Publications
2024
Systemic delivery of bictegravir and tenofovir alafenamide using dissolving microneedles for HIV preexposure prophylaxis.
Zhang, C., Wu, Y., Hutton, A. R. J., Hidayat Bin Sabri, A., Hobson, J. J., Savage, A. C., . . . Donnelly, R. F. (2024). Systemic delivery of bictegravir and tenofovir alafenamide using dissolving microneedles for HIV preexposure prophylaxis.. International journal of pharmaceutics, 124317. doi:10.1016/j.ijpharm.2024.124317
2023
Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters
Neary, M., Sharp, J., Gallardo-Toledo, E., Herriott, J., Kijak, E., Bramwell, C., . . . Owen, A. (2023). Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters. VIRUSES-BASEL, 15(8). doi:10.3390/v15081744
Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations.
Curley, P., Hobson, J. J., Liptrott, N. J., Makarov, E., Al-Khouja, A., Tatham, L., . . . Owen, A. (2023). Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations.. Pharmaceutics, 15(7), 1835. doi:10.3390/pharmaceutics15071835
2022
Aqueous (co)polymer stabilisers for size-controlled 2-5 nm gold nanoparticle synthesis with tuneable catalytic activity
Traynor, D. J., Urena-Horno, E., Hobson, J. J., Croft, E. J., Edwards, S. E., Rannard, S. P., & Giardiello, M. (2022). Aqueous (co)polymer stabilisers for size-controlled 2-5 nm gold nanoparticle synthesis with tuneable catalytic activity. NEW JOURNAL OF CHEMISTRY, 46(36), 17282-17291. doi:10.1039/d2nj03257k
2021
Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection
Hobson, J. J., Savage, A. C., Dwyer, A., Unsworth, C., Massam, J., Arshad, U., . . . Rannard, S. (n.d.). Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. Nanoscale. doi:10.1039/d1nr00309g
Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection
Hobson, J., Savage, A., Dwyer, A., Unsworth, C., Arshad, U., Pertinez, H., . . . Rannard, S. (2021). Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. doi:10.26434/chemrxiv.13587035.v1
2020
Mucus-responsive functionalized emulsions: design, synthesis and study of novel branched polymers as functional emulsifiers
Edwards, S. E., Flynn, S., Hobson, J. J., Chambon, P., Cauldbeck, H., & Rannard, S. P. (2020). Mucus-responsive functionalized emulsions: design, synthesis and study of novel branched polymers as functional emulsifiers. RSC ADVANCES, 10(51), 30463-30475. doi:10.1039/d0ra05820c
Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected, drug-free, anticoagulant activity
Hobson, J. J., Rannard, S. P., Owen, A., & Liptrott, N. J. (2020). Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected, drug-free, anticoagulant activity. Nanomedicine. doi:10.2217/nnm-2019-0447
2019
Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations
Hobson, J. J., Curley, P., Savage, A. C., Al-khouja, A., Siccardi, M., Flexner, C., . . . Rannard, S. P. (2019). Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations. NANOSCALE ADVANCES, 1(11), 4301-4307. doi:10.1039/c9na00529c
Semi-solid pro-drug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs for combination HIV therapies
Hobson, J., Al-Khouja, A., Curley, P., Flexner, C., Meyers, C., Owen, A., & Rannard, S. (2017). Semi-solid pro-drug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs for combination HIV therapies. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from https://www.webofscience.com/
Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
Hobson, J., Al-Khouja, A., Curley, P., Meyers, D., Flexner, C., Siccardi, M., . . . Rannard, S. P. (2019). Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies. Nature Communications, 10. doi:10.1038/s41467-019-09354-z
2018
The potential value of nanomedicine and novel oral dosage forms in the treatment of HIV.
Hobson, J. J., Owen, A., & Rannard, S. P. (2018). The potential value of nanomedicine and novel oral dosage forms in the treatment of HIV. NANOMEDICINE, 13(16), 1963-1965. doi:10.2217/nnm-2018-0182
Improved Oral In Vivo Pharmacokinetics of Novel Oil in Water Solid Drug Nanoparticle formulations of Tenofovir Disoproxil Fumarate for the treatment of HIV
Curley, P., Hobson, J., David, C., Box, H., Neary, M. G., Sharp, J., . . . Owen, A. (n.d.). Improved Oral In Vivo Pharmacokinetics of Novel Oil in Water Solid Drug Nanoparticle formulations of Tenofovir Disoproxil Fumarate for the treatment of HIV. In CLINAM European Foundation for Clinical Nanomedicine.
Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems
Hobson, J., Edwards, S., Slater, R., Martin, P., Owen, A., & Rannard, S. P. (2018). Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems. RSC Advances. doi:10.1039/c8ra01944d
Development of prodrug approaches for long-acting nanoformulations of emtricitabine-based regimens
Al-Khouja, A., Hobson, J., Meyers, D., Curley, P., Siliciano, J., Siliciano, R., . . . Meyers, C. (2017). Development of prodrug approaches for long-acting nanoformulations of emtricitabine-based regimens. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from https://www.webofscience.com/
Development of Prodrug Approaches for Long-Acting Nanoformulations of Emtricitabine-Based Regimens
Al-Khouja, A., Hobson, J. J., Henriquez, S., Meyers, D., Curley, P., Siccardi, M., . . . Meyers, C. L. F. (2018). Development of Prodrug Approaches for Long-Acting Nanoformulations of Emtricitabine-Based Regimens. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/
Solid drug nanoparticles synthesised using spontaneous nanoprecipitation of tenofovir disoproxil fumerate: From proof of concept to in vivo pharmacokinetics of improved oral dosage
Hobson, J., Curley, P., Al-khouja, A., Siccardi, M., Flexner, C., Meyers, C., . . . Rannard, S. (2018). Solid drug nanoparticles synthesised using spontaneous nanoprecipitation of tenofovir disoproxil fumerate: From proof of concept to in vivo pharmacokinetics of improved oral dosage. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 256. Retrieved from https://www.webofscience.com/
2017
In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line
Curley, P., Giardiello, M., Liptrott, N. J., Dickens, D., Moss, D. M., Hobson, J. J., . . . Owen, A. (2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine, 2(3), 157-169. doi:10.1002/jin2.32
Simulating intestinal transporter and enzyme activity in a physiologically based pharmacokinetic model for tenofovir disoproxil fumarate.
