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Joseph Slupsky

Professor Joseph Slupsky
B.Sc., Ph.D.

Contact

J.R.Slupsky@liverpool.ac.uk

+44 (0)151 706 4318

+44 (0)151 794 5552

Publications

Selected publications

  1. Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells (Journal article - 2015)
  2. LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells (Journal article - 2013)
  3. B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII (Journal article - 2007)
  4. Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells (Journal article - 2010)
  5. Enhancing BCR signals at the cell membrane (Journal article - 2015)
  6. Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy Within Primary CLL Cells. (Journal article - 2021)
  7. Multiplexed profiling of RNA and protein expression signatures in individual cells using flow or mass cytometry (Journal article - 2019)
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2024

Highly Multiplexed and Simultaneous Characterization of Protein and RNA in Single Cells by Flow or Mass Cytometry Platforms Using Proximity Ligation Assay for RNA.

Duckworth, A. D., Slupsky, J. R., & Kalakonda, N. (2024). Highly Multiplexed and Simultaneous Characterization of Protein and RNA in Single Cells by Flow or Mass Cytometry Platforms Using Proximity Ligation Assay for RNA.. Methods in molecular biology (Clifton, N.J.), 2752, 143-165. doi:10.1007/978-1-0716-3621-3_10

DOI
10.1007/978-1-0716-3621-3_10
Journal article

2023

Deep Immune Profiling Identifies Novel T-Cell Subpopulations That Influence Specific Clinical Outcomes in Chronic Lymphocytic Leukaemia (CLL)

Lim, Y. J., Duckworth, A., Clarke, K., Kennedy, P., Oates, M., Gornall, M., . . . Pettitt, A. (2023). Deep Immune Profiling Identifies Novel T-Cell Subpopulations That Influence Specific Clinical Outcomes in Chronic Lymphocytic Leukaemia (CLL). Blood, 142(Supplement 1), 4626. doi:10.1182/blood-2023-185091

DOI
10.1182/blood-2023-185091
Journal article

High Dimensional Detection of Non-Malignant B-Cells and Its Clinical Implications in Patients with Chronic Lymphocytic Leukaemia (CLL) Undergoing Frontline Therapy

Lim, Y. J., Duckworth, A., Clarke, K., Oates, M., Gornall, M., Kalakonda, N., . . . Pettitt, A. (2023). High Dimensional Detection of Non-Malignant B-Cells and Its Clinical Implications in Patients with Chronic Lymphocytic Leukaemia (CLL) Undergoing Frontline Therapy. Blood, 142(Supplement 1), 1894. doi:10.1182/blood-2023-185018

DOI
10.1182/blood-2023-185018
Journal article

Immunomodulatory Effects of Chemo-Immunotherapy ± Idelalisib in Chronic Lymphocytic Leukaemia (CLL)

Lim, Y. J., Duckworth, A., Clarke, K., Oates, M., Gornall, M., Kalakonda, N., . . . Pettitt, A. (2023). Immunomodulatory Effects of Chemo-Immunotherapy ± Idelalisib in Chronic Lymphocytic Leukaemia (CLL). Blood, 142(Supplement 1), 1455. doi:10.1182/blood-2023-185063

DOI
10.1182/blood-2023-185063
Journal article

Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity

DOI
10.1101/2023.06.05.543731
Preprint

CREATION OF ISOGENIC CELL LINE MODELS OF 17P DELETION TO STUDY CLONAL EVOLUTION AND MECHANISMS OF THERAPY RESISTANCE IN CLL AND DLBCL

van Kampen, F. L., Glenn, M., Pettitt, A., Kalakonda, N., & Slupsky, J. (2023). CREATION OF ISOGENIC CELL LINE MODELS OF 17P DELETION TO STUDY CLONAL EVOLUTION AND MECHANISMS OF THERAPY RESISTANCE IN CLL AND DLBCL. Hematological Oncology, 41(S2), 798-799. doi:10.1002/hon.3165_647

DOI
10.1002/hon.3165_647
Journal article

Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib

Till, K. J., Abdullah, M., Alnassfan, T., Janet, G. Z., Marks, T., Coma, S., . . . Slupsky, J. R. (2023). Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-30148-3

DOI
10.1038/s41598-023-30148-3
Journal article

2022

PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling

DOI
10.1101/2022.09.04.506520
Preprint

Development of a bispecific Antibody–Drug Conjugate targeting CD7 and CD33 to treat Acute Myeloid Leukaemia

DOI
10.1101/2022.07.17.500350
Preprint

2021

2020

Investigation of detaching cells as a potential in vitro model of epithelial–mesenchymal transition in a metastatic pancreatic cancer cell line

Hale, J., Evans, A., Al-Selwi, Y., Costello, E., Slupsky, J., Palmer, D., & Greenhalf, W. (2020). Investigation of detaching cells as a potential in vitro model of epithelial–mesenchymal transition in a metastatic pancreatic cancer cell line. Pancreatology, 20, S134-S135. doi:10.1016/j.pan.2020.07.251

DOI
10.1016/j.pan.2020.07.251
Journal article

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.

