Publications
Selected publications
- Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells (Journal article - 2015)
- LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells (Journal article - 2013)
- B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII (Journal article - 2007)
- Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells (Journal article - 2010)
- Enhancing BCR signals at the cell membrane (Journal article - 2015)
- Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy Within Primary CLL Cells. (Journal article - 2021)
- Multiplexed profiling of RNA and protein expression signatures in individual cells using flow or mass cytometry (Journal article - 2019)
2024
Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.
Kennedy, P. T., Saulters, E. L., Duckworth, A. D., Lim, Y. J., Woolley, J. F., Slupsky, J. R., . . . Dahal, L. N. (2024). Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.. Molecular therapy : the journal of the American Society of Gene Therapy, 32(2), 457-468. doi:10.1016/j.ymthe.2023.11.028
Highly Multiplexed and Simultaneous Characterization of Protein and RNA in Single Cells by Flow or Mass Cytometry Platforms Using Proximity Ligation Assay for RNA.
Duckworth, A. D., Slupsky, J. R., & Kalakonda, N. (2024). Highly Multiplexed and Simultaneous Characterization of Protein and RNA in Single Cells by Flow or Mass Cytometry Platforms Using Proximity Ligation Assay for RNA.. Methods in molecular biology (Clifton, N.J.), 2752, 143-165. doi:10.1007/978-1-0716-3621-3_10
2023
Deep Immune Profiling Identifies Novel T-Cell Subpopulations That Influence Specific Clinical Outcomes in Chronic Lymphocytic Leukaemia (CLL)
Lim, Y. J., Duckworth, A., Clarke, K., Kennedy, P., Oates, M., Gornall, M., . . . Pettitt, A. (2023). Deep Immune Profiling Identifies Novel T-Cell Subpopulations That Influence Specific Clinical Outcomes in Chronic Lymphocytic Leukaemia (CLL). Blood, 142(Supplement 1), 4626. doi:10.1182/blood-2023-185091
High Dimensional Detection of Non-Malignant B-Cells and Its Clinical Implications in Patients with Chronic Lymphocytic Leukaemia (CLL) Undergoing Frontline Therapy
Lim, Y. J., Duckworth, A., Clarke, K., Oates, M., Gornall, M., Kalakonda, N., . . . Pettitt, A. (2023). High Dimensional Detection of Non-Malignant B-Cells and Its Clinical Implications in Patients with Chronic Lymphocytic Leukaemia (CLL) Undergoing Frontline Therapy. Blood, 142(Supplement 1), 1894. doi:10.1182/blood-2023-185018
Immunomodulatory Effects of Chemo-Immunotherapy ± Idelalisib in Chronic Lymphocytic Leukaemia (CLL)
Lim, Y. J., Duckworth, A., Clarke, K., Oates, M., Gornall, M., Kalakonda, N., . . . Pettitt, A. (2023). Immunomodulatory Effects of Chemo-Immunotherapy ± Idelalisib in Chronic Lymphocytic Leukaemia (CLL). Blood, 142(Supplement 1), 1455. doi:10.1182/blood-2023-185063
Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity
CREATION OF ISOGENIC CELL LINE MODELS OF 17P DELETION TO STUDY CLONAL EVOLUTION AND MECHANISMS OF THERAPY RESISTANCE IN CLL AND DLBCL
van Kampen, F. L., Glenn, M., Pettitt, A., Kalakonda, N., & Slupsky, J. (2023). CREATION OF ISOGENIC CELL LINE MODELS OF 17P DELETION TO STUDY CLONAL EVOLUTION AND MECHANISMS OF THERAPY RESISTANCE IN CLL AND DLBCL. Hematological Oncology, 41(S2), 798-799. doi:10.1002/hon.3165_647
Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib
Till, K. J., Abdullah, M., Alnassfan, T., Janet, G. Z., Marks, T., Coma, S., . . . Slupsky, J. R. (2023). Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-30148-3
2022
PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling
Hay, J., Tarafdar, A., Holroyd, A. K., Moka, H. A., Dunn, K. M., Alshayeb, A., . . . Michie, A. M. (2022). PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling. CANCERS, 14(23). doi:10.3390/cancers14236006
PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling
Development of a bispecific Antibody–Drug Conjugate targeting CD7 and CD33 to treat Acute Myeloid Leukaemia
2021
Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy Within Primary CLL Cells.
