. doi:10.1038/s41467-023-40592-4
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023)
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023). NATURE. doi:10.1038/s41586-023-06383-z
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease
Barnes, E., Goodyear, C. S., Willicombe, M., Gaskell, C., Siebert, S., de Silva, T. I., . . . McInnes, I. B. (2023). SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. NATURE MEDICINE, 29(7), 1760-+. doi:10.1038/s41591-023-02414-4
HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation
Yang, H., Sun, H., Brackenridge, S., Zhuang, X., Wing, P. A. C., Quastel, M., . . . McMichael, A. J. (2023). HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation. SCIENCE IMMUNOLOGY, 8(84). doi:10.1126/sciimmunol.abl8881
Obesity Differs from Diabetes Mellitus in Antibody and T Cell Responses Post COVID-19 Recovery
Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection
Bharucha, T., Gangadharan, B., Kumar, A., Myall, A. C., Ayhan, N., Pastorino, B., . . . SEAe, C. (2023). Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection. JOURNAL OF PROTEOME RESEARCH, 22(6), 1614-1629. doi:10.1021/acs.jproteome.2c00563
Antibody signatures in hospitalized hand, foot and mouth disease patients with acute enterovirus A71 infection
You, L., Chen, J., Cheng, Y., Li, Y., Chen, Y. -Q., Ying, T., . . . Yu, H. (2023). Antibody signatures in hospitalized hand, foot and mouth disease patients with acute enterovirus A71 infection. PLOS PATHOGENS, 19(6). doi:10.1371/journal.ppat.1011420
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. NATURE, 617(7962), 764-+. doi:10.1038/s41586-023-06034-3
Neurological manifestations of COVID-19 in adults and children.
Cho, S. -M., White, N., Premraj, L., Battaglini, D., Fanning, J., Suen, J., . . . ISARIC Clinical Characterisation Group. (2023). Neurological manifestations of COVID-19 in adults and children.. Brain : a journal of neurology, 146(4), 1648-1661. doi:10.1093/brain/awac332
Diagnostic performance of different specimens in detecting enterovirus A71 in children with hand, foot and mouth disease
Zhou, Y., Zhou, C., Wang, K., Qiu, Q., Cheng, Y., Li, Y., . . . Yu, H. (2023). Diagnostic performance of different specimens in detecting enterovirus A71 in children with hand, foot and mouth disease. VIROLOGICA SINICA, 38(2), 268-275. doi:10.1016/j.virs.2022.11.004
Adeno-associated virus 2 infection in children with non-A-E hepatitis.
Ho, A., Orton, R., Tayler, R., Asamaphan, P., Herder, V., Davis, C., . . . Thomson, E. C. (2023). Adeno-associated virus 2 infection in children with non-A-E hepatitis.. Nature. doi:10.1038/s41586-023-05948-2
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
Evolution of Long-Term Hybrid Immunity in Healthcare Workers after Different Covid-19 Vaccination Regimens: A Longitudinal Observational Cohort Study
Moore, S., Kronsteiner, B., Longet, S., Adele, S., Deeks, A., Liu, C., . . . Consortium, P. I. T. C. H. (2023). Evolution of Long-Term Hybrid Immunity in Healthcare Workers after Different Covid-19 Vaccination Regimens: A Longitudinal Observational Cohort Study. Med. doi:10.1016/j.medj.2023.02.004
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens
Moore, S. C., Kronsteiner, B., Longet, S., Adele, S., Deeks, A. S., Liu, C., . . . PITCH, C. (2023). Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens. MED, 4(3), 191-+. doi:10.1016/j.medj.2023.02.004
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.
Kartsonaki, C., Baillie, J. K., Barrio, N. G., Baruch, J., Beane, A., Blumberg, L., . . . ISARIC Clinical Characterisation Group. (2023). Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.. International journal of epidemiology, dyad012. doi:10.1093/ije/dyad012
Evaluation of eight lateral flow tests for the detection of anti-SARS-CoV-2 antibodies in a vaccinated population
Greenland-Bews, C., Byrne, R. L. L., Owen, S. I. I., Watkins, R. L. L., Bengey, D., Buist, K., . . . Adams, E. R. R. (2023). Evaluation of eight lateral flow tests for the detection of anti-SARS-CoV-2 antibodies in a vaccinated population. BMC INFECTIOUS DISEASES, 23(1). doi:10.1186/s12879-023-08033-1
CD4+ and CD8+ T cell and antibody correlates of protection against Delta vaccine breakthrough infection: A nested case-control study within the PITCH study
Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.
Turtle, L., Thorpe, M., Drake, T. M., Swets, M., Palmieri, C., Russell, C. D., . . . Docherty, A. B. (2023). Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.. PLoS medicine, 20(1), e1004086. doi:10.1371/journal.pmed.1004086
Exposed seronegative: Cellular immune responses to SARS-CoV-2 in the absence of seroconversion
Jay, C., Ratcliff, J., Turtle, L., Goulder, P., & Klenerman, P. (2023). Exposed seronegative: Cellular immune responses to SARS-CoV-2 in the absence of seroconversion. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1092910
Age- and sex-specific differences in immune responses to BNT162b2 COVID-19 and live-attenuated influenza vaccines in UK adolescents.
Jay, C., Adland, E., Csala, A., Lim, N., Longet, S., Ogbe, A., . . . Goulder, P. (2023). Age- and sex-specific differences in immune responses to BNT162b2 COVID-19 and live-attenuated influenza vaccines in UK adolescents.. Frontiers in immunology, 14, 1248630. doi:10.3389/fimmu.2023.1248630
Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members
Jay, C., Adland, E., Csala, A., Dold, C., Edmans, M., Hackstein, C. -P., . . . Jones, L. C. (2023). Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1248658
Impact of peptide:HLA complex stability for the identification of SARS-CoV-2-specific CD8<SUP>+</SUP>T cells
Lie-Andersen, O., Hubbe, M. L., Subramaniam, K., Steen-Jensen, D., Bergmann, A. C., Justesen, D., . . . Hansen, M. (2023). Impact of peptide:HLA complex stability for the identification of SARS-CoV-2-specific CD8<SUP>+</SUP>T cells. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1151659
SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study
Parker, E., Thomas, J., Roper, K. J., Ijaz, S., Edwards, T., Marchesin, F., . . . Pollakis, G. (2023). SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1146702
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402
T cell immune memory after covid-19 and vaccination.