Figueiredo, C. R., Kalirai, H., Sacco, J. J., Azevedo, R. A., Duckworth, A., Slupsky, J. R., . . . Coupland, S. E. (2020). Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.. The Journal of Pathology, 250(4), 420-439. doi:10.1002/path.5384

DOI
10.1002/path.5384
Journal article

2019

Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells

DOI
10.1101/841312
Preprint

POTENTIAL THERAPEUTIC ADVANTAGE FOR DUVELISIB IN MANTLE CELL LYMPHOMA: PI3Kδ AND OVEREXPRESSED PI3Kγ IN LYMPHOMA CELLS HAVE SPECIALIZED FUNCTIONAL ROLES

Till, K. J., Gallardo Zapata, J., Marks, T., Weaver, D. T., Pachter, J. A., Abdullah, M., . . . Slupsky, J. R. (2019). POTENTIAL THERAPEUTIC ADVANTAGE FOR DUVELISIB IN MANTLE CELL LYMPHOMA: PI3Kδ AND OVEREXPRESSED PI3Kγ IN LYMPHOMA CELLS HAVE SPECIALIZED FUNCTIONAL ROLES. In Hematological Oncology Vol. 37 (pp. 511-512). Wiley. doi:10.1002/hon.194_2631

DOI
10.1002/hon.194_2631
Conference Paper

PF370 SIGNAL-OMICS ANALYSIS OF THE IMPACT OF THERAPY ON BCR SIGNALLING IN CHRONIC LYMPHOCYTIC LEUKAEMIA

Linley, A., Kalakonda, N., MacEwan, D., Prior, I., & Slupsky, J. (2019). PF370 SIGNAL-OMICS ANALYSIS OF THE IMPACT OF THERAPY ON BCR SIGNALLING IN CHRONIC LYMPHOCYTIC LEUKAEMIA. HemaSphere, 3(S1), 136-137. doi:10.1097/01.hs9.0000559692.06651.82

DOI
10.1097/01.hs9.0000559692.06651.82
Journal article

2018

Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9

Maerken, M., MacEwan, D., Harper, N., Slupsky, J. R., & Linley, A. (2018). Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-113804

DOI
10.1182/blood-2018-99-113804
Conference Paper

2017

2016

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis

Abu-Alainin, W., Gana, T., Liloglou, L., Olayanju, A., Barrera Briceno, L., Ferguson, R., . . . Costello-Goldring, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. Journal of Pathology, 238(3), 423-433. doi:10.1002/path.4665

DOI
10.1002/path.4665
Journal article

2015

Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukaemia cells

Till, K., Pettitt, A., & Slupsky, J. (n.d.). Expression of functional sphingosine-1 phosphate receptor-1is reduced by B cell receptor signaling and increased byinhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukaemia cells. The Journal of Immunology, 194. doi:10.4049/jimmunol.1402304

DOI
10.4049/jimmunol.1402304
Journal article

Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1phosphate receptors and integrins

Middle, S., Coupland, S. E., Taktak, A., Kidgell, V., Slupsky, J. R., Pettitt, A. R., & Till, K. J. (2015). Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1phosphate receptors and integrins. EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 4. doi:10.1186/s40164-015-0004-3

DOI
10.1186/s40164-015-0004-3
Journal article

Slupsky JR. Enhancing BCR signals at the cell membrane. Blood. 2015;125(4):586-587.

Slupsky JR. Enhancing BCR signals at the cell membrane. Blood. 2015;125(4):586-587. (2015). Blood, 125(12), 2008. doi:10.1182/blood-2015-02-627679

DOI
10.1182/blood-2015-02-627679
Journal article

Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells

Till, K. J., Pettitt, A., & Slupsky, J. (2015). Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells. Journal of Immunology, 194(5), 2439-2446. doi:10.4049/jimmunol.1402304

DOI
10.4049/jimmunol.1402304
Journal article

Enhancing BCR signals at the cell membrane

Slupsky, J. R. (2015). Enhancing BCR signals at the cell membrane. BLOOD, 125(4), 586-587. doi:10.1182/blood-2014-11-611756

DOI
10.1182/blood-2014-11-611756
Journal article

Enhancing BCR signals at the cell membrane (vol 125, pg 586, 2015)

Slupsky, J. R. (2015). Enhancing BCR signals at the cell membrane (vol 125, pg 586, 2015). BLOOD, 125(12), 2008. Retrieved from https://www.webofscience.com/

Journal article

Subversion of PKCα signalling in B cell progenitors results in an upregulation of PKCβII expression and leukaemogenesis

Tarafdar, A., Vukovik, M., Cosimo, E., Dunn, K., Slupsky, J. R., & Michie, A. M. (2015). Subversion of PKCα signalling in B cell progenitors results in an upregulation of PKCβII expression and leukaemogenesis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 73). Retrieved from https://www.webofscience.com/

Conference Paper

2014

Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy.