Moss, D. M., Domanico, P., Watkins, M., Park, S., Randolph, R., Wring, S., . . . Owen, A. (2017). Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(7). doi:10.1128/AAC.00105-17
Long Acting Release of Water-Soluble Compounds Formulated as Solid Drug Nanoparticles Dispersed in Injectable Oils
Hobson, J. J., Curley, P., Al-Khouja, A., Freel Meyers, C., Flexner, C., Owen, A., & Rannard, S. (2017, July 10). Long Acting Release of Water-Soluble Compounds Formulated as Solid Drug Nanoparticles Dispersed in Injectable Oils. In Royal Society of Chemistry UK Colloids 2017. Manchester, UK.
A Proof-of-Concept for Long Acting Release of Water-Soluble Compounds as Solid Drug Nanoparticles Dispersed in Injectable Oils
Hobson, J. J., Widger, B., Farrance, K., Curley, P., Al-Khouja, A., Flexner, C., . . . Rannard, S. (2017, April 3). A Proof-of-Concept for Long Acting Release of Water-Soluble Compounds as Solid Drug Nanoparticles Dispersed in Injectable Oils. In European Nanomedicine Conference. Kings College, London.
New branched polymer architectures for nano and macro emulsion stabilisation and targeting/delivery of therapeutic molecules
Hobson, J., Edwards, S., Owen, A., & Rannard, S. (2017). New branched polymer architectures for nano and macro emulsion stabilisation and targeting/delivery of therapeutic molecules. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from https://www.webofscience.com/
Solid drug nanoparticles synthesised using water-in-oil emulsion templating and nanoprecipitation: From proof of concept to in vitro validation of long acting depot
Hobson, J., Curley, P., Al-khouja, A., Meyers, C., Flexner, C., Owen, A., & Rannard, S. (2017). Solid drug nanoparticles synthesised using water-in-oil emulsion templating and nanoprecipitation: From proof of concept to in vitro validation of long acting depot. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from https://www.webofscience.com/
2016
Improving Intestinal Permeation of Poorly Water Soluble Drugs Using Polymer Stabilised Oil-in-Water Nanoemulsions
Hobson, J. J., Slater, R., Martin, P., Owen, A., & Rannard, S. (2017, January 26). Improving Intestinal Permeation of Poorly Water Soluble Drugs Using Polymer Stabilised Oil-in-Water Nanoemulsions. In Royal Society of Chemisty: Chemical Nanosciences and Nanotecnology Network Meeting. Keele Hall.
Development and Characterisation of Antiretroviral Drugs Encapsulated in Polymer Stabilised oil-in-water Nanoemulsions
Abstract (2016). In Journal of Interdisciplinary Nanomedicine Vol. 1 (pp. 35-82). Wiley. doi:10.1002/jin2.14
Development and Characterisation of Antiretroviral Drugs Encapsulated in Polymer Stabilised Oil-in-Water Nanoemulsions
Hobson, J. J., Slater, R., Martin, P., Owen, A., & Rannard, S. (2016, September 25). Development and Characterisation of Antiretroviral Drugs Encapsulated in Polymer Stabilised Oil-in-Water Nanoemulsions. In 4th Congress on Innovation in Drug Delivery. Juan-Le-Pins, Antibes, France.
Nanoemulsions
Rannard, S., Owen, A., Hobson, J., Liptrott, N., & Chambon, P. (2016, February 3). WO2016124925, Nanoemulsions.
2013
Immunological Safety Assessment and Viral Efficacy of Novel Pickering Stabilised Nanoemulsions Containing Lopinavir and Efavirenz
Hobson, J. J., Liptrott, N., Martin, P., Ford, J., Slater, R., Rannard, S., & Owen, A. (2013, June 23). Immunological Safety Assessment and Viral Efficacy of Novel Pickering Stabilised Nanoemulsions Containing Lopinavir and Efavirenz. In Clinical Nanomedicine and Targeted Medicine. Basel, Switzerland.
Prediction of Etravirine Pharmacogenetics using a Physiologically Based Pharmacokinetic approach
Siccardi, M., Olagunju, A., Curley, P., Hobson, J., Khoo, S., Back, D., & Owen, A. (2013). Prediction of Etravirine Pharmacogenetics using a Physiologically Based Pharmacokinetic approach. In 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, USA.
2011
Development and Cytotoxic assessment of novel “Pickering-like” stabilisers for emulsion based delivery of Antiretroviral drugs
Hobson, J. J., Slater, R., Rannard, S., & Owen, A. (n.d.). Development and Cytotoxic assessment of novel “Pickering-like” stabilisers for emulsion based delivery of Antiretroviral drugs. Poster session presented at the meeting of In Vitro Toxicology Society Annual Meeting. Liverpool, UK.
Undated
Development and characterisation of antiretroviral drugs encapsulated in polymer stabilised oil-in-water nanoemulsions
Hobson, J. (n.d.). Development and characterisation of antiretroviral drugs encapsulated in polymer stabilised oil-in-water nanoemulsions. (PhD Thesis, University of Liverpool).