Wang, L., Nicols, A., Turtle, L., Richter, A., Duncan, C. J., Dunachie, S. J., . . . Payne, R. P. (2023). T cell immune memory after covid-19 and vaccination.. BMJ medicine, 2(1), e000468. doi:10.1136/bmjmed-2022-000468
2022
Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people
Green, M. A., Hungerford, D. J., Hughes, D. M., Garcia-Finana, M., Turtle, L., Cheyne, C., . . . Buchan, I. (2022). Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people. BMC INFECTIOUS DISEASES, 22(1). doi:10.1186/s12879-022-07878-2
Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality
Alam, A. M., Gillespie, C. S., Goodall, J., Damodar, T., Turtle, L., Vasanthapuram, R., . . . Michael, B. D. (2022). Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality. PLOS NEGLECTED TROPICAL DISEASES, 16(11). doi:10.1371/journal.pntd.0010952
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
Kotanidis, C. P., Xie, C., Alexander, D., Rodrigues, J. C. L., Burnham, K., Mentzer, A., . . . Antoniades, C. (2022). Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19. LANCET DIGITAL HEALTH, 4(10), E705-E716. doi:10.1016/S2589-7500(22)00132-7
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway (vol 7, pg 1161, 2022)
Willett, B. J., Grove, J., MacLean, O. A., Wilkie, C., De Lorenzo, G., Furnon, W., . . . Thomson, E. C. (2022). SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway (vol 7, pg 1161, 2022). NATURE MICROBIOLOGY, 7(10), 1709. doi:10.1038/s41564-022-01241-6
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves
Wysocki, O., Zhou, C., Rogado, J., Huddar, P., Shotton, R., Tivey, A., . . . Co-Care, E. S. M. O. (2022). An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves. Cancers, 14(16). doi:10.3390/cancers14163931
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibanez-Prada, E. D., Rello, J., . . . Olliaro, P. L. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. CRITICAL CARE, 26(1). doi:10.1186/s13054-022-04155-1
mRNA vaccination drives differential mucosal neutralizing antibody profiles in naive and SARS-CoV-2 previously-infected individuals
Longet, S., Hargreaves, A., Healy, S., Brown, R., Hornsby, H. R., Meardon, N., . . . Carroll, M. W. (2022). mRNA vaccination drives differential mucosal neutralizing antibody profiles in naive and SARS-CoV-2 previously-infected individuals. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.953949
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
Evans, R. A., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J. C., Shikotra, A., . . . Brightling, C. E. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. LANCET RESPIRATORY MEDICINE, 10(8), 761-775. doi:10.1016/S2213-2600(22)00127-8
Clinical features and management of human monkeypox: a retrospective observational study in the UK
Adler, H., Gould, S., Hine, P., Snell, L. B., Wong, W., Houlihan, C. F., . . . Price, N. M. (2022). Clinical features and management of human monkeypox: a retrospective observational study in the UK. LANCET INFECTIOUS DISEASES, 22(8), 1153-1162. doi:10.1016/S1473-3099(22)00228-6
Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients
Ijaz, S., Dicks, S., Jegatheesan, K., Parker, E., Katsanovskaja, K., Vink, E., . . . Tedder, R. S. (2022). Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients. JOURNAL OF INFECTION, 85(2), 152-160. doi:10.1016/j.jinf.2022.05.033
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
Willett, B. J., Grove, J., MacLean, O. A., Wilkie, C., De Lorenzo, G., Furnon, W., . . . Thomson, E. C. (2022). SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. NATURE MICROBIOLOGY, 7(8), 1161-+. doi:10.1038/s41564-022-01143-7
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
Garcia-Gallo, E., Merson, L., Kennon, K., Kelly, S., Citarella, B. W., Fryer, D. V., . . . Reyes, L. F. (2022). ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01534-9
SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2
Eales, O., Page, A. J., de Oliveira Martins, L., Wang, H., Bodinier, B., Haw, D., . . . Elliott, P. (2022). SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases, 22(1). doi:10.1186/s12879-022-07628-4
Comparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naive and convalescent healthcare workers
Phillips, E., Adele, S., Malone, T., Deeks, A., Stafford, L., Dobson, S. L., . . . Dunachie, S. J. (2022). Comparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naive and convalescent healthcare workers. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. doi:10.1093/cei/uxac042
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning
Nickbakhsh, S., Hughes, J., Christofidis, N., Griffiths, E., Shaaban, S., Enright, J., . . . Smith-Palmer, A. (2022). Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports, 12(1). doi:10.1038/s41598-022-15661-1
Whole-genome sequencing reveals host factors underlying critical COVID-19
Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., . . . Baillie, J. K. (2022). Whole-genome sequencing reveals host factors underlying critical COVID-19. NATURE, 607(7917), 97-+. doi:10.1038/s41586-022-04576-6
Flavivirus cross-reactivity would explain the apparent findings of Japanese encephalitis virus infection in Nigeria.
Bharucha, T., Zitzmann, N., Newton, P., Dubot-Pérès, A., & Turtle, L. (2022). Flavivirus cross-reactivity would explain the apparent findings of Japanese encephalitis virus infection in Nigeria.. Journal of immunoassay & immunochemistry, 43(4), 463-465. doi:10.1080/15321819.2022.2039184
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages
Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages. MSPHERE, 7(3). doi:10.1128/msphere.00913-21
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study
Klaser, K., Molteni, E., Graham, M., Canas, L. S., Osterdahl, M. F., Antonelli, M., . . . Duncan, E. L. (2022). COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-14016-0
A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus.
Pichl, T., Wedderburn, C. J., Hoskote, C., Turtle, L., & Bharucha, T. (2022). A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus.. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 119, 102-110. doi:10.1016/j.ijid.2022.03.010
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Donovan-Banfield, I., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers. GIGASCIENCE, 11. doi:10.1093/gigascience/giac045
Establishment of CORONET, COVID-19 Risk in Oncology Evaluation Tool, to Identify Patients With Cancer at Low Versus High Risk of Severe Complications of COVID-19 Disease On Presentation to Hospital.