Duckworth, A., Glenn, M., Slupsky, J. R., Packham, G., & Kalakonda, N. (2014). Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy.. Blood, 123(21), 3277-3285. doi:10.1182/blood-2013-11-539049

DOI
10.1182/blood-2013-11-539049
Journal article

THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA

Neill, D. R., Saint, G. L., Bricio-Moreno, L., Fothergill, J., Southern, K. W., Winstanley, C., . . . Flanagan, B. F. (2014). THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA. PLoS One, 9(5). doi:10.1371/journal.pone.0095892.

DOI
10.1371/journal.pone.0095892.
Journal article

Targeting Cell Metabolism In Chronic Lymphocytic Leukaemia (CLL); A Viable Therapeutic Approach?

E. Clapham, C., R. Pettitt, A., & R. Slupsky, J. (n.d.). Targeting Cell Metabolism In Chronic Lymphocytic Leukaemia (CLL); A Viable Therapeutic Approach?. Journal of Hematology And Oncology Research, 1(1), 7-23. doi:10.14302/issn.2372-6601.jhor-13-346

DOI
10.14302/issn.2372-6601.jhor-13-346
Journal article

2013

LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells

Talab, F., Allen, J. C., Thompson, V., Lin, K., & Slupsky, J. R. (2013). LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells. MOLECULAR CANCER RESEARCH, 11(5), 541-554. doi:10.1158/1541-7786.MCR-12-0415-T

DOI
10.1158/1541-7786.MCR-12-0415-T
Journal article

Differential induction of PRDM1 in chronic lymphocytic leukaemia

Duckworth, A. D., Glenn, M. A., Venkateswarlu, P., Slupsky, J. R., Cawley, J. C., & Kalakonda, N. (2013). Differential induction of PRDM1 in chronic lymphocytic leukaemia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 45). Retrieved from https://www.webofscience.com/

Conference Paper

Expression of monocarboxylate transporters-1 and-4 in circulating and CD40L-stimulated chronic lymphocytic leukaemia (CLL) cells

Clapham, C. E., Slupsky, J. R., & Pettitt, A. R. (2013). Expression of monocarboxylate transporters-1 and-4 in circulating and CD40L-stimulated chronic lymphocytic leukaemia (CLL) cells. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 42). Retrieved from https://www.webofscience.com/

Conference Paper

High LCK expression in the malignant cells of chronic lymphocytic leukaemia is a marker of good disease prognosis

Allen, J. C., Talab, F., Thompson, V., Lin, K., Packham, G., & Slupsky, J. R. (2013). High LCK expression in the malignant cells of chronic lymphocytic leukaemia is a marker of good disease prognosis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 47). Retrieved from https://www.webofscience.com/

Conference Paper

Lck is an important mediator of BCR-induced signalling in chronic lymphocytic leukaemia cells

Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2013). Lck is an important mediator of BCR-induced signalling in chronic lymphocytic leukaemia cells. BRITISH JOURNAL OF HAEMATOLOGY, 161, 19. Retrieved from https://www.webofscience.com/

Journal article

Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF

McNamara, P. S., Fonceca, A. M., Howarth, D., Correia, J. B., Slupsky, J. R., Trinick, R. E., . . . Flanagan, B. F. (2013). Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF. THORAX, 68(1), 76-81. doi:10.1136/thoraxjnl-2012-202288

DOI
10.1136/thoraxjnl-2012-202288
Journal article

2012

Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak

Melarangi, T., Zhuang, J., Lin, K., Rockliffe, N., Bosanquet, A. G., Oates, M., . . . Pettitt, A. R. (2012). Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak. CELL DEATH & DISEASE, 3. doi:10.1038/cddis.2012.102

DOI
10.1038/cddis.2012.102
Journal article

Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia

Allen, J. C., & Slupsky, J. R. (2012). Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia. In P. Oppezzo (Ed.), Chronic Lymphocytic Leukemia (pp. 153-178). Rijeka, Croatia: InTech.

Chapter

2011

2.5 Lck is an Important Mediator of BCR-induced Signaling in CLL Cells

Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2011). 2.5 Lck is an Important Mediator of BCR-induced Signaling in CLL Cells. Clinical Lymphoma Myeloma and Leukemia, 11, S162. doi:10.1016/j.clml.2011.09.038

DOI
10.1016/j.clml.2011.09.038
Journal article

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression

Lucas, C. M., Harris, R. J., Giannoudis, A., Copland, M., Slupsky, J. R., & Clark, R. E. (2011). Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. BLOOD, 117(24), 6660-6668. doi:10.1182/blood-2010-08-304477

DOI
10.1182/blood-2010-08-304477
Journal article

c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells

Allen, J. C., Talab, F., Zuzel, M., Lin, K., & Slupsky, J. R. (2011). c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells. BLOOD, 117(8), 2414-2422. doi:10.1182/blood-2010-08-301176

