Publications
Selected publications
- Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis (Journal article - 2021)
- Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver. (Journal article - 2021)
- Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts. (Journal article - 2019)
- Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host (Journal article - 2018)
- Targeting Secreted Protease/Anti-Protease Balance as a Vaccine Strategy against the Helminth Fasciola hepatica (Journal article - 2022)
2024
Protection of mice against cecal ligation and puncture-induced polymicrobial sepsis by a Fasciola hepatica helminth defence molecule.
Fazekas, B., Hamon, S., De Marco Verissimo, C., Cwiklinski, K., López Corrales, J., Gaughan, S., . . . Lalor, R. (2024). Protection of mice against cecal ligation and puncture-induced polymicrobial sepsis by a Fasciola hepatica helminth defence molecule.. Shock (Augusta, Ga.). doi:10.1097/shk.0000000000002489
Moonlighting on the Fasciola hepatica tegument: Enolase, a glycolytic enzyme, interacts with the extracellular matrix and fibrinolytic system of the host
O’Kelly, E., Cwiklinski, K., De Marco Verissimo, C., Calvani, N. E. D., López Corrales, J., Jewhurst, H., . . . González-Miguel, J. (n.d.). Moonlighting on the Fasciola hepatica tegument: Enolase, a glycolytic enzyme, interacts with the extracellular matrix and fibrinolytic system of the host. PLOS Neglected Tropical Diseases, 18(8), e0012069. doi:10.1371/journal.pntd.0012069
Exploring the utility of circulating miRNAs as diagnostic biomarkers of fasciolosis.
Chowdhury, S., Ricafrente, A., Cwiklinski, K., Sais, D., Dalton, J. P., Tran, N., & Donnelly, S. (2024). Exploring the utility of circulating miRNAs as diagnostic biomarkers of fasciolosis.. Scientific reports, 14(1), 7431. doi:10.1038/s41598-024-57704-9
2023
Glycan complexity and heterogeneity of glycoproteins in somatic extracts and secretome of the infective stage of the helminth Fasciola hepatica
De Marco Verissimo, C., Cwiklinski, K., Nilsson, J., Mirgorodskaya, E., Jin, C., Karlsson, N. G., & Dalton, J. P. (2023). Glycan complexity and heterogeneity of glycoproteins in somatic extracts and secretome of the infective stage of the helminth Fasciola hepatica. Molecular and Cellular Proteomics, 100684. doi:10.1016/j.mcpro.2023.100684
Fasciola hepatica antioxidant and protease-inhibitor cocktail recombinant vaccines administered five times elicit potent and sustained immune responses in sheep but do not confer protection
Cwiklinski, K., McEvoy, A., Corrales, J. L., Jewhurst, H., Calvani, N. E. D., De Marco Verissimo, C., . . . Lalor, R. (2023). Fasciola hepatica antioxidant and protease-inhibitor cocktail recombinant vaccines administered five times elicit potent and sustained immune responses in sheep but do not confer protection. Veterinary Parasitology, 110049. doi:10.1016/j.vetpar.2023.110049
The use of cathepsin L1 (FhCL1) serological ELISA in sentinel screening for liver fluke on sheep farms
Corrales, J. L., McEvoy, A., Lalor, R., Cwiklinski, K., Doyle, S., Parkinson, M., . . . Dorey, A. L. (2023). The use of cathepsin L1 (FhCL1) serological ELISA in sentinel screening for liver fluke on sheep farms. Veterinary Parasitology: Regional Studies and Reports, 100924. doi:10.1016/j.vprsr.2023.100924
A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance
Beesley, N. J., Cwiklinski, K., Allen, K., Hoyle, R. C., Spithill, T. W., La Course, E. J., . . . Hodgkinson, J. E. (n.d.). A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance. PLOS Pathogens, 19(1), e1011081. doi:10.1371/journal.ppat.1011081
2022
Omics tools enabling vaccine discovery against fasciolosis
Cwiklinski, K., & Dalton, J. P. (2022). Omics tools enabling vaccine discovery against fasciolosis. TRENDS IN PARASITOLOGY, 38(12), 1068-1079. doi:10.1016/j.pt.2022.09.009
Exploiting Comparative Omics to Understand the Pathogenic and Virulence-Associated Protease: Anti-Protease Relationships in the Zoonotic Parasites <i>Fasciola hepatica</i> and <i>Fasciola gigantica</i>