Linley, A. J., Karydis, L. I., Mondru, A. K., D'Avola, A., Al Shmrany, H., Cicconi, S., . . . Slupsky, J. R. (2021). Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells. CLINICAL CANCER RESEARCH, 27(20), 5647-5659. doi:10.1158/1078-0432.CCR-21-0161
Poor prognosis is ZAP70'ed into focus in CLL
Linley, A. J., & Slupsky, J. R. (2021). Poor prognosis is ZAP70'ed into focus in CLL. BLOOD, 137(26), 3586-3587. doi:10.1182/blood.2021011270
2020
Investigation of detaching cells as a potential in vitro model of epithelial–mesenchymal transition in a metastatic pancreatic cancer cell line
Hale, J., Evans, A., Al-Selwi, Y., Costello, E., Slupsky, J., Palmer, D., & Greenhalf, W. (2020). Investigation of detaching cells as a potential in vitro model of epithelial–mesenchymal transition in a metastatic pancreatic cancer cell line. Pancreatology, 20, S134-S135. doi:10.1016/j.pan.2020.07.251
A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations
Azar, A. A., Michie, A. M., Tarafdar, A., Malik, N., Menon, G. K., Till, K. J., . . . Slupsky, J. R. (2020). A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-70191-y
Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.
Figueiredo, C. R., Kalirai, H., Sacco, J. J., Azevedo, R. A., Duckworth, A., Slupsky, J. R., . . . Coupland, S. E. (2020). Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.. The Journal of Pathology, 250(4), 420-439. doi:10.1002/path.5384
2019
Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells
POTENTIAL THERAPEUTIC ADVANTAGE FOR DUVELISIB IN MANTLE CELL LYMPHOMA: PI3Kδ AND OVEREXPRESSED PI3Kγ IN LYMPHOMA CELLS HAVE SPECIALIZED FUNCTIONAL ROLES
Till, K. J., Gallardo Zapata, J., Marks, T., Weaver, D. T., Pachter, J. A., Abdullah, M., . . . Slupsky, J. R. (2019). POTENTIAL THERAPEUTIC ADVANTAGE FOR DUVELISIB IN MANTLE CELL LYMPHOMA: PI3Kδ AND OVEREXPRESSED PI3Kγ IN LYMPHOMA CELLS HAVE SPECIALIZED FUNCTIONAL ROLES. In Hematological Oncology Vol. 37 (pp. 511-512). Wiley. doi:10.1002/hon.194_2631
PF370 SIGNAL-OMICS ANALYSIS OF THE IMPACT OF THERAPY ON BCR SIGNALLING IN CHRONIC LYMPHOCYTIC LEUKAEMIA
Linley, A., Kalakonda, N., MacEwan, D., Prior, I., & Slupsky, J. (2019). PF370 SIGNAL-OMICS ANALYSIS OF THE IMPACT OF THERAPY ON BCR SIGNALLING IN CHRONIC LYMPHOCYTIC LEUKAEMIA. HemaSphere, 3(S1), 136-137. doi:10.1097/01.hs9.0000559692.06651.82
Ibrutinib is safer than we think
Slupsky, J. R. (2019). Ibrutinib is safer than we think. BLOOD, 133(19), 2006-2007. doi:10.1182/blood-2019-03-901009
Multiplexed profiling of RNA and protein expression signatures in individual cells using flow or mass cytometry
Duckworth, A. D., Gherardini, P. F., Sykorova, M., Yasin, F., Nolan, G. P., Slupsky, J. R., & Kalakonda, N. (2019). Multiplexed profiling of RNA and protein expression signatures in individual cells using flow or mass cytometry. Nature Protocols, 14(03), 901-920. doi:10.1038/s41596-018-0120-8
2018
Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9
Maerken, M., MacEwan, D., Harper, N., Slupsky, J. R., & Linley, A. (2018). Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-113804
New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Wilson, L. J., Linley, A., Hammond, D. E., Hood, F. E., Coulson, J. M., MacEwan, D. J., . . . Prior, I. A. (2018). New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome. CANCER RESEARCH, 78(1), 15-29. doi:10.1158/0008-5472.CAN-17-2291
2017
Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome
Till, K. J., Allen, J. C., Talab, F., Lin, K., Allsup, D., Cawkwell, L., . . . Slupsky, J. R. (2017). Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-17021-w
Transcriptional mechanism of vascular endothelial growth factor-induced expression of protein kinase CβII in chronic lymphocytic leukaemia cells
Al-Sanabra, O., Duckworth, A. D., Glenn, M. A., Brown, B. R., Angelillo, P., Lee, K., . . . Slupsky, J. R. (2017). Transcriptional mechanism of vascular endothelial growth factor-induced expression of protein kinase CβII in chronic lymphocytic leukaemia cells. Scientific Reports, 7. doi:10.1038/srep43228
2016
Targeting B-cell receptor signaling in leukemia and lymphoma: how and why?