DOI
10.1182/blood-2010-08-301176
Journal article

2010

C-Abl Regulates Mcl-1 Gene Expression In Chronic Lymphocytic Leukaemia Cells

Allen, J. C., Zuzel, M., Lin, K., & Slupsky, J. R. (2010). C-Abl Regulates Mcl-1 Gene Expression In Chronic Lymphocytic Leukaemia Cells. Blood, 116(21), 3579. doi:10.1182/blood.v116.21.3579.3579

DOI
10.1182/blood.v116.21.3579.3579
Journal article

Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells

Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2010). Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells. Blood, 116(21), 375. doi:10.1182/blood.v116.21.375.375

DOI
10.1182/blood.v116.21.375.375
Journal article

Mechanisms of monoclonal antibody-induced platelet activation.

Slupsky, J. R. (2010). Mechanisms of monoclonal antibody-induced platelet activation..

Journal article

Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells

Abrams, S. T., Brown, B. R. B., Zuzel, M., & Slupsky, J. R. (2010). Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells. BLOOD, 115(22), 4447-4454. doi:10.1182/blood-2009-06-229872

DOI
10.1182/blood-2009-06-229872
Journal article

Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells

Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2010). Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells. In BLOOD Vol. 116 (pp. 169-170). Retrieved from https://www.webofscience.com/

Conference Paper

2007

B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII

Abrams, S. T., Lakum, T., Lin, K., Jones, G. M., Treweeke, A. T., Farahani, M., . . . Slupsky, J. R. (2007). B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII. BLOOD, 109(3), 1193-1201. doi:10.1182/blood-2006-03-012021

DOI
10.1182/blood-2006-03-012021
Journal article

Central role of protein kinase Cε in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia

Slupsky, J. R., Kamiguti, A. S., Harris, R. J., Cawley, J. C., & Zuzel, M. (2007). Central role of protein kinase Cε in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia. AMERICAN JOURNAL OF PATHOLOGY, 170(2), 745-754. doi:10.2353/ajpath.2007.060557

DOI
10.2353/ajpath.2007.060557
Journal article

2006

c-Abl expression in chronic lymphocytic leukemia cells: Clinical and therapeutic implications

Lin, K., Glenn, M. A., Harris, R. J., Duckworth, A. D., Dennett, S., Cawley, J. C., . . . Slupsky, J. R. (2006). c-Abl expression in chronic lymphocytic leukemia cells: Clinical and therapeutic implications. CANCER RESEARCH, 66(15), 7801-7809. doi:10.1158/0008-5472.CAN-05-3901

DOI
10.1158/0008-5472.CAN-05-3901
Journal article

2005

Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia

Kamiguti, A. S., Serrander, L., Lin, K., Harris, R. J., Cawley, J. C., Allsup, D. J., . . . Zuzel, M. (2005). Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. JOURNAL OF IMMUNOLOGY, 175(12), 8424-8430. doi:10.4049/jimmunol.175.12.8424

DOI
10.4049/jimmunol.175.12.8424
Journal article

Over-Expression of c-Abl in CLL Cells Is Associated with Advanced Disease, and Contributes to CLL-Cell Survival through Activation of NF-kB.

Lin, K., Harris, R. J., Dennett, S., Cawley, J. C., Zuzel, M., & Slupsky, J. R. (2005). Over-Expression of c-Abl in CLL Cells Is Associated with Advanced Disease, and Contributes to CLL-Cell Survival through Activation of NF-kB.. Blood, 106(11), 1191. doi:10.1182/blood.v106.11.1191.1191

DOI
10.1182/blood.v106.11.1191.1191
Journal article

B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia

Allsup, D. J., Kamiguti, A. S., Lin, K., Sherrington, P. D., Matrai, Z., Slupsky, J. R., . . . Zuzel, N. (2005). B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia. CANCER RESEARCH, 65(16), 7328-7337. doi:10.1158/0008-5472.CAN-03-1563

DOI
10.1158/0008-5472.CAN-03-1563
Journal article

Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia

Kamiguti, A. S., Serrander, L., Lin, K., Harris, R. J., Cawley, J. C., Allsup, D. J., . . . Zuzel, M. (2005). Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol., 175(12), 8424-8430. Retrieved from http://www.jimmunol.org/cgi/content/full/175/12/8424

Journal article

Over-expression of c-Abl in CLL cells is associated with advanced disease, and contributes to CLL-cell survival through activation of NF-kB

Lin, K., Harris, R. J., Dennett, S., Cawley, J. C., Zuzel, M., & Slupsky, J. R. (2005). Over-expression of c-Abl in CLL cells is associated with advanced disease, and contributes to CLL-cell survival through activation of NF-kB. In BLOOD Vol. 106 (pp. 348A). Retrieved from https://www.webofscience.com/

Conference Paper

2004

Function and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells

Syrovets, T., Colognato, R., Slupsky, J. R., & Simmet, T. (2004). Function and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. In FASEB JOURNAL Vol. 18 (pp. C301). Retrieved from https://www.webofscience.com/

