Publications
Selected publications
- Toxoplasma gondii‐infected natural killer cells display a hypermotility phenotype in vivo (Journal article - 2015)
- Motile invaded neutrophils in the small intestine of <i>Toxoplasma gondii</i>-infected mice reveal a potential mechanism for parasite spread (Journal article - 2013)
- Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus (Journal article - 2012)
- An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium (Journal article - 2019)
- Developing a 3D intestinal epithelium model for livestock species (Journal article - 2019)
2021
Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus.
Wang, Y., Sharma, P., Jefferson, M., Zhang, W., Bone, B., Kipar, A., . . . Wileman, T. (2021). Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus.. The EMBO Journal, e105543. doi:10.15252/embj.2020105543
2020
Stem cell‐derived enteroid cultures as a tool for dissecting host‐parasite interactions in the small intestinal epithelium
Hares, M. F., Tiffney, E. -A., Johnston, L. J., Luu, L., Stewart, C. J., Flynn, R. J., & Coombes, J. L. (2020). Stem cell‐derived enteroid cultures as a tool for dissecting host‐parasite interactions in the small intestinal epithelium. Parasite Immunology. doi:10.1111/pim.12765
The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal respiratory infection by influenza A virus at epithelial surfaces
Wang, Y., Zhang, W., Jefferson, M., Sharma, P., Bone, B., Kipar, A., . . . Wileman, T. (2020). The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal respiratory infection by influenza A virus at epithelial surfaces. doi:10.1101/2020.01.15.907873
2019
Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract
Carvalho, A. L., Fonseca, S., Miquel-Clopés, A., Cross, K., Kok, K. S., Wegmann, U., . . . Carding, S. R. (2019). Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract. Journal of Extracellular Vesicles, 8(1). doi:10.1080/20013078.2019.1632100
An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium
Luu, L., Johnston, L. J., Derricott, H., Armstrong, S. D., Randle, N., Hartley, C. S., . . . Coombes, J. L. (2019). An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 9. doi:10.3389/fcimb.2019.00300
Developing a 3D intestinal epithelium model for livestock species
Derricott, H., Luu, L., Fong, W. Y., Hartley, C. S., Johnston, L. J., Armstrong, S. D., . . . Coombes, J. L. (2019). Developing a 3D intestinal epithelium model for livestock species. Cell and Tissue Research, 375(02), 409-424. doi:10.1007/s00441-018-2924-9
2018
Proteomic Profiling of Enteroid Cultures Skewed Towards Development of Specific Epithelial Lineages
Luu, L., Matthews, Z. J., Armstrong, S. D., Powell, P., Wileman, T., Wastling, J. M., & Coombes, J. L. (2018). Proteomic Profiling of Enteroid Cultures Skewed Towards Development of Specific Epithelial Lineages. Proteomics, 18(16). doi:10.1002/pmic.201800132
Parasitized Natural Killer cells do not facilitate the spread of <i>Toxoplasma gondii</i> to the brain
Petit-Jentreau, L., Glover, C., & Coombes, J. L. (2018). Parasitized Natural Killer cells do not facilitate the spread of <i>Toxoplasma gondii</i> to the brain. PARASITE IMMUNOLOGY, 40(4). doi:10.1111/pim.12522
2017
Purinergic Signaling: A Common Path in the Macrophage Response against Mycobacterium tuberculosis and Toxoplasma gondii
Petit-Jentreau, L., Tailleux, L., & Coombes, J. L. (2017). Purinergic Signaling: A Common Path in the Macrophage Response against <i>Mycobacterium tuberculosis</i> and <i>Toxoplasma gondii</i>. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 7, 1-7. doi:10.3389/fcimb.2017.00347
2015
Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo
Ueno, N., Lodoen, M. B., Hickey, G. L., Robey, E. A., & Coombes, J. L. (2015). Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo. Immunology and Cell Biology, 93(05), 508-513. doi:10.1038/icb.2014.106
Toxoplasma gondii‐infected natural killer cells display a hypermotility phenotype in vivo
Ueno, N., Lodoen, M. B., Hickey, G., Robey, E. A., & Coombes, J. (2015). Toxoplasma gondii‐infected natural killer cells display a hypermotility phenotype in vivo. Immunology and Cell Biology, 93(5), 508-513. doi:10.1038/icb.2014.106
Dynamic two-photon imaging of the immune response to <i>Toxoplasma gondii</i> infection
Luu, L., & Coombes, J. L. (2015). Dynamic two-photon imaging of the immune response to <i>Toxoplasma gondii</i> infection. PARASITE IMMUNOLOGY, 37(3), 118-126. doi:10.1111/pim.12161
Immunity to <i>Toxoplasma gondii</i> - into the 21st century
Coombes, J. L., & Hunter, C. A. (2015). Immunity to <i>Toxoplasma gondii</i> - into the 21st century. PARASITE IMMUNOLOGY, 37(3), 105-107. doi:10.1111/pim.12177
2014
Monophasic expression of FliC by <i>Salmonella</i> 4,[5], 12:i:-DT193 does not alter its pathogenicity during infection of porcine intestinal epithelial cells
Crayford, G., Coombes, J. L., Humphrey, T. J., & Wigley, P. (2014). Monophasic expression of FliC by <i>Salmonella</i> 4,[5], 12:i:-DT193 does not alter its pathogenicity during infection of porcine intestinal epithelial cells. MICROBIOLOGY-SGM, 160, 2507-2516. doi:10.1099/mic.0.081349-0
Monophasic expression of FliC by Salmonella 4,[5],12:i:- DT193 does not alter its pathogenicity during infection of porcine intestinal epithelial cells
Crayford, G., Coombes, J. L., Humphrey, T. J., & Wigley, P. (2014). Monophasic expression of FliC by Salmonella 4,[5],12:i:- DT193 does not alter its pathogenicity during infection of porcine intestinal epithelial cells. Microbiology, 160(11), 2507-2516. doi:10.1099/mic.0.081349-0
Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii
Han, S. -J., Melichar, H. J., Coombes, J., Chan, S. W., Koshy, A. A., Boothroyd, J. C., . . . Robey, E. A. (2014). Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii. Immunology and Cell Biology, 92(10), 872-881. doi:10.1038/icb.2014.70
2013
Motile invaded neutrophils in the small intestine of <i>Toxoplasma gondii</i>-infected mice reveal a potential mechanism for parasite spread
Coombes, J. L., Charsar, B. A., Han, S. -J., Halkias, J., Chan, S. W., Koshy, A. A., . . . Robey, E. A. (2013). Motile invaded neutrophils in the small intestine of <i>Toxoplasma gondii</i>-infected mice reveal a potential mechanism for parasite spread. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(21), E1913-E1922. doi:10.1073/pnas.1220272110
2012
Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus
Coombes, J. L., Han, S. -J., van Rooijen, N., Raulet, D. H., & Robey, E. A. (2012). Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus. CELL REPORTS, 2(1), 124-135. doi:10.1016/j.celrep.2012.06.001
2011
Faculty Opinions recommendation of T lymphocytes negatively regulate lymph node lymphatic vessel formation.