Allen, J. C., Talab, F., & Slupsky, J. R. (2016). Targeting B-cell receptor signaling in leukemia and lymphoma: how and why?. International journal of hematologic oncology, 5(1), 37-53. doi:10.2217/ijh-2016-0003
UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis
Abu-Alainin, W., Gana, T., Liloglou, L., Olayanju, A., Barrera Briceno, L., Ferguson, R., . . . Costello-Goldring, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. Journal of Pathology, 238(3), 423-433. doi:10.1002/path.4665
2015
CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p
Farahani, M., Rubbi, C., Liu, L., Slupsky, J. R., & Kalakonda, N. (2015). CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p. PLOS ONE, 10(10). doi:10.1371/journal.pone.0141429
Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukaemia cells
Till, K., Pettitt, A., & Slupsky, J. (n.d.). Expression of functional sphingosine-1 phosphate receptor-1is reduced by B cell receptor signaling and increased byinhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukaemia cells. The Journal of Immunology, 194. doi:10.4049/jimmunol.1402304
Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1phosphate receptors and integrins
Middle, S., Coupland, S. E., Taktak, A., Kidgell, V., Slupsky, J. R., Pettitt, A. R., & Till, K. J. (2015). Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1phosphate receptors and integrins. EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 4. doi:10.1186/s40164-015-0004-3
Slupsky JR. Enhancing BCR signals at the cell membrane. Blood. 2015;125(4):586-587.
Slupsky JR. Enhancing BCR signals at the cell membrane. Blood. 2015;125(4):586-587. (2015). Blood, 125(12), 2008. doi:10.1182/blood-2015-02-627679
Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells
Till, K. J., Pettitt, A., & Slupsky, J. (2015). Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells. Journal of Immunology, 194(5), 2439-2446. doi:10.4049/jimmunol.1402304
Enhancing BCR signals at the cell membrane
Slupsky, J. R. (2015). Enhancing BCR signals at the cell membrane. BLOOD, 125(4), 586-587. doi:10.1182/blood-2014-11-611756
Enhancing BCR signals at the cell membrane (vol 125, pg 586, 2015)
Slupsky, J. R. (2015). Enhancing BCR signals at the cell membrane (vol 125, pg 586, 2015). BLOOD, 125(12), 2008. Retrieved from https://www.webofscience.com/
Subversion of PKCα signalling in B cell progenitors results in an upregulation of PKCβII expression and leukaemogenesis
Tarafdar, A., Vukovik, M., Cosimo, E., Dunn, K., Slupsky, J. R., & Michie, A. M. (2015). Subversion of PKCα signalling in B cell progenitors results in an upregulation of PKCβII expression and leukaemogenesis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 73). Retrieved from https://www.webofscience.com/
2014
Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy.
Duckworth, A., Glenn, M., Slupsky, J. R., Packham, G., & Kalakonda, N. (2014). Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy.. Blood, 123(21), 3277-3285. doi:10.1182/blood-2013-11-539049
THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA
Neill, D. R., Saint, G. L., Bricio-Moreno, L., Fothergill, J., Southern, K. W., Winstanley, C., . . . Flanagan, B. F. (2014). THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA. PLoS One, 9(5). doi:10.1371/journal.pone.0095892.
Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?
Slupsky, J. R. (2014). Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?. Scientifica, 2014, 208928. doi:10.1155/2014/208928
Targeting Cell Metabolism In Chronic Lymphocytic Leukaemia (CLL); A Viable Therapeutic Approach?
E. Clapham, C., R. Pettitt, A., & R. Slupsky, J. (n.d.). Targeting Cell Metabolism In Chronic Lymphocytic Leukaemia (CLL); A Viable Therapeutic Approach?. Journal of Hematology And Oncology Research, 1(1), 7-23. doi:10.14302/issn.2372-6601.jhor-13-346
2013
LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells
Talab, F., Allen, J. C., Thompson, V., Lin, K., & Slupsky, J. R. (2013). LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells. MOLECULAR CANCER RESEARCH, 11(5), 541-554. doi:10.1158/1541-7786.MCR-12-0415-T
Differential induction of PRDM1 in chronic lymphocytic leukaemia
Duckworth, A. D., Glenn, M. A., Venkateswarlu, P., Slupsky, J. R., Cawley, J. C., & Kalakonda, N. (2013). Differential induction of PRDM1 in chronic lymphocytic leukaemia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 45). Retrieved from https://www.webofscience.com/
Expression of monocarboxylate transporters-1 and-4 in circulating and CD40L-stimulated chronic lymphocytic leukaemia (CLL) cells
Clapham, C. E., Slupsky, J. R., & Pettitt, A. R. (2013). Expression of monocarboxylate transporters-1 and-4 in circulating and CD40L-stimulated chronic lymphocytic leukaemia (CLL) cells. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 42). Retrieved from https://www.webofscience.com/
High LCK expression in the malignant cells of chronic lymphocytic leukaemia is a marker of good disease prognosis
Allen, J. C., Talab, F., Thompson, V., Lin, K., Packham, G., & Slupsky, J. R. (2013). High LCK expression in the malignant cells of chronic lymphocytic leukaemia is a marker of good disease prognosis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 47). Retrieved from https://www.webofscience.com/
Lck is an important mediator of BCR-induced signalling in chronic lymphocytic leukaemia cells
Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2013). Lck is an important mediator of BCR-induced signalling in chronic lymphocytic leukaemia cells. BRITISH JOURNAL OF HAEMATOLOGY, 161, 19. Retrieved from https://www.webofscience.com/
Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF
McNamara, P. S., Fonceca, A. M., Howarth, D., Correia, J. B., Slupsky, J. R., Trinick, R. E., . . . Flanagan, B. F. (2013). Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF. THORAX, 68(1), 76-81. doi:10.1136/thoraxjnl-2012-202288
2012
Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak
Melarangi, T., Zhuang, J., Lin, K., Rockliffe, N., Bosanquet, A. G., Oates, M., . . . Pettitt, A. R. (2012). Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak. CELL DEATH & DISEASE, 3. doi:10.1038/cddis.2012.102
Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia
Allen, J. C., & Slupsky, J. R. (2012). Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia. In P. Oppezzo (Ed.), Chronic Lymphocytic Leukemia (pp. 153-178). Rijeka, Croatia: InTech.