Conference Paper

2003

Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells

Colognato, R., Slupsky, J. R., Jendrach, M., Burysek, L., Syrovets, T., & Simmet, T. (2003). Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. BLOOD, 102(7), 2645-2652. doi:10.1182/blood-2002-08-2497

DOI
10.1182/blood-2002-08-2497
Journal article

The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL)

Aziz, K. A., Till, K. J., Chen, H. J., Slupsky, J. R., Campbell, F., Cawley, J. C., & Zuzel, M. (2003). The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL). BLOOD, 102(3), 1051-1056. doi:10.1182/blood-2002-12-3737

DOI
10.1182/blood-2002-12-3737
Journal article

Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways

Kamiguti, A. S., Harris, R. J., Slupsky, J. R., Baker, P. K., Cawley, J. C., & Zuzel, M. (2003). Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways. ONCOGENE, 22(15), 2272-2284. doi:10.1038/sj.onc.1206398

DOI
10.1038/sj.onc.1206398
Journal article

Malignant cell signalling in chronic lymphocytic and hairy-cell leukaemias.

Kamiguti, A. S., Slupsky, J. R., & Zuzel, M. (2003). Malignant cell signalling in chronic lymphocytic and hairy-cell leukaemias.. In S. G. Pandalai (Ed.), Recent Research Developments in Haematology (Vol. 1, pp. 81-101). Trivandrum: Transworld Research Network.

Chapter

2002

Response of hairy cells to IFN-α involves induction of apoptosis through autocrine TNF-α and protection by adhesion

Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to IFN-α involves induction of apoptosis through autocrine TNF-α and protection by adhesion. BLOOD, 100(2), 647-653. doi:10.1182/blood.V100.2.647

DOI
10.1182/blood.V100.2.647
Journal article

Characterization of protease-activated receptor expression in human peripheral monocytes and antigen presenting cells

Colognato, R., Slupsky, J. R., Jendrach, M., Syrovets, T., & Simmet, T. (2002). Characterization of protease-activated receptor expression in human peripheral monocytes and antigen presenting cells. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol. 365 (pp. R76). Retrieved from https://www.webofscience.com/

Conference Paper

Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion

Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion. Blood, 100(2), 647-653.

Journal article

Response of hairy cells to α-IFN involves induction of apoptosis through autocrine TNF-α and protection by adhesion.

Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to α-IFN involves induction of apoptosis through autocrine TNF-α and protection by adhesion.. In BLOOD Vol. 100 (pp. 596A). Retrieved from https://www.webofscience.com/

Conference Paper

2001

Active Ras induces heterodimerization of cRaf and BRaf

Weber, C. K., Slupsky, J. R., Kalmes, H. A., & Rapp, U. R. (2001). Active Ras induces heterodimerization of cRaf and BRaf. CANCER RESEARCH, 61(9), 3595-3598. Retrieved from https://www.webofscience.com/

Journal article

Regulation of protease-activated receptor-1 and-2 expression on antigen presenting cells by cytokines

Colognato, R., Slupsky, J. R., Jendrach, M., Burysek, L., & Simmet, T. (2001). Regulation of protease-activated receptor-1 and-2 expression on antigen presenting cells by cytokines. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol. 363 (pp. R82). Retrieved from https://www.webofscience.com/

Conference Paper

2000

Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIα

Syrovets, T., Büchele, B., Gedig, E., Slupsky, J. R., & Simmet, T. (2000). Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIα. MOLECULAR PHARMACOLOGY, 58(1), 71-81. doi:10.1124/mol.58.1.71

DOI
10.1124/mol.58.1.71
Journal article

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

Weber, C. K., Slupsky, J. R., Herrmann, C., Schuler, M., Rapp, U. R., & Block, C. (2000). Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes. ONCOGENE, 19(2), 169-176. doi:10.1038/sj.onc.1203261

DOI
10.1038/sj.onc.1203261
Journal article

1999

Binding of Gβγ subunits to cRaf1 downregulates G-protein-coupled receptor signalling

Slupsky, J. R., Quitterer, U., Weber, C. K., Gierschik, P., Lohse, M. J., & Rapp, U. R. (1999). Binding of Gβγ subunits to cRaf1 downregulates G-protein-coupled receptor signalling. CURRENT BIOLOGY, 9(17), 971-974. doi:10.1016/S0960-9822(99)80426-6

DOI
10.1016/S0960-9822(99)80426-6
Journal article

1998

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

Henn, V., Slupsky, J. R., Gräfe, M., Anagnostopoulos, I., Förster, R., Müller-Berghaus, G., & Kroczek, R. A. (1998). CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. NATURE, 391(6667), 591-594. doi:10.1038/35393

DOI
10.1038/35393
Journal article

Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40

Slupsky, J. R., Kalbas, M., Willuweit, A., Henn, V., Kroczek, R. A., & Müller-Berghaus, G. (1998). Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40. THROMBOSIS AND HAEMOSTASIS, 80(6), 1008-1014. Retrieved from https://www.webofscience.com/