Lee, R. J., Wysocki, O., Zhou, C., Shotton, R., Tivey, A., Lever, L., . . . Armstrong, A. C. (2022). Establishment of CORONET, COVID-19 Risk in Oncology Evaluation Tool, to Identify Patients With Cancer at Low Versus High Risk of Severe Complications of COVID-19 Disease On Presentation to Hospital.. JCO clinical cancer informatics, 6, e2100177. doi:10.1200/cci.21.00177
<SUP>1</SUP>H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization
Correia, G. D. S., Takis, P. G., Sands, C. J., Kowalka, A. M., Tan, T., Turtle, L., . . . Lewis, M. R. (2022). <SUP>1</SUP>H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization. ANALYTICAL CHEMISTRY, 94(19), 6919-6923. doi:10.1021/acs.analchem.2c00466
Differences in Outcomes and Factors Associated With Mortality Among Patients With SARS-CoV-2 Infection and Cancer Compared With Those Without Cancer A Systematic Review and Meta-analysis
Khoury, E., Nevitt, S., Madsen, W. R., Turtle, L., Davies, G., & Palmieri, C. (2022). Differences in Outcomes and Factors Associated With Mortality Among Patients With SARS-CoV-2 Infection and Cancer Compared With Those Without Cancer A Systematic Review and Meta-analysis. JAMA NETWORK OPEN, 5(5). doi:10.1001/jamanetworkopen.2022.10880
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179
SARS-CoV-2-Specific T Cell Responses Are Not Associated with Protection against Reinfection in Hemodialysis Patients
Shankar, S., Beckett, J., Tipton, T., Ogbe, A., Kasanyinga, M., Dold, C., . . . Klenerman, P. (2022). SARS-CoV-2-Specific T Cell Responses Are Not Associated with Protection against Reinfection in Hemodialysis Patients. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 33(5), 883-887. doi:10.1681/ASN.2021121587
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, J. K. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3
Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves
Swann, O. V., Pollock, L., Holden, K. A., Munro, A. P. S., Bennett, A., Williams, T. C., . . . Investigators, I. (2022). Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves. PEDIATRIC RESEARCH. doi:10.1038/s41390-022-02052-5
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
Divergent trajectories of antiviral memory after SARS-CoV-2 infection
Tomic, A., Skelly, D. T., Ogbe, A., O'Connor, D., Pace, M., Adland, E., . . . Dunachie, S. J. (2022). Divergent trajectories of antiviral memory after SARS-CoV-2 infection. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-28898-1
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Ahern, D. J., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., Angus, B., . . . Zurke, Y. -X. (2022). A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. CELL, 185(5), 916-+. doi:10.1016/j.cell.2022.01.012
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission
Aggarwal, D., Page, A. J., Schaefer, U., Savva, G. M., Myers, R., Volz, E., . . . Harrison, E. M. (2022). Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-28371-z
Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service
Egan, C., Turtle, L., Thorpe, M., Harrison, E. M., Semple, M. G., & Docherty, A. B. (2022). Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service. ANAESTHESIA. doi:10.1111/anae.15677
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
Aggarwal, D., Warne, B., Jahun, A. S., Hamilton, W. L., Fieldman, T., du Plessis, L., . . . Consor, C. G. U. K. C. O. G. -U. K. (2022). Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-021-27942-w
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Mouse models of Japanese encephalitis virus infection: A systematic review and meta-analysis using a meta-regression approach.
Bharucha, T., Cleary, B., Farmiloe, A., Sutton, E., Hayati, H., Kirkwood, P., . . . Turtle, L. (2022). Mouse models of Japanese encephalitis virus infection: A systematic review and meta-analysis using a meta-regression approach.. PLoS neglected tropical diseases, 16(2), e0010116. doi:10.1371/journal.pntd.0010116
Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303
Methods of SARS-CoV-2 Inactivation.
Anderson, E. R., Prince, T., Turtle, L., Hughes, G. L., & Patterson, E. I. (2022). Methods of SARS-CoV-2 Inactivation.. Methods in molecular biology (Clifton, N.J.), 2452, 465-473. doi:10.1007/978-1-0716-2111-0_25
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629
T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study
Angyal, A., Longet, S., Moore, S. C., Payne, R. P., Harding, A., Tipton, T., . . . de, S. T. I. (2022). T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study. LANCET MICROBE, 3(1), E21-E31. doi:10.1016/S2666-5247(21)00275-5
2021
Context-specific emergence and growth of the SARS-CoV-2 Delta variant.
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-x
The value of open-source clinical science in pandemic response: lessons from ISARIC
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Antiviral activity of Molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and implications for the therapeutic window and resistance
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
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A Systematic Evaluation of IgM and IgG Antibody Assay Accuracy in Diagnosing Acute Zika Virus Infection in Brazil: Lessons Relevant to Emerging Infections
Griffiths, M. (2021). A Systematic Evaluation of IgM and IgG Antibody Assay Accuracy in Diagnosing Acute Zika Virus Infection in Brazil: Lessons Relevant to Emerging Infections. Journal of Clinical Microbiology.
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
Payne, R. P., Longet, S., Austin, J. A., Skelly, D. T., Dejnirattisai, W., Adele, S., . . . Dunachie, S. (2021). Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. CELL, 184(23), 5699-+. doi:10.1016/j.cell.2021.10.011
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
Evans, R. A., McAuley, H., Harrison, E. M., Shikotra, A., Singapuri, A., Sereno, M., . . . Brightling, C. E. (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(11), 1275-1287. doi:10.1016/S2213-2600(21)00383-0
A prenylated dsRNA sensor protects against severe COVID-19
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624
Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post-COVID-19 Convalescent Samples
Shrwani, K., Sharma, R., Krishnan, M., Jones, T., Mayora-Neto, M., Cantoni, D., . . . Zhang, Q. (2021). Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post-COVID-19 Convalescent Samples. JOURNAL OF INFECTIOUS DISEASES, 224(8), 1305-1315. doi:10.1093/infdis/jiab333
The legacy of ZikaPLAN: a transnational research consortium addressing Zika
Wilder-Smith, A., Brickley, E. B., Ximenes, R. A. D. A., Miranda-Filho, D. D. B., Turchi Martelli, C. M., Solomon, T., . . . Preet, R. (2021). The legacy of ZikaPLAN: a transnational research consortium addressing Zika. GLOBAL HEALTH ACTION, 14. doi:10.1080/16549716.2021.2008139
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Zucman, D. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5
Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave
Read, J. M., Green, C. A., Harrison, E. M., Docherty, A. B., Funk, S., Harrison, J., . . . Semple, M. G. (2021). Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. LANCET, 398(10305), 1037-1038. doi:10.1016/S0140-6736(21)01786-4
Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . Toh, C. -H. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492
LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK
Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In Annals of oncology : official journal of the European Society for Medical Oncology Vol. 32 (pp. S1337).
Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol
Sigfrid, L., Drake, T. M., Pauley, E., Jesudason, E. C., Olliaro, P., Lim, W. S., . . . Scott, J. T. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. LANCET REGIONAL HEALTH-EUROPE, 8. doi:10.1016/j.lanepe.2021.100186
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.
Twohig, K. A., Nyberg, T., Zaidi, A., Thelwall, S., Sinnathamby, M. A., Aliabadi, S., . . . COVID-19 Genomics UK (COG-UK) consortium. (2021). Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.. The Lancet. Infectious diseases, 22(1), 35-42. doi:10.1016/s1473-3099(21)00475-8
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern
Skelly, D. T., Harding, A. C., Gilbert-Jaramillo, J., Knight, M. L., Longet, S., Brown, A., . . . James, W. S. (2021). Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25167-5
Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK
Vaselli, N. M., Setiabudi, W., Subramaniam, K., Adams, E. R., Turtle, L., Iturriza-Gomara, M., . . . Hungerford, D. (2021). Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06443-7
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1
Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7
Meng, B., Kemp, S. A., Papa, G., Datir, R., Ferreira, I. A. T. M., Marelli, S., . . . Gupta, R. K. (2021). Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7. CELL REPORTS, 35(13). doi:10.1016/j.celrep.2021.109292
Divergent trajectories of antiviral memory after SARS-Cov-2 infection
Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-x
Kinetics of the neutralising antibody response in patients with hand, foot, and mouth disease caused by EV-A71: A longitudinal cohort study in Zhengzhou during 2017-2019
Qiu, Q., Zhou, J., Cheng, Y., Zhou, Y., Liang, L., Cui, P., . . . Yu, H. (2021). Kinetics of the neutralising antibody response in patients with hand, foot, and mouth disease caused by EV-A71: A longitudinal cohort study in Zhengzhou during 2017-2019. EBIOMEDICINE, 68. doi:10.1016/j.ebiom.2021.103398
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England
Volz, E., Mishra, S., Chand, M., Barrett, J. C., Johnson, R., Geidelberg, L., . . . Ferguson, N. M. (2021). Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. NATURE, 593(7858), 266-+. doi:10.1038/s41586-021-03470-x
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium., Ahern, D., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., . . . Zurke, Y. -X. (2021). A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. doi:10.1101/2021.05.11.21256877
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., . . . Gupta, R. K. (2021). Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. NATURE, 593(7857), 136-+. doi:10.1038/s41586-021-03412-7
Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
Graham, M. S., Sudre, C. H., May, A., Antonelli, M., Murray, B., Varsaysky, T., . . . Ourselin, S. (2021). Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. LANCET PUBLIC HEALTH, 6(5), E335-E345. doi:10.1016/S2468-2667(21)00055-4
Self-sampling of capillary blood for SARS-CoV-2 serology
Brown, L., Byrne, R. L., Fraser, A., Owen, S. I., Cubas-Atienzar, A. I., Williams, C. T., . . . Adams, E. R. (2021). Self-sampling of capillary blood for SARS-CoV-2 serology. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-86008-5
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
Ogbe, A., Kronsteiner, B., Skelly, D. T., Pace, M., Brown, A., Adland, E., . . . Dunachie, S. (2021). T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21856-3
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y. A., Schimanski, L., . . . Joly, E. (2021). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-22045-y
Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol
Sigfrid, L., Drake, T., Pauley, E., Jesudason, E., Olliaro, P., Lim, W. S., . . . ISARIC4C investigators. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2021.03.18.21253888
Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol
Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873
What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol.
Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J., . . . Scott, J. T. (2021). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol.. BMJ Open, 11(3), e043887. doi:10.1136/bmjopen-2020-043887
Genetic mechanisms of critical illness in COVID-19
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y
Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Salguero, J., . . . Hiscox, J. (2021). Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans. doi:10.1101/2021.03.03.433753
SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies.
Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies
Garrod, G., Owen, S., Baillie, K., Baldwin, L., Brown, L., Byrne, R., . . . Adams, E. (2021). Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies. doi:10.12688/wellcomeopenres.16522.1
Haematological malignancy and nosocomial transmission are associated with an increased risk of death from COVID-19: results of a multi-center UK cohort.