2011
2.5 Lck is an Important Mediator of BCR-induced Signaling in CLL Cells
Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2011). 2.5 Lck is an Important Mediator of BCR-induced Signaling in CLL Cells. Clinical Lymphoma Myeloma and Leukemia, 11, S162. doi:10.1016/j.clml.2011.09.038
Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression
Lucas, C. M., Harris, R. J., Giannoudis, A., Copland, M., Slupsky, J. R., & Clark, R. E. (2011). Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. BLOOD, 117(24), 6660-6668. doi:10.1182/blood-2010-08-304477
c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells
Allen, J. C., Talab, F., Zuzel, M., Lin, K., & Slupsky, J. R. (2011). c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells. BLOOD, 117(8), 2414-2422. doi:10.1182/blood-2010-08-301176
2010
C-Abl Regulates Mcl-1 Gene Expression In Chronic Lymphocytic Leukaemia Cells
Allen, J. C., Zuzel, M., Lin, K., & Slupsky, J. R. (2010). C-Abl Regulates Mcl-1 Gene Expression In Chronic Lymphocytic Leukaemia Cells. Blood, 116(21), 3579. doi:10.1182/blood.v116.21.3579.3579
Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells
Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2010). Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells. Blood, 116(21), 375. doi:10.1182/blood.v116.21.375.375
Mechanisms of monoclonal antibody-induced platelet activation.
Slupsky, J. R. (2010). Mechanisms of monoclonal antibody-induced platelet activation..
Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells
Abrams, S. T., Brown, B. R. B., Zuzel, M., & Slupsky, J. R. (2010). Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells. BLOOD, 115(22), 4447-4454. doi:10.1182/blood-2009-06-229872
Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells
Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2010). Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells. In BLOOD Vol. 116 (pp. 169-170). Retrieved from https://www.webofscience.com/
2007
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII
Abrams, S. T., Lakum, T., Lin, K., Jones, G. M., Treweeke, A. T., Farahani, M., . . . Slupsky, J. R. (2007). B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII. BLOOD, 109(3), 1193-1201. doi:10.1182/blood-2006-03-012021
Central role of protein kinase Cε in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia
Slupsky, J. R., Kamiguti, A. S., Harris, R. J., Cawley, J. C., & Zuzel, M. (2007). Central role of protein kinase Cε in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia. AMERICAN JOURNAL OF PATHOLOGY, 170(2), 745-754. doi:10.2353/ajpath.2007.060557
2006
c-Abl expression in chronic lymphocytic leukemia cells: Clinical and therapeutic implications
Lin, K., Glenn, M. A., Harris, R. J., Duckworth, A. D., Dennett, S., Cawley, J. C., . . . Slupsky, J. R. (2006). c-Abl expression in chronic lymphocytic leukemia cells: Clinical and therapeutic implications. CANCER RESEARCH, 66(15), 7801-7809. doi:10.1158/0008-5472.CAN-05-3901
2005
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia
Kamiguti, A. S., Serrander, L., Lin, K., Harris, R. J., Cawley, J. C., Allsup, D. J., . . . Zuzel, M. (2005). Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. JOURNAL OF IMMUNOLOGY, 175(12), 8424-8430. doi:10.4049/jimmunol.175.12.8424
Over-Expression of c-Abl in CLL Cells Is Associated with Advanced Disease, and Contributes to CLL-Cell Survival through Activation of NF-kB.