Journal article

Raf-dependent signaling pathways in cell growth and differentiation

Slupsky, J. R., Weber, C. K., Ludwig, S., & Rapp, U. R. (1998). Raf-dependent signaling pathways in cell growth and differentiation. In Cell Growth and Oncogenesis (pp. 75-95). Birkhäuser Basel. doi:10.1007/978-3-0348-8950-6_6

DOI
10.1007/978-3-0348-8950-6_6
Chapter

1997

The platelet antigens CD9, CD42 and integrin alpha(IIb)beta(IIIa) can be topographically associated and transduce functionally similar signals

Slupsky, J. R., Kamiguti, A. S., Rhodes, N. P., Cawley, J. C., Shaw, A. R. E., & Zuzel, M. (1997). The platelet antigens CD9, CD42 and integrin alpha(IIb)beta(IIIa) can be topographically associated and transduce functionally similar signals. EUROPEAN JOURNAL OF BIOCHEMISTRY, 244(1), 168-175. doi:10.1111/j.1432-1033.1997.00168.x

DOI
10.1111/j.1432-1033.1997.00168.x
Journal article

Analysis of CD9, CD32 and p67 signalling: Use of degranulated platelets indicates direct involvement of CD9 and p67 in integrin activation

Slupsky, J. R., Cawley, J. C., Kaplan, C., & Zuzel, M. (1997). Analysis of CD9, CD32 and p67 signalling: Use of degranulated platelets indicates direct involvement of CD9 and p67 in integrin activation. BRITISH JOURNAL OF HAEMATOLOGY, 96(2), 275-286. doi:10.1046/j.1365-2141.1997.d01-2011.x

DOI
10.1046/j.1365-2141.1997.d01-2011.x
Journal article

TRAP (CD40 ligand) on activated platelets triggers a pro-inflammatory reaction of endothelial cells

Henn, V., Slupsky, J. R., Grafe, M., Muller-Berghaus, G., & Kroczek, R. A. (1997). TRAP (CD40 ligand) on activated platelets triggers a pro-inflammatory reaction of endothelial cells. In Immunobiology Vol. 197 (pp. 305).

Conference Paper

1996

GTP gamma S-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not via tyrosine kinases

Lowe, G. M., Slupsky, J. R., Galvani, D. W., & Edwards, S. W. (1996). GTP gamma S-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not via tyrosine kinases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 220(3), 484-490. doi:10.1006/bbrc.1996.0431

DOI
10.1006/bbrc.1996.0431
Journal article

GTPγS-Stimulated Phospholipase D Activation in Human Neutrophils Occurs by Protein Kinase C-Dependent and -Independent Pathways but Not via Tyrosine Kinases

Lowe, G. M., Slupsky, J. R., Galvani, D. W., & Edwards, S. W. (1996). GTPγS-Stimulated Phospholipase D Activation in Human Neutrophils Occurs by Protein Kinase C-Dependent and -Independent Pathways but Not via Tyrosine Kinases. Biochemical and Biophysical Research Communications, 220(3), 484-490. doi:10.1006/bbrc.1996.0431

DOI
10.1006/bbrc.1996.0431
Journal article

CD9 associates with CD36 to form novel high density molecular aggregates in collagen stimulated human platelets.

Shaw, A. R. E., Seehafer, J. G., & Slupsky, J. R. (1996). CD9 associates with CD36 to form novel high density molecular aggregates in collagen stimulated human platelets.. In BLOOD Vol. 88 (pp. 95). Retrieved from https://www.webofscience.com/

Conference Paper

1995

CD9, 41 & 42 on platelets can be topographically associated and transduce functionally similar signals.

Slupsky, J. R., Shaw, R. E., & Zuzel, M. (1995). CD9, 41 & 42 on platelets can be topographically associated and transduce functionally similar signals.. In BLOOD Vol. 86 (pp. 2196). Retrieved from https://www.webofscience.com/

Conference Paper

ENDOTHELIAL-CELLS EXPRESS A FUNCTIONALLY IDENTICAL BUT IMMUNOLOGICALLY DIFFERENT VARIANT OF PLATELET GLYCOPROTEIN-IB

SLUPSKY, J. R., KROPP, B., & POTZSCH, B. (1995). ENDOTHELIAL-CELLS EXPRESS A FUNCTIONALLY IDENTICAL BUT IMMUNOLOGICALLY DIFFERENT VARIANT OF PLATELET GLYCOPROTEIN-IB. In THROMBOSIS AND HAEMOSTASIS Vol. 73 (pp. 909). Retrieved from https://www.webofscience.com/