Cwiklinski, K., & Dalton, J. P. (2022). Exploiting Comparative Omics to Understand the Pathogenic and Virulence-Associated Protease: Anti-Protease Relationships in the Zoonotic Parasites <i>Fasciola hepatica</i> and <i>Fasciola gigantica</i>. GENES, 13(10). doi:10.3390/genes13101854
Two Distinct Superoxidase Dismutases (SOD) Secreted by the Helminth Parasite <i>Fasciola hepatica</i> Play Roles in Defence against Metabolic and Host Immune Cell-Derived Reactive Oxygen Species (ROS) during Growth and Development
Calvani, N. E. D., Verissimo, C. D. M., Jewhurst, H. L., Cwiklinski, K., Flaus, A., & Dalton, J. P. (2022). Two Distinct Superoxidase Dismutases (SOD) Secreted by the Helminth Parasite <i>Fasciola hepatica</i> Play Roles in Defence against Metabolic and Host Immune Cell-Derived Reactive Oxygen Species (ROS) during Growth and Development. ANTIOXIDANTS, 11(10). doi:10.3390/antiox11101968
Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-Like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system
De Marco Verissimo, C., López Corrales, J., Dorey, A. L., Cwiklinski, K., Lalor, R., Calvani, N. E. D., . . . Dalton, J. P. (2022). Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system.. Epidemiology and infection, 150, e128. doi:10.1017/s0950268822001078
Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the zoonotic helminth parasite Fasciola hepatica
Ricafrente, A., Cwiklinski, K., Nguyen, H., Dalton, J. P., Tran, N., & Donnelly, S. (2022). Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the zoonotic helminth parasite Fasciola hepatica. BMC Genomics, 23(1). doi:10.1186/s12864-022-08644-z
Targeting Secreted Protease/Anti-Protease Balance as a Vaccine Strategy against the Helminth Fasciola hepatica
Cwiklinski, K., Drysdale, O., López Corrales, J., Corripio-Miyar, Y., De Marco Verissimo, C., Jewhurst, H., . . . Dalton, J. P. (2022). Targeting Secreted Protease/Anti-Protease Balance as a Vaccine Strategy against the Helminth <i>Fasciola hepatica</i>.. Vaccines, 10(2), 155. doi:10.3390/vaccines10020155
Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins
De Marco Verissimo, C., Jewhurst, H. L., Dobó, J., Gál, P., Dalton, J. P., & Cwiklinski, K. (n.d.). Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins. PLOS Pathogens, 18(1), e1010226. doi:10.1371/journal.ppat.1010226
2021
Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis
Lalor, R., Cwiklinski, K., Calvani, N. E. D., Dorey, A., Hamon, S., Corrales, J. L., . . . De Marco Verissimo, C. (2021). Pathogenicity and virulence of the liver flukes <i>Fasciola hepatica</i> and <i>Fasciola</i><i>Gigantica</i> that cause the zoonosis Fasciolosis.. Virulence, 12(1), 2839-2867. doi:10.1080/21505594.2021.1996520
The discovery of <i>Fasciola hepatica</i> and its life cycle.
Andrews, S. J., Cwiklinski, K., & Dalton, J. P. (2021). The discovery of <i>Fasciola hepatica</i> and its life cycle.. In Fasciolosis (pp. 1-22). CABI. doi:10.1079/9781789246162.0001
Applying 'omics' technologies to understand <i>Fasciola</i> spp. biology.
Cwiklinski, K., Verissimo, C. D. M., McVeigh, P., Donnelly, S., & Dalton, J. P. (2021). Applying 'omics' technologies to understand <i>Fasciola</i> spp. biology.. In Fasciolosis (pp. 338-378). CABI. doi:10.1079/9781789246162.0011
The Zoonotic Helminth Parasite Fasciola hepatica: Virulence-Associated Cathepsin B and Cathepsin L Cysteine Peptidases Secreted by Infective Newly Excysted Juveniles (NEJ)
Barbour, T., Cwiklinski, K., Lalor, R., Dalton, J. P., & De Marco Verissimo, C. (2021). The Zoonotic Helminth Parasite <i>Fasciola hepatica</i><i>:</i> Virulence-Associated Cathepsin B and Cathepsin L Cysteine Peptidases Secreted by Infective Newly Excysted Juveniles (NEJ).. Animals : an open access journal from MDPI, 11(12), 3495. doi:10.3390/ani11123495
Proteomics of Host-Helminth Interactions.
Robinson, M. W., & Cwiklinski, K. (2021). Proteomics of Host-Helminth Interactions.. Pathogens (Basel, Switzerland), 10(10), 1317. doi:10.3390/pathogens10101317
Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA).