Lin, K., Harris, R. J., Dennett, S., Cawley, J. C., Zuzel, M., & Slupsky, J. R. (2005). Over-Expression of c-Abl in CLL Cells Is Associated with Advanced Disease, and Contributes to CLL-Cell Survival through Activation of NF-kB.. Blood, 106(11), 1191. doi:10.1182/blood.v106.11.1191.1191
B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia
Allsup, D. J., Kamiguti, A. S., Lin, K., Sherrington, P. D., Matrai, Z., Slupsky, J. R., . . . Zuzel, N. (2005). B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia. CANCER RESEARCH, 65(16), 7328-7337. doi:10.1158/0008-5472.CAN-03-1563
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia
Kamiguti, A. S., Serrander, L., Lin, K., Harris, R. J., Cawley, J. C., Allsup, D. J., . . . Zuzel, M. (2005). Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol., 175(12), 8424-8430. Retrieved from http://www.jimmunol.org/cgi/content/full/175/12/8424
Over-expression of c-Abl in CLL cells is associated with advanced disease, and contributes to CLL-cell survival through activation of NF-kB
Lin, K., Harris, R. J., Dennett, S., Cawley, J. C., Zuzel, M., & Slupsky, J. R. (2005). Over-expression of c-Abl in CLL cells is associated with advanced disease, and contributes to CLL-cell survival through activation of NF-kB. In BLOOD Vol. 106 (pp. 348A). Retrieved from https://www.webofscience.com/
2004
Function and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells
Syrovets, T., Colognato, R., Slupsky, J. R., & Simmet, T. (2004). Function and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. In FASEB JOURNAL Vol. 18 (pp. C301). Retrieved from https://www.webofscience.com/
2003
Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells
Colognato, R., Slupsky, J. R., Jendrach, M., Burysek, L., Syrovets, T., & Simmet, T. (2003). Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. BLOOD, 102(7), 2645-2652. doi:10.1182/blood-2002-08-2497
The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL)
Aziz, K. A., Till, K. J., Chen, H. J., Slupsky, J. R., Campbell, F., Cawley, J. C., & Zuzel, M. (2003). The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL). BLOOD, 102(3), 1051-1056. doi:10.1182/blood-2002-12-3737
Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways
Kamiguti, A. S., Harris, R. J., Slupsky, J. R., Baker, P. K., Cawley, J. C., & Zuzel, M. (2003). Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways. ONCOGENE, 22(15), 2272-2284. doi:10.1038/sj.onc.1206398
Malignant cell signalling in chronic lymphocytic and hairy-cell leukaemias.
Kamiguti, A. S., Slupsky, J. R., & Zuzel, M. (2003). Malignant cell signalling in chronic lymphocytic and hairy-cell leukaemias.. In S. G. Pandalai (Ed.), Recent Research Developments in Haematology (Vol. 1, pp. 81-101). Trivandrum: Transworld Research Network.
2002
Response of hairy cells to IFN-α involves induction of apoptosis through autocrine TNF-α and protection by adhesion
Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to IFN-α involves induction of apoptosis through autocrine TNF-α and protection by adhesion. BLOOD, 100(2), 647-653. doi:10.1182/blood.V100.2.647
Characterization of protease-activated receptor expression in human peripheral monocytes and antigen presenting cells
Colognato, R., Slupsky, J. R., Jendrach, M., Syrovets, T., & Simmet, T. (2002). Characterization of protease-activated receptor expression in human peripheral monocytes and antigen presenting cells. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol. 365 (pp. R76). Retrieved from https://www.webofscience.com/
Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion
Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion. Blood, 100(2), 647-653.
Response of hairy cells to α-IFN involves induction of apoptosis through autocrine TNF-α and protection by adhesion.
Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to α-IFN involves induction of apoptosis through autocrine TNF-α and protection by adhesion.. In BLOOD Vol. 100 (pp. 596A). Retrieved from https://www.webofscience.com/
2001
Active Ras induces heterodimerization of cRaf and BRaf
Weber, C. K., Slupsky, J. R., Kalmes, H. A., & Rapp, U. R. (2001). Active Ras induces heterodimerization of cRaf and BRaf. CANCER RESEARCH, 61(9), 3595-3598. Retrieved from https://www.webofscience.com/
Regulation of protease-activated receptor-1 and-2 expression on antigen presenting cells by cytokines
