Publications
2023
Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590
International Pediatric COVID-19 Severity Over the Course of the Pandemic
Zhu, Y., Almeida, F. J., Baillie, J. K., Bowen, A. C., Britton, P. N., Brizuela, M. E., . . . Short, K. R. (2023). International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA PEDIATRICS. doi:10.1001/jamapediatrics.2023.3117
TNFR2<SUP>+</SUP> regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing y? T cells in the lung
Xu, R., Jacques, L. C., Khandaker, S., Leon-Rios, M., Beentjes, D., Wei, X., . . . Kadioglu, A. (2023). TNFR2<SUP>+</SUP> regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing y? T cells in the lung. CELL REPORTS, 42(2). doi:10.1016/j.celrep.2023.112054
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402
2022
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges
Audshasai, T., Coles, J. A., Panagiotou, S., Khandaker, S., Scales, H. E., Kjos, M., . . . Yang, M. (2022). Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges. MBIO, 13(4). doi:10.1128/mbio.01024-22
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020)
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2022). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020). SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08813-w
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629
2021
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353
A prenylated dsRNA sensor protects against severe COVID-19
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8
Helicobacter pylori infection in diabetes mellitus patients with peptic ulcer disease
Khatun, S., Shadia, K., Mahmud, M., Mazumder, S., Dutta, I. K., Rahman, F., . . . Haq, J. A. (n.d.). Helicobacter pylori infection in diabetes mellitus patients with peptic ulcer disease. IMC Journal of Medical Science, 14(2), 27-32. doi:10.3329/imcjms.v14i2.52832
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020)
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2021). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020). SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-86214-1
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873
2020
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685
Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2020). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-73454-w
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249
Helicobacter pylori CagA seropositivity in adult Bangladeshi patients with peptic ulcer and erosion
Rahman, F., Shadia, K., Khatun, S., Mahmud, M., Dutta, I. K., & Haq, J. A. (n.d.). Helicobacter pylori CagA seropositivity in adult Bangladeshi patients with peptic ulcer and erosion. IMC Journal of Medical Science, 14(1), 36-40. doi:10.3329/imcjms.v14i1.47453
Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
Jacques, L. C., Panagiotou, S., Baltazar, M., Senghore, M., Khandaker, S., Xu, R., . . . Kadioglu, A. (2020). Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-15751-6
Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease
Shears, R. K., Jacques, L. C., Naylor, G., Miyashita, L., Shadia, K., Lebre, F., . . . Kadioglu, A. (2020). Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease. Journal of Allergy and Clinical Immunology, 145(4), 1272-1284.e6. doi:10.1016/j.jaci.2019.11.039
2019
Effect of Respiratory Syncytial Virus infection on Streptococcus pneumoniae colonisation and invasive disease
Shadia, K. (2019, November 7). Effect of Respiratory Syncytial Virus infection on Streptococcus pneumoniae colonisation and invasive disease.
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival
Subramanian, K., Neill, D. R., Malak, H., Spelmink, L., Khandaker, S., Marchiori, G., . . . Henriques-Normark, B. (2019). Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nature Microbiology, 4(1), 62-70. doi:10.1038/s41564-018-0280-x
2017
Evaluation of Rapid stool antigen test for the diagnosis of Helicobacter pylori infection in patients with dyspepsia
Khatun, S., Rahman, F., Shadia, K., Dutta, I. K., Hoq, M. N., Akter, F., & Haq, J. A. (n.d.). Evaluation of Rapid stool antigen test for the diagnosis of Helicobacter pylori infection in patients with dyspepsia. IMC Journal of Medical Science, 10(2), 39-44. doi:10.3329/imcjms.v10i2.31108
2016
Activity of Mecillinam and Clavulanic Acid on ESBL Producing and Non- ESBL Producing Escherichia Coli Isolated From UTI Cases
Shadia, K., Ahmed, A. A., Barai, L., Rahman, F., Tahmina, N., & Haq, J. A. (n.d.). Activity of Mecillinam and Clavulanic Acid on ESBL Producing and Non- ESBL Producing Escherichia Coli Isolated From UTI Cases. Ibrahim Medical College Journal, 8(2), 56-60. doi:10.3329/imcj.v8i2.26680
2015
Adenosine Deaminase Assay in Different Body Fluids for the Diagnosis of Tubercular Infection
Shadia, K. (2015). Adenosine Deaminase Assay in Different Body Fluids for the Diagnosis of Tubercular Infection. American Journal of Biomedical and Life Sciences, 3(3), 49. doi:10.11648/j.ajbls.20150303.14
2013
Comparison of Three Mycobacterial DNA Extraction Methods from Extrapulmonary Samples for PCR Assay
Shadia, K., Anwar, S., Banu, S., Saleh, A. A., & Miah, M. R. A. (n.d.). Comparison of Three Mycobacterial DNA Extraction Methods from Extrapulmonary Samples for PCR Assay. Ibrahim Medical College Journal, 6(1), 9-11. doi:10.3329/imcj.v6i1.14711
2012
Trends Of Antibiotic Susceptibility Of Salmonella Enterica Serovar Typhi And Paratyphi In An Urban Hospital Of Dhaka City Over 6 Years Period
Shadia, K., Borhan, S. B., Hasin, H., Rahman, S., Sultana, S., Barai, L., . . . Haq, J. A. (2012). Trends Of Antibiotic Susceptibility Of Salmonella Enterica Serovar Typhi And Paratyphi In An Urban Hospital Of Dhaka City Over 6 Years Period. Ibrahim Medical College Journal, 5(2), 42-45. doi:10.3329/imcj.v5i2.10097
Undated
Inhaled Delivery of Killed Bacillus Subtilis Spores Protects Against Acute Viral Infections Caused by Influenza, RSV and SARS-CoV-2
Xu, R., Hong, H. A., Shadia, K., Baltazar, M., Allehyani, N., Beentjes, D., . . . Kadioglu, A. (n.d.). Inhaled Delivery of Killed Bacillus Subtilis Spores Protects Against Acute Viral Infections Caused by Influenza, RSV and SARS-CoV-2.