Bhogal, T., Khan, U. T., Lee, R., Stockdale, A., Hesford, C., Potti-Dhananjaya, V., . . . Palmieri, C. (2021). Haematological malignancy and nosocomial transmission are associated with an increased risk of death from COVID-19: results of a multi-center UK cohort.. Leukemia & lymphoma, 1-16. doi:10.1080/10428194.2021.1876865
Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020
Guillain-Barre syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
Leonhard, S. E., Halstead, S., Lant, S. B., de Albuquerque, M. D. F. P. M., de Brito, C. A. A., de Albuquerque, L. B. B., . . . Ferreira, M. L. B. (2021). Guillain-Barre syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. JOURNAL OF THE NEUROLOGICAL SCIENCES, 420. doi:10.1016/j.jns.2020.117272
Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England
Leclerc, Q., Fuller, N., Keogh, R., Diaz-Ordaz, K., Sekula, R., Semple, M., . . . Knight, G. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England. doi:10.1101/2021.01.14.21249791
Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2
Long-term neurodevelopment outcomes of hand, foot and mouth disease inpatients infected with EV-A71 or CV-A16, a retrospective cohort study
Liang, L., Cheng, Y., Li, Y., Shang, Q., Huang, J., Ma, C., . . . Yu, H. (2021). Long-term neurodevelopment outcomes of hand, foot and mouth disease inpatients infected with EV-A71 or CV-A16, a retrospective cohort study. EMERGING MICROBES & INFECTIONS, 10(1), 545-554. doi:10.1080/22221751.2021.1901612
T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study
The Impact of Viral Mutations on Recognition by SARS-CoV-2 Specific T-Cells
2020
Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study
Docherty, A., Mulholland, R., Lone, N., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . for ISARIC4C investigators. (2020). Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study. doi:10.1101/2020.12.19.20248559
Establishment of CORONET; COVID-19 Risk in Oncology Evaluation Tool to identify cancer patients at low versus high risk of severe complications of COVID-19 infection upon presentation to hospital
Lee, R. J., Zhou, C., Wysocki, O., Shotton, R., Tivey, A., Lever, L., . . . Armstrong, A. C. (2020). Establishment of CORONET; COVID-19 Risk in Oncology Evaluation Tool to identify cancer patients at low versus high risk of severe complications of COVID-19 infection upon presentation to hospital. doi:10.1101/2020.11.30.20239095
Enterovirus genomic load and disease severity among children hospitalised with hand, foot and mouth disease
Song, C., Zhou, Y., Li, Y., Liang, L., Turtle, L., Wang, F., . . . Yu, H. (2020). Enterovirus genomic load and disease severity among children hospitalised with hand, foot and mouth disease. EBIOMEDICINE, 62. doi:10.1016/j.ebiom.2020.103078
A systematic evaluation of IgM and IgG antibody assay accuracy in diagnosing acute Zika Virus infection in Brazil; lessons relevant to emerging infections
COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study.
ISARIC Clinical Characterisation Group. (2020). COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study.. medRxiv. doi:10.1101/2020.10.26.20219519
The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
Thomson, E., Rosen, L., Shepherd, J., Spreafico, R., da Silva Filipe, A., Wojcechowskyj, J., . . . Snell, G. (2020). The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity. doi:10.1101/2020.11.04.355842
Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Investigators, I. (2020). Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. NATURE IMMUNOLOGY, 21(11), 1336-1345. doi:10.1038/s41590-020-0782-6
Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.
Geretti, A. M., Stockdale, A. J., Kelly, S. H., Cevik, M., Collins, S., Waters, L., . . . Semple, M. G. (2020). Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. doi:10.1093/cid/ciaa1605
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y., Schimanski, L., . . . Joly, E. (2020). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. doi:10.21203/rs.3.rs-91353/v2
Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19
Clark, J., Penrice-Randal, R., Sharma, P., Kipar, A., Dong, X., Pennington, S., . . . Stewart, J. (2020). Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19. doi:10.1101/2020.10.13.334532
Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism
Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2
Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19
Gupta, R., Harrison, E., Ho, A., Docherty, A., Knight, S., van Smeden, M., . . . Noursadeghi, M. (2020). Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19. doi:10.1101/2020.10.09.20209957
Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19
Thwaites, R., Sevilla Uruchurtu, A. S., Siggins, M., Liew, F., Russell, C., Moore, S., . . . Openshaw, P. J. M. (2020). Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19. doi:10.1101/2020.10.08.20209411
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus.
Andersson, M. I., Arancibia-Carcamo, C. V., Auckland, K., Baillie, J. K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus.. Wellcome open research, 5, 181. doi:10.12688/wellcomeopenres.16002.2
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y., Schimanski, L., . . . Joly, E. (2020). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. doi:10.1101/2020.10.02.20205831
Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study
Brito Ferreira, M. L., Pessoa Militao de Albuquerque, M. D. F., Antunes de Brito, C. A., de Oliveira Franca, R. F., Porto Moreira, A. J., de Morais Machado, M. I., . . . Solomon, T. (2020). Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study. LANCET NEUROLOGY, 19(10), 826-839. doi:10.1016/S1474-4422(20)30232-5
Genetic mechanisms of critical illness in Covid-19
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A., Rawlik, K., Parkinson, N., . . . Baillie, K. (2020). Genetic mechanisms of critical illness in Covid-19. doi:10.1101/2020.09.24.20200048
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339
Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium
Palmieri, C., Turtle, L., Docherty, A., Harrison, E., Drake, T., Greenhalf, B., . . . Semple, M. G. (2020). Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium. In ANNALS OF ONCOLOGY Vol. 31 (pp. S992). doi:10.1016/j.annonc.2020.08.1735
What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study
Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J. H., . . . Scott, J. (2020). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study. doi:10.1101/2020.08.26.20180950
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249
Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study
Geretti, A. M., Stockdale, A., Kelly, S., Cevik, M., Collins, S., Waters, L., . . . Group, C. H. A. S. E. S. (2020). Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study. doi:10.2139/ssrn.3666248
Complete protection for mice conferred by a DNA vaccine based on the Japanese encephalitis virus P3 strain used to prepare the inactivated vaccine in China
Zheng, X., Yu, X., Wang, Y., Turtle, L., Cui, M., Wang, R., & Yin, C. (2020). Complete protection for mice conferred by a DNA vaccine based on the Japanese encephalitis virus P3 strain used to prepare the inactivated vaccine in China. VIROLOGY JOURNAL, 17(1). doi:10.1186/s12985-020-01400-3
Robust, reproducible clinical patterns in hospitalised patients with COVID-19
Millar, J., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, K. (2020). Robust, reproducible clinical patterns in hospitalised patients with COVID-19. doi:10.1101/2020.08.14.20168088
Methods of inactivation of SARS-CoV-2 for downstream biological assays.