Colognato, R., Slupsky, J. R., Jendrach, M., Burysek, L., & Simmet, T. (2001). Regulation of protease-activated receptor-1 and-2 expression on antigen presenting cells by cytokines. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol. 363 (pp. R82). Retrieved from https://www.webofscience.com/
2000
Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIα
Syrovets, T., Büchele, B., Gedig, E., Slupsky, J. R., & Simmet, T. (2000). Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIα. MOLECULAR PHARMACOLOGY, 58(1), 71-81. doi:10.1124/mol.58.1.71
Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes
Weber, C. K., Slupsky, J. R., Herrmann, C., Schuler, M., Rapp, U. R., & Block, C. (2000). Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes. ONCOGENE, 19(2), 169-176. doi:10.1038/sj.onc.1203261
1999
Binding of Gβγ subunits to cRaf1 downregulates G-protein-coupled receptor signalling
Slupsky, J. R., Quitterer, U., Weber, C. K., Gierschik, P., Lohse, M. J., & Rapp, U. R. (1999). Binding of Gβγ subunits to cRaf1 downregulates G-protein-coupled receptor signalling. CURRENT BIOLOGY, 9(17), 971-974. doi:10.1016/S0960-9822(99)80426-6
1998
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
Henn, V., Slupsky, J. R., Gräfe, M., Anagnostopoulos, I., Förster, R., Müller-Berghaus, G., & Kroczek, R. A. (1998). CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. NATURE, 391(6667), 591-594. doi:10.1038/35393
Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40
Slupsky, J. R., Kalbas, M., Willuweit, A., Henn, V., Kroczek, R. A., & Müller-Berghaus, G. (1998). Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40. THROMBOSIS AND HAEMOSTASIS, 80(6), 1008-1014. Retrieved from https://www.webofscience.com/
Raf-dependent signaling pathways in cell growth and differentiation
Slupsky, J. R., Weber, C. K., Ludwig, S., & Rapp, U. R. (1998). Raf-dependent signaling pathways in cell growth and differentiation. In Cell Growth and Oncogenesis (pp. 75-95). Birkhäuser Basel. doi:10.1007/978-3-0348-8950-6_6
1997
The platelet antigens CD9, CD42 and integrin alpha(IIb)beta(IIIa) can be topographically associated and transduce functionally similar signals
Slupsky, J. R., Kamiguti, A. S., Rhodes, N. P., Cawley, J. C., Shaw, A. R. E., & Zuzel, M. (1997). The platelet antigens CD9, CD42 and integrin alpha(IIb)beta(IIIa) can be topographically associated and transduce functionally similar signals. EUROPEAN JOURNAL OF BIOCHEMISTRY, 244(1), 168-175. doi:10.1111/j.1432-1033.1997.00168.x
Analysis of CD9, CD32 and p67 signalling: Use of degranulated platelets indicates direct involvement of CD9 and p67 in integrin activation
Slupsky, J. R., Cawley, J. C., Kaplan, C., & Zuzel, M. (1997). Analysis of CD9, CD32 and p67 signalling: Use of degranulated platelets indicates direct involvement of CD9 and p67 in integrin activation. BRITISH JOURNAL OF HAEMATOLOGY, 96(2), 275-286. doi:10.1046/j.1365-2141.1997.d01-2011.x
TRAP (CD40 ligand) on activated platelets triggers a pro-inflammatory reaction of endothelial cells
Henn, V., Slupsky, J. R., Grafe, M., Muller-Berghaus, G., & Kroczek, R. A. (1997). TRAP (CD40 ligand) on activated platelets triggers a pro-inflammatory reaction of endothelial cells. In Immunobiology Vol. 197 (pp. 305).
1996
GTP gamma S-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not via tyrosine kinases
Lowe, G. M., Slupsky, J. R., Galvani, D. W., & Edwards, S. W. (1996). GTP gamma S-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not via tyrosine kinases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 220(3), 484-490. doi:10.1006/bbrc.1996.0431
GTPγS-Stimulated Phospholipase D Activation in Human Neutrophils Occurs by Protein Kinase C-Dependent and -Independent Pathways but Not via Tyrosine Kinases
Lowe, G. M., Slupsky, J. R., Galvani, D. W., & Edwards, S. W. (1996). GTPγS-Stimulated Phospholipase D Activation in Human Neutrophils Occurs by Protein Kinase C-Dependent and -Independent Pathways but Not via Tyrosine Kinases. Biochemical and Biophysical Research Communications, 220(3), 484-490. doi:10.1006/bbrc.1996.0431
CD9 associates with CD36 to form novel high density molecular aggregates in collagen stimulated human platelets.
Shaw, A. R. E., Seehafer, J. G., & Slupsky, J. R. (1996). CD9 associates with CD36 to form novel high density molecular aggregates in collagen stimulated human platelets.. In BLOOD Vol. 88 (pp. 95). Retrieved from https://www.webofscience.com/
1995
CD9, 41 & 42 on platelets can be topographically associated and transduce functionally similar signals.