López Corrales, J., Cwiklinski, K., De Marco Verissimo, C., Dorey, A., Lalor, R., Jewhurst, H., . . . Dalton, J. P. (2021). Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA).. Veterinary parasitology, 298, 109517. doi:10.1016/j.vetpar.2021.109517
Antigen-specific response of CD4+ T cells and hepatic lymph node cells to Fasciola hepatica-derived molecules at the early and late stage of the infection in sheep
Pérez-Caballero, R., Martínez-Moreno, F. J., Corripio-Miyar, Y., McNeilly, T. N., Cwiklinski, K., Dalton, J. P., . . . Buffoni, L. (2021). Antigen-specific response of CD4+ T cells and hepatic lymph node cells to Fasciola hepatica-derived molecules at the early and late stage of the infection in sheep. Veterinary Research, 52(1). doi:10.1186/s13567-021-00963-5
Recognition Pattern of the Fasciola hepatica Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics
Becerro-Recio, D., González-Miguel, J., Ucero, A., Sotillo, J., Martínez-Moreno, Á., Pérez-Arévalo, J., . . . Siles-Lucas, M. (2021). Recognition Pattern of the <i>Fasciola hepatica</i> Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics.. Pathogens (Basel, Switzerland), 10(6), 725. doi:10.3390/pathogens10060725
Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests
De Marco Verissimo, C., O'Brien, C., López Corrales, J., Dorey, A., Cwiklinski, K., Lalor, R., . . . Doyle, S. (2021). Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests.. Epidemiology and infection, 149, e140. doi:10.1017/s0950268821001308
<i>Eudiplozoon nipponicum</i> (Monogenea, Diplozoidae) and its adaptation to haematophagy as revealed by transcriptome and secretome profiling
Vorel, J., Cwiklinski, K., Roudnicky, P., Ilgova, J., Jedlickova, L., Dalton, J. P., . . . Kasny, M. (2021). <i>Eudiplozoon nipponicum</i> (Monogenea, Diplozoidae) and its adaptation to haematophagy as revealed by transcriptome and secretome profiling. BMC GENOMICS, 22(1). doi:10.1186/s12864-021-07589-z
Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses
Tran, N., Ricafrente, A., To, J., Lund, M., Marques, T. M., Gama-Carvalho, M., . . . Donnelly, S. (2021). Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses.. Scientific reports, 11(1), 6712. doi:10.1038/s41598-021-86125-1
Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP)
Mathew, R., Wunderlich, J., Thivierge, K., Cwiklinski, K., Dumont, C., Tilley, L., . . . Dalton, J. P. (2021). Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP).. Scientific reports, 11(1), 2854. doi:10.1038/s41598-021-82499-4
Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver.
Cwiklinski, K., Robinson, M. W., Donnelly, S., & Dalton, J. P. (2021). Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver.. BMC genomics, 22(1), 46. doi:10.1186/s12864-020-07326-y
Autonomous Non Antioxidant Roles for Fasciola hepatica Secreted Thioredoxin-1 and Peroxiredoxin-1
Dorey, A., Cwiklinski, K., Rooney, J., De Marco Verissimo, C., López Corrales, J., Jewhurst, H., . . . Lalor, R. (n.d.). Autonomous Non Antioxidant Roles for Fasciola hepatica Secreted Thioredoxin-1 and Peroxiredoxin-1. Frontiers in Cellular and Infection Microbiology, 11. doi:10.3389/fcimb.2021.667272
2020
Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed ‘clamp-like’ mechanism of binding and inhibition
Pritsch, I. C., Tikhonova, I. G., Jewhurst, H. L., Drysdale, O., Cwiklinski, K., Molento, M. B., . . . Verissimo, C. D. M. (2020). Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition.. BMC molecular and cell biology, 21(1), 90. doi:10.1186/s12860-020-00335-5
An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica
Smith, D., Cwiklinski, K., Jewhurst, H., Tikhonova, I. G., & Dalton, J. P. (2020). An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica.. Scientific reports, 10(1), 20657. doi:10.1038/s41598-020-77687-7
Fasciola hepatica Extracellular Vesicles isolated from excretory-secretory products using a gravity flow method modulate dendritic cell phenotype and activity
Murphy, A., Cwiklinski, K., Lalor, R., O'Connell, B., Robinson, M. W., Gerlach, J., . . . O'Neill, S. M. (2020). Fasciola hepatica Extracellular Vesicles isolated from excretory-secretory products using a gravity flow method modulate dendritic cell phenotype and activity.. PLoS neglected tropical diseases, 14(9), e0008626. doi:10.1371/journal.pntd.0008626
Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases.