Conference Paper

1994

PROPERTIES OF FIBRINOGEN CLEAVED BY JARARHAGIN, A METALLOPROTEINASE FROM THE VENOM OF BOTHROPS-JARARACA

KAMIGUTI, A. S., SLUPSKY, J. R., ZUZEL, M., & HAY, C. R. M. (1994). PROPERTIES OF FIBRINOGEN CLEAVED BY JARARHAGIN, A METALLOPROTEINASE FROM THE VENOM OF BOTHROPS-JARARACA. THROMBOSIS AND HAEMOSTASIS, 72(2), 244-249. Retrieved from https://www.webofscience.com/

Journal article

1993

C-FMS PROTEIN EXPRESSION BY B-CELLS, WITH PARTICULAR REFERENCE TO THE HAIRY-CELLS OF HAIRY-CELL LEUKEMIA

TILL, K. J., LOPEZ, A., SLUPSKY, J., & CAWLEY, J. C. (1993). C-FMS PROTEIN EXPRESSION BY B-CELLS, WITH PARTICULAR REFERENCE TO THE HAIRY-CELLS OF HAIRY-CELL LEUKEMIA. BRITISH JOURNAL OF HAEMATOLOGY, 83(2), 223-231. doi:10.1111/j.1365-2141.1993.tb08276.x

DOI
10.1111/j.1365-2141.1993.tb08276.x
Journal article

THE PEANUT-AGGLUTININ (PNA)-BINDING SURFACE COMPONENTS OF MALIGNANT PLASMA-CELLS

SLUPSKY, J. R., DUGGANKEEN, M., BOOTH, L. A., KARPAS, A., RHODES, E. G. H., CAWLEY, J. C., & ZUZEL, M. (1993). THE PEANUT-AGGLUTININ (PNA)-BINDING SURFACE COMPONENTS OF MALIGNANT PLASMA-CELLS. BRITISH JOURNAL OF HAEMATOLOGY, 83(4), 567-573. doi:10.1111/j.1365-2141.1993.tb04692.x

DOI
10.1111/j.1365-2141.1993.tb04692.x
Journal article

1992

ROLE OF FC-GAMMA-RII IN PLATELET ACTIVATION BY MONOCLONAL-ANTIBODIES

SLUPSKY, J. R., CAWLEY, J. C., GRIFFITH, L. S., SHAW, A. R. E., & ZUZEL, M. (1992). ROLE OF FC-GAMMA-RII IN PLATELET ACTIVATION BY MONOCLONAL-ANTIBODIES. JOURNAL OF IMMUNOLOGY, 148(10), 3189-3194. Retrieved from https://www.webofscience.com/

Journal article

1991

PLATELET ACTIVATION BY IMMOBILIZED MONOCLONAL-ANTIBODY - EVIDENCE FOR A CD9 PROXIMAL SIGNAL

GRIFFITH, L., SLUPSKY, J., SEEHAFER, J., BOSHKOV, L., & SHAW, A. R. E. (1991). PLATELET ACTIVATION BY IMMOBILIZED MONOCLONAL-ANTIBODY - EVIDENCE FOR A CD9 PROXIMAL SIGNAL. BLOOD, 78(7), 1753-1759. Retrieved from https://www.webofscience.com/

Journal article

Platelet activation by immobilized monoclonal antibody: evidence for a CD9 proximal signal

Griffith, L., Slupsky, J., Seehafer, J., Boshkov, L., & Shaw, A. R. (1991). Platelet activation by immobilized monoclonal antibody: evidence for a CD9 proximal signal. Blood, 78(7), 1753-1759. doi:10.1182/blood.v78.7.1753.1753

DOI
10.1182/blood.v78.7.1753.1753
Journal article

1990

MYRISTIC ACID IS INCORPORATED INTO THE 2 ACYLATABLE DOMAINS OF THE FUNCTIONAL GLYCOPROTEIN CD9 IN ESTER, BUT NOT IN AMIDE BONDS

SEEHAFER, J. G., SLUPSKY, J. R., TANG, S. C., MASELLISSMITH, A., & SHAW, A. R. E. (1990). MYRISTIC ACID IS INCORPORATED INTO THE 2 ACYLATABLE DOMAINS OF THE FUNCTIONAL GLYCOPROTEIN CD9 IN ESTER, BUT NOT IN AMIDE BONDS. BIOCHIMICA ET BIOPHYSICA ACTA, 1039(2), 218-226. doi:10.1016/0167-4838(90)90189-M

DOI
10.1016/0167-4838(90)90189-M
Journal article

ANTI-CD9 MONOCLONAL-ANTIBODIES INDUCE HOMOTYPIC ADHESION OF PRE-B CELL-LINES BY A NOVEL MECHANISM

MASELLISSMITH, A., JENSEN, G. S., SEEHAFER, J. G., SLUPSKY, J. R., & SHAW, A. R. E. (1990). ANTI-CD9 MONOCLONAL-ANTIBODIES INDUCE HOMOTYPIC ADHESION OF PRE-B CELL-LINES BY A NOVEL MECHANISM. JOURNAL OF IMMUNOLOGY, 144(5), 1607-1613. Retrieved from https://www.webofscience.com/