Slupsky, J. R., Shaw, R. E., & Zuzel, M. (1995). CD9, 41 & 42 on platelets can be topographically associated and transduce functionally similar signals.. In BLOOD Vol. 86 (pp. 2196). Retrieved from https://www.webofscience.com/
ENDOTHELIAL-CELLS EXPRESS A FUNCTIONALLY IDENTICAL BUT IMMUNOLOGICALLY DIFFERENT VARIANT OF PLATELET GLYCOPROTEIN-IB
SLUPSKY, J. R., KROPP, B., & POTZSCH, B. (1995). ENDOTHELIAL-CELLS EXPRESS A FUNCTIONALLY IDENTICAL BUT IMMUNOLOGICALLY DIFFERENT VARIANT OF PLATELET GLYCOPROTEIN-IB. In THROMBOSIS AND HAEMOSTASIS Vol. 73 (pp. 909). Retrieved from https://www.webofscience.com/
1994
PROPERTIES OF FIBRINOGEN CLEAVED BY JARARHAGIN, A METALLOPROTEINASE FROM THE VENOM OF BOTHROPS-JARARACA
KAMIGUTI, A. S., SLUPSKY, J. R., ZUZEL, M., & HAY, C. R. M. (1994). PROPERTIES OF FIBRINOGEN CLEAVED BY JARARHAGIN, A METALLOPROTEINASE FROM THE VENOM OF BOTHROPS-JARARACA. THROMBOSIS AND HAEMOSTASIS, 72(2), 244-249. Retrieved from https://www.webofscience.com/
1993
C-FMS PROTEIN EXPRESSION BY B-CELLS, WITH PARTICULAR REFERENCE TO THE HAIRY-CELLS OF HAIRY-CELL LEUKEMIA
TILL, K. J., LOPEZ, A., SLUPSKY, J., & CAWLEY, J. C. (1993). C-FMS PROTEIN EXPRESSION BY B-CELLS, WITH PARTICULAR REFERENCE TO THE HAIRY-CELLS OF HAIRY-CELL LEUKEMIA. BRITISH JOURNAL OF HAEMATOLOGY, 83(2), 223-231. doi:10.1111/j.1365-2141.1993.tb08276.x
THE PEANUT-AGGLUTININ (PNA)-BINDING SURFACE COMPONENTS OF MALIGNANT PLASMA-CELLS
SLUPSKY, J. R., DUGGANKEEN, M., BOOTH, L. A., KARPAS, A., RHODES, E. G. H., CAWLEY, J. C., & ZUZEL, M. (1993). THE PEANUT-AGGLUTININ (PNA)-BINDING SURFACE COMPONENTS OF MALIGNANT PLASMA-CELLS. BRITISH JOURNAL OF HAEMATOLOGY, 83(4), 567-573. doi:10.1111/j.1365-2141.1993.tb04692.x
1992
ROLE OF FC-GAMMA-RII IN PLATELET ACTIVATION BY MONOCLONAL-ANTIBODIES
SLUPSKY, J. R., CAWLEY, J. C., GRIFFITH, L. S., SHAW, A. R. E., & ZUZEL, M. (1992). ROLE OF FC-GAMMA-RII IN PLATELET ACTIVATION BY MONOCLONAL-ANTIBODIES. JOURNAL OF IMMUNOLOGY, 148(10), 3189-3194. Retrieved from https://www.webofscience.com/
1991
PLATELET ACTIVATION BY IMMOBILIZED MONOCLONAL-ANTIBODY - EVIDENCE FOR A CD9 PROXIMAL SIGNAL
GRIFFITH, L., SLUPSKY, J., SEEHAFER, J., BOSHKOV, L., & SHAW, A. R. E. (1991). PLATELET ACTIVATION BY IMMOBILIZED MONOCLONAL-ANTIBODY - EVIDENCE FOR A CD9 PROXIMAL SIGNAL. BLOOD, 78(7), 1753-1759. Retrieved from https://www.webofscience.com/
Platelet activation by immobilized monoclonal antibody: evidence for a CD9 proximal signal
Griffith, L., Slupsky, J., Seehafer, J., Boshkov, L., & Shaw, A. R. (1991). Platelet activation by immobilized monoclonal antibody: evidence for a CD9 proximal signal. Blood, 78(7), 1753-1759. doi:10.1182/blood.v78.7.1753.1753
1990
MYRISTIC ACID IS INCORPORATED INTO THE 2 ACYLATABLE DOMAINS OF THE FUNCTIONAL GLYCOPROTEIN CD9 IN ESTER, BUT NOT IN AMIDE BONDS
SEEHAFER, J. G., SLUPSKY, J. R., TANG, S. C., MASELLISSMITH, A., & SHAW, A. R. E. (1990). MYRISTIC ACID IS INCORPORATED INTO THE 2 ACYLATABLE DOMAINS OF THE FUNCTIONAL GLYCOPROTEIN CD9 IN ESTER, BUT NOT IN AMIDE BONDS. BIOCHIMICA ET BIOPHYSICA ACTA, 1039(2), 218-226. doi:10.1016/0167-4838(90)90189-M
ANTI-CD9 MONOCLONAL-ANTIBODIES INDUCE HOMOTYPIC ADHESION OF PRE-B CELL-LINES BY A NOVEL MECHANISM