Patterson, E. I., Prince, T., Anderson, E. R., Casas-Sanchez, A., Smith, S. L., Cansado-Utrilla, C., . . . Hughes, G. L. (2020). Methods of inactivation of SARS-CoV-2 for downstream biological assays.. The Journal of infectious diseases. doi:10.1093/infdis/jiaa507
Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study
Geretti, A., Stockdale, A., Kelly, S., Villa, G., Turtle, L., Semple, M., & Sabin, C. (2020). Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 23, 13-14. Retrieved from https://www.webofscience.com/
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score
Knight, S., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T., . . . Harrison, E. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. doi:10.1101/2020.07.30.20165464
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus
Andersson, M., Arancibia-Carcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. doi:10.12688/wellcomeopenres.16002.1
ISARIC COVID-19 Clinical Data Report: Final report January 2020 – January 2023
ISARIC Clinical Characterisation Group., Baillie, K., Baruch, J., Beane, A., Blumberg, L., Bozza, F. A., . . . Merson, L. (2020). ISARIC COVID-19 Clinical Data Report: Final report January 2020 – January 2023. doi:10.1101/2020.07.17.20155218
Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . Semple, M. (2020). Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study. doi:10.1101/2020.07.14.20153320
Global outbreak research: harmony not hegemony
Global outbreak research: harmony not hegemony (2020). LANCET INFECTIOUS DISEASES, 20(7), 770-772. doi:10.1016/S1473-3099(20)30440-0
Respiratory failure alone does not suggest central nervous system invasion by SARS-CoV-2
Turtle, L. (2020). Respiratory failure alone does not suggest central nervous system invasion by SARS-CoV-2. JOURNAL OF MEDICAL VIROLOGY, 92(7), 705-706. doi:10.1002/jmv.25828
Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients
Harrison, E., Docherty, A., Barr, B., Buchan, I., Carson, G., Drake, T., . . . Investigators, I. (2020). Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients. doi:10.2139/ssrn.3618215
T cell immunity rather than antibody mediates cross-protection against Zika virus infection conferred by a live attenuated Japanese encephalitis SA14-14-2 vaccine.
Wang, R., Zhen, Z., Turtle, L., Hou, B., Li, Y., Wu, N., . . . An, J. (2020). T cell immunity rather than antibody mediates cross-protection against Zika virus infection conferred by a live attenuated Japanese encephalitis SA14-14-2 vaccine.. Applied microbiology and biotechnology. doi:10.1007/s00253-020-10710-z
Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]
Adams, E. R., Ainsworth, M., Anand, R., Andersson, M. I., Auckland, K., Baillie, J. K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]. Wellcome Open Research, 5. doi:10.12688/wellcomeopenres.15927.1
Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Dong, T. (2020). Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.. bioRxiv. doi:10.1101/2020.06.05.134551
SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus
Andersson, M., Arancibia-Cárcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus. doi:10.1101/2020.05.21.20105486
Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration.
Palmieri, C., Palmer, D., Openshaw, P. J., Baille, J. K., Semple, M. G., & Turtle, L. (2020). Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration.. ESMO Open, 5(3). doi:10.1136/esmoopen-2020-000825
Methods of inactivation of SARS-CoV-2 for downstream biological assays.
Patterson, E. I., Prince, T., Anderson, E. R., Casas-Sanchez, A., Smith, S. L., Cansado-Utrilla, C., . . . Hughes, G. L. (2020). Methods of inactivation of SARS-CoV-2 for downstream biological assays.. bioRxiv : the preprint server for biology. doi:10.1101/2020.05.21.108035
Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel
National COVID Testing Scientific Advisory Panel., Adams, E., Ainsworth, M., Anand, R., Andersson, M., Auckland, K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel. doi:10.1101/2020.04.15.20066407
Two Is Better Than One: Evidence for T-Cell Cross-Protection Between Dengue and Zika and Implications on Vaccine Design.
Subramaniam, K. S., Lant, S., Goodwin, L., Grifoni, A., Weiskopf, D., & Turtle, L. (2020). Two Is Better Than One: Evidence for T-Cell Cross-Protection Between Dengue and Zika and Implications on Vaccine Design.. Frontiers in Immunology, 11, 517. doi:10.3389/fimmu.2020.00517
Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
Moore, S., Penrice-Randal, R., Alruwaili, M., Dong, X., Pullan, S., Carter, D., . . . Hiscox, J. (2020). Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19. doi:10.1101/2020.03.05.20032011
Cross-Protection Against Zika Virus Infection Conferred by a Live Attenuated Japanese Encephalitis SA14-14-2 Vaccine
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus
Andersson, M., Arancibia-Carcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. doi:10.12688/wellcomeopenres.16002.2
2019
'More than devastating'-patient experiences and neurological sequelae of Japanese encephalitis
Turtle, L., Easton, A., Defres, S., Ellul, M., Bovill, B., Hoyle, J., . . . Solomon, T. (2019). 'More than devastating'-patient experiences and neurological sequelae of Japanese encephalitis. JOURNAL OF TRAVEL MEDICINE, 26(7). doi:10.1093/jtm/taz064
Adenovirus Type 7 causing severe lower respiratory tract infection in immunocompetent adults: a comparison of two contrasting cases from an intensive care unit in North West England.
Wingfield, T., Dearden, L., Calvert, P., Osanlou, O., Johnston, B., Chawla, A., . . . Wenstone, R. (2019). Adenovirus Type 7 causing severe lower respiratory tract infection in immunocompetent adults: a comparison of two contrasting cases from an intensive care unit in North West England.. Clinical infection in practice, 2, 100007. doi:10.1016/j.clinpr.2019.100007
Malawian Malaise
Turtle, L., & Kneen, R. (2019). Malawian Malaise. In Case Studies in Neurological Infections of Adults and Children (pp. 265-268). Cambridge University Press. doi:10.1017/9781139628839.062
Two Types of Shaking
Turtle and Gemma Buxton, L. (2019). Two Types of Shaking. In Case Studies in Neurological Infections of Adults and Children (pp. 255-259). Cambridge University Press. doi:10.1017/9781139628839.060
Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: a case for further catch up campaigns?
Turtle, L. C. W. (n.d.). Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: a case for further catch up campaigns?. PLoS Neglected Tropical Diseases, 13. doi:10.1371/journal.pntd.0007269
2018
Closing The Brief Case: A Rare Case of Invasive Amebiasis Requiring Emergency Subtotal Colectomy in an HIV-Positive Man.