De Marco Verissimo, C., Jewhurst, H. L., Tikhonova, I. G., Urbanus, R. T., Maule, A. G., Dalton, J. P., & Cwiklinski, K. (2020). Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases.. PLoS neglected tropical diseases, 14(8), e0008510. doi:10.1371/journal.pntd.0008510
Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs).
Shiels, J., Cwiklinski, K., Alvarado, R., Thivierge, K., Cotton, S., Gonzales Santana, B., . . . Dalton, J. P. (2020). Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs).. PLoS neglected tropical diseases, 14(7), e0008470. doi:10.1371/journal.pntd.0008470
2019
Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts.
Zhang, X. -X., Cwiklinski, K., Hu, R. -S., Zheng, W. -B., Sheng, Z. -A., Zhang, F. -K., . . . Zhu, X. -Q. (2019). Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts.. BMC genomics, 20(1), 729. doi:10.1186/s12864-019-6103-5
Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells
de la Torre-Escudero, E., Gerlach, J. Q., Bennett, A. P. S., Cwiklinski, K., Jewhurst, H. L., Huson, K. M., . . . Robinson, M. W. (2019). Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells.. PLoS neglected tropical diseases, 13(1), e0007087. doi:10.1371/journal.pntd.0007087
2018
In silico analyses of protein glycosylating genes in the helminth Fasciola hepatica (liver fluke) predict protein-linked glycan simplicity and reveal temporally-dynamic expression profiles.
McVeigh, P., Cwiklinski, K., Garcia-Campos, A., Mulcahy, G., O'Neill, S. M., Maule, A. G., & Dalton, J. P. (2018). In silico analyses of protein glycosylating genes in the helminth Fasciola hepatica (liver fluke) predict protein-linked glycan simplicity and reveal temporally-dynamic expression profiles.. Scientific reports, 8(1), 11700. doi:10.1038/s41598-018-29673-3
Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization.
Dominguez, M. F., González-Miguel, J., Carmona, C., Dalton, J. P., Cwiklinski, K., Tort, J., & Siles-Lucas, M. (2018). Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization.. Veterinary parasitology, 258, 46-52. doi:10.1016/j.vetpar.2018.06.011
Clonal amplification of Fasciola hepatica in Galba truncatula: within and between isolate variation of triclabendazole-susceptible and -resistant clones
Hodgkinson, J. E., Cwiklinski, K., Beesley, N., Hartley, C., Allen, K., & Williams, D. (2018). Clonal amplification of Fasciola hepatica in Galba truncatula: within and between isolate variation of triclabendazole-susceptible and -resistant clones. Parasites and Vectors, 11, 9 pages. doi:10.1186/s13071-018-2952-z
Advances in Fasciola hepatica research using ‘omics’ technologies
Cwiklinski, K., & Dalton, J. P. (2018). Advances in Fasciola hepatica research using 'omics' technologies.. International journal for parasitology, 48(5), 321-331. doi:10.1016/j.ijpara.2017.12.001
Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host
Cwiklinski, K., Jewhurst, H., McVeigh, P., Barbour, T., Maule, A. G., Tort, J., . . . Dalton, J. P. (2018). Infection by the Helminth Parasite <i>Fasciola hepatica</i> Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host.. Molecular & cellular proteomics : MCP, 17(4), 792-809. doi:10.1074/mcp.ra117.000445
2017
Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica
Ruiz-Campillo, M. T., Molina Hernandez, V., Escamilla, A., Stevenson, M., Perez, J., Martinez-Moreno, A., . . . Cwiklinski, K. (2017). Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica.. Scientific reports, 7(1), 2782. doi:10.1038/s41598-017-03094-0
2016
Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host
Ravidà, A., Cwiklinski, K., Aldridge, A. M., Clarke, P., Thompson, R., Gerlach, J. Q., . . . O'Neill, S. M. (2016). Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host.. Molecular & cellular proteomics : MCP, 15(10), 3139-3153. doi:10.1074/mcp.m116.059774
Unexpected Activity of a Novel Kunitz-type Inhibitor
Smith, D., Tikhonova, I. G., Jewhurst, H. L., Drysdale, O. C., Dvořák, J., Robinson, M. W., . . . Dalton, J. P. (2016). Unexpected Activity of a Novel Kunitz-type Inhibitor: INHIBITION OF CYSTEINE PROTEASES BUT NOT SERINE PROTEASES.. The Journal of biological chemistry, 291(37), 19220-19234. doi:10.1074/jbc.m116.724344