MASELLISSMITH, A., JENSEN, G. S., SEEHAFER, J. G., SLUPSKY, J. R., & SHAW, A. R. E. (1990). ANTI-CD9 MONOCLONAL-ANTIBODIES INDUCE HOMOTYPIC ADHESION OF PRE-B CELL-LINES BY A NOVEL MECHANISM. JOURNAL OF IMMUNOLOGY, 144(5), 1607-1613. Retrieved from https://www.webofscience.com/
1989
EVIDENCE THAT MONOCLONAL-ANTIBODIES AGAINST CD9 ANTIGEN INDUCE SPECIFIC ASSOCIATION BETWEEN CD9 AND THE PLATELET GLYCOPROTEIN-IIB-GLYCOPROTEIN-IIIA COMPLEX
SLUPSKY, J. R., SEEHAFER, J. G., TANG, S. C., MASELLISSMITH, A., & SHAW, A. R. E. (1989). EVIDENCE THAT MONOCLONAL-ANTIBODIES AGAINST CD9 ANTIGEN INDUCE SPECIFIC ASSOCIATION BETWEEN CD9 AND THE PLATELET GLYCOPROTEIN-IIB-GLYCOPROTEIN-IIIA COMPLEX. JOURNAL OF BIOLOGICAL CHEMISTRY, 264(21), 12289-12293. Retrieved from https://www.webofscience.com/
MONOCLONAL-ANTIBODIES REACTIVE WITH HAIRY-CELL LEUKEMIA
VISSER, L., SHAW, A., SLUPSKY, J., VOS, H., & POPPEMA, S. (1989). MONOCLONAL-ANTIBODIES REACTIVE WITH HAIRY-CELL LEUKEMIA. BLOOD, 74(1), 320-325. Retrieved from https://www.webofscience.com/
1988
THE FUNCTIONAL GLYCOPROTEIN-CD9 IS VARIABLY ACYLATED - LOCALIZATION OF THE VARIABLY ACYLATED REGION TO A MEMBRANE-ASSOCIATED PEPTIDE CONTAINING THE BINDING-SITE FOR THE AGONISTIC MONOCLONAL-ANTIBODY 50H.19
SEEHAFER, J. G., TANG, S. C., SLUPSKY, J. R., & SHAW, A. R. E. (1988). THE FUNCTIONAL GLYCOPROTEIN-CD9 IS VARIABLY ACYLATED - LOCALIZATION OF THE VARIABLY ACYLATED REGION TO A MEMBRANE-ASSOCIATED PEPTIDE CONTAINING THE BINDING-SITE FOR THE AGONISTIC MONOCLONAL-ANTIBODY 50H.19. BIOCHIMICA ET BIOPHYSICA ACTA, 957(3), 399-410. doi:10.1016/0167-4838(88)90231-2
THE FUNCTIONAL CELL-SURFACE GLYCOPROTEIN CD9 IS DISTINGUISHED BY BEING THE MAJOR FATTY-ACID ACYLATED AND A MAJOR IODINATED CELL-SURFACE COMPONENT OF THE HUMAN-PLATELET
SEEHAFER, J. G., SLUPSKY, J. R., TANG, S. C., & SHAW, A. R. E. (1988). THE FUNCTIONAL CELL-SURFACE GLYCOPROTEIN CD9 IS DISTINGUISHED BY BEING THE MAJOR FATTY-ACID ACYLATED AND A MAJOR IODINATED CELL-SURFACE COMPONENT OF THE HUMAN-PLATELET. BIOCHIMICA ET BIOPHYSICA ACTA, 952(1), 92-100. doi:10.1016/0167-4838(88)90105-7
1987
CHARACTERIZATION OF CARDIAC CALSEQUESTRIN
SLUPSKY, J. R., OHNISHI, M., CARPENTER, M. R., & REITHMEIER, R. A. F. (1987). CHARACTERIZATION OF CARDIAC CALSEQUESTRIN. BIOCHEMISTRY, 26(20), 6539-6544. doi:10.1021/bi00394a038
CALSEQUESTRIN121Supported by grants from the Medical Research Council of Canada (D.H.M.), the Heart and Stroke Foundation of Ontario (D.H.M.), the Muscular Dystrophy Association of Canada (D.H.M. and R.A.F.R.) and the Alberta Heritage Foundation for Medical Research (R.A.F.R and M.O.).2Present address: Membrane Biology Group, Department of Medicine, Room 7307, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Reithmeier, R. A. F., Ohnishi, M., Carpenter, M. R., Slupsky, J. R., Gounden, K., Fliegel, L., . . . MacLennan, D. H. (1987). CALSEQUESTRIN121Supported by grants from the Medical Research Council of Canada (D.H.M.), the Heart and Stroke Foundation of Ontario (D.H.M.), the Muscular Dystrophy Association of Canada (D.H.M. and R.A.F.R.) and the Alberta Heritage Foundation for Medical Research (R.A.F.R and M.O.).2Present address: Membrane Biology Group, Department of Medicine, Room 7307, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8. In Calcium-Binding Proteins in Health and Disease (pp. 62-71). Elsevier. doi:10.1016/b978-0-12-521040-9.50013-9