Wingfield, T., Ball, R., Woolley, S. D., Campbell, F., Heath, R. M., Beeching, N. J., & Turtle, L. (2018). Closing The Brief Case: A Rare Case of Invasive Amebiasis Requiring Emergency Subtotal Colectomy in an HIV-Positive Man.. Journal of clinical microbiology, 56(8), e01704-e01717. doi:10.1128/jcm.01704-17
The Brief Case: A Rare Case of Invasive Amebiasis Requiring Emergency Subtotal Colectomy in an HIV-Positive Man
Wingfield, T., Ball, R., Woolley, S. D., Campbell, F., Heath, R. M., Beeching, N. J., & Turtle, L. (2018). The Brief Case: A Rare Case of Invasive Amebiasis Requiring Emergency Subtotal Colectomy in an HIV-Positive Man. JOURNAL OF CLINICAL MICROBIOLOGY, 56(8). doi:10.1128/JCM.01703-17
Japanese encephalitis - the prospects for new treatments
Turtle, L., & Solomon, T. (2018). Japanese encephalitis - the prospects for new treatments. Nature Reviews Neurology, 14(5), 298-313. doi:10.1038/nrneurol.2018.30
Structural study of the C-terminal domain of non-structural protein 1 from Japanese encephalitis virus
Poonsiri, T., Wright, G. S. A., Diamond, M. S., Turtle, L., Solomon, T., & Antonyuk, S. V. (2018). Structural study of the C-terminal domain of non-structural protein 1 from Japanese encephalitis virus. Journal of Virology, 92(7). doi:10.1128/jvi.01868-17
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series
Mehta, R., Soares, C. N., Medialdea-Carrera, R., Ellul, M., Texeira da Silva, M. T., Rosala-Hallas, A., . . . Solomon, T. (2018). The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. PLoS Neglected Tropical Diseases, 12(2). doi:10.1371/journal.pntd.0006212
2017
Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans
Grifoni, A., Pham, J., Sidney, J., O'Rourke, P. H., Paul, S., Peters, B., . . . Sette, A. (2017). Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans. JOURNAL OF VIROLOGY, 91(24). doi:10.1128/JVI.01469-17
Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas
Grifoni, A., Angelo, M. A., Lopez, B., O'Rourke, P. H., Sidney, J., Cerpas, C., . . . Weiskopf, D. (2017). Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas. Frontiers in Immunology, 8. doi:10.3389/fimmu.2017.01309
Cellular Immune Responses to Live Attenuated Japanese Encephalitis (JE) Vaccine SA14-14-2 in Adults in a JE/dengue Co- Endemic Area
Turtle, L. C. W., Tatullo, F., Bali, T., Ravi, V., Soni, M., Chan, S., . . . Solomon, T. (2017). Cellular Immune Responses to Live Attenuated Japanese Encephalitis (JE) Vaccine SA14-14-2 in Adults in a JE/dengue Co- Endemic Area. PLoS Neglected Tropical Diseases, 11(01), 23 pages. doi:10.1371/journal.pntd.0005263
Haloprogin
Ramos-Martín, V., & Hope, W. (2017). Haloprogin. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 2933-2935). doi:10.1201/9781315152110
2016
Human T cell responses to Japanese encephalitis virus in health and disease
Turtle, L., Bali, T., Buxton, G., Chib, S., Chan, S., Soni, M., . . . Solomon, T. (2016). Human T cell responses to Japanese encephalitis virus in health and disease. Journal of Experimental Medicine, 213(7), 1331-1352. doi:10.1084/jem.20151517
2015
An integrated model of care for neurological infections: the first six years of referrals to a specialist service at a university teaching hospital in Northwest England
Turtle, L., Jung, A., Beeching, N. J., Cocker, D., Davies, G. R., Nicolson, A., . . . Solomon, T. (2015). An integrated model of care for neurological infections: the first six years of referrals to a specialist service at a university teaching hospital in Northwest England. BMC INFECTIOUS DISEASES, 15. doi:10.1186/s12879-015-1109-3
A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal (vol 10, e0122608, 2015)
Rayamajhi, A., Nightingale, S., Bhatta, N. K., Singh, R., Ledger, E., Bista, K. P., . . . Solomon, T. (2015). A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal (vol 10, e0122608, 2015). PLOS ONE, 10(8). doi:10.1371/journal.pone.0136008
A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal
Rayamajhi, A., Nightingale, S., Bhatta, N. K., Singh, R., Ledger, E., Bista, K. P., . . . Solomon, T. (2015). A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal. PLOS ONE, 10(4). doi:10.1371/journal.pone.0122608
A Survey of UK Healthcare Workers’ Attitudes on Volunteering to Help with the Ebola Outbreak in West Africa
Turtle, L., McGill, F., Bettridge, J., Matata, C., Christley, R., & Solomon, T. (2015). A Survey of UK Healthcare Workers’ Attitudes on Volunteering to Help with the Ebola Outbreak in West Africa. PLoS ONE, 10(3). doi:10.1371/journal.pone.0120013
2014
A case of iatrogenic adrenal suppression after co-administration of cobicistat and fluticasone nasal drops
Lewis, J., Turtle, L., Khoo, S., & Nsutebu, E. (2014). A case of iatrogenic adrenal suppression after co-administration of cobicistat and fluticasone nasal drops. AIDS, 28(17), 2636-2637. doi:10.1097/QAD.0000000000000462
EBOLA CRISIS What stops healthcare workers volunteering to fight Ebola in west Africa?