Journal article

1989

EVIDENCE THAT MONOCLONAL-ANTIBODIES AGAINST CD9 ANTIGEN INDUCE SPECIFIC ASSOCIATION BETWEEN CD9 AND THE PLATELET GLYCOPROTEIN-IIB-GLYCOPROTEIN-IIIA COMPLEX

SLUPSKY, J. R., SEEHAFER, J. G., TANG, S. C., MASELLISSMITH, A., & SHAW, A. R. E. (1989). EVIDENCE THAT MONOCLONAL-ANTIBODIES AGAINST CD9 ANTIGEN INDUCE SPECIFIC ASSOCIATION BETWEEN CD9 AND THE PLATELET GLYCOPROTEIN-IIB-GLYCOPROTEIN-IIIA COMPLEX. JOURNAL OF BIOLOGICAL CHEMISTRY, 264(21), 12289-12293. Retrieved from https://www.webofscience.com/

Journal article

MONOCLONAL-ANTIBODIES REACTIVE WITH HAIRY-CELL LEUKEMIA

VISSER, L., SHAW, A., SLUPSKY, J., VOS, H., & POPPEMA, S. (1989). MONOCLONAL-ANTIBODIES REACTIVE WITH HAIRY-CELL LEUKEMIA. BLOOD, 74(1), 320-325. Retrieved from https://www.webofscience.com/

Journal article

1988

THE FUNCTIONAL GLYCOPROTEIN-CD9 IS VARIABLY ACYLATED - LOCALIZATION OF THE VARIABLY ACYLATED REGION TO A MEMBRANE-ASSOCIATED PEPTIDE CONTAINING THE BINDING-SITE FOR THE AGONISTIC MONOCLONAL-ANTIBODY 50H.19

SEEHAFER, J. G., TANG, S. C., SLUPSKY, J. R., & SHAW, A. R. E. (1988). THE FUNCTIONAL GLYCOPROTEIN-CD9 IS VARIABLY ACYLATED - LOCALIZATION OF THE VARIABLY ACYLATED REGION TO A MEMBRANE-ASSOCIATED PEPTIDE CONTAINING THE BINDING-SITE FOR THE AGONISTIC MONOCLONAL-ANTIBODY 50H.19. BIOCHIMICA ET BIOPHYSICA ACTA, 957(3), 399-410. doi:10.1016/0167-4838(88)90231-2

DOI
10.1016/0167-4838(88)90231-2
Journal article

THE FUNCTIONAL CELL-SURFACE GLYCOPROTEIN CD9 IS DISTINGUISHED BY BEING THE MAJOR FATTY-ACID ACYLATED AND A MAJOR IODINATED CELL-SURFACE COMPONENT OF THE HUMAN-PLATELET

SEEHAFER, J. G., SLUPSKY, J. R., TANG, S. C., & SHAW, A. R. E. (1988). THE FUNCTIONAL CELL-SURFACE GLYCOPROTEIN CD9 IS DISTINGUISHED BY BEING THE MAJOR FATTY-ACID ACYLATED AND A MAJOR IODINATED CELL-SURFACE COMPONENT OF THE HUMAN-PLATELET. BIOCHIMICA ET BIOPHYSICA ACTA, 952(1), 92-100. doi:10.1016/0167-4838(88)90105-7

DOI
10.1016/0167-4838(88)90105-7
Journal article

1987

CHARACTERIZATION OF CARDIAC CALSEQUESTRIN

SLUPSKY, J. R., OHNISHI, M., CARPENTER, M. R., & REITHMEIER, R. A. F. (1987). CHARACTERIZATION OF CARDIAC CALSEQUESTRIN. BIOCHEMISTRY, 26(20), 6539-6544. doi:10.1021/bi00394a038

DOI
10.1021/bi00394a038
Journal article

CALSEQUESTRIN121Supported by grants from the Medical Research Council of Canada (D.H.M.), the Heart and Stroke Foundation of Ontario (D.H.M.), the Muscular Dystrophy Association of Canada (D.H.M. and R.A.F.R.) and the Alberta Heritage Foundation for Medical Research (R.A.F.R and M.O.).2Present address: Membrane Biology Group, Department of Medicine, Room 7307, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8

Reithmeier, R. A. F., Ohnishi, M., Carpenter, M. R., Slupsky, J. R., Gounden, K., Fliegel, L., . . . MacLennan, D. H. (1987). CALSEQUESTRIN121Supported by grants from the Medical Research Council of Canada (D.H.M.), the Heart and Stroke Foundation of Ontario (D.H.M.), the Muscular Dystrophy Association of Canada (D.H.M. and R.A.F.R.) and the Alberta Heritage Foundation for Medical Research (R.A.F.R and M.O.).2Present address: Membrane Biology Group, Department of Medicine, Room 7307, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8. In Calcium-Binding Proteins in Health and Disease (pp. 62-71). Elsevier. doi:10.1016/b978-0-12-521040-9.50013-9

DOI
10.1016/b978-0-12-521040-9.50013-9
Chapter