Robey, E., & Coombes, J. (2011). Faculty Opinions recommendation of T lymphocytes negatively regulate lymph node lymphatic vessel formation.. doi:10.3410/f.8095960.8746054
2010
Dynamic imaging of host-pathogen interactions <i>in vivo</i>
Coombes, J. L., & Robey, E. A. (2010). Dynamic imaging of host-pathogen interactions <i>in vivo</i>. NATURE REVIEWS IMMUNOLOGY, 10(5), 353-364. doi:10.1038/nri2746
2009
Regulatory Lymphocytes and Intestinal Inflammation
Izcue, A., Coombes, J. L., & Powrie, F. (2009). Regulatory Lymphocytes and Intestinal Inflammation. ANNUAL REVIEW OF IMMUNOLOGY, 27, 313-338. doi:10.1146/annurev.immunol.021908.132657
2008
Small intestinal CD103<SUP>+</SUP> dendritic cells display unique functional properties that are conserved between mice and humans
Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J. L., . . . Agace, W. W. (2008). Small intestinal CD103<SUP>+</SUP> dendritic cells display unique functional properties that are conserved between mice and humans. JOURNAL OF EXPERIMENTAL MEDICINE, 205(9), 2139-2149. doi:10.1084/jem.20080414
Dendritic cells in intestinal immune regulation
Coombes, J. L., & Powrie, F. (2008). Dendritic cells in intestinal immune regulation. NATURE REVIEWS IMMUNOLOGY, 8(6), 435-446. doi:10.1038/nri2335
2007
A functionally specialized population of mucosal CD103<SUP>+</SUP> DCs induces Foxp3<SUP>+</SUP> regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Carcamo, C. V., Hall, J., Sun, C. -M., Belkaid, Y., & Powrie, F. (2007). A functionally specialized population of mucosal CD103<SUP>+</SUP> DCs induces Foxp3<SUP>+</SUP> regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism. JOURNAL OF EXPERIMENTAL MEDICINE, 204(8), 1757-1764. doi:10.1084/jem.20070590
Control of intestinal homeostasis by regulatory T cells and dendritic cells
Coombes, J. L., & Maloy, K. J. (2007). Control of intestinal homeostasis by regulatory T cells and dendritic cells. SEMINARS IN IMMUNOLOGY, 19(2), 116-126. doi:10.1016/j.smim.2007.01.001
2006
Characterization of Foxp3<SUP>+</SUP>CD4<SUP>+</SUP>CD25<SUP>+</SUP> and IL-10-secreting CD4<SUP>+</SUP>CD25<SUP>+</SUP> T cells during cure of colitis
Uhlig, H. H., Coombes, J., Mottet, C., Izcue, A., Thompson, C., Fanger, A., . . . Powrie, F. (2006). Characterization of Foxp3<SUP>+</SUP>CD4<SUP>+</SUP>CD25<SUP>+</SUP> and IL-10-secreting CD4<SUP>+</SUP>CD25<SUP>+</SUP> T cells during cure of colitis. JOURNAL OF IMMUNOLOGY, 177(9), 5852-5860. doi:10.4049/jimmunol.177.9.5852
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
Izcue, A., Coombes, J. L., & Powrie, F. (2006). Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. IMMUNOLOGICAL REVIEWS, 212, 256-271. doi:10.1111/j.0105-2896.2006.00423.x
2005
Essential role for CD103 in the T cell-mediated regulation of experimental colitis
Annacker, O., Coombes, J. L., Malmstrom, V., Uhlig, H. H., Bourne, T., Johansson-Lindbom, B., . . . Powrie, F. (2005). Essential role for CD103 in the T cell-mediated regulation of experimental colitis. JOURNAL OF EXPERIMENTAL MEDICINE, 202(8), 1051-1061. doi:10.1084/jem.20040662
Regulatory T cells and intestinal homeostasis
Coombes, J. L., Robinson, N. J., Maloy, K. J., Uhlig, H. H., & Powrie, F. (2005). Regulatory T cells and intestinal homeostasis. IMMUNOLOGICAL REVIEWS, 204, 184-194. doi:10.1111/j.0105-2896.2005.00250.x