A prospective view of animal and human Fasciolosis
Cwiklinski, K., O'Neill, S. M., Donnelly, S., & Dalton, J. P. (2016). A prospective view of animal and human Fasciolosis.. Parasite immunology, 38(9), 558-568. doi:10.1111/pim.12343
Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans
Garcia-Campos, A., Ravidà, A., Nguyen, D. L., Cwiklinski, K., Dalton, J. P., Hokke, C. H., . . . Mulcahy, G. (2016). Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans.. PLoS neglected tropical diseases, 10(5), e0004688. doi:10.1371/journal.pntd.0004688
2015
The Extracellular Vesicles of the Helminth Pathogen, <i>Fasciola hepatica</i>: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis
Cwiklinski, K., de la Torre-Escudero, E., Trelis, M., Bernal, D., Dufresne, P. J., Brennan, G. P., . . . Robinson, M. W. (2015). The Extracellular Vesicles of the Helminth Pathogen, <i>Fasciola hepatica</i>: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis. MOLECULAR & CELLULAR PROTEOMICS, 14(12), 3258-3273. doi:10.1074/mcp.M115.053934
<i>Fasciola hepatica</i> from naturally infected sheep and cattle in Great Britain are diploid
Beesley, N. J., Cwiklinski, K., Williams, D. J. L., & Hodgkinson, J. (2015). <i>Fasciola hepatica</i> from naturally infected sheep and cattle in Great Britain are diploid. PARASITOLOGY, 142(9), 1196-1201. doi:10.1017/S0031182015000499
Characterisation of a novel panel of polymorphic microsatellite loci for the liver fluke, Fasciola hepatica, using a next generation sequencing approach
Cwiklinski, K., Allen, K., LaCourse, J., Williams, D., Paterson, S., & Hodgkinson, J. (2015). Characterisation of a novel panel of polymorphic microsatellite loci for the liver fluke, Fasciola hepatica, using a next generation sequencing approach. Infection, Genetics and Evolution, 32, 298-304. doi:10.1016/j.meegid.2015.03.014
The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution
Cwiklinski, K., Dalton, J. P., Dufresne, P. J., La Course, J., Williams, D., Hodgkinson, J., & Paterson, S. (2015). The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution. Genome Biology, 16. doi:10.1186/s13059-015-0632-2
Fasciola hepatica vaccine: we may not be there yet but we're on the right road.
Molina-Hernández, V., Molina-Hernández, V., Mulcahy, G., Pérez, J., Martínez-Moreno, Á., Donnelly, S., . . . Cwiklinski, K. (2015). Fasciola hepatica vaccine: we may not be there yet but we're on the right road.. Veterinary parasitology, 208(1-2), 101-111. doi:10.1016/j.vetpar.2015.01.004
2013
Identification of putative markers of triclabendazole resistance by a genome-wide analysis of genetically recombinant <i>Fasciola hepatica</i>
Hodgkinson, J., Cwiklinski, K., Beesley, N. J., Paterson, S., & Williams, D. J. L. (2013). Identification of putative markers of triclabendazole resistance by a genome-wide analysis of genetically recombinant <i>Fasciola hepatica</i>. PARASITOLOGY, 140(12), 1523-1533. doi:10.1017/S0031182013000528
Transcriptome analysis of a parasitic clade V nematode: Comparative analysis of potential molecular anthelmintic targets in Cylicostephanus goldi
Cwiklinski, K., Merga, J. Y., Lake, S. L., Hartley, C., Matthews, J. B., Paterson, S., & Hodgkinson, J. E. (2013). Transcriptome analysis of a parasitic clade V nematode: Comparative analysis of potential molecular anthelmintic targets in Cylicostephanus goldi. International Journal for Parasitology, 43(11), 917-927. doi:10.1016/j.ijpara.2013.06.010
2012
New insights into sequence variation in the IGS region of 21 cyathostomin species and the implication for molecular identification.
Cwiklinski, K., Kooyman, F. N. J., Van Doorn, D. C. K., Matthews, J. B., & Hodgkinson, J. E. (2012). New insights into sequence variation in the IGS region of 21 cyathostomin species and the implication for molecular identification.. Parasitology, 139(8), 1063-1073. doi:10.1017/s0031182012000467
2009
Cloning and analysis of a Trichinella pseudospiralis muscle larva secreted serine protease gene.
Cwiklinski, K., Meskill, D., Robinson, M. W., Pozio, E., Appleton, J. A., & Connolly, B. (2009). Cloning and analysis of a Trichinella pseudospiralis muscle larva secreted serine protease gene.. Veterinary parasitology, 159(3-4), 268-271. doi:10.1016/j.vetpar.2008.10.036