Solomon, T., Turtle, L., McGill, F., Matata, C., & Christley, R. (2014). EBOLA CRISIS What stops healthcare workers volunteering to fight Ebola in west Africa?. BMJ-BRITISH MEDICAL JOURNAL, 349. doi:10.1136/bmj.g6443
Encephalitis, Viral
Turtle, L., & Solomon, T. (2014). Encephalitis, Viral. In Encyclopedia of the Neurological Sciences (pp. 20-24). Elsevier. doi:10.1016/b978-0-12-385157-4.00375-4
Japanese encephalitis virus infection
Griffiths, M. J., Turtle, L., & Solomon, T. (2014). Japanese encephalitis virus infection. In NEUROVIROLOGY (Vol. 123, pp. 561-576). Retrieved from https://www.webofscience.com/
2013
Innate Immune Mechanisms in Japanese Encephalitis Virus Infection: Effect on Transcription of Pattern Recognition Receptors in Mouse Neuronal Cells and Brain Tissue
Fadnis, P. R., Ravi, V., Desai, A., Turtle, L., & Solomon, T. (2013). Innate Immune Mechanisms in Japanese Encephalitis Virus Infection: Effect on Transcription of Pattern Recognition Receptors in Mouse Neuronal Cells and Brain Tissue. VIRAL IMMUNOLOGY, 26(6), 366-377. doi:10.1089/vim.2013.0016
Japanese Encephalitis Virus Infection
Turtle, L., & Solomon, T. (2013). Japanese Encephalitis Virus Infection. In Viral Infections of the Human Nervous System (pp. 271-293). Springer Basel. doi:10.1007/978-3-0348-0425-7_11
2012
In routine UK hospital practice T-SPOT.TB™ is useful in some patients with a modest pre-test probability of active tuberculosis
Turtle, L., Kemp, T., Davies, G. R., Squire, S. B., Beeching, N. J., & Beadsworth, M. B. J. (2012). In routine UK hospital practice T-SPOT.TB™ is useful in some patients with a modest pre-test probability of active tuberculosis. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 23(4), 363-367. doi:10.1016/j.ejim.2012.01.002
In routine UK hospital practice T-SPOT.TB™ is useful in some patients with a modest pre-test probability of active tuberculosis.
Turtle, L., Kemp, T., Davies, G. R., Squire, S. B., Beeching, N. J., & Beadsworth, M. B. J. (2012). In routine UK hospital practice T-SPOT.TB™ is useful in some patients with a modest pre-test probability of active tuberculosis.. European journal of internal medicine, 23(4), 363-367. doi:10.1016/j.ejim.2012.01.002
1636 Intravenous immunoglobulin to treat Japanese encephalitis; a randomised controlled trial in Nepalese children
Nightingale, S., Rayamajhi, A., Bhatta, N., Ledger, E., Griffiths, M., Turtle, L., . . . Solomon, T. (2012). 1636 Intravenous immunoglobulin to treat Japanese encephalitis; a randomised controlled trial in Nepalese children. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 83 (pp. e1.141-e1). BMJ. doi:10.1136/jnnp-2011-301993.24
Encephalitis caused by flaviviruses
Turtle, L., Griffiths, M. J., & Solomon, T. (2012). Encephalitis caused by flaviviruses. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 105(3), 219-223. doi:10.1093/qjmed/hcs013
Encephalitis caused by flaviviruses.
Turtle, L., Griffiths, M. J., & Solomon, T. (2012). Encephalitis caused by flaviviruses.. QJM., 105(3), 219-223. doi:10.1093/qjmed/hcs013
2011
Intensive Care Usage by HIV-Positive Patients in the HAART Era.
Turtle, L., Vyakernam, R., Menon-Johansson, A., Nelson, M. R., & Soni, N. (2011). Intensive Care Usage by HIV-Positive Patients in the HAART Era.. Interdisciplinary perspectives on infectious diseases, 2011, 847835. doi:10.1155/2011/847835
'Septrin psychosis' among renal transplant patients with <i>Pneumocystis jirovecii</i> pneumonia
Walker, L. E., Thomas, S., McBride, C., Howse, M., Turtle, L. C. W., Vivancos, R., . . . Beadsworth, M. B. J. (2011). 'Septrin psychosis' among renal transplant patients with <i>Pneumocystis jirovecii</i> pneumonia. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 66(5), 1117-1119. doi:10.1093/jac/dkr050
'Septrin psychosis' among renal transplant patients with Pneumocystis jirovecii pneumonia.
Walker, L. E., Thomas, S., McBride, C., Howse, M., Turtle, L. C. W., Vivancos, R., . . . Beadsworth, M. B. J. (2011). 'Septrin psychosis' among renal transplant patients with Pneumocystis jirovecii pneumonia.. The Journal of antimicrobial chemotherapy, 66(5), 1117-1119. doi:10.1093/jac/dkr050
2009
An evaluation of the usefulness of neuroimaging for the diagnosis of Japanese encephalitis
Dung, N. M., Turtle, L., Chong, W. K., Mai, N. T., Thao, T. T., Thuy, T. T., . . . Solomon, T. (2009). An evaluation of the usefulness of neuroimaging for the diagnosis of Japanese encephalitis. JOURNAL OF NEUROLOGY, 256(12), 2052-2060. doi:10.1007/s00415-009-5249-5
Severe pneumonia caused by ciprofloxacin resistant panton-valentine leukocidin producing community acquired meticillin resistant <i>Staphylococcus aureus</i>
Turtle, L., Wey, E., & James, E. (2009). Severe pneumonia caused by ciprofloxacin resistant panton-valentine leukocidin producing community acquired meticillin resistant <i>Staphylococcus aureus</i>. JOURNAL OF INFECTION, 58(1), 86-87. doi:10.1016/j.jinf.2008.10.008
2008
Tics, Twitches, Tales: The Experiences of Gilles de la Tourette's Syndrome
Turtle, L., & Robertson, M. M. (2008). Tics, Twitches, Tales: The Experiences of Gilles de la Tourette's Syndrome. AMERICAN JOURNAL OF ORTHOPSYCHIATRY, 78(4), 449-455. doi:10.1037/a0014329
2007
Medical emergencies in human immunodeficiency virus infected patients
Turtle, L. (2007). Medical emergencies in human immunodeficiency virus infected patients. Current Anaesthesia & Critical Care, 18(2), 94-106. doi:10.1016/j.cacc.2007.03.004
2003
Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium insensitive phospholipase A<sub>2</sub> gene expression
Lawrence, K. M., Scarabelli, T. M., Turtle, L., Chanalaris, A., Townsend, P. A., Carroll, C. J., . . . Latchman, D. S. (2003). Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium insensitive phospholipase A<sub>2</sub> gene expression. FASEB JOURNAL, 17(13), 2313-+. doi:10.1096/fj.02-0832fje
Undated
T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study
Angyal, A., Longet, S., Moore, S., Payne, R. P., Harding, A., Tipton, T., . . . Group, P. I. T. C. H. C. (n.d.). T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study.